National Toxicology Program

CASRN: 335-67-1

Formula: C8-H-F15-O2

Synonyms/Common Names:

• C8 CARBOXYLIC ACID
• PENTADECAFLUOROOCTANOIC ACID (9CI)

Known Uses:

Dielectric liquid material proposed for use to replace PCBs in transformers

Nomination Background

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C20614B) On Test 
  • Rats: Harlan Sprague-Dawley
  • Dose: MR: 0, 20, 40, 300, 300/0, 300/20, 300/40, or 300/80 ppm
• 2-YEAR (Dosed-Feed)  (C20614) On Test 
  • Rats: Harlan Sprague-Dawley
  • Dose: FR: 0, 300, OR 1000 PPM; MR: 0, 150, OR 300; 60/SEX

Special Studies

• Cell Proliferation (Gavage)  (S0174) Completed 
  • Citation: CUNNINGHAM, ET.AL., REGULATION OF PERFLUOROOCTANOIC ACID-INDUCED PEROXISOMAL ENZYME ACTIVITIES & HEPATOCELLULAR GROWTH BY ADRENAL HORMONES, HEPATOLOGY 15:316-322,1992.
  • Male Rats: Sprague Dawley
  • Dose: 150 MG/KG

Genetic Toxicology

• Salmonella  (A98283) Completed 
  •  Equivocal 

Organ Systems Toxicity

• GD 6 to PND 21 Conventional Teratology (Gavage) Selected (R91070)  
  • Rats: Sprague Dawley