
Testing Status of Agents at NTP

Testing Status of Agents at NTP
Home » Testing Information » Testing Status of Agents at NTP » Melatonin » NTP NOMINATION HISTORY AND REVIEW - Melatonin
Aldrich (1994) Catalog Handbook of Fine Chemicals
1994-1995, Milwaukee, WI, Aldrich Chemical Co., Inc., p. 891
Anon. (1994a) Sales of melatonin grow in US. Gazeta Mercantil, (13 Sept. 1994), (20.418), 10
[Abstract 00319233. In: Dialog, 1996c]
Anon. (1994b) Dorland's Illustrated Medical Dictionary,
28th ed., Philadelphia, PA, W.B. Saunders Co., p. 1005
Anon. (1995a) Marker briefs: Melatonin. Chem.
Mark. Rep., (16 Oct. 1995) 248(16), 16-17
Anon. (1995b) Advertisement: Melatonin. Chem.
Mark. Rep., (13 Feb. 1995) 247(7), 20
Anon. (1995c) Alternative medicine approvals based
on pilot efficacy trials urged by consultant. The Tan Sheet,
(June 12, 1995) 3(Issue 24) [Abstract 00124331. In: Dialog,
1996b]
Anon. (1995d) Israel: Finetech to begin melatonin
production in Mar 1996. Chimie Actualities, (25 Dec 1995)
(572), B6 [Abstract 00387957. In: Dialog, 1996c]
Anon. (1995e) UK ends free sale of melatonin. World
Pharm. News, (OTC News Supplement, Nov 1995), (21), 4 [Abstract
0535647. In: Dialog, 1996d]
Anon. (1995f) Herbal Roulette. Consumer Reports,
[November 1995] 60(11), 698-705
Anon. (1996a) Melatonin. Chem. Mark. Rep.,
[11 March 1996] 249(11), 15
Anon. (1996b) Advertisements: US Air In Flight
Magazine; Rodman's Drug Store advertising sheet; General Nutrition
Centers (GNC) advertising leaflet
Anon. (1996c) European measures against melatonin.
World Pharm. News, (OTC News Supplement, Feb 1996), (24),
3 [Abstract 0543562. In: Dialog, 1996d]
Blask, D.E., Pelletier, D.B., Hill, S.M., Lemus-Wilson,
A., Grosso, D.S., Wilson, S.T. & Wise, M.E. (1991) Pineal
melatonin inhibition of tumor promotion in the N-nitroso-N-methylurea
model of mammary carcinogenesis: potential involvement of antiestrogenic
mechanisms in vivo. J. Cancer Res. Clin. Oncol.,
117, 526-532
Budavari, S., ed. (1989) The Merck Index,
11th ed., Rahway, NJ, Merck & Co., Inc., p. 912
Calbiochem (1995) Calbiochem Transduction Catalog
& Technical Resource 1995, San Diego, CA, Calbiochem-Novabiochem
International, p. 220
Cavallo, A. & Hassan, M. (1995) Stability of
melatonin in aqueous solution. J. Pineal Res., 18(2),
90-92
Chemical Information Services, Inc. (1995) International
Directory of Pharmaceutical Ingredients, 1995/96 edition,
Dallas, TX, CIS Information Services, Inc., pp 605,71A,76A,124A
Cordell, G.A. (1978) Alkaloids. In: Grayson, M.,
ed., Kirk-Othmer Encyclopedia of Chemical Technology, 3rd
ed., Vol. 1, New York, John Wiley & Sons, Inc., p. 906
CVM (1996) Melatonin Freedom of Information Summary,
Rockville, MD, Center for Veterinary Medicine, Food and Drug Administration,
Department of Health and Human Services, Internet address: http://www.cvm.fda.gov/
Dialog (1996) Dialog Information Service Databases:
a) TSCA Inventory (file 52); b) F-D-C- Reports (file 187); c)
Chemical Business NewsBase (file 319); d) Pharmaceutical News
Index/Health News Daily (files 42/43), Palo Alto, CA, The DIALOG
Information Retrieval Services, searched March, 1996
Dubocovich, M.L. (1988) Pharmacology and function
of melatonin receptors. FASEB J., 2(12), 2765-2773
Engeland, W.C. (1995) Hormones. In: Howe-Grant, M., ed., Kirk-Othmer Encyclopedia of Chemical
Technology, 4th ed., Vol.
13, New York, John Wiley & Sons, Inc., pp. 357-370
Fluka (1995) Fluka Chemika-BioChemika 1995/96,
Ronkonkoma, NY, Fluka Chemical Corp., p. 930
Garcia-Patterson, A., Puig-Domingo, M. & Webb,
S.M. (1996) Mini Review. Thirty years of human pineal research:
do we know its clinical relevance? J. Pineal Res., 20,
1-6
Garfinkel, D., Laudon, M., Nof, D. & Zisapel,
N. (1995) Improvement of sleep quality in elderly people by controlled-release
melatonin. The Lancet, 346, 541-543
Genzyme Corp. (1994) Material Safety Data Sheet:
Melatonin, Cambridge, MA, Pharmaceuticals Division, Genzyme
Corporation
Hashizume, T. Santo, H., Tsujisawa, H., Kosaka, K.,
Ozawa, T., Yamashita, M. & Kinae, N. (1991) Mutagenic activities
of tryptophan metabolites before and after nitrite treatment.
Food Chem. Toxicol. 29(12), 839-844
Hill, S.M., Spriggs, L.L., Simon, M.A., Muraoka,
H. & Blask, D.E. (1992) The growth inhibitory action of melatonin
on human breast cancer cells is linked to the estrogen response
system. Cancer Lett., 64, 249-256
Horn, A.S. (1981) Neuroregulators. In: Grayson, M.,
ed., Kirk-Othmer Encyclopedia of Chemical Technology, 3rd
ed., Vol. 15, New York, John Wiley & Sons, Inc., pp. 771-772
Hunter, D., ed. (1995) ChemicalWeek 1996 Buyers'
Guide, New York, Chemical Week Associates, p. 312
Kuney, J.H., ed. (1995) Chemcyclopedia 1995 -
The Manual of Commercially Available Chemicals, Washington,
DC, American Chemical Society, p. 432
Lissoni, P., Barni, S., Ardizzoia, A., Tancini, G.,
Conti, A. & Maestroni, G. (1994a) A randomized study with
the pineal hormone melatonin versus supportive care alone in patients
with brain metastases due to solid neoplasms. Cancer, 73(3),
699-701
Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A.,
Ricci, G., Aldeghi, R., Brivio, F., Tisi, E., Rovelli, F., Rescaldani,
R., Quadro, G. & Maestroni, G. (1994b) A randomized study
with subcutaneous low dose interleukin 2 alone vs interleukin
2 plus the pineal neurohormone melatonin in advanced solid neoplasms
other than renal cancer and melanoma. Br. J. Cancer, 69,
196-199
Lissoni, P., Barni, S., Tancini, G., Crispino, S.,
Paolorossi, F., Lucini, V., Mariani, M., Cattaneo, G., Esposti,
D., Esposti, G. & Fraschini, F. (1987) Clinical study of melatonin
in untreatable advanced cancer patients. Tumori, 73,
475-480
Lissoni, P., Brivio, F., Ardizzola, A., Tancini,
G. & Barni, S. (1993) Subcutaneous therapy with low-dose interleukin-2
plus the neurohormone melatonin in metastatic gastric cancer patients
with low performance status. Tumori, 79, 401-404
Malakhova, N.V. & Raushenbakh, M.O. (1986) Transplacental
carcinogenic action of the serotonin derivative 5-methoxyindolyl-3-acetic
acid. Bull. Exp. Biol. Med., 101(5), 670-672
Mauviard, F., Raynaud, F., Geoffriau, M., Claustrat,
B. & Pevet, P. (1995) 5-Methoxypsoralen inhibits 6-hydroxylation
of melatonin in the rat. Biol. Signals, 4(1), 32-41
[Abstract: CA 123,74831]
Neville, S. Arendt, J. & Ioannides, C. (1989)
A study of the mutagenicity of melatonin and 6-hydroxymelatonin.
J. Pineal Research, 6, 73-76
NLM (1996b) RTECS (Registry of Toxic Effects of
Chemical Substances), Bethesda, MD, searched March, 1996 [Accession
No. 21800]
Nordlund, J.J. & Lerner, A.B. (1977) The effects
of melatonin on skin color and on the release of pituitary hormones.
J. Clin. Endocrinol. Metab., 45(4), 768-774
Oaknin-Bendahan, S., Anis, Y., Nir, I. & Zisapel,
N. (1995) Effects of long-term administration of melatonin and
a putative antagonist on the ageing rat. NeuroReport, 6,
785-788
Olin, B.R., ed. (1996) American Drug Index,
40th Anniversary Edition, St. Louis, MO, Facts and Comparisons
Co., p. 458
PDR (1996) Physicians' Desk Reference, 50th
ed., Montvale, N.J., Medical Economics Company, p. 779
Pierpaoli, W. & Maestroni, G.J.M. (1987) Melatonin:
a principal neuroimmunoregulatory and anti-stress hormone: its
anti-aging effects. Immunol. Lett., 16, 355-362
Pierpaoli, W. & Regelson, W. (1994) Pineal control
of aging: effect of melatonin and pineal grafting on aging mice.
Proc. Natl. Acad. Sci., 91, 787-791
Pierrefiche, G. Topall, G., Courboin, G., Henriet, I. & Laborit, H. (1993) Antioxidant activity of melatonin in mice. Res. Cammun. Chem. Path. Pharm., 80(2), 211-223
Praast, G., Bartsch, C., Bartsh, H., Mecke, D. &
Lippert, T.H. (1995) Hepatic hydroxylation of melatonin in the
rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene
- implications for cancer etiology. Experientia, 51,
349-355
Recio, J., Mediavilla, R.J., Cardinali, D.P. &
Sanchez-Barcelo, E.J. (1994) Pharmacological profile and diurnal
rhythmicity of 2-[125I]iodomelatonin binding sites in murine mammary
tissue. J. Pineal Res., 16, 10-17
Reiter, R. (1991) Pineal melatonin: cell biology
of its synthesis and of its physiological interactions. Endocrine
Reviews, 12(2), 151-180
Reiter, R. (1993) Interactions of the pineal hormone
melatonin with oxygen-centered free radicals: a brief review.
Brazilian J. Med. Biol. Res., 26(11), 1141-1155
[Abstract: AN 94184230]
Reiter, R.J., Barlow-Walden, L., Poeggeler, B., Heiden,
S.M. & Clayton, R.J. (1996) Twenty-four hour urinary excretion
of 6-hydroxymelatonin sulfate in Down syndrome subjects. J.
Pineal Res., 20, 45-50
Reiter, R.J., Melchiorri, D., Sewerynek, E., Poeggeler,
B., Barlow-Walden, L., Chuang, J., Ortiz, G.C. & Acuna-Castroviejo,
D. (1995) A review of the evidence supporting melatonin's role
as an antioxidant. J. Pineal Res., 18, 1-11
Robinson, W.A., Dreiling, L., Gonzalez, R. &
Balmer, C. (1995) Treatment of human metastatic malignant melanoma
with high dose oral melatonin. In: Fraschini et al., eds.,
(1995) The pineal gland and its hormones, New York, Plenum
Press, pp. 219-225
Sax, N.I. & Lewis, R.J., Sr., eds. (1989) Dangerous Properties of Industrial Materials, 7th ed., Vol. III, New York,
Van Nostrand Reinhold, p. 2175
Shellard, S.A., Whelan, R.D.H. & Hill, B.T. (1989)
Growth inhibitory and cytotoxic effects of melatonin and its metabolites
on human tumour cell lines in vitro. Br. J. Cancer,
60, 288-290
Sigma (1996) Biochemicals, Organic Compounds and
Diagnostic Reagents, St. Louis, MO, Sigma Chemical Co., p.670
Singer, S.S., Hagedorn, J.E., Smith, D.M. & Williams,
J.L. (1995) The enzymatic basis for the rat liver 6-hydroxy-melatonin
sulfotransferase activity. J. Pineal Res., 18, 49-55
Spectrum (1995) Spectrum Bulk Chemicals &
Intermediates, New Brunswick, N.J., Spectrum Chemical Mfg.
Corp., p. S-73
Stieglitz, A., Spiegelhalter, F., Klante, G. &
Heldmaier, G. (1995) Urinary 6-sulphatoxymelatonin excretion reflects
pineal melatonin secretion in the Djungarian hamster (Phodopus
sungorus). J. Pineal Res., 18, 69-76
STN (1996) STN International database file: CHEMCATS.
Columbus, OH, Chemical Abstracts Service, searched March, 1996
Subramanian, A. & Kothari, L. (1991) Melatonin,
a suppressor of spontaneous murine mammary tumors. J. Pineal
Res., 10(3), 136-140
Sugden, D. (1983) Psychopharmacological effects of
melatonin in mouse and rat. J. Pharmacol. Experim. Therap.,
227(3), 587-591
Sze, S.F., Ng, T.B. & Liu, W.K. (1993) Antiproliferative
effect of pineal indoles on cultured tumor cell lines. J. Pineal
Res., 14, 27-33
Tamarkin, L., Cohen, M., Roselle, D., Reichert, C.,
Lippman, M. & Chabner, B. (1981) Melatonin inhibition and
pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced
mammary tumors in the rat. Cancer Res., 41, 4432-4436
Tamarkin, L., Danforth, D., Lichter, A., DeMoss,
E., Cohen, M., Chabner, B. & Lippman, M. (1982) Decreased
nocturnal plasma melatonin peak in patients with estrogen receptor
positive breast cancer. Science, 216, 1003-1005
Tan, D.-X., Pöeggeler, B., Reiter, R., Chen,
L.-D., Chen S., Manchester, L.C. & Barlow-Walden, L.R. (1993)
The pineal hormone melatonin inhibits DNA-adduct formation induced
by the chemical carcinogen safrole in vivo. Cancer Lett.,
70, 65-71
Tedesco, S.C., Morton, D.J. & Reiter, R.J. (1994)
Hydroxyindole-O-methyltransferase activity in the pineal gland
of the muskox (Ovibos moschatus). J. Pineal Res.,
16, 121-126
Ubeda, A., Trillo, M.A., House, D.E. & Blackman,
C.F. (1995a) Melatonin enhances junctional transfer in normal
C3H/10T1/2 cells. Cancer Lett., 91, 241-245
Ubeda, A., Trillo, M.A., House, D.E. & Blackman,
C.F. (1995b) A 50 Hz magnetic field blocks melatonin-induced enhancement
of junctional transfer in normal C3H/10T1/2 cells. Carcinogenesis,
16(12), 2945-2949
US International Trade Commission (1991) Synthetic
Organic Chemicals, US Production and Sales, 1989 (USITC Publication
2470), Washington, DC, US Government Printing Office, p. 6-13
US International Trade Commission (1993) Synthetic
Organic Chemicals, US Production and Sales, 1991 (USITC Publication
2607), Washington, DC, US Government Printing Office, p. 6-12
US International Trade Commission (1994a) Synthetic
Organic Chemicals, US Production and Sales, 1992 (USITC Publication
2720), Washington, DC, US Government Printing Office, p. 3-20
US International Trade Commission (1994b) Synthetic
Organic Chemicals, US Production and Sales, 1989 (USITC Publication
2810), Washington, DC, US Government Printing Office, p. 3-183
Van, H., ed. (1995) OPD The Green Book Chemical
Buyers Directory 1996, New York, NY, Schnell Publishing Co.,
p. 418
Voordouw, B.C.G., Euser, R., Verdonk, R.E.R., Alberda,
B.T., De Jong, F.H., Drogendijk, A.C., Fauser, B.C.J.M. &
Cohen, M. (1992) Melatonin and melatonin-progestin combinations
alter pituitary-ovarian function in women and can inhibit ovulation.
J. Clin. Endocrin. Metab., 74(1), 108-111
Weast, R.C. & Astle, M.J. (1985) Handbook
of Data on Organic Compounds, Boca Raton, FL, CRC Press, Inc.,
p.
Webb, S.M. & Puig-Domingo, M. (1995) Role of
melatonin in health and disease. Clin. Endocrinol., 42,
221-234
Williams, R.T. (1959) Detoxication Mechanisms,
2nd ed., London, Chapman Hall Ltd., p. 668-669
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