National Toxicology Program

National Toxicology Program

Polyvinyl alcohol

http://ntp.niehs.nih.gov/go/TS-9002895

CASRN: 9002-89-5

Formula: (C2-H4-O)x-

Synonyms/Common Names:

  • HOMOPOLYMER ETHANOL (9CI)
  • VINYL ALCOHOL, POLYMERS (8CI)

Known Uses:

PVA film for intravaginal administration of spermicides. Textile warp sizing and finishing. Adhesives. Pesticides. Pigment in TV picture tubes.

Short-Term Toxicity

  • 4 weeks (Intravaginal)  (C88066)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 20 UL OF 25% PVA - NO RESTRAINT, 20 UL OF 25% PVA WITH RESTRAINT; 50/GROUP.

Long-Term Carcinogenicity

  • 2 years (Intravaginal)  (C88066)  Report Complete 
    • TR-474 (NIH Number: 98-3964; NTIS Number: PB98-148869)  (Peer Review Approval 12/12/1996A )
      Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (CASRN 9002-89-5) in Female B6C3F1 Mice (Intravaginal Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Female Mice No Evidence 
    • Dose: 25% PVA, VEHICLE, UNTREATED; 100/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravaginal; Intravenous)  (S0695)  Completed 
    • Citation: Sanders, J.M. & Matthews, H.B. Vaginal Absorption of Polyvinyl Alcohol in Fischer 344 Rats Human Human Toxicology (1990) 9, 000-000
    • Male Rats: F344/N; Female Rats: F344/N; Male Rats: F344/N
The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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