TDMS Study 05098-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
P-NITROPHENOL
NTP Experiment-Test: 05098-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
Facility: Hazleton, Maryland
Chemical CAS #: 100-02-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Moribund Sacrifice 20 27 22 25
Natural Death 5 7 5 7
Accidently Killed 1
Survivors
Terminal Sacrifice 35 26 33 27
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (53) (56) (54)
Adenocarcinoma 1 (2%)
Intestine Large, Cecum (57) (56) (59) (56)
Intestine Large, Colon (56) (56) (58) (57)
Adenocarcinoma 1 (2%)
Intestine Small, Duodenum (58) (56) (57) (53)
Adenocarcinoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (57) (57) (60) (56)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Jejunum (55) (54) (56) (55)
Hemangiosarcoma 1 (2%)
Liver (60) (60) (60) (60)
Hemangiosarcoma 1 (2%)
Sarcoma, Metastatic 1 (2%)
Mesentery (1) (2) (1)
Pancreas (60) (57) (60) (60)
Salivary Glands (60) (59) (60) (60)
Stomach, Forestomach (60) (60) (60) (60)
Squamous Cell Papilloma 2 (3%)
Stomach, Glandular (60) (59) (60) (60)
Fibrous Histiocytoma 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (59) (60) (60)
Adrenal Gland, Medulla (59) (58) (59) (60)
Pheochromocytoma Benign 1 (2%)
Parathyroid Gland (34) (30) (30) (25)
Pituitary Gland (54) (56) (54) (56)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (58) (58) (56) (59)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Fibrosarcoma 1 (100%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (60) (57) (60) (59)
Adenoma 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Teratoma NOS 1 (2%)
Thecoma Benign 1 (2%)
Thecoma Malignant 1 (2%)
Uterus (60) (58) (60) (59)
Adenocarcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%) 1 (2%)
Polyp Stromal 4 (7%) 2 (3%) 6 (10%) 1 (2%)
Sarcoma Stromal 1 (2%) 2 (3%) 1 (2%) 3 (5%)
Schwannoma Malignant 2 (3%)
Cervix, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (58) (60)
Lymph Node (60) (60) (60) (60)
Lymph Node, Mandibular (57) (60) (60) (60)
Lymph Node, Mesenteric (60) (57) (59) (58)
Spleen (60) (60) (60) (60)
Hemangiosarcoma 1 (2%) 1 (2%)
Page 3
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (47) (49) (42) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (43) (44) (42)
Adenocarcinoma 1 (2%)
Skin (60) (60) (60) (60)
Other, Trichoepithelioma 1 (2%)
Skin, Site of Application-No Mass (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 7 (12%) 7 (12%) 8 (13%) 6 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 4 (7%) 2 (3%) 5 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 2 (3%)
Carcinoma 1 (2%) 1 (2%)
Nose (60) (59) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Fibrosarcoma 1 (50%)
Harderian Gland (1) (2)
Adenoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Urinary Bladder (57) (54) (56) (57)
Page 4
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Lymphocytic 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 25 16 28 26
Total Primary Neoplasms 32 22 36 34
Total Animals with Benign Neoplasms 15 10 15 14
Total Benign Neoplasms 17 13 17 16
Total Animals with Malignant Neoplasms 13 8 16 17
Total Malignant Neoplasms 14 9 19 18
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Accidently Killed 4 1 3
Moribund Sacrifice 22 34 23 21
Natural Death 5 8 11 12
Survivors
Moribund Sacrifice 1 1
Terminal Sacrifice 28 17 26 23
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (51) (47) (50) (48)
Intestine Large, Colon (55) (54) (53) (54)
Carcinoma 1 (2%)
Intestine Large, Rectum (54) (51) (51) (53)
Cystadenoma 1 (2%)
Intestine Small, Ileum (56) (55) (53) (55)
Intestine Small, Jejunum (56) (51) (51) (51)
Liver (60) (59) (60) (60)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Adenoma 1 (2%) 3 (5%) 5 (8%) 1 (2%)
Mesentery (2) (2) (1)
Hemangiosarcoma 1 (50%)
Pancreas (60) (58) (60) (60)
Salivary Glands (60) (58) (60) (60)
Carcinoma 1 (2%)
Stomach (60) (59) (60) (60)
Stomach, Forestomach (59) (58) (60) (60)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (59) (58) (59) (60)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (58) (60) (60)
Capsule, Adenoma 1 (2%)
Adrenal Gland, Cortex (60) (58) (59) (59)
Adenoma 4 (7%) 6 (10%) 6 (10%) 5 (8%)
Adenoma, Multiple 1 (2%)
Bilateral, Adenoma 1 (2%)
Adrenal Gland, Medulla (60) (58) (60) (59)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (59) (56) (58) (59)
Adenoma 1 (2%)
Pituitary Gland (54) (54) (50) (52)
Pars Distalis, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2) (3)
Lipoma 1 (50%) 3 (100%)
Sarcoma 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (58) (60) (59)
Leiomyoma 1 (2%)
Prostate (56) (54) (54) (47)
Carcinoma 1 (2%)
Testes (59) (58) (59) (59)
Embryonal Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (58) (59) (59)
Lymph Node (60) (59) (60) (60)
Mediastinal, Carcinoma, Metastatic 1 (2%)
Lymph Node, Mandibular (56) (57) (60) (60)
Lymph Node, Mesenteric (57) (58) (60) (58)
Spleen (60) (58) (60) (60)
Thymus (46) (45) (43) (40)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Hemangiosarcoma 1 (2%)
Site of Application-Mass, Keratoacanthoma 1 (2%)
Site of Application-Mass, Papilloma 1 (2%)
Tail, Hemangiosarcoma 1 (2%)
Skin, Site of Application-No Mass (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (59) (60)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (60) (60)
Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (58) (60) (60)
Alveolar/Bronchiolar Adenoma 4 (7%) 9 (16%) 12 (20%) 5 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 5 (8%) 8 (14%) 6 (10%) 6 (10%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%)
Nose (60) (58) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (1) (3)
Harderian Gland (1) (2)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Urinary Bladder (57) (55) (57) (59)
Carcinoma 1 (2%)
Page 9
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia 1 (2%)
Lymphoma Malignant Histiocytic 2 (3%) 2 (3%)
Lymphoma Malignant Lymphocytic 2 (3%) 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%) 3 (5%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 20 33 33 21
Total Primary Neoplasms 24 40 45 29
Total Animals with Benign Neoplasms 13 23 22 12
Total Benign Neoplasms 13 25 27 14
Total Animals with Malignant Neoplasms 9 13 14 13
Total Malignant Neoplasms 11 15 18 15
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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