National Toxicology Program

National Toxicology Program

Dimethyl morpholinophosphoramidate

http://ntp.niehs.nih.gov/go/TS-10641-C

CASRN: 597-25-1

Formula: C6-H14-N-O4-P

Synonyms/Common Names:

  • DMMPA
  • 4-MORPHOLINYLPHOSPHONIC ACID DIMETHYL ESTER (9CI)

Known Uses:

Stimulant for nerve agents in chemical defense training; not produced commercially in U.S.

Short-Term Toxicity

  • 14-Day (Gavage)  (C54740)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54740)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54740)  Report Complete 
    • TR-298 (NIH Number: 86-2554; NTIS Number: PB86-186491)  (Peer Review Approval 11/02/1984A )
      Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CASRN 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • Chromosome Aberrations  (963455)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (499883)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Drosophila  (475748)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (652921)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (960949)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 
  • Sister Chromatid Exchanges  (963445)  Completed 
    • Mice
    • Sister Chromatid  Not a Valid Test 
  • Sister Chromatid Exchanges  (963455)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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