National Toxicology Program

CASRN: 1763-23-1

Formula: C8-H-F17-O3-S

Synonyms/Common Names:

• C8 SULFONATE
• HEPTADECAFLUOROOCTANE-1-SULPHONIC ACID
• 1-OCTANESULFONIC ACID, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-HEPTADECAFLUORO
• PERFLUOROOCTANE SULFONIC ACID

Known Uses:

Surface-active agents in aqueous media. Chemical intermediate; acid catalyst for photoresists surfactant in fire fighting foam; surfactant for alkaline cleaners; emulsifier in floor polish; mist suppressant for metal plating baths; surfactant for etching acids for circuit boards; pesticide active ingredient for ant bait traps.

Nomination Background

Planned Carcinogenicity/Toxicity

• 4 days (Gavage) Selected (C04004)  
  • Rats: Harlan Sprague-Dawley
  • Dose: Male rats: 1 ml/mg.

Short-Term Toxicity

• 28 days (Gavage)  (C20617)  On Test 
  • Rats: Harlan Sprague-Dawley
  • Dose: M&F: 0, 0.312, 0.625, 1.25, 2.5, or 5 mg/kg.

Modified One-Generation

• Dose Range Finding Selected (MOG04004)  
  • Dose Range finding
  • Rats: Harlan Sprague-Dawley

Genetic Toxicology

• Micronucleus  (G04004)  Completed 
  • Rats
• Salmonella  (A33826)  Completed 
  •  Negative 

Organ Systems Toxicity

• 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R04046)  
  • Rats: Sprague Dawley