TDMS Study 05109-11 Pathology Tables
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
Facility: Battelle Columbus Laboratory
Chemical CAS #: 102-71-6
Lock Date: 07/29/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|
| 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Necrotizing | |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 3 1 1 1 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Necrotizing | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 2 |
Artery, Inflammation, Chronic Active | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 2|
Inflammation, Chronic Active | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|
| 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 2 2 |
Hyperplasia | 2 1 1 2 2 |
Hypertrophy | 3 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | |
Pars Distalis, Angiectasis | 2 3 1 2 4 3 2 2 3 3 2 2 3 3|
Pars Distalis, Cyst | X X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 3 2 2 3 3 3 2 2 2 2 3|
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
Inflammation, Chronic Active | 1 1 3 3 1 2 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
Hematocyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Glandular | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|
| 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Site of Application-No | |
Mass, Erosion | |
Face, Abscess | |
Head, Inflammation, Chronic Active | 3 |
Inguinal, Acanthosis | |
Inguinal, Inflammation, Chronic | |
Active | 1 |
Site of Application-No Mass, | |
Acanthosis | |
Site of Application-No Mass, | |
Inflammation, Chronic Active | |
Site of Application-No Mass, Ulcer, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
Hemorrhage | 1 2 2 |
Hydrocephalus | 3 2 2 3 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 4| 7| 6| 7| 4| 5| 7| 3| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 2| 3| 3| 6| 9| 3| 2| 5| 6| 3| 7| 2| 5| 4| 3| 3| 5| 7| 2| 2| 2| 1| 1|
| 3| 6| 9| 1| 0| 7| 9| 0| 9| 7| 6| 1| 4| 9| 7| 2| 0| 8| 7| 4| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3 3 3 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 2 1 1 2 2 1 2 1 2 1 1 1 1 2 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|
| 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic | 2 1 1 1 1 1 1|
Inflammation, Necrotizing | 2 |
Necrosis, Coagulative | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Necrotizing | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Artery, Inflammation, Chronic Active | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 2 1 2 2 1 1 1 1 2 2 2 1 1|
Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|
| 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 3 2 3 1 1 1 |
Hyperplasia | 2 2 2 2 1 2 |
Hypertrophy | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + M + + + + M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | X |
Pars Distalis, Angiectasis | 2 3 3 3 3 2 1 3 3 4 3 3 4 2 4 2 2|
Pars Distalis, Cyst | X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Inflammation, Chronic Active | 1 3 2 2 |
Duct, Dilatation | 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X |
Hematocyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Glandular | 2 |
Lumen, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|
| 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 2 2 2 2 2 2 2 2 2 2 4 3 2 4 1|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Site of Application-No | |
Mass, Erosion | 3 |
Face, Abscess | 4 |
Head, Inflammation, Chronic Active | |
Inguinal, Acanthosis | |
Inguinal, Inflammation, Chronic | |
Active | |
Site of Application-No Mass, | |
Acanthosis | 2 2 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 3 |
Site of Application-No Mass, Ulcer, | |
Multiple | 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X|
Hemorrhage | |
Hydrocephalus | 3 2 2 2 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 3 1 1 2 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 4| 7| 4| 5| 4| 6| 7| 5| 7| 7| 4| 6| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 5| 2| 3| 1| 5| 3| 5| 9| 5| 9| 2| 8| 3| 2| 5| 3| 9| 1| 3| 3| 3| 3|
| 7| 0| 1| 7| 9| 0| 8| 7| 0| 7| 3| 7| 1| 8| 2| 0| 9| 7| 9| 0| 3| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mononuclear Cell | 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 1 3 2 1 1 1 1 1 1 3 2 2 2 2 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5| | |
| 0| 7| 1| 8| 0| 9| 9| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Perforation | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X | 21 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X | 2 |
Hepatodiaphragmatic Nodule | X X | 11 |
Inflammation, Chronic | 1 1 1 | 21 1.1|
Inflammation, Necrotizing | | 1 2.0|
Necrosis, Coagulative | 2 | 2 2.0|
Bile Duct, Hyperplasia | 2 1 2 1 1 | 16 1.4|
Hepatocyte, Vacuolization Cytoplasmic| | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Necrotizing | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 | 5 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | | 2 4.0|
Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Inflammation, Necrotizing | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5| | |
| 0| 7| 1| 8| 0| 9| 9| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 1 1 1 1 2 | 41 1.2|
Inflammation, Chronic Active | | 1 2.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | 1 2 2 | 15 1.8|
Hyperplasia | 2 1 1 2 | 15 1.7|
Hypertrophy | | 2 2.5|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 | 9 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Craniopharyngeal Duct, Pars Distalis,| | |
Cyst | | 1 |
Pars Distalis, Angiectasis | 2 4 1 4 2 3 | 37 2.6|
Pars Distalis, Cyst | X X X X | 30 |
Pars Distalis, Hyperplasia | 2 2 3 | 18 2.3|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 | 33 2.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 2 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Hyperplasia | | 3 2.0|
Inflammation, Chronic Active | | 11 1.8|
Duct, Dilatation | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Atrophy | | 1 4.0|
Cyst | X | 3 |
Hematocyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5| | |
| 0| 7| 1| 8| 0| 9| 9| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic, Glandular | | 1 2.0|
Lumen, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 2 2 2 3 2 2 2 | 47 2.1|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Epidermis, Site of Application-No | | |
Mass, Erosion | | 1 3.0|
Face, Abscess | | 1 4.0|
Head, Inflammation, Chronic Active | | 1 3.0|
Inguinal, Acanthosis | 1 | 1 1.0|
Inguinal, Inflammation, Chronic | | |
Active | 1 | 2 1.0|
Site of Application-No Mass, | | |
Acanthosis | | 2 2.0|
Site of Application-No Mass, | | |
Inflammation, Chronic Active | | 2 2.5|
Site of Application-No Mass, Ulcer, | | |
Multiple | | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 6| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 7| 3| 1| 2| 1| 3| 2| 5| | |
| 0| 7| 1| 8| 0| 9| 9| 0| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 18 |
Hemorrhage | | 3 1.7|
Hydrocephalus | 2 3 | 10 2.4|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 1 | 16 1.4|
Alveolar Epithelium, Hyperplasia | 3 | 4 1.8|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 | 34 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 9 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 11 2.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 4.0|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 2 1 1 1 2 1 2 | 54 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|
| 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
Inflammation, Necrotizing | 4 |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hypertrophy | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 2 1 1 1 1 1 1 1 2 1|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 1 1 1 2 2 2|
Hyperplasia | 2 1 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|
| 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | |
Pars Distalis, Angiectasis | 3 4 4 2 3 2 2 2 2 3 2 4 2 1 1 2|
Pars Distalis, Cyst | X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3|
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 |
Inflammation, Chronic Active | 1 1 1 2 2 3 1|
Duct, Dilatation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 1 2 2 3 1 2 2 1 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|
| 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Site of Application-No | |
Mass, Erosion | 3 |
Inguinal, Acanthosis | 2 |
Inguinal, Inflammation, Chronic | |
Active | 1 |
Site of Application-No Mass, | |
Acanthosis | 2 2 2 2 1|
Site of Application-No Mass, | |
Inflammation, Chronic Active | 4 2 2 2 |
Site of Application-No Mass, Ulcer, | |
Multiple | 4 3 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Maxilla, Abscess | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X |
Hydrocephalus | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 |
Inflammation, Necrotizing | 4 |
Metaplasia, Osseous | 1 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1|
Perivascular, Edema | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 4| 5| 4| 7| 7| 5| 5| 6|
DAY ON TEST | 3| 3| 2| 3| 3| 0| 3| 3| 0| 4| 5| 3| 2| 3| 3| 5| 3| 5| 9| 5| 1| 2| 7| 3| 6|
| 1| 1| 9| 1| 4| 4| 0| 1| 8| 3| 7| 0| 9| 0| 0| 7| 0| 7| 5| 7| 5| 9| 9| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 2 1 2 2 1 2 2 2 1 1 2 1 3 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|
DAY ON TEST | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|
| 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | 1 1 1 2 1 1|
Inflammation, Necrotizing | |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 1 1 3 2 1 2 1|
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 3 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 1 2 3 1 1 |
Hyperplasia | 2 2 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|
DAY ON TEST | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|
| 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | X |
Pars Distalis, Angiectasis | 2 2 3 1 4 2 2 3 2 4 2 2 4 |
Pars Distalis, Cyst | X X X X X X X|
Pars Distalis, Hyperplasia | 2 3 2 3 2 2 2 2|
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Chronic Active | 1 1 4 1 2 1 1 1 2 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lipocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 1 2 2 1 2 2 2 2 2 1 2 2 1 3 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|
DAY ON TEST | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|
| 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Site of Application-No | |
Mass, Erosion | 3 3 3 3 3 |
Inguinal, Acanthosis | |
Inguinal, Inflammation, Chronic | |
Active | |
Site of Application-No Mass, | |
Acanthosis | 2 3 3 2 2 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 2 3 2 2 2 |
Site of Application-No Mass, Ulcer, | |
Multiple | 2 4 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 |
Maxilla, Abscess | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hydrocephalus | 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Inflammation, Necrotizing | |
Metaplasia, Osseous | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Perivascular, Edema | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 7| 7| 6| 6| 6| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 4| 6| 4|
DAY ON TEST | 5| 5| 2| 3| 0| 3| 3| 7| 9| 4| 3| 5| 3| 3| 2| 7| 3| 2| 6| 3| 6| 2| 5| 9| 5|
| 7| 7| 9| 0| 0| 0| 1| 3| 1| 9| 1| 7| 1| 1| 7| 8| 1| 9| 2| 0| 2| 9| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
63 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 2 1 2 2 2 1 2 1 1 2 2 2 2 1 1 2 1 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 5| 4| 7| 7| | |
DAY ON TEST | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3| | |
| 0| 6| 1| 9| 9| 1| 3| 7| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
63 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 3 1.0|
Basophilic Focus | X X X X X | 28 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X | 11 |
Inflammation, Chronic | 1 1 1 2 1 1 1 1 | 22 1.1|
Inflammation, Necrotizing | | 1 4.0|
Mixed Cell Focus | | 2 |
Necrosis, Coagulative | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 | 15 1.3|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.5|
Kupffer Cell, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Inflammation, Necrotizing | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 | 9 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | 3 | 4 3.3|
Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 1 1 2 1 1 1 | 33 1.2|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 5| 4| 7| 7| | |
DAY ON TEST | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3| | |
| 0| 6| 1| 9| 9| 1| 3| 7| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
63 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | 2 1 | 16 1.6|
Hyperplasia | 1 2 2 | 21 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 8 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Craniopharyngeal Duct, Pars Distalis,| | |
Cyst | | 1 |
Pars Distalis, Angiectasis | 2 4 4 2 3 2 | 35 2.5|
Pars Distalis, Cyst | X X X X | 22 |
Pars Distalis, Hyperplasia | 2 3 4 3 2 | 24 2.3|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 | 29 2.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 5 1.8|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Hyperplasia | 2 2 | 8 2.3|
Inflammation, Chronic Active | 1 2 | 19 1.6|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 3 3.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 5| 4| 7| 7| | |
DAY ON TEST | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3| | |
| 0| 6| 1| 9| 9| 1| 3| 7| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
63 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 1 3.0|
Infiltration Cellular, Lipocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 1 2 2 2 2 2 | 44 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Epidermis, Site of Application-No | | |
Mass, Erosion | | 6 3.0|
Inguinal, Acanthosis | | 1 2.0|
Inguinal, Inflammation, Chronic | | |
Active | | 1 1.0|
Site of Application-No Mass, | | |
Acanthosis | 2 | 11 2.1|
Site of Application-No Mass, | | |
Inflammation, Chronic Active | 2 | 11 2.3|
Site of Application-No Mass, Ulcer, | | |
Multiple | | 8 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Osteopetrosis | 3 | 3 3.0|
Maxilla, Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X | 15 |
Hydrocephalus | 3 2 | 9 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 2 | 18 1.1|
Inflammation, Necrotizing | | 1 4.0|
Metaplasia, Osseous | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 7| 5| 4| 7| 7| | |
DAY ON TEST | 0| 7| 3| 2| 2| 3| 8| 5| 2| 3| | |
| 0| 6| 1| 9| 9| 1| 3| 7| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
63 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mononuclear Cell | 1 1 1 1 1 1 1 | 43 1.0|
Perivascular, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 9 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | | 3 4.0|
Retina, Atrophy | | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 2 2 | 52 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|
| 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 |
Basophilic Focus | X X X X X X X X X X X X X|
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X X X|
Inflammation, Chronic | 1 1 1 1 2 1 1 1 1 1 1|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
__________________________________________________________________________|
Mesentery | + |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 2 1 |
Artery, Inflammation, Chronic Active | 3 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + M + + + + + + + + + + + + + + + + + +|
Aorta, Polyarteritis, Chronic | |
Mesenteric Artery, Polyarteritis, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|
| 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 1 3 1 1 2 |
Hyperplasia | 2 1 2 1 1 2 2 2|
Hypertrophy | 2 |
Karyomegaly | 1|
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 4 3 4 2 2 3 2 3 2 2 2 3 3 4 2 3 4 |
Pars Distalis, Cyst | X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 3 3 3 2 2|
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 1 1 1 2 2 1 |
Duct, Dilatation | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Infiltration | |
Cellular, Mononuclear Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|
| 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 1 1 3 2 3 2 1 2 3 2 2 2 3 1 2 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Site of Application-No | |
Mass, Erosion | 3 3 3 3 3 3 3 3 |
Inguinal, Inflammation, Chronic | |
Active | 1 1 |
Site of Application-No Mass, | |
Acanthosis | 2 1 1 2 2 2 2 2 2 2 3 3 2 2 2 2 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 |
Site of Application-No Mass, Ulcer | 2 2 |
Site of Application-No Mass, Ulcer, | |
Multiple | 4 3 2 2 4 4 4 4 4 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
Hydrocephalus | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Mediastinum, Polyarteritis, | |
Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 6| 4| 7| 7| 7| 6| 7| 6| 3| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 1| 3| 3| 2| 5| 2| 5| 3| 5| 4| 5| 0| 2| 3| 0| 3| 7| 9| 1| 3| 2| 3| 3|
| 4| 5| 4| 0| 0| 9| 7| 9| 7| 9| 7| 8| 7| 0| 9| 0| 0| 1| 3| 9| 9| 1| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 4 4 4 |
Retina, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 2 2 2 1 2 1 2 1 1 1 2 2 1 2 1 2 1 3 2|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|
| 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 1 1 2 1 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 2|
Hepatocyte, Vacuolization Cytoplasmic| 3|
__________________________________________________________________________|
Mesentery | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 2 1 2 2 1 |
Artery, Inflammation, Chronic Active | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 3|
Epithelium, Hyperplasia | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Polyarteritis, Chronic | 2 |
Mesenteric Artery, Polyarteritis, | |
Chronic | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|
| 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 2 1 1 1 2 1 1 3|
Hyperplasia | 2 1 2 1 1 2 2 |
Hypertrophy | 2|
Karyomegaly | |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1 3 2 2 2 2 1 2 2 4 2|
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 4|
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 3 1 |
Duct, Dilatation | 3 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node | + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Mediastinal, Sinus, Infiltration | |
Cellular, Mononuclear Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|
| 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Granuloma | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 2 1 2 2 2 2 2 2 3 2 3 2 2 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Site of Application-No | |
Mass, Erosion | 3 3 3 3 3 |
Inguinal, Inflammation, Chronic | |
Active | |
Site of Application-No Mass, | |
Acanthosis | 3 2 2 2 2 1 3 2 3 2 2 2 3 2 2 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 2 2 1 3 2 2 2 4 2 2 2 3 2 2 |
Site of Application-No Mass, Ulcer | 1 2 1 |
Site of Application-No Mass, Ulcer, | |
Multiple | 3 3 4 4 2 4 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hydrocephalus | 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Mediastinum, Polyarteritis, | |
Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 5| 5| 5| 2| 7| 9| 3| 4| 1| 3| 3| 2| 1| 3| 9| 3| 7| 1| 8| 3| 2| 3| 2| 5| 3|
| 7| 7| 7| 2| 0| 1| 0| 4| 8| 1| 0| 9| 0| 1| 3| 0| 7| 9| 4| 0| 9| 0| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 2 2 2 1 2 2 1 3 1 1 2 2 2 1 1 2 1 2|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7| | |
| 0| 8| 7| 1| 9| 9| 9| 7| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 3 2.0|
Basophilic Focus | X X X X X | 31 |
Eosinophilic Focus | X | 5 |
Hepatodiaphragmatic Nodule | X X X X | 12 |
Inflammation, Chronic | 1 1 1 1 1 | 29 1.1|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 | 18 1.2|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Perivascular, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 1 | 17 1.3|
Artery, Inflammation, Chronic Active | | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | | 2 3.5|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
Aorta, Polyarteritis, Chronic | | 1 2.0|
Mesenteric Artery, Polyarteritis, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7| | |
| 0| 8| 7| 1| 9| 9| 9| 7| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 1 1 2 1 1 | 41 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | 1 | 19 1.5|
Hyperplasia | 2 1 | 17 1.6|
Hypertrophy | | 2 2.0|
Karyomegaly | | 1 1.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 57 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 4 3 3 4 2 | 36 2.6|
Pars Distalis, Cyst | X X X X | 33 |
Pars Distalis, Hyperplasia | | 20 2.3|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 | 27 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 2 1 | 10 1.7|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Hyperplasia | 3 4 | 4 3.0|
Inflammation, Chronic Active | 3 1 1 1 2 | 20 1.4|
Duct, Dilatation | | 4 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7| | |
| 0| 8| 7| 1| 9| 9| 9| 7| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Mediastinal, Sinus, Infiltration | | |
Cellular, Mononuclear Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Sinus, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + | 57 |
Granuloma | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 2 2 2 2 1 3 1 2 | 50 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Epidermis, Site of Application-No | | |
Mass, Erosion | 3 3 3 | 16 3.0|
Inguinal, Inflammation, Chronic | | |
Active | | 2 1.0|
Site of Application-No Mass, | | |
Acanthosis | 2 2 3 3 2 3 | 37 2.2|
Site of Application-No Mass, | | |
Inflammation, Chronic Active | 2 2 2 3 2 1 | 37 2.1|
Site of Application-No Mass, Ulcer | 2 2 | 7 1.7|
Site of Application-No Mass, Ulcer, | | |
Multiple | 2 4 3 | 22 3.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 3| 2| 3| 2| 5| 3| 7| | |
| 0| 8| 7| 1| 9| 9| 9| 7| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | 2 3 2 | 10 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 | 17 1.1|
Alveolar Epithelium, Hyperplasia | | 1 4.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 1 | 37 1.0|
Artery, Mediastinum, Polyarteritis, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 1 2 | 8 1.6|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 | 9 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 6 |
Lens, Cataract | | 5 4.0|
Retina, Atrophy | 4 | 6 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 3 1 1 1 1 3 1 1 | 49 1.6|
Cortex, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|
DAY ON TEST | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|
| 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 2 1 |
Bile Duct, Hyperplasia | 2 1 1 2 1 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Perivascular, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 3 |
Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 3 1 |
Hyperplasia | 1 2 1 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|
DAY ON TEST | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|
| 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + M + + M + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 2 2 4 3 2 4 2 3 |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 1 1 3 1 2 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Horn, Dilatation | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 2 2 2 1 1 2 2 1 1 2 3 1 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|
DAY ON TEST | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|
| 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Epidermis, Site of Application-No | |
Mass, Erosion | 3 2 3 3 1 |
Head, Acanthosis | |
Head, Inflammation, Chronic Active | |
Head, Ulcer | |
Inguinal, Inflammation, Chronic | |
Active | 2 |
Site of Application-No Mass, | |
Acanthosis | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2|
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 3 3 1 2 2 2|
Site of Application-No Mass, Ulcer | 2 1 1 1 4 1 |
Site of Application-No Mass, Ulcer, | |
Multiple | 3 4 2 4 2 2|
Tail, Acanthosis | 2 |
Tail, Hyperkeratosis | 3 |
Tail, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | |
Hydrocephalus | 2 2 3 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Myelin, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 2 1 1 1 2 |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 4| 6| 4| 4| 7| 4| 4| 7| 7| 7| 7| 3| 6| 4| 4| 7| 6| 5| 3| 3|
DAY ON TEST | 6| 5| 1| 3| 5| 5| 7| 5| 5| 0| 5| 5| 2| 3| 2| 2| 5| 3| 6| 3| 3| 9| 2| 8| 5|
| 7| 7| 0| 1| 7| 7| 0| 7| 7| 0| 7| 7| 9| 0| 9| 9| 3| 3| 3| 9| 1| 0| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 1 2 2 2 1 2 2 3 1 1 2 2 1 1 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|
DAY ON TEST | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|
| 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 2 1 2 2 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 1 1 1 2|
Hepatocyte, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 2 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 1 2 2 2 2 |
Hyperplasia | 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|
DAY ON TEST | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|
| 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + M + + + + + + + M + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 2 4 3 3 4 3 2 2 2|
Pars Distalis, Cyst | X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 1 2 2 2 4 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Inflammation, Chronic Active | 1 2 3 |
Duct, Dilatation | 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Horn, Dilatation | 3 3 |
Lumen, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 1 2 2 2 2 2 2 2 4 1 2 2 1 4 2 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|
DAY ON TEST | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|
| 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Epidermis, Site of Application-No | |
Mass, Erosion | 3 3 3 3 3 3 3 |
Head, Acanthosis | 2 2 |
Head, Inflammation, Chronic Active | 2 2 |
Head, Ulcer | 4 |
Inguinal, Inflammation, Chronic | |
Active | |
Site of Application-No Mass, | |
Acanthosis | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 2 2 2 3 1 3 2 2 2 2 2 3 2 2 2 3 |
Site of Application-No Mass, Ulcer | 4 2 3 |
Site of Application-No Mass, Ulcer, | |
Multiple | 3 1 3 2 2 4 3 3 4 2 2 3 |
Tail, Acanthosis | |
Tail, Hyperkeratosis | |
Tail, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | 2 |
Hydrocephalus | 2 2 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Myelin, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 1 1 |
Pigmentation, Hemosiderin | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 7| 5| 2| 6| 3| 4| 4| 6| 6| 7| 7| 1| 4| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6|
DAY ON TEST | 5| 1| 8| 5| 3| 9| 5| 5| 4| 1| 3| 3| 2| 5| 3| 1| 3| 8| 2| 3| 3| 2| 3| 5| 7|
| 7| 3| 8| 0| 1| 4| 9| 7| 4| 7| 1| 1| 5| 7| 0| 8| 0| 8| 9| 0| 1| 2| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 1 1 1 1 1 2 2 1 3 2 2 1 1 2 2 1 1 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 6| 6| 7| 7| | |
DAY ON TEST | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2| | |
| 8| 6| 9| 9| 1| 0| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X | 11 |
Eosinophilic Focus | X | 5 |
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Chronic | 1 1 1 1 | 23 1.2|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative | | 2 1.5|
Bile Duct, Hyperplasia | 2 1 | 13 1.4|
Hepatocyte, Vacuolization Cytoplasmic| | 4 1.3|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | 1 | 3 2.7|
Epithelium, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 1 1 | 36 1.2|
Atrium, Thrombosis | X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 6| 6| 7| 7| | |
DAY ON TEST | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2| | |
| 8| 6| 9| 9| 1| 0| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty | 2 | 11 1.6|
Hyperplasia | | 6 1.5|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M + + + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 1 1 3 3 4 2 4 4 | 29 2.8|
Pars Distalis, Cyst | X | 20 |
Pars Distalis, Hyperplasia | 2 3 3 | 15 2.2|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 | 10 1.7|
Duct, Dilatation | | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Horn, Dilatation | 2 | 3 2.7|
Lumen, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 5 3.4|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 6| 6| 7| 7| | |
DAY ON TEST | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2| | |
| 8| 6| 9| 9| 1| 0| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 58 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | 2 1 2 3 | 44 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Epidermis, Site of Application-No | | |
Mass, Erosion | 2 3 | 14 2.7|
Head, Acanthosis | | 2 2.0|
Head, Inflammation, Chronic Active | | 2 2.0|
Head, Ulcer | | 1 4.0|
Inguinal, Inflammation, Chronic | | |
Active | | 1 2.0|
Site of Application-No Mass, | | |
Acanthosis | 2 2 2 3 1 2 | 38 2.0|
Site of Application-No Mass, | | |
Inflammation, Chronic Active | 2 2 2 3 2 2 | 38 2.1|
Site of Application-No Mass, Ulcer | | 9 2.1|
Site of Application-No Mass, Ulcer, | | |
Multiple | 4 3 4 4 1 4 | 24 2.9|
Tail, Acanthosis | | 1 2.0|
Tail, Hyperkeratosis | | 1 3.0|
Tail, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 12 |
Hemorrhage | | 1 2.0|
Hydrocephalus | 2 3 2 3 | 13 2.3|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 6| 6| 7| 7| | |
DAY ON TEST | 5| 5| 2| 2| 3| 2| 2| 4| 2| 2| | |
| 8| 6| 9| 9| 1| 0| 4| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Sciatic, Myelin, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 2 1 | 22 1.2|
Pigmentation, Hemosiderin | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 | 34 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 8 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 4 | 1 4.0|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 1 1 2 1 2 2 1 2 | 46 1.5|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|
| 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 1 2 1 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 2 3 1 2 1 1 2 1 1 1 3 1 2 1 3 1 2 1 3 1|
Hepatocyte, Degeneration, Cystic | 2 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 4 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Necrotizing | 4 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 4 1 3 1 3 2 |
Artery, Inflammation, Chronic Active | 3 |
Artery, Thrombosis | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multiple | |
Granuloma | |
Inflammation, Necrotizing | 2 4 |
Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Erosion | 2 2 |
Inflammation, Necrotizing | 2 3 |
__________________________________________________________________________|
Tongue | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|
| 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Mesenteric Artery, Polyarteritis, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 1 2 2 2 1 2 1 2 1 2 2 2 2 1|
Inflammation, Chronic Active | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 1 1 2 2 1 |
Hyperplasia | 2 1 1 1 2 2 1 1 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 1 1 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 4 2 2 4 2 2 2 4 3 1 3 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Distalis, Infarct | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Ectasia | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 3 2 4 4 2 3 4 4 |
Mineralization | 1 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 3 2 3 2 1 1 1 2 2 2 2 2 2 1 2 3 1 3 1|
Duct, Dilatation | 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|
| 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 2 4 2 3 2 2 2 2 1 2 2 1 2 2 3 2|
Inflammation, Hemorrhagic | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 3 2 3 3 3 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 2 2 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 2 3 2 2 |
Necrosis, Coagulative | 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Cystic | 2 2 1 1 2 2 2 2 4 1 1 3 1 4 2 2 1 2 2 |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | 3 |
Inflammation, Proliferative | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-Mass, | |
Fibrosis | 4 |
Foot, Acanthosis | |
Foot, Hyperkeratosis | |
Foot, Inflammation, Chronic Active | |
Inguinal, Acanthosis | 1 |
Site of Application-No Mass, | |
Acanthosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|
| 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Abscess | 3 |
Maxilla, Fibrosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X |
Gliosis | 3 |
Hemorrhage | |
Hydrocephalus | 2 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 |
Perivascular, Edema | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 3 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 2 2 1 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hyperplasia | 3 |
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 3 2 2 3 3 2 2 3 3 2 2 2 2 3 2 2 2 3 2 2 3 3 2|
Cortex, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 5| 5| 4| 7| 7| 7| 7| 4| 7| 6| 4| 5| 4| 7| 7| 7| 6| 7| 4|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 5| 7| 5| 3| 2| 2| 2| 5| 3| 7| 5| 5| 5| 0| 3| 2| 7| 3| 5|
| 1| 1| 0| 1| 8| 1| 4| 7| 6| 0| 9| 7| 9| 6| 0| 0| 6| 0| 6| 5| 0| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Hemorrhagic | 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|
DAY ON TEST | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|
| 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1 1 1 2 |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 2 1 3 1 2 3 2 3 1 3 2 2 2 2 1 2 1 2 1 1 2 1|
Hepatocyte, Degeneration, Cystic | 2 1 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Necrotizing | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 1 1 1 2 2 2|
Artery, Inflammation, Chronic Active | |
Artery, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body, Multiple | |
Granuloma | |
Inflammation, Necrotizing | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Erosion | 3 2 |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Tongue | |
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|
DAY ON TEST | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|
| 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Mesenteric Artery, Polyarteritis, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2|
Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 2 2 2 2 2 2 1|
Hyperplasia | 1 2 2 2 2 2 |
Hypertrophy | 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 2 1 2 1 1 1 4 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 2 3 2 2 3 4 1 2 4 2|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 |
Pars Distalis, Infarct | 4 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 3 3 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Ectasia | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 4 4 2 4 4 4 4 |
Mineralization | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 2 2 2 3 2 1 1 2 1 2 1 2 3 2 2 2 1 2 2|
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|
DAY ON TEST | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|
| 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 4 1 1 2 2 2 1 3 3 2 1 1 3 2 2 2 2 3 2 3 4 2|
Inflammation, Hemorrhagic | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 4 3 4 3 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X X X X|
Interstitial Cell, Hyperplasia | 1 2 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 2 3 3 4 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Cystic | 3 3 2 3 2 4 2 2 2 2 1 4 1 4 1 1 1 2 2 1 3|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Inflammation, Proliferative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-Mass, | |
Fibrosis | |
Foot, Acanthosis | |
Foot, Hyperkeratosis | |
Foot, Inflammation, Chronic Active | |
Inguinal, Acanthosis | 2 |
Site of Application-No Mass, | |
Acanthosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|
DAY ON TEST | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|
| 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Abscess | |
Maxilla, Fibrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X |
Gliosis | |
Hemorrhage | 3 |
Hydrocephalus | 2 2 2 3 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 |
Perivascular, Edema | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 1 2 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Hyperplasia | |
Necrosis, Coagulative | 2 |
Nephropathy, Chronic | 3 2 2 2 3 3 2 4 3 3 2 3 2 3 2 2 3 3 3 3 2 2 2 3|
Cortex, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 5| 7| 4| 6| 4| 7| 5| 5| 7| 7| 0| 7| 7| 5| 4| 5| 7|
DAY ON TEST | 1| 5| 5| 5| 3| 3| 0| 2| 8| 0| 5| 4| 5| 2| 3| 9| 2| 3| 1| 3| 3| 8| 5| 3| 3|
| 0| 6| 6| 4| 1| 0| 5| 9| 6| 5| 6| 2| 2| 9| 6| 1| 9| 1| 2| 0| 0| 9| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Hemorrhagic | 4 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 5| 7| 6| 6| 4| 6| 7| | |
DAY ON TEST | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3| | |
| 6| 2| 6| 4| 9| 9| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | | 1 4.0|
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | X | 7 |
Clear Cell Focus | | 5 |
Eosinophilic Focus | | 2 |
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation, Chronic | 1 1 1 | 12 1.2|
Mixed Cell Focus | | 1 |
Necrosis, Coagulative | | 1 3.0|
Bile Duct, Hyperplasia | 2 1 2 2 1 2 2 1 3 | 56 1.8|
Hepatocyte, Degeneration, Cystic | 2 | 8 1.8|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 6 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Fat, Inflammation, Necrotizing | 3 | 6 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 1 2 | 23 1.6|
Artery, Inflammation, Chronic Active | | 1 3.0|
Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Foreign Body, Multiple | 2 | 1 2.0|
Granuloma | 3 | 1 3.0|
Inflammation, Necrotizing | 3 4 | 4 3.3|
Epithelium, Hyperplasia | 2 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Erosion | 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 5| 7| 6| 6| 4| 6| 7| | |
DAY ON TEST | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3| | |
| 6| 2| 6| 4| 9| 9| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Necrotizing | | 2 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Mineralization | | 1 2.0|
Mesenteric Artery, Polyarteritis, | | |
Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 1 1 2 2 2 1 2 2 2 | 51 1.8|
Inflammation, Chronic Active | | 1 2.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | 2 1 2 | 21 1.6|
Hyperplasia | 2 | 15 1.6|
Hypertrophy | 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 1 2 3 | 28 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 55 |
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 3 4 4 1 | 30 2.7|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 2 | 9 2.0|
Pars Distalis, Infarct | | 1 4.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 8 1.9|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 5| 7| 6| 6| 4| 6| 7| | |
DAY ON TEST | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3| | |
| 6| 2| 6| 4| 9| 9| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Ectasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atrophy | 2 4 3 4 | 26 3.2|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 1 1 2 2 1 2 2 2 3 | 54 1.8|
Duct, Dilatation | | 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 3 2 2 4 4 3 1 4 2 | 52 2.3|
Inflammation, Hemorrhagic | | 1 4.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | 3 4 3 4 | 24 2.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Polyarteritis | X X | 9 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 | 21 1.1|
Seminiferous Tubule, Atrophy | 4 2 | 10 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Fibrosis | 2 | 10 2.5|
Necrosis, Coagulative | | 3 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + M M | 56 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 58 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 5| 7| 6| 6| 4| 6| 7| | |
DAY ON TEST | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3| | |
| 6| 2| 6| 4| 9| 9| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 2 2 2 2 3 3 | 46 2.1|
Inflammation, Chronic | | 1 4.0|
Inflammation, Chronic Active | | 2 2.5|
Inflammation, Proliferative | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Dermis, Site of Application-Mass, | | |
Fibrosis | | 1 4.0|
Foot, Acanthosis | 4 | 1 4.0|
Foot, Hyperkeratosis | 4 | 1 4.0|
Foot, Inflammation, Chronic Active | 2 | 1 2.0|
Inguinal, Acanthosis | | 2 1.5|
Site of Application-No Mass, | | |
Acanthosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Maxilla, Abscess | | 1 3.0|
Maxilla, Fibrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 15 |
Gliosis | | 1 3.0|
Hemorrhage | | 1 3.0|
Hydrocephalus | 3 3 2 | 14 2.2|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 1 | 8 1.1|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 1 | 17 1.0|
Perivascular, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 5| 7| 6| 6| 4| 6| 7| | |
DAY ON TEST | 5| 0| 7| 5| 2| 0| 1| 5| 7| 3| | |
| 6| 2| 6| 4| 9| 9| 8| 6| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 5 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 12 2.0|
Respiratory Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 4 | 1 4.0|
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 2.0|
Hyperplasia | | 1 3.0|
Necrosis, Coagulative | | 1 2.0|
Nephropathy, Chronic | 2 3 2 4 3 2 2 4 3 | 58 2.5|
Cortex, Cyst | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Inflammation, Hemorrhagic | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|
| 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
32 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Nodular | 3 |
Inflammation, Chronic | 1 1 1 1 1 2 1 1 2 2 1|
Mixed Cell Focus | X X |
Necrosis, Coagulative | 2 |
Bile Duct, Hyperplasia | 2 2 2 3 3 2 1 1 1 3 2 1 1 2 1 1 2 3 2 1|
Hepatocyte, Degeneration, Cystic | 2 1 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Inflammation, Necrotizing | 3 4 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 1 1 1 1 1 1 1 |
Acinus, Hyperplasia, Nodular | |
Artery, Inflammation, Chronic Active | 2 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Necrotizing | 4 |
Mineralization | 4 |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Necrotizing | 3 1 |
Mineralization | 4 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|
| 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
32 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 3 2 2 2 2 1 1 2 1 1 2 1 2 1 2 2 2 1 2|
Inflammation, Suppurative | 2 |
Mineralization | 3 |
Atrium, Thrombosis | |
Valve, Bacterium | X |
Valve, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 2 2 1 1 2 |
Hyperplasia | 2 2 2 2 2 2 2 |
Hypertrophy | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 2 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | |
Hyperplasia | 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 2 2 3 4 4 2 2 2 3 4 3 3 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2|
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 2 2 2 3 2 4 4 4 3|
Inflammation, Chronic Active | |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|
| 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
32 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 3 1 2 1 3 2 1 1 1 1 2 2 4 2 1 2 2 2 2 1|
Duct, Dilatation | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 4 3 2 3 2 2 3 2 3 2 3 2 2 2 3 3 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 2 2 3 2 3 3 3 |
Mineralization | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X X X |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + M|
Hyperplasia, Cystic | 2 2 2 1 2 2 2 3 3 1 3 3 3 1 1 4 2 1 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-No Mass, | |
Fibrosis | |
Foot, Ulcer | |
Inguinal, Acanthosis | 2 |
Inguinal, Inflammation, Chronic | |
Active | 2 |
Inguinal, Ulcer | 4 |
Site of Application-No Mass, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 6| 6| 5| 4| 4| 6| 7| 7| 5| 4| 6| 6| 4| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 3| 1| 8| 7| 0| 4| 2| 5| 4| 5| 6| 0| 3| 0| 5| 9| 0| 5| 1| 5| 3| 9| 7| 3| 3|
| 0| 8| 4| 8| 8| 9| 0| 8| 3| 6| 7| 2| 1| 7| 6| 4| 4| 6| 0| 6| 1| 9| 7| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
32 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | 1 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 1 1 |
Tail, Inflammation, Chronic Active | 3 |
Tail, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X |
Hemorrhage | 2 2 |
Hydrocephalus | 2 3 3 2 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1|
Fat, Mediastinum, Atrophy | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Suppurative | 3 |
Mineralization | |
Necrosis, Coagulative | 2 |
Nephropathy, Chronic | 2 4 3 2 3 2 3 3 2 2 2 3 3 2 2 2 2 3 2 4 2 2 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|
| 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
32 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Nodular | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 1 1 1 1 1 3 2 2 1 1 1 2 2 1 2 2 3 2 1 3 |
Hepatocyte, Degeneration, Cystic | 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Necrotizing | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 1 2 3 |
Acinus, Hyperplasia, Nodular | 3 |
Artery, Inflammation, Chronic Active | |
Perivascular, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Necrotizing | 3 4 |
Mineralization | |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 1 |
Inflammation, Necrotizing | |
Mineralization | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|
| 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
32 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 2 1 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 1 2 2 |
Inflammation, Suppurative | |
Mineralization | |
Atrium, Thrombosis | X |
Valve, Bacterium | |
Valve, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 1 1 1 1 1 2 1|
Hyperplasia | 2 1 1 1 2 1 |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 4 4 2 2 4 4 2 3 3 3 2 3 3|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 3 3 4 3 3 2 4 3|
Inflammation, Chronic Active | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|
| 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
32 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 |
Inflammation, Chronic Active | 1 1 2 1 2 3 1 2 1 2 4 2 1 3 2 2 1 3 2 2 1 1 1|
Duct, Dilatation | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 1 2 1 2 1 2 2 2 3 1 2 2 3 1 1 2 3 2 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 3 3 3 3 3 3|
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 |
Seminiferous Tubule, Atrophy | 4 4 2 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + M + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 1 3 2 2 2 3 2 3 1 1 3|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-No Mass, | |
Fibrosis | 4 |
Foot, Ulcer | |
Inguinal, Acanthosis | |
Inguinal, Inflammation, Chronic | |
Active | 1 |
Inguinal, Ulcer | |
Site of Application-No Mass, | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 5| 4| 6| 5| 7| 6| 6| 5| 5| 4| 4| 7| 4| 7| 4| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 5| 3| 4| 5| 1| 6| 2| 2| 3| 7| 7| 5| 6| 2| 8| 3| 5| 1| 5| 2| 1| 5| 2| 1|
| 0| 6| 0| 9| 6| 9| 4| 7| 1| 5| 2| 3| 6| 7| 9| 4| 0| 6| 9| 8| 4| 3| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
32 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | |
Site of Application-No Mass, | |
Inflammation, Chronic Active | |
Tail, Inflammation, Chronic Active | |
Tail, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X |
Hemorrhage | 2 2 |
Hydrocephalus | 2 2 2 3 3 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 1 1|
Fat, Mediastinum, Atrophy | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Inflammation, Suppurative | |
Mineralization | |
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 3 3 2 3 3 2 2 2 2 2 1 2 2 3 2 3 3 3 2 2 3 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| | |
DAY ON TEST | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3| | |
| 6| 0| 0| 4| 6| 6| 1| 1| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
32 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | | 1 4.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 7 |
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X | 4 |
Hepatodiaphragmatic Nodule | X X | 5 |
Hyperplasia, Nodular | | 1 3.0|
Inflammation, Chronic | 1 1 1 | 24 1.1|
Mixed Cell Focus | X | 3 |
Necrosis, Coagulative | 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 1 2 3 1 1 1 2 2 | 49 1.7|
Hepatocyte, Degeneration, Cystic | 1 1 | 6 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Fat, Inflammation, Necrotizing | | 7 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 3 2 | 21 1.5|
Acinus, Hyperplasia, Nodular | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Necrotizing | | 3 3.7|
Mineralization | | 1 4.0|
Epithelium, Hyperplasia | 3 3 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| | |
DAY ON TEST | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3| | |
| 6| 0| 0| 4| 6| 6| 1| 1| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
32 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 3 2.0|
Inflammation, Necrotizing | | 2 2.0|
Mineralization | | 1 4.0|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 1 2 1 2 1 2 2 2 1 | 52 1.7|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 3.0|
Atrium, Thrombosis | | 1 |
Valve, Bacterium | | 1 |
Valve, Inflammation, Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration, Fatty | 2 1 2 1 1 | 17 1.4|
Hyperplasia | 2 1 1 1 | 17 1.6|
Hypertrophy | 1 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 1 1 2 | 22 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Cyst | | 1 |
Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 2 4 1 4 3 | 36 2.8|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 2 3 2 | 16 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 | 24 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| | |
DAY ON TEST | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3| | |
| 6| 0| 0| 4| 6| 6| 1| 1| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
32 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atrophy | 4 3 4 | 25 3.2|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 3 3.0|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 2 2 2 | 53 1.7|
Duct, Dilatation | | 4 3.3|
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + | 59 |
Inflammation, Chronic Active | 2 2 2 3 2 2 3 2 | 52 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | 4 3 2 2 | 22 2.9|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Polyarteritis | | 4 |
Interstitial Cell, Hyperplasia | 1 1 | 22 1.1|
Seminiferous Tubule, Atrophy | | 8 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 3 3.7|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 10 |
Inguinal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 4 3 | 3 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis, Coagulative | 4 | 1 4.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| | |
DAY ON TEST | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3| | |
| 6| 0| 0| 4| 6| 6| 1| 1| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
32 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + + + + M + | 53 |
Hyperplasia, Cystic | 2 2 4 2 2 | 37 2.1|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Dermis, Site of Application-No Mass, | | |
Fibrosis | | 1 4.0|
Foot, Ulcer | 4 | 1 4.0|
Inguinal, Acanthosis | | 1 2.0|
Inguinal, Inflammation, Chronic | | |
Active | | 2 1.5|
Inguinal, Ulcer | | 1 4.0|
Site of Application-No Mass, | | |
Acanthosis | | 1 1.0|
Site of Application-No Mass, | | |
Inflammation, Chronic Active | | 2 1.0|
Tail, Inflammation, Chronic Active | | 1 3.0|
Tail, Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X | 19 |
Hemorrhage | | 4 2.0|
Hydrocephalus | 2 2 | 19 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 5 1.2|
Mineralization | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 | 23 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| | |
DAY ON TEST | 5| 3| 9| 3| 0| 1| 3| 3| 2| 3| | |
| 6| 0| 0| 4| 6| 6| 1| 1| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
32 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fat, Mediastinum, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 2 | 11 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 3 | 1 3.0|
Necrosis, Coagulative | | 1 2.0|
Nephropathy, Chronic | 2 3 4 2 2 2 3 3 2 4 | 58 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|
| 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 1 1 1 |
Leukocytosis | |
Necrosis, Coagulative | 4 |
Bile Duct, Hyperplasia | 2 3 2 2 2 1 2 3 3 2 2 1 1 1 1 3 1 1 2 1 1 2 3|
Hepatocyte, Degeneration, Cystic | 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Inflammation, Necrotizing | 4 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Necrotizing | 4 3 |
Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Glandular | |
Inflammation, Necrotizing | 3 |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 1 3 2 2 2 1 2 1 2 1 2 2 2 1 1 3 1 |
Atrium, Thrombosis | X |
Endocardium, Atrium, Proliferation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|
| 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 1 2 2 3 |
Hyperplasia | 2 1 2 1 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 1 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + M + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | |
Pars Distalis, Angiectasis | 2 4 2 4 4 2 2 2 3 4 2 4 1 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 3 2 |
Pars Distalis, Infarct | 4 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
C-Cell, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 2 3 3 2 2 3|
Granuloma Sperm | |
Fat, Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 1 2 2 1 2 2 2 2 1 3 1 2 2|
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 1 1 3 2 3 2 2 2 1 2 1 2 2 2 3 1 2 1 1 |
Inflammation, Hemorrhagic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 2 3 3 3 4 3 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X X X |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 1 1 2 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|
| 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Sinus, Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | X |
Fibrosis | 2 3 2|
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | |
Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 2 2 2 1 2 2 2 1 4 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-No Mass, | |
Fibrosis | |
Inguinal, Acanthosis | |
Inguinal, Inflammation, Chronic | |
Active | |
Site of Application-No Mass, | |
Acanthosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Abscess | |
Maxilla, Fibrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | |
Hydrocephalus | 4 2 2 3 3 |
__________________________________________________________________________|
Peripheral Nerve | + + |
Sciatic, Myelin, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 3| 7| 4| 5| 4| 7| 4| 5| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 5| 3| 3| 7| 3| 7| 2| 5| 0| 5| 1| 5| 7| 3| 3| 5| 5| 4| 3| 2|
| 4| 4| 1| 1| 0| 6| 0| 4| 9| 1| 9| 2| 6| 0| 6| 9| 6| 4| 0| 1| 6| 6| 2| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 2 |
White Matter, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Nephropathy, Chronic | 2 2 2 3 3 1 3 3 2 3 1 4 2 2 2 4 2 2 3 3 2 2 2 1 3|
Pigmentation, Hemosiderin | |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|
DAY ON TEST | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|
| 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X|
Clear Cell Focus | X|
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 |
Leukocytosis | 2 |
Necrosis, Coagulative | 2 |
Bile Duct, Hyperplasia | 1 3 2 3 1 1 2 3 1 2 1 2 2 2 1 1 3 1 3 1 3 3|
Hepatocyte, Degeneration, Cystic | 2 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Necrotizing | 4 4 2 |
Epithelium, Hyperplasia | 2 3 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Glandular | 2 |
Inflammation, Necrotizing | 4 |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 2 2 1 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2|
Atrium, Thrombosis | |
Endocardium, Atrium, Proliferation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|
DAY ON TEST | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|
| 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 1 2 2 2 2 2 1|
Hyperplasia | 2 2 2 1 1 4 1 1 1 2 2 |
Hypertrophy | 2 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Craniopharyngeal Duct, Pars Distalis,| |
Cyst | X |
Pars Distalis, Angiectasis | 2 3 4 2 4 4 2 4 3 3|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 |
Pars Distalis, Infarct | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
C-Cell, Hyperplasia | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 3 4 3 4 2 3 2 |
Granuloma Sperm | 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 4 2 2 2 2 2 3 2 2 1 1 2 2 1 2 3 2 2 1 4|
Duct, Dilatation | 4 4 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 2 1 3 2 1 3 1 2 1 3 3 1 2 2 2 4 2 3 2|
Inflammation, Hemorrhagic | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 3 3 3 3 2 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X X |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|
DAY ON TEST | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|
| 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Mediastinal, Sinus, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Developmental Malformation | |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | 4 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + M + M + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 1 4 1 3 4 1 1 1 2 2 3 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-No Mass, | |
Fibrosis | 4 |
Inguinal, Acanthosis | |
Inguinal, Inflammation, Chronic | |
Active | |
Site of Application-No Mass, | |
Acanthosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Abscess | 2 |
Maxilla, Fibrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + M + + + + + + + +|
Compression | X X X X X |
Hemorrhage | 2 |
Hydrocephalus | 2 2 2 3 |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Myelin, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 6| 4| 7| 7| 4| 7| 6| 6| 7| 3| 6| 7| 4| 5| 5| 7| 5| 6| 7| 7|
DAY ON TEST | 8| 0| 5| 4| 2| 5| 5| 3| 3| 5| 2| 1| 3| 3| 6| 2| 1| 5| 6| 2| 2| 7| 3| 1| 3|
| 4| 2| 3| 9| 4| 2| 6| 1| 0| 6| 9| 7| 1| 0| 5| 3| 0| 6| 2| 2| 9| 5| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
63 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | 4 4 3|
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
Abscess | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Nephropathy, Chronic | 2 2 1 3 3 3 2 2 3 2 4 3 2 3 1 2 4 3 2 2 3 2 2 4 2|
Pigmentation, Hemosiderin | 3 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 0| 2| 3| 3| 1| 1| 5| 8| | |
| 1| 2| 9| 0| 1| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
63 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 59 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 59 |
Parasite Metazoan | X | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 59 |
Angiectasis | | 2 2.0|
Basophilic Focus | | 4 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | | 3 |
Hepatodiaphragmatic Nodule | X | 7 |
Inflammation, Chronic | 1 1 1 1 | 19 1.1|
Leukocytosis | | 1 2.0|
Necrosis, Coagulative | | 2 3.0|
Bile Duct, Hyperplasia | 2 2 1 2 2 3 1 1 | 53 1.8|
Hepatocyte, Degeneration, Cystic | 1 | 6 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 5 2.2|
__________________________________________________________________________|____________|
Mesentery | + | 11 |
Fat, Inflammation, Necrotizing | 4 | 6 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 59 |
Acinus, Atrophy | 2 1 2 | 19 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Necrotizing | 4 3 4 | 8 3.5|
Epithelium, Hyperplasia | 2 2 | 9 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 59 |
Erosion | | 1 2.0|
Hyperplasia, Glandular | | 1 2.0|
Inflammation, Necrotizing | 3 | 3 3.3|
Necrosis, Coagulative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 0| 2| 3| 3| 1| 1| 5| 8| | |
| 1| 2| 9| 0| 1| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
63 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 | 52 1.8|
Atrium, Thrombosis | | 1 |
Endocardium, Atrium, Proliferation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 59 |
Degeneration, Fatty | 2 3 2 1 | 20 1.9|
Hyperplasia | 1 2 2 | 19 1.6|
Hypertrophy | 2 | 6 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 59 |
Hyperplasia | 1 2 2 1 1 | 22 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + M | 53 |
Cyst | | 1 |
Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 58 |
Craniopharyngeal Duct, Pars Distalis,| | |
Cyst | | 1 |
Pars Distalis, Angiectasis | 2 2 4 2 2 2 | 29 2.8|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 3 2 | 15 2.3|
Pars Distalis, Infarct | | 1 4.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 | 32 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 59 |
Hyperplasia | 4 | 1 4.0|
C-Cell, Hyperplasia | | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 59 |
Atrophy | 2 3 4 2 2 2 | 27 2.8|
Granuloma Sperm | | 1 2.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + | 58 |
Inflammation, Chronic Active | 1 1 3 2 1 2 2 | 51 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 0| 2| 3| 3| 1| 1| 5| 8| | |
| 1| 2| 9| 0| 1| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
63 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | | 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 59 |
Inflammation, Chronic Active | 1 2 2 2 1 3 2 3 | 50 2.0|
Inflammation, Hemorrhagic | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 59 |
Atrophy | 4 2 3 3 | 23 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 59 |
Polyarteritis | X X | 9 |
Interstitial Cell, Hyperplasia | 1 1 | 19 1.1|
Seminiferous Tubule, Atrophy | 4 3 | 14 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 59 |
Hyperplasia | | 5 4.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 16 |
Mediastinal, Sinus, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Developmental Malformation | | 1 |
Fibrosis | | 5 2.2|
Hematopoietic Cell Proliferation | | 2 2.5|
Necrosis, Coagulative | 4 | 2 4.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + M + | 54 |
Hyperplasia, Cystic | 1 4 4 4 1 4 | 37 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 59 |
Dermis, Site of Application-No Mass, | | |
Fibrosis | | 1 4.0|
Inguinal, Acanthosis | 2 | 1 2.0|
Inguinal, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Site of Application-No Mass, | | |
Acanthosis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 0| 2| 3| 3| 1| 1| 5| 8| | |
| 1| 2| 9| 0| 1| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
63 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
Maxilla, Abscess | | 1 2.0|
Maxilla, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 58 |
Compression | | 10 |
Hemorrhage | | 1 2.0|
Hydrocephalus | | 9 2.6|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
Sciatic, Myelin, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Hemorrhage | | 1 2.0|
White Matter, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 59 |
Inflammation, Chronic Active | 1 | 6 1.0|
Alveolar Epithelium, Hyperplasia | | 3 3.7|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 | 20 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 3 1.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 | 8 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 3 4.0|
Retina, Atrophy | | 3 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 4| 5| | |
DAY ON TEST | 3| 0| 2| 3| 3| 1| 1| 5| 8| | |
| 1| 2| 9| 0| 1| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
63 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
Nephropathy, Chronic | 3 4 2 3 2 3 4 2 3 | 59 2.5|
Pigmentation, Hemosiderin | | 1 3.0|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|
| 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | |
Congestion | 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 2 2 3 1 2 2 2 2 2 1 3 1 3 2 1 1 2 2 2 1|
Hepatocyte, Degeneration, Cystic | 1 3 1 1 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Necrotizing | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Acinus, Atrophy | 2 1 1 1 2 2 2 1 |
Acinus, Hyperplasia, Nodular | 2 2 |
Artery, Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 2 2 2 2 2 2 2 2 1 3 1 2 2 2 2 2 2 1 2 2 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 1 1 1 1 2 2 2 2 2 1 1|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|
| 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 2 1 2 1 1 2 2 2 2 1|
Hypertrophy | 2 2 2 |
Karyomegaly | 1 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 1 2 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 3 1 2 3 3 2 2 3 2 4 3 2 3 3 4 4|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 2 |
Pars Distalis, Infarct | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 2|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 3 3 2 3 3 4 4 3 |
Fibrosis | 2 |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 2 2 2 3 2 2 2 1 1 2 2 2 1 3 2 1 1 2 1 1|
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Inflammation, Chronic Active | 2 3 3 2 3 2 2 2 1 3 1 2 1 3 3 2 3 3 1 2 3 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 3 3 3 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X X |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 2 4 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|
| 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 2 4 4 2 2 1 1 2 2 1 4 2 1 3 2 2 2|
Inflammation, Chronic Active | |
Inflammation, Proliferative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-No Mass, | |
Fibrosis | |
Epidermis, Site of Application-No | |
Mass, Erosion | |
Neck, Ventral, Inflammation, Chronic | |
Active | |
Prepuce, Inflammation, Suppurative | 3 |
Site of Application-No Mass, | |
Acanthosis | 2 1 1 1 2 |
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 1 2 2 |
Site of Application-No Mass, Ulcer | 2 |
Site of Application-No Mass, Ulcer, | |
Multiple | 4 |
Tail, Acanthosis | 3 |
Tail, Hyperkeratosis | 4 |
Tail, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
Femur, Cyst | |
Maxilla, Abscess | |
Maxilla, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 5| 7| 7| 6| 7| 6| 4| 4| 7| 7| 7| 4| 5| 7| 4| 6| 5| 4| 6|
DAY ON TEST | 2| 0| 6| 3| 3| 6| 5| 2| 3| 4| 3| 9| 5| 5| 3| 2| 3| 5| 5| 3| 5| 1| 6| 5| 8|
| 9| 2| 4| 1| 0| 7| 8| 9| 1| 2| 0| 1| 6| 6| 1| 9| 1| 9| 8| 1| 6| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
Hydrocephalus | 3 2 2 2 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1|
Mediastinum, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 1 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 2 3 3 3 4 3 3 2 3 2 2 1 2 3 3 4 2 2 2 3 3 1 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Hemorrhagic | 2 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|
DAY ON TEST | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|
| 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X|
Clear Cell Focus | X |
Congestion | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 1 1 1 1 2 1 1|
Mixed Cell Focus | X |
Necrosis, Coagulative | 1 2 |
Bile Duct, Hyperplasia | 1 1 3 1 1 1 3 2 2 1 2 2 2 2 1 3 1 1 2 2 1 2|
Hepatocyte, Degeneration, Cystic | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Necrotizing | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
Acinus, Atrophy | 1 1 1 1 1 1 |
Acinus, Hyperplasia, Nodular | 3 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 2 4 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + M + + +|
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 1 2 2 1 2 1 1 2 2 1 2 2 1 1 2 1 2 2 2|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|
DAY ON TEST | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|
| 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 1 2 2 1 1 2 2 2 2 |
Hypertrophy | 2 2 |
Karyomegaly | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + M M + M +|
Cyst | X |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 4 4 2 4 2 2 2 4 3 3 4 3|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 3 2 2 |
Pars Distalis, Infarct | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 3 4 2 |
Fibrosis | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 2 1 1 2 2 2 2 1 2 2 2 2 2 1 3 2 1 2 2 2 1 2|
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
Inflammation, Chronic Active | 1 1 2 2 3 1 3 2 1 2 1 3 2 4 2 3 1 2 3 3 3 2 4 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | X X |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|
DAY ON TEST | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|
| 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + M M + +|
Hyperplasia, Cystic | 2 3 3 2 1 2 4 4 2 3 2 2 2 2 3|
Inflammation, Chronic Active | 3 |
Inflammation, Proliferative | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Site of Application-No Mass, | |
Fibrosis | |
Epidermis, Site of Application-No | |
Mass, Erosion | 3 |
Neck, Ventral, Inflammation, Chronic | |
Active | |
Prepuce, Inflammation, Suppurative | |
Site of Application-No Mass, | |
Acanthosis | 1 1 2 2 2|
Site of Application-No Mass, | |
Inflammation, Chronic Active | 2 2 2|
Site of Application-No Mass, Ulcer | 4 2 4|
Site of Application-No Mass, Ulcer, | |
Multiple | |
Tail, Acanthosis | |
Tail, Hyperkeratosis | |
Tail, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Femur, Cyst | X |
Maxilla, Abscess | |
Maxilla, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 5| 4| 7| 7| 4| 6| 4| 7| 7| 5| 6| 7| 4| 7| 4| 4| 5| 5| 7| 6| 5|
DAY ON TEST | 2| 5| 3| 7| 0| 5| 2| 2| 5| 4| 5| 3| 3| 4| 4| 3| 5| 3| 4| 0| 6| 4| 2| 6| 7|
| 4| 6| 1| 0| 2| 6| 9| 9| 6| 9| 6| 1| 0| 6| 2| 0| 6| 0| 4| 4| 2| 3| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X|
Hydrocephalus | 2 2 3 2 3 3 4 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 |
Mediastinum, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic Active | 2 2 1 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 2|
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 4 2 2 4 2 2 3 2 3 4 3 2 3 1 3 2 2 3 2 2 2 2|
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Hemorrhagic | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 7| 6| 5| 7| 6| 7| 6| | |
DAY ON TEST | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4| | |
| 6| 2| 2| 2| 8| 5| 8| 0| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 10 |
Clear Cell Focus | | 1 |
Congestion | | 1 2.0|
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Chronic | | 15 1.1|
Mixed Cell Focus | X | 2 |
Necrosis, Coagulative | | 2 1.5|
Bile Duct, Hyperplasia | 1 3 2 2 1 1 2 3 2 | 52 1.8|
Hepatocyte, Degeneration, Cystic | | 8 1.6|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Inflammation, Necrotizing | 3 4 | 4 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 1.0|
Acinus, Atrophy | 2 1 2 | 17 1.4|
Acinus, Hyperplasia, Nodular | | 3 2.3|
Artery, Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Necrotizing | 3 4 3 | 6 3.3|
Epithelium, Hyperplasia | 3 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
Mesenteric Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 2 2 2 1 2 2 2 | 55 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 7| 6| 5| 7| 6| 7| 6| | |
DAY ON TEST | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4| | |
| 6| 2| 2| 2| 8| 5| 8| 0| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | 1 1 | 22 1.4|
Hyperplasia | 1 2 1 | 24 1.6|
Hypertrophy | | 5 2.0|
Karyomegaly | | 1 1.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 1 1 1 | 21 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
Cyst | | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 3 3 4 4 4 3 2 | 39 3.0|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 | 18 2.1|
Pars Distalis, Infarct | 4 | 1 4.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 | 35 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Cyst | X | 1 |
C-Cell, Hyperplasia | 2 1 | 9 1.6|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atrophy | 2 3 3 | 20 3.1|
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 2 2 2 1 2 2 2 2 | 58 1.7|
Duct, Dilatation | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 7| 6| 5| 7| 6| 7| 6| | |
DAY ON TEST | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4| | |
| 6| 2| 2| 2| 8| 5| 8| 0| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia, Cystic | | 1 3.0|
Inflammation, Chronic Active | 1 3 2 2 2 3 2 2 3 | 56 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | 2 3 3 | 13 3.1|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Polyarteritis | X | 6 |
Interstitial Cell, Hyperplasia | 1 1 1 1 | 25 1.0|
Seminiferous Tubule, Atrophy | 4 | 9 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 4 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 7 2.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Coagulative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M M + + + + | 54 |
Hyperplasia, Cystic | 3 1 3 2 3 2 2 | 42 2.3|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Proliferative | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Dermis, Site of Application-No Mass, | | |
Fibrosis | 4 | 1 4.0|
Epidermis, Site of Application-No | | |
Mass, Erosion | | 1 3.0|
Neck, Ventral, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Prepuce, Inflammation, Suppurative | | 1 3.0|
Site of Application-No Mass, | | |
Acanthosis | 2 | 11 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 7| 6| 5| 7| 6| 7| 6| | |
DAY ON TEST | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4| | |
| 6| 2| 2| 2| 8| 5| 8| 0| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Site of Application-No Mass, | | |
Inflammation, Chronic Active | 2 | 8 1.9|
Site of Application-No Mass, Ulcer | | 4 3.0|
Site of Application-No Mass, Ulcer, | | |
Multiple | | 1 4.0|
Tail, Acanthosis | | 1 3.0|
Tail, Hyperkeratosis | | 1 4.0|
Tail, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 |
Femur, Cyst | | 1 |
Maxilla, Abscess | 3 | 1 3.0|
Maxilla, Fibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X X X X | 21 |
Hydrocephalus | 2 2 2 4 | 18 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 5 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 13 1.0|
Mediastinum, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 |
Inflammation, Chronic Active | 4 2 | 9 2.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 8 2.4|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05109-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIETHANOLAMINE Date: 04/18/97
Route: DERMAL,SOLUTION Time: 08:55:31
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 7| 6| 5| 7| 6| 7| 6| | |
DAY ON TEST | 5| 7| 7| 2| 8| 3| 1| 9| 3| 4| | |
| 6| 2| 2| 2| 8| 5| 8| 0| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 4 | 2 4.0|
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy, Chronic | 1 2 2 3 2 2 4 2 3 3 | 60 2.5|
Renal Tubule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Inflammation, Hemorrhagic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
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