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Endocrine Disruptors Low-Dose Peer Review: Selected Studies

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As of October 2000

John Ashby

  1. Ashby, J., H. Tinwell, et al. (1999). "Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate glad of CF1 mice exposed in utero." Regulatory Toxicology and Pharmacology 30: 156-166.

  2. Ashby, J., H. Tinwell, et al. (2000). "Current issues in Mutation Research. DNA adducts, estrogenicity and rodent diets." Mutation Research (in press).

  3. Ashby, J., H. Tinwell, et al. (2000). "Uterotrophic activity of a "phytoestrogen-free" rat diet." Environmental Health Perspectives 108(1): A12-A13.

  4. Ashby, J., H. Tinwell. (2000). "Activity of bisphenol A in pregnant SD and Alpk rats: preliminary data." (Unpublished Abstract).

  5. Odum, J., P. A. Lefevre, et al. (1997). "The rodent uterotrophic assay: critical protocol features, studies with nonylphenols and comparison with a yeast estrogenicity assay." Regulatory Toxicology and Pharmacology 25: 176-188.

  6. Odum, J. and J. Ashby (1999). "Neonatal exposure of male rats to nonylphenol has no effect on the reproductive tract." Toxicological Science (in press).

  7. Odum, J., I. T. G. Pyrah, et al. (1999). "Comparative activities of p-nonylphenol and diethylstilbestrol in noble rat mammary gland and uterotrophic assays." Regulatory Toxicology and Pharmacology 29: 184-195.

  8. Odum, J., I. T. G. Pyrah, et al. (1999). "Effects of p-nonylphenol and diethylstilbestrol on the alderley park rat: comparison of mammary gland and uterus sensitivity following oral gavage or implanted mini-pumps." Journal of Applied Toxicology 19: 367-378.

  9. Tinwell, H., R. Joiner, et al. (2000). "Uterotrophic activity of bisphenol A in the immature mouse." Regulatory Toxicology and Pharmacology (in press).

Barry Delclos

  1. Delclos, K. B., T. J. Bucci, et al. (2000). "Effects of dietary genistein exposure during development on male and female CD rats." In prep (Unpublished Abstract).

  2. Delclos, K. B., J. R. Latendresse, et al. (2000). "Effects of dietary ethinyl estradiol exposure during development on male and female CD rats." In prep (Unpublished Abstract).

  3. Delclos, K. B., J. R. Latendresse, et al. (2000). "Effects of dietary p-nonylphenol exposure during development on male and female CD rats." In prep (Unpublished Abstract).

  4. Germolec, D. R., J. A. Munson, et al. (2000). "Immunotoxicity of genistein in male and female Sprague Dawley rats." (Unpublished Final Report-Executive Summary).

  5. Germolec, D. R., J. A. Munson, et al. (2000). "Immunotoxicity of methoxychlor in male and female Sprague Dawley rats." (Unpublished Final Report-Executive Summary).

  6. Germolec, D. R., J. A. Munson, et al. (2000). "Immunotoxicity of nonylphenol in male and female Sprague Dawley rats." (Unpublished Final Report-Executive Summary).

  7. Laurenzana, E. M., C. C. Weis, et al. (2000). "Effect of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and adult rats." In prep (Unpublished Abstract).

  8. Laurenzana, E. M., C. C. Weis, et al. (2000). "Effect of dietarily administered endocrine active agents on hepatic testosterone metabolism, CYP450, and estrogen receptor alpha expression." In prep (Unpublished Abstract).

  9. Meredith, J. M., C. Bennett, et al. (2000). "Ethinylestradiol and genistein, but not vinclozolin, decrease the volume of the SDN-POA in male rats." Society for Neuroscience Abstracts (in press).

  10. Scallet, A. C., C. Bennett, et al. (1999). "Decreased volume of the sexually dimorphic nucleus of the medial preoptic area (SDN-POA) in male rats after chronic nonylphenol exposure." Society for Neuroscience Abstracts 25: 227.

John O'Connor

  1. Biegel, L. B., J. C. Cook, et al. (1998). "Effects of 17ß-estradiol on serum hormone concentrations and estrous cycle in female Crl:CD BR rats: effects on parental and first generation rats." Toxicological Sciences 44: 143-154.

  2. Biegel, L. B., J. A. Flaws, et al. (1998). "90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17ß-estradiol." Toxicological Sciences 44: 116-142.

  3. Cook, J. C., L. Johnson, et al. (1998). "Effects of dietary 17ß-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats." Toxicological Sciences 44: 155-168.

  4. O'Connor, J. C., S. R. Frame, et al. (1998). "Sensitivity of a tier I screening battery compared to an in utero exposure for detecting the estrogen receptor agonist 17ß-estradiol." Toxicological Sciences 44: 169-184.

Frederick vom Saal

  1. Alworth, L. C., K. L. Howdeshell, et al. (1999). Uterine response to estradiol: low-dose facilitation and high-dose inhibition due to fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice. Paper presented at the Environmental Hormones meeting, Tulane University, New Orleans, October.

  2. Howdeshell, K. L., A. K. Hotchkiss, et al. (1999). "Exposure to bisphenol A advances puberty." Nature 401: 763-764.

  3. Howdeshell, K. L. and F. S. vom Saal (2000). "Developmental exposure to bisphenol A: interaction with endogenous estradiol during pregnancy in mice." American Zoologist 40(3). (in press).

  4. Nagel, S. C., F. S. vom Saal, et al. (1997). "Relative binding affinity-serum modified access assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol." Environmental Health Perspectives 105(1): 70-76.

  5. Palanza, P., S. Parmigiani, et al. (1999). "Prenatal exposure to low doses of the estrogenic chemicals diethylstilbestrol and o,p'-DDT alters aggressive behavior of male and female house mice." Pharmacology Biochemistry and Behavior 64(4): 665-672.

  6. Thayer, K. A., R. L. Ruhlen, et al. (2000). "Altered reproductive organs in male mice exposed prenatally to sub-clinical doses of 17a-ethinyl estradiol." (in press).

  7. Timms, B. G., S. L. Petersen, et al. (1999). "Prostate gland growth during development is stimulated in both male and female rat fetuses by intrauterine proximity to female fetuses." Journal of Urology 161: 1694-1701.

  8. vom Saal, F. S., B. G. Timms, et al. (1997). "Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses." Proceedings of the National Academy of Sciences 94: 2056-2061.

  9. vom Saal, F. S., P. S. Cooke, et al. (1998). "A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior." Toxicology and Industrial Health 14 (1/2): 239-260.

  10. vom Saal, F.S., K.L. Howdeshell, et al. (2000). High sensitivity of the fetal prostate to endogenous and environmental estrogens. Paper to be presented at the Bisphenol A: low dose effects-high dose effects meeting, Freie Universitat, Berlin, November.

  11. Welshons, W. V., S. C. Nagel, et al. (1999). "Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice." Toxicology and Industrial Health 15: 12-25.

Nira Ben-Jonathan

  1. Khurana, S., S. Ranmal, et al. (2000). "Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression." Endocrinology (in press).

  2. Long, X., R. Steinmetz, et al. (2000). "Strain differences in vaginal responses to the xenoestrogen bisphenol A." Environmental Health Perspectives 108(3): 243-247.

  3. Steinmetz, R., N. G. Brown, et al. (1997). "The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo." Endocrinology 138(5): 1780-1786.

  4. Steinmetz, R., N. Mitchner, et al. (1998). "The xenoestrogen bisphenol A induces growth, differentiation and c-fos gene expression in the female reproductive tract." Endocrinology 139(6): 2741-2747.

Ibrahim Chahoud

  1. Chahoud, I. "Studies on the reproductive effects of in utero exposure to bisphenol A and ethinyl estradiol of male and female Sprague Dawley rat offspring." (3 Abstracts).

Robert Chapin

  1. Chapin, R. E., M. W. Harris, et al. (1997). "The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function." Fundamental and Applied Toxicology 40: 138-157.

  1. Chapin, R. E. (1999). Study of rats exposed to methoxychlor. The Toxicology Forum: dose-response considerations for potential endocrine active substances, Washington, DC, April.

  2. Chapin, R. E., J. Delaney, et al. (1999). "The effects of 4-nonylphenol in rats: a multigeneration reproduction study." Toxicological Sciences 52: 80-91.

Makoto Ema

  1. Ema, M. (2000). "Two-generation reproduction study of bisphenol A in rats." (Unpublished Study Report).

Earl Gray

  1. Gray, L. E., J. Ostby, et al. (1999). "Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat." Toxicology and Industrial Health 15: 48-64.

  1. Wolf, C., J. Ostby, et al. (2000). "Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study." Biology of Reproduction 62(Supplement): 247.

Ping Lee

  1. Lee, P. C. (1998). "Disruption of male reproductive tract development by administration of the xenoestrogen, nonylphenol, to male new born rats." Endocrine 9(1): 105-111.

Retha Newbold

  1. Newbold, R. (1995). "Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens." Environmental Health Perspectives 103(7): 83-87.

  1. Newbold, R. R., W. N. Jefferson, et al. (1997). "Uterine carcinoma in mice treated neonatally with Tamoxifen." Carcinogenesis 18(12): 2293-2298.

  2. Newbold, R. R., R. B. Hanson, et al. (1998). "Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol." Carcinogenesis 19(9): 1655-1663.

  3. Newbold, R. R., R. B. Hanson, et al. (2000). "Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol." Carcinogenesis 21(7): 1355-1363.

  4. Newbold, R. R. (2000). "Dose related changes in male reproductive tract tissues following prenatal exposure to diethylstilbestrol." (Unpublished Abstract).

  5. Newbold, R. R., E. P. Banks, et al. (2000). "Low doses of diethylstilbestrol during development result in permanent alterations in the reproductive tract." (Unpublished Abstract).

Jimmy Spearow

  1. Spearow, J. L., P. Doemeny, et al. (1999). "Genetic variation in susceptibility to endocrine disruption by estrogen in mice." Science 285: 1259-1261.

  2. Spearow, J. L., T. Sofos, et al. (2000). Genetic variation in sensitivity to endocrine disruption by estrogenic agents. Paper modified from a poster presented at the Second Annual UC Davis Conference for Environmental Health Scientists, Napa, California, August.

Rochelle Tyl

  1. Tyl, R. W., C. B. Myers, et al. (1999). "Two-generation reproduction study with para-tert-octylphenol in rats." Regulatory Toxicology and Pharmacology 30: 81-95.

  2. Tyl, R. W., C. B. Myers, et al. (2000). "Three-generation reproductive toxicity evaluation of bisphenol A administered in the feed to CD (Sprague-Dawley) rats." RTI Study No 65C-07036-000 (Draft Final Report).

John Waechter

  1. Cagen, S. Z., J. M. Waechter, et al. (1999). "Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A." Toxicological Sciences 50: 36-44.

  2. Cagen, S. Z., J. M. Waechter, et al. (1999). "Normal reproductive organ development in wistar rats exposed to bisphenol A in the drinking water." Regulatory Toxicology and Pharmacology 30: 130-139.

Frank Welsch

  1. Elswick, B. A., F. Welsch, et al. (2000). "Effect of different sampling designs on outcome of endocrine disruptor studies." Reproductive Toxicology (in press).

  2. Elswick, B. A., D. B. Janszen, et al. (2000). "Effects of perinatal exposure to low doses of bisphenol A in male offspring of Sprague-Dawley rats." Toxicological Sciences 54(Supplement): 256A.

  3. Welsch, F., B. A. Elswick, et al. (2000). "Effects of perinatal exposure to low doses of bisphenol A on female offspring of Sprague-Dawley rats." Toxicological Sciences 54(Supplement): 256A.

  4. Welsch, F., B. A. Elswick, et al. (2000). "Lack of effects of perinatal exposure to low doses of bisphenol A on male rat offspring ventral prostate glands." In prep (Unpublished Abstract).

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Web page last updated on February 15, 2006