National Toxicology Program

CASRN: 700-06-1

Formula: C9-H9-N-O

Synonyms/Common Names:

• 3-(HYDROXYMETHYL)INDOLE
• 1H-INDOLE-3-METHANOL (9CI)

Known Uses:

Natural component of brassica vegetables; marketed as a dietary supplement and cancer preventative agent

Nomination Background

Short-Term Toxicity

• 90 days (Gavage)  (C20006)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 18.75, 37.5, 75, 150, OR 300 MG/KG; 20/SEX/DOSE M: 0, 15.6, 31.25, 62.5, 125, OR 250 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C20006B)  Report Draft 
  • TR-584  (Peer Review Approval 02/00/2014E )
    Toxicology and Carcinogenesis Studies of Indole-3-carbinol (CASRN 700-06-1) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
  • Dose: R: 0, 75, 150, OR 300 MG/KG; M: 0, 62.5, 125, OR 250 MG/KG; 50/SEX/SPECIES/DOSE.

Genetic Toxicology

• Micronucleus  (A31749)  Completed 
  • Rats: Fischer 344
  • Male Negative 
• Micronucleus  (A94530)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A34549)  Completed 
  •  Equivocal 
• Salmonella  (A35905)  Completed 
  •  Positive