National Toxicology Program

CASRN: 99-59-2

Formula: C7-H8-N2-O3

Synonyms/Common Names:

• 2-METHOXY-5-NITROBENZENAMINE (9CI)

Known Uses:

Dye intermediate

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01934)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01934)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.05,0.4 %/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01934)  Report Complete 
  • TR-127 (NIH Number: 78-1382; NTIS Number: PB287411)  (Peer Review Approval 06/29/1978A )
    Bioassay of 5-Nitro-o-anisidine for Possible Carcinogenicity (CASRN 99-59-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Equivocal 
  • Female Mice Positive 
  • Dose: R: 0,.4,.8, M: 0,.4,.8,1.6 %/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (509998)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberation Negative 
• Drosophila  (168140)  Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (241914)  Completed 
  • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
• Drosophila  (313175)  Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
• Salmonella  (116557)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive