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2',3'-Dideoxycytidine (7481-89-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0023747


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2',3'-Dideoxycytidine (7481-89-2).
Micronucleus - Mice
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2',3'-Dideoxycytidine (7481-89-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2',3'-Dideoxycytidine (7481-89-2).
Bacterial Mutagenicity
View
  • Weakly Positive

Citation Information


NTP. 2',3'-Dideoxycytidine (7481-89-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C89007) of 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB) in B6C3F1 Mice Exposed via Gavage
18-33 Day Evaluation of the Toxicity (C89030) of Interferon AD + ddC (AIDS Initiative) (INTDDCCOMB) in B6C3F1 Mice Exposed via Subcutaneous Injection
26-Week Evaluation of the Toxicity (C88073C) of 2',3'-Dideoxycytidine (7481-89-2) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C88073) of 2',3'-Dideoxycytidine (7481-89-2) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88073B) of 2',3'-Dideoxycytidine (7481-89-2) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C88073) of 2',3'-Dideoxycytidine (7481-89-2) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2',3'-Dideoxycytidine (7481-89-2) in Micronucleus Study 029073 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2',3'-Dideoxycytidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 258838
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (C88073C) of 2',3'-Dideoxycytidine (DDC) (DTXSID0023747) in Mouse
Toxicokinetic Evaluation (K88073-1) of 2',3'-Dideoxycytidine (DDC) (DTXSID0023747) in Mouse
Toxicokinetic Evaluation (K88073-2) of 2',3'-Dideoxycytidine (DDC) (DTXSID0023747) in Mouse