National Toxicology Program

Planned National Toxicology Program Studies of Hexavalent Chromium

Nomination Background

  Toxicity Evaluation Study Protocols

• 13-Week and 2-Year F344/N rat and B6C3F₁ mouse studies
• 13-Week comparative BALB/C and AM3-C57Bl/6 mouse toxicity studies and, AM3-C57Bl/6 mouse mutagenesis studies
• Immunological Evaluation

Preliminary Results of the 13-Week F344 rat and B6C3F₁ Mouse Studies

Preliminary Results of the comparative 13-week toxicity study of Sodium Dichromate Dihydrate in male BC3F₁, BALB/C, and AM3-C57Bl/6 transgenic mice and Evaluation of in vivo mutagenicity of Sodium Dichromate Dihydrate

Genetic toxicity of sodium dichromate dihydrate in NTP peripheral blood micronucleus tests

  Hexavalent Chromium Public Meeting - July 24, 2002

• Federal Register Notice
• Meeting Roster, Agenda and Staff Presentations (including public comments)
• Recommendations for the Proposed Studies of Hexavalent Chromium Carcinogenicity and Toxicokinetics Developed by the Expert Scientific Panel

Special Toxicokinetics Study

  Reproductive Studies of Hexavalent Chromium

• Reproductive Toxicity of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to BALB/c Mice
• Reproductive Toxicity of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to SD Rats
• Reproductive Toxicity (Testicular) of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to BALB/c Mice

Current Status of the NTP Hexavalent Chromium Studies (Sodium Dichromate Dihydrate)