TR 395 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) PROBENECID NTP Experiment-Test: 05030-02 Report: PEIRPT03 Study Type: CHRONIC Date: 09/04/94 Route: GAVAGE Time: 15:09:51 Facility: TSI Mason Research Chemical CAS #: 000057669 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG FEMALE LF HF ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund 9 9 9 Dead 8 7 9 Accident 1 Survivors Terminal Sacrifice 32 31 32 Moribund 1 Other 1 1 Animals Examined Microscopically 49 49 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (48) (15) (49) Lymphoid Nodule, Hyperplasia 1 (7%) Intestine Small, Ileum (47) (16) (46) Necrosis 1 (2%) Lymphoid Nodule, Hyperplasia 1 (2%) Intestine Small, Jejunum (46) (14) (44) Necrosis 1 (2%) Lymphoid Nodule, Hemorrhage 1 (2%) Lymphoid Nodule, Hyperplasia 1 (2%) Liver (48) (49) (49) Angiectasis 2 (4%) Basophilic Focus 2 (4%) 2 (4%) Clear Cell Focus 1 (2%) Congestion 1 (2%) Cyst 2 (4%) Eosinophilic Focus 2 (4%) Fatty Change 1 (2%) Fatty Change, Diffuse 1 (2%) 1 (2%) Fatty Change, Focal 2 (4%) 8 (16%) 2 (4%) Hematopoietic Cell Proliferation 1 (2%) 7 (14%) 7 (14%) Mineralization 2 (4%) Necrosis 10 (21%) 4 (8%) 4 (8%) Necrosis, Coagulative 1 (2%) 1 (2%) Bile Duct, Hyperplasia, Cystic 1 (2%) Mesentery (3) (5) (9) Hemorrhage 1 (20%) Inflammation, Acute 1 (33%) 3 (60%) 8 (89%) Inflammation, Chronic Active 1 (33%) Fat, Inflammation, Chronic Active 1 (33%) 1 (20%) Fat, Necrosis 1 (33%) 1 (20%) 1 (11%) Pancreas (48) (19) (47) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG FEMALE LF HF ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Acinus, Atrophy 1 (2%) Acinus, Hyperplasia 2 (4%) Salivary Glands (45) (15) (49) Mineralization 1 (2%) Stomach, Forestomach (47) (49) (49) Acanthosis 11 (23%) 11 (22%) 7 (14%) Hyperkeratosis 14 (30%) 12 (24%) 9 (18%) Inflammation, Acute 2 (4%) 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) Mineralization 1 (2%) Necrosis 2 (4%) 6 (12%) 1 (2%) Stomach, Glandular (46) (48) (48) Dilatation 1 (2%) Hyperplasia 5 (11%) 14 (29%) 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) Necrosis 1 (2%) Pigmentation 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (15) (49) Cardiomyopathy 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (48) (14) (49) Capsule, Hyperplasia 38 (79%) 7 (50%) 43 (88%) Adrenal Gland, Cortex (48) (14) (49) Accessory Adrenal Cortical Nodule 1 (2%) Cyst 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 1 (7%) 5 (10%) Hyperplasia 37 (77%) 7 (50%) 39 (80%) Hypertrophy 1 (2%) 1 (2%) Adrenal Gland, Medulla (44) (13) (44) Degeneration 1 (2%) Pituitary Gland (41) (13) (38) Angiectasis 1 (2%) Pars Distalis, Angiectasis 3 (7%) 5 (13%) Pars Distalis, Cyst 1 (3%) Pars Distalis, Hyperplasia 13 (32%) 2 (15%) 8 (21%) Pars Distalis, Hyperplasia, Focal 1 (2%) 1 (3%) Pars Intermedia, Hyperplasia 1 (3%) Thyroid Gland (48) (48) (48) Infiltration Cellular, Lymphocyte 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG FEMALE LF HF ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Follicle, Cyst 1 (2%) 1 (2%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (47) (48) (50) Abscess 1 (2%) 3 (6%) 11 (22%) Angiectasis 2 (4%) Cyst 4 (9%) 4 (8%) 9 (18%) Degeneration, Cystic 12 (26%) 9 (19%) 7 (14%) Hemorrhage 2 (4%) 1 (2%) 2 (4%) Hyperplasia 1 (2%) 1 (2%) Inflammation, Acute 1 (2%) Mineralization 2 (4%) 1 (2%) Pigmentation 3 (6%) 1 (2%) Bilateral, Abscess 4 (8%) Uterus (48) (30) (50) Angiectasis 1 (2%) Cyst 1 (3%) Hemorrhage 1 (2%) 1 (2%) Hyperplasia 1 (2%) Inflammation, Acute 1 (2%) 2 (7%) 2 (4%) Mineralization 1 (2%) Necrosis 1 (3%) 1 (2%) Endometrium, Hyperplasia 36 (75%) 14 (47%) 33 (66%) Vagina (1) (1) Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (48) (14) (49) Myelofibrosis 13 (27%) 5 (10%) Lymph Node (43) (26) (45) Hematopoietic Cell Proliferation 1 (2%) Lumbar, Angiectasis 1 (4%) Lumbar, Hematopoietic Cell Proliferation 3 (12%) 6 (13%) Lumbar, Infiltration Cellular, Plasma Cell 1 (2%) 8 (31%) 5 (11%) Lumbar, Infiltration Cellular, Histiocyte 1 (4%) Mandibular, Hematopoietic Cell Proliferation 2 (4%) Mandibular, Infiltration Cellular, Plasma a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG FEMALE LF HF ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Cell 1 (2%) Mediastinal, Hematopoietic Cell Proliferation 1 (2%) Mediastinal, Infiltration Cellular, Plasma Cell 2 (8%) 1 (2%) Pancreatic, Angiectasis 1 (2%) Pancreatic, Hematopoietic Cell Proliferation 1 (4%) 2 (4%) Renal, Hematopoietic Cell Proliferation 2 (8%) 4 (9%) Renal, Hemorrhage 1 (4%) Renal, Infiltration Cellular, Plasma Cell 1 (2%) 8 (31%) 3 (7%) Renal, Infiltration Cellular, Histiocyte 1 (4%) Lymph Node, Mesenteric (41) (20) (44) Angiectasis 4 (10%) 4 (9%) Depletion Lymphoid 1 (2%) Hematopoietic Cell Proliferation 3 (7%) 2 (10%) 7 (16%) Hemorrhage 1 (5%) Infiltration Cellular, Plasma Cell 1 (2%) 3 (15%) 2 (5%) Infiltration Cellular, Histiocyte 1 (5%) Necrosis 1 (2%) Spleen (48) (25) (49) Angiectasis 1 (2%) Atrophy 1 (2%) Hematopoietic Cell Proliferation 24 (50%) 15 (60%) 32 (65%) Hemorrhage 1 (4%) Necrosis 1 (2%) Thrombosis 1 (4%) Lymphoid Follicle, Hyperplasia 2 (4%) 3 (6%) Thymus (42) (12) (42) Angiectasis 1 (2%) Depletion Lymphoid 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (46) (16) (48) Bacterium 1 (2%) Cyst Epithelial Inclusion 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG FEMALE LF HF ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (23) (49) Bacterium 2 (4%) Congestion 1 (2%) Hemorrhage 4 (8%) 1 (4%) 1 (2%) Infiltration Cellular, Histiocyte 2 (4%) 1 (4%) 1 (2%) Inflammation, Acute 4 (8%) Inflammation, Chronic Active 2 (9%) Pleura, Abscess 2 (9%) Pleura, Inflammation, Acute 2 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (1) (2) Mineralization 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (48) (19) (49) Cyst 1 (2%) Degeneration 1 (2%) Hydronephrosis 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 1 (5%) Cortex, Mineralization 1 (2%) 1 (5%) 1 (2%) Papilla, Mineralization 1 (2%) 2 (4%) Renal Tubule, Pigmentation 1 (2%) Renal Tubule, Regeneration 1 (2%) Urinary Bladder (44) (13) (47) Edema 1 (2%) Infiltration Cellular, Polymorphonuclear 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG MALE LM HM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Dead 7 6 13 Moribund 5 19 13 Gavage Death 2 Survivors Terminal Sacrifice 38 23 24 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (40) (40) Hemorrhage 1 (2%) Intestine Large (49) (49) (47) Anus, Inflammation, Chronic Active 1 (2%) Anus, Necrosis 1 (2%) Intestine Large, Colon (49) (49) (47) Lymphoid Nodule, Hyperplasia 2 (4%) Intestine Large, Rectum (48) (45) (40) Inflammation, Acute 1 (3%) Necrosis 1 (3%) Intestine Small, Duodenum (48) (45) (42) Necrosis 1 (2%) Intestine Small, Ileum (48) (44) (43) Epithelium, Hyperplasia 1 (2%) Lymphoid Nodule, Hyperplasia 1 (2%) 2 (5%) Intestine Small, Jejunum (48) (43) (39) Lymphoid Nodule, Hyperplasia 1 (2%) Liver (50) (50) (50) Angiectasis 1 (2%) Clear Cell Focus 2 (4%) Cyst 1 (2%) 1 (2%) Fatty Change, Focal 2 (4%) 1 (2%) 2 (4%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hemorrhage 1 (2%) Mineralization 3 (6%) Necrosis 4 (8%) 8 (16%) 14 (28%) Necrosis, Coagulative 1 (2%) Pigmentation 2 (4%) Mesentery (1) (2) (1) Fat, Inflammation, Chronic Active 1 (100%) Fat, Mineralization 1 (100%) Fat, Necrosis 2 (100%) Pancreas (47) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG MALE LM HM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Acinus, Atrophy 1 (2%) Acinus, Hypertrophy 2 (4%) Stomach (49) (50) (48) Submucosa, Inflammation, Chronic Active 1 (2%) Stomach, Forestomach (49) (50) (48) Acanthosis 2 (4%) 3 (6%) 7 (15%) Acanthosis, Focal 1 (2%) 1 (2%) Hyperkeratosis 7 (14%) 5 (10%) 10 (21%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 2 (4%) Necrosis 3 (6%) 4 (8%) Stomach, Glandular (47) (50) (45) Hyperplasia 2 (4%) 1 (2%) 1 (2%) Inflammation, Chronic Active 3 (6%) Mineralization 1 (2%) Necrosis 2 (4%) 1 (2%) Pigmentation 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (50) (50) Cardiomyopathy 1 (2%) Inflammation, Acute 2 (4%) Inflammation, Chronic Active 1 (2%) 1 (2%) Mineralization 2 (4%) Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (48) (50) (49) Capsule, Hyperplasia 23 (48%) 22 (44%) 30 (61%) Capsule, Hyperplasia, Focal 1 (2%) 2 (4%) Adrenal Gland, Cortex (48) (50) (49) Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%) Hemorrhage 1 (2%) Hyperplasia 22 (46%) 23 (46%) 28 (57%) Hypertrophy 1 (2%) Adrenal Gland, Medulla (48) (44) (46) Hyperplasia 7 (15%) 10 (23%) 6 (13%) Islets, Pancreatic (47) (49) (49) Hyperplasia 1 (2%) 2 (4%) Parathyroid Gland (31) (35) (28) Cyst 1 (4%) Hyperplasia 1 (4%) Pituitary Gland (38) (44) (44) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG MALE LM HM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 1 (2%) 1 (2%) Pars Distalis, Hyperplasia, Adenomatous 1 (3%) Thyroid Gland (48) (50) (47) Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (12) (15) (21) Dilatation 5 (42%) 3 (20%) 8 (38%) Inflammation, Acute 1 (8%) 2 (10%) Inflammation, Chronic 1 (7%) Inflammation, Chronic Active 4 (33%) 4 (27%) 5 (24%) Necrosis 4 (33%) 4 (27%) 4 (19%) Prostate (48) (46) (50) Inflammation, Acute 2 (4%) 2 (4%) 4 (8%) Inflammation, Chronic Active 2 (4%) Necrosis 1 (2%) Epithelium, Hyperplasia 2 (4%) Seminal Vesicle (49) (50) (50) Hemorrhage 1 (2%) Inflammation, Acute 1 (2%) 2 (4%) Inflammation, Chronic Active 1 (2%) Testes (49) (50) (50) Atrophy 1 (2%) Spermatocele 1 (2%) Interstitial Cell, Hyperplasia 1 (2%) Seminiferous Tubule, Atrophy 1 (2%) 2 (4%) 2 (4%) Seminiferous Tubule, Mineralization 1 (2%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) Angiectasis 1 (2%) Lymph Node (44) (45) (42) Axillary, Infiltration Cellular, Plasma Cell 1 (2%) 2 (4%) 1 (2%) Axillary, Infiltration Cellular, Lymphocyte 1 (2%) Inguinal, Infiltration Cellular, Lymphocyte 1 (2%) Lumbar, Hematopoietic Cell Proliferation 3 (7%) Lumbar, Hyperplasia, Plasma Cell 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG MALE LM HM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lumbar, Infiltration Cellular, Plasma Cell 2 (5%) 7 (16%) 2 (5%) Lumbar, Infiltration Cellular, Lymphocyte 1 (2%) Lumbar, Infiltration Cellular, Histiocyte 1 (2%) Lumbar, Inflammation, Acute 1 (2%) Mandibular, Necrosis 1 (2%) Mediastinal, Angiectasis 1 (2%) Mediastinal, Hematopoietic Cell Proliferation 1 (2%) Mediastinal, Infiltration Cellular, Histiocyte 1 (2%) Pancreatic, Hematopoietic Cell Proliferation 1 (2%) Renal, Hematopoietic Cell Proliferation 1 (2%) Renal, Infiltration Cellular, Plasma Cell 1 (2%) 2 (4%) 3 (7%) Renal, Infiltration Cellular, Histiocyte 2 (4%) Lymph Node, Mesenteric (44) (42) (38) Angiectasis 20 (45%) 19 (45%) 14 (37%) Hematopoietic Cell Proliferation 4 (9%) 6 (14%) 9 (24%) Necrosis 1 (3%) Spleen (49) (50) (48) Angiectasis 2 (4%) Atrophy 1 (2%) Depletion Lymphoid 2 (4%) 1 (2%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 19 (39%) 25 (50%) 29 (60%) Hyperplasia, Lymphoid 1 (2%) Necrosis 1 (2%) Lymphoid Follicle, Hyperplasia 1 (2%) Thymus (47) (36) (36) Atrophy 1 (2%) 1 (3%) 1 (3%) Depletion Lymphoid 4 (11%) 2 (6%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (47) (49) (48) Hemorrhage 1 (2%) Hyperplasia, Basal Cell 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 1 (2%) Necrosis 1 (2%) 2 (4%) Inguinal, Fungus 1 (2%) Inguinal, Inflammation, Chronic Active 1 (2%) Inguinal, Necrosis 1 (2%) Prepuce, Acanthosis 1 (2%) Prepuce, Hemorrhage 1 (2%) 1 (2%) Prepuce, Inflammation, Acute 1 (2%) Prepuce, Inflammation, Chronic Active 2 (4%) 1 (2%) Prepuce, Necrosis 2 (4%) 3 (6%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG MALE LM HM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - CONT Subcutaneous Tissue, Mineralization 1 (2%) Subcutaneous Tissue, Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (49) (50) (50) Joint, Hyperostosis 1 (2%) Tarsal, Hyperostosis 35 (71%) 33 (66%) 36 (72%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) Bacterium 1 (2%) Congestion 2 (4%) 2 (4%) Hemorrhage 6 (12%) 2 (4%) 4 (8%) Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 2 (4%) Inflammation, Acute 2 (4%) 2 (4%) 2 (4%) Necrosis 1 (2%) Pigmentation 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) Nose (40) (45) (43) Edema 1 (3%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) Atrophy 1 (2%) Bacterium 1 (2%) Casts Protein 3 (6%) 4 (8%) Congestion 1 (2%) 1 (2%) Glomerulosclerosis 4 (8%) Hydronephrosis 1 (2%) 1 (2%) Inflammation, Acute 4 (8%) 1 (2%) Inflammation, Chronic 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PROBENECID Date: 09/04/94 Route: GAVAGE Time: 15:09:51 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG MALE LM HM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Inflammation, Chronic Active 1 (2%) 1 (2%) Cortex, Mineralization 16 (33%) 4 (8%) 9 (18%) Papilla, Mineralization 2 (4%) 3 (6%) Papilla, Necrosis 1 (2%) 2 (4%) 1 (2%) Renal Tubule, Casts Protein 1 (2%) 1 (2%) Renal Tubule, Regeneration 1 (2%) 4 (8%) Urinary Bladder (48) (49) (47) Calculus Micro Observation Only 1 (2%) 2 (4%) 2 (4%) Inflammation, Acute 2 (4%) 3 (6%) Inflammation, Chronic Active 2 (4%) Mineralization 1 (2%) Necrosis 3 (6%) 1 (2%) Transitional Epithelium, Hyperplasia 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 79471-79471/79471 --multipart-boundary--