National Toxicology Program

National Toxicology Program

Indole-3-carbinol

http://ntp.niehs.nih.gov/go/TS-M990063

CASRN: 700-06-1

Formula: C9-H9-N-O

Synonyms/Common Names:

  • 3-(HYDROXYMETHYL)INDOLE
  • 1H-INDOLE-3-METHANOL (9CI)

Known Uses:

Natural component of brassica vegetables; marketed as a dietary supplement and cancer preventative agent

Nomination Background

Short-Term Toxicity

  • 90 days (Gavage)  (C20006)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 18.75, 37.5, 75, 150, OR 300 MG/KG; 20/SEX/DOSE M: 0, 15.6, 31.25, 62.5, 125, OR 250 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20006B)  Report Draft 
    • TR-584  (Peer Review Approval 05/22/2014E )
      Toxicology and Carcinogenesis Studies of Indole-3-carbinol (CASRN 700-06-1) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0, 75, 150, OR 300 MG/KG; M: 0, 62.5, 125, OR 250 MG/KG; 50/SEX/SPECIES/DOSE.

Genetic Toxicology

  • Micronucleus  (A31749)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A94530)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A34549)  Completed 
    •  Equivocal 
  • Salmonella  (A35905)  Completed 
    •  Positive 
The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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