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tert-Butyl alcohol (75-65-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020204


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Male, Mice
  • Some Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to tert-Butyl alcohol (75-65-0).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to tert-Butyl alcohol (75-65-0).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to tert-Butyl alcohol (75-65-0).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to tert-Butyl alcohol (75-65-0).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to tert-Butyl alcohol (75-65-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. tert-Butyl alcohol (75-65-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-436 Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
TOX-53 Toxicity Studies oft-Butyl Alcohol Administered in F344/N Rats and B6C3F1Mice (Inhalation Studies) (CASRN 75-65-0)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118

Study Data


Toxicity and Carcinogenicity Studies


18-Day Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
18-Day Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C55367B) of tert-Butyl Alcohol (75-65-0) in F344/N Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C55367B) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C55367B) of tert-Butyl Alcohol (75-65-0) in F344/N Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C55367B) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice Exposed via Dosed Water

Genetic Toxicology Studies


Genetic Toxicity Evaluation of tert-Butyl Alcohol (75-65-0) in Micronucleus Study A00971 in B6C3F1 Mice
Genetic Toxicity Evaluation of tert-Butyl Alcohol (75-65-0) in Micronucleus Study A26596 in B6C3F1 Mice
Genetic Toxicity Evaluation of tert-Butyl Alcohol (75-65-0) in Micronucleus Study A50244 in F344 Rats
Genetic Toxicity Evaluation of tert-Butyl Alcohol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 875987
Summary Data