Testing Status of Agents at NTP

beta-Thioguanidine deoxyriboside

http://ntp.niehs.nih.gov/go/TS-C01581

CASRN: 789-61-7

Formula: C10-H13-N5-O3-S

Synonyms/Common Names:

  • 2'-DEOXY-6-THIOGUANOSINE (9CI)
  • BETA-TGDR

Known Uses:

Anticancer drug

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01581)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01581)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0,3,60, M: 0,.38,3 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01581)  Report Complete 
    • TR-057 (NIH Number: 78-1363; NTIS Number: PB281540)  (Peer Review Approval 02/18/1978A )
      Bioassay of ß-TGdR for Possible Carcinogenicity (CASRN 789-61-7)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Positive 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: R: 0,3.5,7, M: 0,1,4 MG/KG/35 PER GROUP.

Back to top

Web page last updated on May 14, 2013

File Assistance: Free downloads for viewing files.

USA.gov is the U.S. government's official web portal to all federal, state, and local government web resources and services U.S. Department of Health and Human Services
The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.