U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Vinylidene chloride (75-35-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8021438


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
  • Some Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Vinylidene chloride (75-35-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Vinylidene chloride (75-35-4).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Vinylidene chloride (75-35-4).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Vinylidene chloride (75-35-4).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Vinylidene chloride (75-35-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-582 Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
Schantel A Hayes, Arun R Pandiri, Thai-vu T Ton , Hue-Hua L Hong , Natasha P Clayton, Keith R Shockley, Shyamal D Peddada, Kevin Gerrish, Michael Wyde, Robert C Sills, Mark J Hoenerhoff. Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol. 2016 Jan;44(1):71-87. PMID: 26682919
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Vinylidene Chloride (75-35-4) in Micronucleus Study A71539 in B6C3F1 Mice
Genetic Toxicity Evaluation of Vinylidene Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 121030
Summary Data