National Toxicology Program

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Birnbaum, LS (2009). Leading the Worlds Premier Environmental Health Organization: A Message from Linda Birnbaum. Environmental Health Perspectives 117(4): A138-A138. 
DOI: http://dx.doi.org/10.1289/ehp.12670

Chen, B, Gagnon, M, Shahangian, S, Anderson, NL, Howerton, DA and Boone, JD (2009). Good laboratory practices for molecular genetic testing for heritable diseases and conditions. MMWR Recomm Rep 58(RR-6): 1-37; quiz CE-1-4. 
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19521335

Chen, F and Castranova, V (2009). Beyond apoptosis of JNK1 in liver cancer. Cell Cycle 8(8): 1145-7. 
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19270500

Cheng, Y, Wright, SH, Hooth, MJ and Sipes, IG (2009). Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2. Drug Metabolism and Disposition 37(4): 909-916. 
DOI: http://dx.doi.org/10.1124/dmd.108.022681

Cui, Y and Freedman, JH (2009). Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene expression. J Biol Chem 284(37): 24925-32.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19556237
DOI: http://dx.doi.org/10.1074/jbc.M109.026609

Cullen, JM, Brown, DL, Kissling, GE, Foley, JF, Rizzo, J, Marion, PL, Parron, VI and French, JE (2009). Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis. Toxicologic Pathology 37(3): 333-342.
DOI: http://dx.doi.org/10.1177/0192623309333137

DeKeyser, JG, Stagliano, MC, Auerbach, SS, Prabhu, KS, Jones, AD and Omiecinski, CJ (2009). Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human Constitutive Androstane Receptor Splice Variant CAR2. Molecular Pharmacology 75(5): 1005-1013.
DOI: http://dx.doi.org/10.1124/mol.108.053702

Delclos, KB, Weis, CC, Bucci, TJ, Olson, G, Mellick, P, Sadovova, N, Latendresse, JR, Thorn, B and Newbold, RR (2009). Overlapping but distinct effects of genistein and ethinyl estradiol (EE(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies. Reprod Toxicol 27(2): 117-32.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19159674
DOI: http://dx.doi.org/10.1016/j.reprotox.2008.12.005

Elespuru, RK, Agarwal, R, Atrakchi, AH, Bigger, CA, Heflich, RH, Jagannath, DR, Levy, DD, Moore, MM, Ouyang, Y, Robison, TW, Sotomayor, RE, Cimino, MC and Dearfield, KL (2009). Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays. Toxicol Sci 109(2): 172-9.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19336498
DOI: http://dx.doi.org/10.1093/toxsci/kfp067

Elmore, SA and Peddada, SD (2009). Points to consider on the statistical analysis of rodent cancer bioassay data when incorporating historical control data. Toxicol Pathol 37(5): 672-6.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19516052
DOI: http://dx.doi.org/10.1177/0192623309339606

Estill, CF, Baron, PA, Beard, JK, Hein, MJ, Larsen, LD, Rose, L, Schaefer, FW, 3rd, Noble-Wang, J, Hodges, L, Lindquist, HD, Deye, GJ and Arduino, MJ (2009). Recovery efficiency and limit of detection of aerosolized Bacillus anthracis Sterne from environmental surface samples. Appl Environ Microbiol 75(13): 4297-306.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19429546
DOI: http://dx.doi.org/10.1128/AEM.02549-08

Fang, F, Quinlan, P, Ye, W, Barber, MK, Umbach, DM, Sandler, DP and Kamel, F (2009). Workplace exposures and the risk of amyotrophic lateral sclerosis. Environ Health Perspect 117(9): 1387-92.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/9750102
DOI: http://dx.doi.org/10.1289/ehp.0900580

Fang, JL and Beland, FA (2009). Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci 111(1): 120-30.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19541796
DOI: http://dx.doi.org/10.1093/toxsci/kfp136

Ferguson, SA and Boctor, SY (2009). Use of food wafers for multiple daily oral treatments in young rats. J Am Assoc Lab Anim Sci 48(3): 292-5.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19476719

Ferguson, SA, Delclos, KB, Newbold, RR and Flynn, KM (2009). Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague-Dawley rats. Neurotoxicol Teratol 31(3): 143-8.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19452615

Fu, PP, Chiang, HM, Xia, Q, Chen, T, Chen, BH, Yin, JJ, Wen, KC, Lin, G and Yu, H (2009). Quality assurance and safety of herbal dietary supplements. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27(2): 91-119.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19412857
DOI: http://dx.doi.org/10.1080/10590500902885676

Garantziotis, S, Li, Z, Potts, EN, Kimata, K, Zhuo, L, Morgan, DL, Savani, RC, Noble, PW, Foster, WM, Schwartz, DA and Hollingsworth, JW (2009). Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J Biol Chem 284(17): 11309-17.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19164299
DOI: http://dx.doi.org/10.1074/jbc.M802400200

Garantziotis, S, Li, ZW, Potts, EN, Kimata, K, Zhuo, LS, Morgan, DL, Savani, RC, Noble, PW, Foster, WM, Schwartz, DA and Hollingsworth, JW (2009). Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. Journal of Biological Chemistry 284(17): 11309-11317.
DOI: http://dx.doi.org/10.1074/jbc.M802400200

Gohlke, JM, Stockton, P, Sieber, S, Foley, J and Portier, CJ (2009). AhR-mediated gene expression in the developing mouse telencephalon. Birth Defects Research Part A  Clinical and Molecular Teratology 85(5): 405-405.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19465110

Hettick, JM, Ruwona, TB and Siegel, PD (2009). Structural elucidation of isocyanate-peptide adducts using tandem mass spectrometry. J Am Soc Mass Spectrom 20(8): 1567-75.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19477659
DOI: http://dx.doi.org/10.1016/j.jasms.2009.04.016

Hopf, NB, Waters, MA and Ruder, AM (2009). Cumulative exposure estimates for polychlorinated biphenyls using a job-exposure matrix. Chemosphere 76(2): 185-93.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/9394668
DOI: http://dx.doi.org/10.1016/j.chemosphere.2009.03.058

Howroyd, P, Allison, N, Foley, JF and Hardisty, J (2009). Apparent alveolar bronchiolar tumors arising in the mediastinum of F344 rats. Toxicologic Pathology 37(3): 351-358.
DOI: http://dx.doi.org/10.1177/0192623309332988

Ismailoglu, UB, Scott, MR and Fedan, JS (2009). Effects of cytokines on mechanical and epithelial bioelectric responses to methacholine and hyperosmolarity in guinea-pig airways: an in vitro study. Eur J Pharmacol 612(1-3): 115-21.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19383494
DOI: http://dx.doi.org/10.1016/j.ejphar.2009.04.025

Joseph, PN, Iolanti, JM, Donahue, R, Andrew, ME, Trevisan, M, Burchfiel, CM and Dorn, J (2009). Police Work and Subclinical Atherosclerosis. J Occup Environ Med.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19430318
DOI: http://dx.doi.org/10.1097/JOM.0b013e3181a02252

Joseph, PN, Violanti, JM, Donahue, R, Andrew, ME, Trevisan, M, Burchfiel, CM and Dorn, J (2009). Police work and subclinical atherosclerosis. J Occup Environ Med 51(6): 700-7.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19530342

Kai, K, DCosta, S, Sills, RC and Kim, Y (2009). Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines. Cancer Letters 278(1): 49-55.
DOI: http://dx.doi.org/10.1016/j.canlet.2008.12.023

Kang, HS, Beak, JY, Kim, YS, Herbert, R and Jetten, AM (2009). Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol 29(10): 2556-69.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19273592
DOI: http://dx.doi.org/10.1128/MCB.01620-08

Kavlock, RJ, Austin, CP and Tice, RR (2009). Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment. Risk Analysis 29(4): 485-487.
DOI: http://dx.doi.org/10.1111/j.1539-6924.2008.01168.x

Kreiss, K and Hubbs, A (2009). Letter to the Editor : RE: Galbraith D and Weill D (2009), Popcorn lung and bronchiolitis obliterans: a critical appraisal 82:407-416. Int Arch Occup Environ Health.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19533162
DOI: http://dx.doi.org/10.1007/s00420-009-0435-4

Kuempel, ED, Wheeler, MW, Smith, RJ, Vallyathan, V and Green, FH (2009). Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States. Am J Respir Crit Care Med 180(3): 257-64.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19423717
DOI: http://dx.doi.org/10.1164/rccm.200806-840OC

Lee, EG, Harper, M, Bowen, RB and Slaven, J (2009). Evaluation of COSHH essentials: methylene chloride, isopropanol, and acetone exposures in a small printing plant. Ann Occup Hyg 53(5): 463-74.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19435980
DOI: http://dx.doi.org/10.1093/annhyg/mep023

Lee, L, Flemmer, M, Lee, EG, Harper, M, Lin, MI, Groves, W, Freivalds, A and Slaven, J (2009). A novel physiologic sampling pump capable of rapid response to breathing. J Environ Monit 11(5): 1020-7.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19436860
DOI: http://dx.doi.org/10.1039/b816699d

Lowe, BD and Krieg, EF (2009). Relationships between observational estimates and physical measurements of upper limb activity. Ergonomics 52(5): 569-83.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19424924
DOI: http://dx.doi.org/10.1080/00140130802449682

Lowe, BD, Schrader, SM and Breitenstein, MJ (2009). Letter to the Editor. Appl Ergon.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19433322
DOI: http://dx.doi.org/10.1016/j.apergo.2009.04.003

McKernan, JL, Toraason, MA, Fernback, JE and Petersen, MR (2009). Presence of tungsten-containing fibers in tungsten refining and manufacturing processes. Ann Occup Hyg 53(3): 215-24.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19126624
DOI: http://dx.doi.org/10.1093/annhyg/men078

Morrison, JP, Ton, TV, Collins, JB, Switzer, RC, Little, PB, Morgan, DL and Sills, RC (2009). Gene Expression Studies Reveal That DNA Damage, Vascular Perturbation, and Inflammation Contribute to the Pathogenesis of Carbonyl Sulfide Neurotoxicity. Toxicologic Pathology 37(4): 502-511.
DOI: http://dx.doi.org/10.1177/0192623309335631

Murphy, WJ, Byrne, DC, Gauger, D, Ahroon, WA, Berger, E, Gerges, SN, McKinley, R, Witt, B and Krieg, EF (2009). Results of the National Institute for Occupational Safety and Health-U.S. Environmental Protection Agency interlaboratory comparison of American National Standards Institute S12.6-1997 Methods A and B. J Acoust Soc Am 125(5): 3262-77.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19425669
DOI: http://dx.doi.org/10.1121/1.3095803

Newbold, RR, Jefferson, WN and Padilla-Banks, E (2009). Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environ Health Perspect 117(6): 879-85.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19590677
DOI: http://dx.doi.org/10.1289/ehp.0800045

Newbold, RR, Padilla-Banks, E and Jefferson, WN (2009). Environmental estrogens and obesity. Mol Cell Endocrinol 304(1-2): 84-9.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19433252
DOI: http://dx.doi.org/10.1016/j.mce.2009.02.024

Pogribny, IP, Shpyleva, SI, Muskhelishvili, L, Bagnyukova, TV, Jill James, S and Beland, FA (2009). Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet. Mutat Res 669(1-2): 56-62.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19442675
DOI: http://dx.doi.org/10.1016/j.mrfmmm.2009.05.003

Pogribny, IP, Tryndyak, VP, Bagnyukova, TV, Melnyk, S, Montgomery, B, Ross, SA, Latendresse, JR, Rusyn, I and Beland, FA (2009). Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol 51(1): 176-86.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19450891
DOI: http://dx.doi.org/10.1016/j.jhep.2009.03.021

Ruder, AM, Butler, MA, Sanderson, WT, Carreon, T, Waters, MA and Zivkovich, ZE (2009). The NIOSH retrospective pesticide reference database. J Agric Saf Health 15(2): 143-56.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19496343

Ruder, AM, Carreon, T, Butler, MA, Calvert, GM, Davis-King, KE, Waters, MA, Schulte, PA, Mandel, JS, Morton, RF, Reding, DJ and Rosenman, KD (2009). Exposure to farm crops, livestock, and farm tasks and risk of glioma: the Upper Midwest Health Study. Am J Epidemiol 169(12): 1479-91.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19403843
DOI: http://dx.doi.org/10.1093/aje/kwp075

Sager, TM and Castranova, V (2009). Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide. Part Fibre Toxicol 6(15).
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19413904
DOI: http://dx.doi.org/10.1186/1743-8977-6-15

Sanders, JM, Bucher, JR, Peckham, JC, Kissling, GE, Hejtmancik, MR and Chhabra, RS (2009). Carcinogenesis studies of cresols in rats and mice. Toxicology 257(1-2): 33-39.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19114085

Savolainen, SM, Foley, JF and Elmore, SA (2009). Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5. Toxicol Pathol 37(4): 395-414.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19359541
DOI: http://dx.doi.org/10.1177/0192623309335060

Schindler, EM, Hindes, A, Gribben, EL, Burns, CJ, Yin, Y, Lin, MH, Owen, RJ, Longmore, GD, Kissling, GE, Arthur, JSC and Efimova, T (2009). p38 delta mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Research 69(11): 4648-4655.
DOI: http://dx.doi.org/10.1158/0008-5472.can-08-4455

Song, MO, Li, J and Freedman, JH (2009). Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics 38(3): 386-401.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19549813
DOI: http://dx.doi.org/10.1152/physiolgenomics.00083.2009

Stone, JE, Kissling, GE, Lujan, SA, Rogozin, IB, Stith, CM, Burgers, PM and Kunkel, TA (2009). Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta. Nucleic Acids Res 37(11): 3774-87.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19380376
DOI: http://dx.doi.org/10.1093/nar/gkp238

Stone, JE, Kissling, GE, Lujan, SA, Rogozin, IB, Stith, CM, Burgers, PMJ and Kunkel, TA (2009). Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase. Nucleic Acids Research 37(11): 3774-3787.
DOI: http://dx.doi.org/10.1093/nar/gkp238

Stout, MD, Herbert, RA, Kissling, GE, Collins, BJ, Travlos, GS, Witt, KL, Melnick, RL, Abdo, KM, Malarkey, DE and Hooth, MJ (2009). Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environ Health Perspect 117(5): 716-22.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19479012
DOI: http://dx.doi.org/10.1289/ehp.0800208

Stout, MD, Nyska, A, Collins, BJ, Witt, KL, Kissling, GE, Malarkey, DE and Hooth, MJ (2009). Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years. Food Chem Toxicol 47(4): 729-33.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19166900
DOI: http://dx.doi.org/10.1016/j.fct.2009.01.006

Sun, J, Von Tungeln, LS, Hines, W and Beger, RD (2009). Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis. J Chromatogr B Analyt Technol Biomed Life Sci 877(24): 2557-65.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19615953
DOI: http://dx.doi.org/10.1016/j.jchromb.2009.06.033

Thomas, R, Gohlke, JM, Stopper, GF, Parham, FM and Portier, CJ (2009). Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure. Genome Biol 10(4): R44.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19393085
DOI: http://dx.doi.org/10.1186/gb-2009-10-4-r44

Tryndyak, VP, Ross, SA, Beland, FA and Pogribny, IP (2009). Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog 48(6): 479-87.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18942116
DOI: http://dx.doi.org/10.1002/mc.20484

Virji, MA, Woskie, SR, Waters, M, Brueck, S, Stancescu, D, Gore, R, Estill, C and Prince, M (2009). Agreement between task-based estimates of the full-shift noise exposure and the full-shift noise dosimetry. Ann Occup Hyg 53(3): 201-14.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19282390
DOI: http://dx.doi.org/10.1093/annhyg/mep010

Von Tungeln, LS, Churchwell, MI, Doerge, DR, Shaddock, JG, McGarrity, LJ, Heflich, RH, da Costa, GG, Marques, MM and Beland, FA (2009). DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide. Int J Cancer 124(9): 2006-15.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19123476
DOI: http://dx.doi.org/10.1002/ijc.24165

Walker, NJ and Bucher, JR (2009). A 21st century paradigm for evaluating the health hazards of nanoscale materials? Toxicol Sci 110(2): 251-4.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19468057
DOI: http://dx.doi.org/10.1093/toxsci/kfp106

Zhang, XD, Hubbs, AF and Siegel, PD (2009). Changes in asthma-like responses after extended removal from exposure to trimellitic anhydride in the Brown Norway rat model. Clin Exp Allergy.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19549025
DOI: http://dx.doi.org/10.1111/j.1365-2222.2009.03304.x

Zhang, Y, Beezhold, K, Castranova, V, Shi, X and Chen, F (2009). Characterization of an alternatively spliced GADD45alpha, GADD45alpha1 isoform, in arsenic-treated epithelial cells. Mol Carcinog 48(5): 454-64.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18942077
DOI: http://dx.doi.org/10.1002/mc.20483

Zhang, Y, Rivera Rosado, LA, Moon, SY and Zhang, B (2009). Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling. J Biol Chem 284(19): 12956-65.
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19269969
DOI: http://dx.doi.org/10.1074/jbc.M807845200

Zhao, J, Bowman, L, Zhang, X, Shi, X, Jiang, B, Castranova, V and Ding, M (2009). Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. J Nanobiotechnology 7(2).
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19379505
DOI: http://dx.doi.org/10.1186/1477-3155-7-2