National Toxicology Program

National Toxicology Program

12th Report on Carcinogens (RoC)

http://ntp.niehs.nih.gov/go/roc12
12th Report on Carcinogens U.S. Department of Health and Human Services Secretary Kathleen Sebelius released the 12th Report on Carcinogens on June 10, 2011. (Press Release) (Federal Register Notice)

The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that is prepared for the HHS Secretary by the National Toxicology Program.

The report identifies agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans.


Download the 12th RoCĀ  (5.5 MB)

Newly reviewed substances in the 12th RoC

Aristolochic acids

Certain glass wool fibers (inhalable)

Cobalt-tungsten carbide: powders and hard metals

12th RoC document

Access Report Contents
  1. Introduction and the Report on Carcinogens Review Process
    1. Introduction(150 KB)
    2. NTP Report on Carcinogens Review Process(310 KB)
  2. Substances Listed in the Twelfth Report on Carcinogens
    1. Listing Status
      1. Known To Be Human Carcinogens(68 KB)
      2. Reasonably Anticipated To Be Human Carcinogens(87 KB)
    2. Substance Profiles
      1. Acetaldehyde(124 KB)
      2. 2-Acetylaminofluorene(90 KB)
      3. Acrylamide(115 KB)
      4. Acrylonitrile(106 KB)
      5. Adriamycin(90 KB)
      6. Aflatoxins(103 KB)
      7. Alcoholic Beverage Consumption(83 KB)
      8. 2-Aminoanthraquinone(109 KB)
      9. o-Aminoazotoluene(82 KB)
      10. 4-Aminobiphenyl(141 KB)
      11. 1-Amino-2,4-dibromoanthraquinone(92 KB)
      12. 1-Amino-2-methylanthraquinone(108 KB)
      13. Amitrole(137 KB)
      14. o-Anisidine and Its Hydrochloride(108 KB)
      15. Aristolochic Acids(216 KB)
      16. Arsenic and Inorganic Arsenic Compounds(109 KB)
      17. Asbestos(107 KB)
      18. Azacitidine(96 KB)
      19. Azathioprine(87 KB)
      20. Basic Red 9 Monohydrochloride(102 KB)
      21. Benzene(156 KB)
      22. Benzidine and Dyes Metabolized to Benzidine(190 KB)
        1. Benzidine
        2. Dyes Metabolized to Benzidine (Benzidine Dye Class)
      23. Benzotrichloride(94 KB)
      24. Beryllium and Beryllium Compounds(106 KB)
      25. 2,2-Bis(bromomethyl)-1,3-propanediol (Technical Grade)(85 KB)
      26. Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether(94 KB)(91.66KB)
      27. Bromodichloromethane(100 KB)
      28. 1,3-Butadiene(136 KB)
      29. 1,4-Butanediol Dimethanesulfonate(79 KB)
      30. Butylated Hydroxyanisole(94 KB)
      31. Cadmium and Cadmium Compounds(116 KB)
      32. Captafol(201 KB)
      33. Carbon Tetrachloride(163 KB)
      34. Ceramic Fibers (Respirable Size)(102 KB)
      35. Chlorambucil(89 KB)
      36. Chloramphenicol(154 KB)
      37. Chlorendic Acid(91 KB)
      38. Chlorinated Paraffins (C12, 60% Chlorine)(96 KB)
      39. Chloroform(178 KB)
      40. 3-Chloro-2-methylpropene(91 KB)
      41. 4-Chloro-o-phenylenediamine(115 KB)
      42. Chloroprene(105 KB)
      43. p-Chloro-o-toluidine and Its Hydrochloride(160 KB)
      44. Chromium Hexavalent Compounds(136 KB)
      45. Cisplatin(141 KB)
      46. Coal Tars and Coal-Tar Pitches(110 KB)
      47. Cobalt Sulfate(148 KB)
      48. CobaltTungsten Carbide: Powders and Hard Metals(175 KB)
      49. Coke-Oven Emissions(88 KB)
      50. p-Cresidine(126 KB)
      51. Cupferron(83 KB)
      52. Cyclophosphamide(109 KB)
      53. Cyclosporin A(144 KB)
      54. Dacarbazine(128 KB)
      55. Danthron(128 KB)
      56. 2,4-Diaminoanisole Sulfate(129 KB)
      57. 2,4-Diaminotoluene(98 KB)
      58. Diazoaminobenzene(133 KB)
      59. 1,2-Dibromo-3-chloropropane(140 KB)
      60. 1,2-Dibromoethane(117 KB)
      61. 2,3-Dibromo-1-propanol(123 KB)
      62. 1,4-Dichlorobenzene(122 KB)
      63. 3,3'-Dichlorobenzidine and Its Dihydrochloride(123 KB)
      64. Dichlorodiphenyltrichloroethane(165 KB)
      65. 1,2-Dichloroethane(158 KB)
      66. Dichloromethane(160 KB)
      67. 1,3-Dichloropropene (Technical Grade)(125 KB)
      68. Diepoxybutane(126 KB)
      69. Diesel Exhaust Particulates(116 KB)
      70. Di(2-ethylhexyl) Phthalate(183 KB)
      71. Diethylstilbestrol(162 KB)
      72. Diethyl Sulfate(139 KB)
      73. Diglycidyl Resorcinol Ether(122 KB)
      74. 3,3'-Dimethoxybenzidine and Dyes Metabolized to 3,3'-Dimethoxybenzidine(138 KB)
        1. 3,3'-Dimethoxybenzidine
        2. Dyes Metabolized to 3,3'-Dimethoxybenzidine (3,3'-Dimethoxybenzidine Dye Class)
      75. 4-Dimethylaminoazobenzene(139 KB)
      76. 3,3'-Dimethylbenzidine and Dyes Metabolized to 3,3'-Dimethylbenzidine(184 KB)
        1. 3,3'-Dimethylbenzidine
        2. Dyes Metabolized to 3,3'-Dimethylbenzidine (3,3'-Dimethylbenzidine Dye Class)
      77. Dimethylcarbamoyl Chloride(124 KB)
      78. 1,1-Dimethylhydrazine(141 KB)
      79. Dimethyl Sulfate(136 KB)
      80. Dimethylvinyl Chloride(121 KB)
      81. 1,4-Dioxane(174 KB)
      82. Disperse Blue(140 KB)
      83. Epichlorohydrin(181 KB)
      84. Erionite(87 KB)
      85. Estrogens, Steroidal(138 KB)
      86. Ethylene Oxide(195 KB)
      87. Ethylene Thiourea(117 KB)
      88. Ethyl Methanesulfonate(88 KB)
      89. Formaldehyde(287 KB) [See Addendum]
      90. Furan(171 KB)
      91. Certain Glass Wool Fibers (Inhalable)(209 KB)
      92. Glycidol(138 KB)
      93. Hepatitis B Virus(103 KB)
      94. Hepatitis C Virus(104 KB)
      95. Heterocyclic Amines (Selected)(239 KB)
        1. 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline
        2. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
        3. 2-Amino-3-methylimidazo[4,5-f]quinoline
        4. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
      96. Hexachlorobenzene(183 KB)
      97. Hexachloroethane(171 KB)
      98. Hexamethylphosphoramide(142 KB)
      99. Human Papillomaviruses: Some Genital-Mucosal Types(112 KB)
      100. Hydrazine and Hydrazine Sulfate(175 KB)
      101. Hydrazobenzene(147 KB)
      102. Ionizing Radiation(203 KB)
        1. X-Radiation and Gamma Radiation
        2. Neutrons
        3. Radon
        4. Thorium Dioxide
      103. Iron Dextran Complex(93 KB)
      104. Isoprene(200 KB)
      105. Kepone(146 KB)
      106. Lead and Lead Compounds(142 KB)
      107. Lindane, Hexachlorocyclohexane (Technical Grade), and Other Hexachlorocyclohexane Isomers(174 KB)
      108. Melphalan(137 KB)
      109. Methoxsalen with Ultraviolet A Therapy(152 KB)
      110. 2-Methylaziridine(145 KB)
      111. 4,4'-Methylenebis(2-chloroaniline)(168 KB)
      112. 4,4'-Methylenebis(N,N-dimethyl)benzenamine(99 KB)
      113. 4,4'-Methylenedianiline and Its Dihydrochloride(164 KB)
      114. Methyleugenol(157 KB)
      115. Methyl Methanesulfonate(127 KB)
      116. Metronidazole(101 KB)
      117. Michlers Ketone(137 KB)
      118. Mineral Oils: Untreated and Mildly Treated(95 KB)
      119. Mirex(166 KB)
      120. Mustard Gas(139 KB)
      121. Naphthalene(170 KB)
      122. 2-Naphthylamine(148 KB)
      123. Nickel Compounds and Metallic Nickel(137 KB)
        1. Nickel Compounds
        2. Metallic Nickel
      124. Nitrilotriacetic Acid(153 KB)
      125. o-Nitroanisole(146 KB)
      126. Nitroarenes (Selected)(339 KB)
        1. 1,6-Dinitropyrene
        2. 1,8-Dinitropyrene
        3. 6-Nitrochrysene
        4. 1-Nitropyrene
        5. 4-Nitropyrene
      127. Nitrobenzene(156 KB)
      128. Nitrofen(100 KB)
      129. Nitrogen Mustard Hydrochloride(151 KB)
      130. Nitromethane(149 KB)
      131. 2-Nitropropane(154 KB)
      132. N-Nitrosamines: 15 Listings(445 KB)
        1. N-Methyl-N'-Nitro-N-Nitrosoguanidine
        2. N-Nitrosodi-n-butylamine
        3. N-Nitrosodiethanolamine
        4. N-Nitrosodiethylamine
        5. N-Nitrosodimethylamine
        6. N-Nitrosodi-n-propylamine
        7. N-Nitroso-N-ethylurea
        8. 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
        9. N-Nitroso-N-methylurea
        10. N-Nitrosomethylvinylamine
        11. N-Nitrosomorpholine
        12. N-Nitrosonornicotine
        13. N-Nitrosopiperidine
        14. N-Nitrosopyrrolidine
        15. N-Nitrososarcosine
      133. Nitrosourea Chemotherapeutic Agents(294 KB)
        1. Bis(chloroethyl) Nitrosourea
        2. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
        3. 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
        4. Chlorozotocin
        5. Streptozotocin
      134. o-Nitrotoluene(207 KB)
      135. Norethisterone(146 KB)
      136. Ochratoxin A(182 KB)
      137. 4,4'-Oxydianiline(149 KB)
      138. Oxymetholone(111 KB)
      139. Phenacetin and Analgesic Mixtures Containing Phenacetin(105 KB)
        1. Phenacetin
        2. Analgesic Mixtures Containing Phenacetin
      140. Phenazopyridine Hydrochloride(137 KB)
      141. Phenolphthalein(119 KB)
      142. Phenoxybenzamine Hydrochloride(96 KB)
      143. Phenytoin and Phenytoin Sodium(210 KB)
      144. Polybrominated Biphenyls(169 KB)
      145. Polychlorinated Biphenyls(148 KB)
      146. Polycyclic Aromatic Hydrocarbons: 15 Listings(218 KB)
        1. Benz[a]anthracene
        2. Benzo[b]fluoranthene
        3. Benzo[j]fluoranthene
        4. Benzo[k]fluoranthene
        5. Benzo[a]pyrene
        6. Dibenz[a,h]acridine
        7. Dibenz[a,j]acridine
        8. Dibenz[a,h]anthracene
        9. 7H-Dibenzo[c,g]carbazole
        10. Dibenzo[a,e]pyrene
        11. Dibenzo[a,h]pyrene
        12. Dibenzo[a,i]pyrene
        13. Dibenzo[a,l]pyrene
        14. Indeno[1,2,3-cd]pyrene
        15. 5-Methylchrysene
      147. Procarbazine and Its Hydrochloride(156 KB)
      148. Progesterone(167 KB)
      149. 1,3-Propane Sultone(147 KB)
      150. β-Propiolactone(110 KB)
      151. Propylene Oxide(166 KB)
      152. Propylthiouracil(147 KB)
      153. Reserpine(109 KB)
      154. Riddelliine(196 KB)
      155. Safrole(156 KB)
      156. Selenium Sulfide(143 KB)
      157. Silica, Crystalline (Respirable Size)(106 KB)
      158. Soots(88 KB)
      159. Strong Inorganic Acid Mists Containing Sulfuric Acid(185 KB)
      160. Styrene(363 KB)
      161. Styrene-7,8-oxide(167 KB)
      162. Sulfallate(137 KB)
      163. Tamoxifen(186 KB)
      164. 2,3,7,8-Tetrachlorodibenzo-p-dioxin(190 KB)
      165. Tetrachloroethylene(181 KB)
      166. Tetrafluoroethylene(157 KB)
      167. Tetranitromethane(148 KB)
      168. Thioacetamide(146 KB)
      169. 4,4'-Thiodianiline(106 KB)
      170. Thiotepa(150 KB)
      171. Thiourea(155 KB)
      172. Tobacco-Related Exposures(156 KB)
        1. Tobacco Smoking
        2. Environmental Tobacco Smoke
        3. SmokelessTobacco
      173. Toluene Diisocyanates(196 KB)
      174. o-Toluidine and Its Hydrochloride(122 KB)
      175. Toxaphene(123 KB)
      176. Trichloroethylene(213 KB)
      177. 2,4,6-Trichlorophenol(174 KB)
      178. 1,2,3-Trichloropropane(177 KB)
      179. Tris(2,3-dibromopropyl) Phosphate(159 KB)
      180. Ultraviolet Radiation Related Exposures(136 KB)
        1. Solar Radiation
        2. Exposure to Sunlamps or Sunbeds
        3. Broad-Spectrum UVR
        4. UVA
        5. UVB
        6. UVC
      181. Urethane(177 KB)
      182. 4-Vinyl-1-cyclohexene Diepoxide(149 KB)
      183. Vinyl Halides (Selected)(166 KB)
        1. Vinyl Bromide
        2. Vinyl Chloride
        3. Vinyl Fluoride
      184. Wood Dust(106 KB)
    3. Glossary(190 KB)
    4. Acronyms and Abbreviations(77 KB)
    5. Units of Measurement(76 KB)
  3. Appendix A: Manufacturing Processes, Occupations, and Exposure Circumstances Classified by IARC as Category 1, Carcinogenic To Humans(67 KB)
  4. Appendix B: Substances Delisted from the Report on Carcinogens(132 KB)
  5. Appendix C: Substances Reviewed but Not Recommended for Listing in the Report on Carcinogens(67 KB)
  6. Appendix D: List of Participants(117 KB)
  7. Appendix E: Chemicals Nominated to the NTP in Fiscal Years 2004 to 2009 for In-Depth Toxicological Evaluation(204 KB)
  8. Appendix F: Substance Names and Common Synonyms(165 KB)
  9. Appendix G: List of Substances by CAS Number(84 KB)

Addendum to the 12th RoC(70 KB)
Official Citation: NTP. 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. 499 pp.

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