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Background Material: Animal Models for the NTP Rodent Cancer Bioassay: Strains & Stocks -- Should We Switch?

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http://ntp.niehs.nih.gov/go/32

  • Mouse Model Historical Control Data [PDF]
  • Rat Model Historical Control Data [PDF]

Selected References and Related Materials:

  • Felton RP and Gaylor DW. (1989) Multistrain experiments for screening toxic substances. J. Tox. Envr. Health 26:399-411.
  • Festing MFW. (1995) Use of a Multistrain Assay Could Improve the NTP Carcinogenesis Bioassay. Environ Health Perspect. 103:44-52. [HTML - external link]
  • 25 Inbred Strains of Mice as Possible Candidates for a Multi-Strain Carcinogenesis Bioassay. Compilation by Dr. Michael FW Festing, May 2005 [PDF]
  • Characteristics of 20 Isogenic Strains of Rats Which are Candidates for Use in an NTP Multi-Strain Carcinogenesis Bioassay. Compilation by Dr. Michael FW Festing, May 2005 [PDF]
  • Festing MFW and Lovell DP. (1996) Reducing the use of laboratory-animals in toxicological research and testing by better experimental-design. J. Royal Statistical Society Series B-Methodological 58:127-140.
  • Goodman DG, Boorman G, Strandberg JD. (1985) Selection and Use of the B6C3F1 Mouse and F344 Rat in Long-Term Bioassays for Carcinogenicity. In: Handbook of Carcinogen Testing, Eds. Milman HA and Weisburger EK, Park Ridge, NJ: Noyes Publications, 282-325.
  • Rao GH, Birnbaum LS, Collins JJ, Tennant RW, Skow LC. (1988) Mouse Strains for Chemical Carcinogenicity Studies: Overview of a Workshop. Fund and Applied Tox 10:385-394.
  • Rao GN and Boorman G. (1990) History of the Fischer 344 Rat. In: Pathology of the Fischer Rat, Eds. Boorman G, Eustis S, Elwell M, Montgomery C, MacKenzie W. San Diego, CA: Academic Press, Inc, 5-8.
  • Rao GN and Boorman G. (1999) History of the B6C3F1 mouse. In: Pathology of the Mouse, Ed, Maronpot R. Vienna, IL: Cache River Press, 1-6.

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Web page last updated on February 15, 2006