Decabromodiphenyl oxide (1163-19-5)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9020376
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
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| Mammalian Cell Mutagenicity |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Bacterial Mutagenicity |
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Publications
TR-309
Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Han X, Wang Y, Chen T, Wilson MJ, Pan F, Wu X, Rui C, Chen D, Tang Q, Wu W. Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1). Toxicol In Vitro. 2019 Oct;60:383-388. doi: 10.1016/j.tiv.2019.05.016. Epub 2019 May 24. PMID: 31132478
Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat
Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick
Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240
GEO: GSE153366
Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240
GEO: GSE153366
Study Data
Toxicity and Carcinogenicity Studies
5-Day Evaluation of the Toxicity (C10672-01) of Decabromodiphenyl Ether (1163-19-5) in Sprague Dawley Rats Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (29 kB)
- I02 - Animal Removals (138 kB)
- I03 - Growth Curve (318 kB)
- I03C - Growth Curve (320 kB)
- I04 - Mean Body Weight Summary (74 kB)
- I04G - Mean Body Weight Gain (45 kB)
- I05 - Clinical Observations Summary (37 kB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (133 kB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (106 kB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (134 kB)
- PA06 - Organ Weights Summary (87 kB)
- PA14 - Individual Animal Pathology Data (304 kB)
- PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (2) (106 kB)
- PA41 - Clinical Chemistry Summary (146 kB)
- PA43 - Hematology Summary (153 kB)
- PA46 - Summary of Gross Pathology (238 kB)
- PA49 - Summary of Cytochrome Activity (52 kB)
- R07 - Hormone Summary (41 kB)
Individual Animal Data
- Individual Animal Body Weight Data (11 kB)
- Individual Animal Clinical Chemistry Data (9 kB)
- Individual Animal Clinical Observations Data (11 kB)
- Individual Animal Cytochrome Activity Data (8 kB)
- Individual Animal Gross Pathology Data (82 kB)
- Individual Animal Hematology Data (9 kB)
- Individual Animal Histopathology Data (5 kB)
- Individual Animal Hormone Data (6 kB)
- Individual Animal Organ Weight Data (8 kB)
- Individual Animal Removal Reasons Data (5 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity of Decabromodiphenyl Oxide (1163-19-5) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Decabromodiphenyl Oxide (1163-19-5) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Decabromodiphenyl Oxide (1163-19-5) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Decabromodiphenyl Oxide (1163-19-5) in Female B6C3F1 Mice Exposed via Dosed Feed
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Decabromodiphenyl Oxide (1163-19-5) in Micronucleus Study A36713 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Decabromodiphenyl Oxide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 185983
Summary Data
- G06 - Ames Summary Data (131 KB)