Summaries & Associations of Study Results

Target Organs and Levels of Evidence for TR-436

Share on Pinterest
http://ntp.niehs.nih.gov/go/8650

Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN		Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
tert-Butyl alcohol
75-65-0		06/21/1994Widely used in the manufacture of perfumes and a variety of cosmetics. It is also used as a raw material in the production of isobutylene, which may be used to produce methyl tertiary butyl ether, a common gasoline additive, or to produce butyl elastomers used in the production of automobile tires. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Water
MALE RATS: 0, 1.25, 2.5, 5 MG/ML; FEMALE RATS: 0, 2.5, 5, 10 MG/ML; MICE 0, 5, 10, 20 MG/ML/60 PER GROUP		Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50
Non-Neoplastic Lesions
  • KIDNEY: MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY; RENAL TUBULE HYPERPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 1/60 0/59 4/59 1/57 OR CARCINOMA 0/60 0/59 0/59 1/57 COMBINED 1/60 0/59 4/59 2/57
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 2/58 3/60 2/59 9/59
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA


Back to top

Web page last updated on May 28, 2013

File Assistance: Free downloads for viewing files.

USA.gov is the U.S. government's official web portal to all federal, state, and local government web resources and services U.S. Department of Health and Human Services
The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.