National Toxicology Program

• General Comments

The following is a list of substances that have been nominated to the RoC.

• Alkenylbenzenes (selected dietary: estragole, myristicin, isosafrole)
  • CAS # 140-67-0 (estragole), CAS # 607-91-0 (myristicin), CAS # 120-58-1 (isosafrole)
  • Naturally occurring organic chemicals used primarily as an additive, flavoring, or fragrance in food products, but may also be in other products such as cosmetic and cleaning agents.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• 1- Bromopropane
  • CAS # 106-94-5
  • Primarily used as a solvent for fats, waxes, or resins and in some spray adhesives and aerosol propellant applications. Also used as an intermediate in the synthesis of pharmaceuticals, insecticides, quarternary ammonium compounds, flavors and fragrances.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Carbon black
  • CAS # 1333-86-4
  • Family of products consisting of elemental carbon in the form of colloidal particles that rapidly form aggregates. The products are used primarily for rubber reinforcement, but are also used as black pigments and for electrical conductivity purposes.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Cumene
  • CAS # 98-82-8
  • An alkylated benzene used primarily to produce phenol and acetone.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Diesel exhaust particulates
  • A mixture of combustion products of diesel fuel; the exact composition of the mixture depends on the nature of the engine, operating conditions, lubricating oil, additives, emission control system, and fuel composition. Occupational exposure occurs primarily among miners (who use diesel power equipment), railroad workers and transportation workers such as truck drivers.
  • Currently listed as Reasonably Anticipated to be a Human Carcinogen in the 12th RoC
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Ethylbenzene
  • CAS # 100-41-4
  • An alkylated benzene used primarily for the manufacture of styrene.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Helicobacter pylori
  • Bacteria responsible for most ulcers and many cases of stomach inflammation (chronic gastritis).
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Indium compounds
  • Indium compounds are chemicals that include the metal indium. Indium phosphide is used primarily in the semiconductor industry; however, most of the semiconductor industry in the U.S. is silicon based. Other indium compounds (such as indium tin oxide) are primarily used in optoelectronics and flat panel display technology.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Iron (excess) or iron overload
  • CAS # 7439-89-6 (elemental iron)
  • Iron is a transition metal that exists mainly in the ferrous (2+) and ferric (3+) oxidation states in biological systems. It is used for medical treatment, as well as for other consumer and industrial needs. It is also found naturally in food. Iron overload disorders can be hereditary, acquired or iatrogenic.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Pentachlorophenol
  • CAS # 87-86-5
  • General biocide that has been used extensively as a fungicide, bactericide, herbicide and insecticide by agriculture and other industries. In 1987, over-the-counter use was banned and other uses restricted. The only current use of pentachlorophenol in the United States is defined as a ‘heavy duty’ wood preservative that is used primarily in the treatment of utility poles and cross arms.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Shiftwork involving light at night
  • Shift work is synonymous with irregular, odd, flexible, variable, unusual, non-standard working hours. Shift work can be with or without night work.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• ortho-Toluidine
  • CAS # 95-53-4
  • Arylamine used as an intermediate to manufacture herbicides, dyes, pigments and rubber chemicals.
  • Currently listed as Reasonably Anticipated to be a Human Carcinogen in the 12th RoC
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Trichloroethylene
  • CAS # 79-01-6
  • Halogenated alkene used mainly as an intermediate for hydrofluorocarbon production (67%) and as a degreaser for metal parts (30%). It is a major ingredient in many consumer products and has been found in food and drinking water, and the environment (ambient air, ground and tap water).
  • Currently listed as Reasonably Anticipated to be a Human Carcinogen in the 12th RoC
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Uranium (depleted)
  • Depleted uranium (DU) is a byproduct of the production of enriched uranium for use in nuclear reactors. It has a lower content of the isotope U-235 and emits fewer alpha particles than natural uranium. Because of its high density, the military uses DU for armor-piercing munitions and armor plates. It has also been used as counterbalance weight in aircraft, and radiation shielding in medical radiation therapy.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments

 
• Viruses (selected): Kaposi's sarcoma – associated herpesvirus, Epstein-Barr virus (EBV), human T-cell lymphotropic virus type 1 (HTLV-1), human immunodeficiency virus (HIV), and Merkel cell polyomavirus (MCV)
  • EBV and Kaposi's sarcoma - associated herpesvirus are members of the herpesvirus family, which are double stranded DNA viruses with a capsid, and cause characteristic lesions. EBV causes infectious mononucleosis.
  • HIV and HTLV-1 are retroviruses; HTLV-1 causes multiple disorders including an inflammatory neurological disease. HIV causes acquired immunodeficiency syndrome.
  • MCV is a non-enveloped, double-stranded DNA virus.
  • Federal Register Notice - Jan. 19, 2012
  • Public Comments