National Toxicology Program

National Toxicology Program

Transgenic model evaluation II (Aspartame)

http://ntp.niehs.nih.gov/go/TS-M990064

CASRN: 22839-47-0

Formula: C14-H18-N2-O5

Synonyms/Common Names:

  • ASPARTAME (TRANSGENIC MODEL EVALUATION II)
  • L-PHENYLALANINE, N-L-ALPHA-ASPARTYL-, 1-METHYL ESTER (9CI)

Known Uses:

Artificial sweetener to be tested using various strains of transgenic animal models.

Short-Term Toxicity

  • 39 weeks (Dosed-Feed)  (C99033B)  Completed 
    • GMM-01 (NIH Number: 06-4459; NTIS Number: PB2006-103430)
      Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies)
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Dose: 0, 3125, 6250, 12500, 25000 OR 50000 PPM; 15 ANIMAL/SEX/DOSE.
  • 39 weeks (Dosed-Feed)  (C99033)  Report Complete 
    • GMM-01 (NIH Number: 06-4459; NTIS Number: PB2006-103430)  (Peer Review Approval 05/22/2003A )
      Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies)
    • Mice: P53 +/- (C57BL/6); Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 3125, 6250, 12500, 25000 OR 50000 PPM; 15 ANIMALS/SEX/DOSE.
The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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