National Toxicology Program

National Toxicology Program

Federal Register Notices


2014
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 79 FR 20217 - Collaborative Workshop on Aquatic Models and 21st Century Toxicology 04-11-2014 2014-08082 NA PDF
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2013
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 78 FR 68076 - Request for Information on Alternative Skin Sensitization Test Methods and Testing Strategies and for Comment on ICCVAM's Proposed Activities 11-13-2013 2013-27095 View PDF
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2012
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 77 FR 61610 - ICCVAM Evaluation Report and Recommendations for Identifying Chemical Eye Hazards With Fewer Animals; Availability of Report; Notice of Transmittal to Federal Agencies 10-10-2012 2012-24868 View PDF
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2 77 FR 52333 - International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward 08-29-2012 2012-21368 NA PDF
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3 77 FR 50510 - Federal Agency Responses to ICCVAM Recommendations on the Usefulness and Limitations of the LUMI-CELL (reg) ER (BG1Luc ER TA) Test Method, an In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals 08-21-2012 2012-20549 NA PDF
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4 78 FR 45253 - SACATM: Announcement of Meeting; Request for Comments 07-26-2012 2013-17919 NA PDF
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5 77 FR 43827 - International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward 07-26-2012 2012-18294 NA PDF
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6 77 FR 43089 - Evaluation of an Up-and-Down Procedure for Acute Dermal Systemic Toxicity Testing: Request for Nominations for an Independent Expert Panel and Submission of Relevant Data 07-23-2012 2012-17787 View PDF
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7 77 FR 43087 - Nomination of an In Vitro Test Method for the Identification of Contact Allergens: Request for Comments and Data 07-23-2012 2012-17788 View PDF
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8 77 FR 41406 - Evaluation of In Vitro Tests for Identifying Eye Injury Hazard Potential of Chemicals and Products: Request for Nominations for an Independent Expert Panel and Submission of Relevant Data 07-13-2012 2012-17118 View PDF
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9 77 FR 40358 - Meeting of SACATM 07-09-2012 2012-16675 NA PDF
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10 77 FR 35395 - Draft Five-Year Plan (2013-2017) for NICEATM and ICCVAM 06-13-2012 2012-14435 View PDF
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11 77 FR 35393 - Availability of ICCVAM Biennial Progress Report 06-13-2012 2012-14436 View PDF
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12 77 FR 22321 - NICEATM Call for Nominations of High Throughput Screening (HTS) Assays for the Tox21 Initiative 04-13-2012 2012-8942 NA PDF
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13 77 FR 11536 - ICCVAM Recommendations on Use of LLNA for Potency Categorization of Chemicals Causing ACD: Availability of Federal Agency Responses 02-27-2012 2012-4541 NA PDF
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14 77 FR 8258 - Availability of ICCVAM Evaluation Report and Recommendations on the Usefulness and Limitations of the LUMI-CELL (reg) ER (BG1Luc ER TA) Test Method, An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals 02-14-2012 2012-3437 NA PDF
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15 77 FR 2064 - Availability of the Report on the International Workshop on Alternative Methods To Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and Future Directions 01-13-2012 2012-563 NA PDF
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2011
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 76 FR 71977 - Update of the NICEATM-ICCVAM Five-Year Plan: Request for Comments 11-21-2011 2011-30001 View PDF
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2 76 FR 50220 - Availability of Draft ICCVAM Recommendations on Using Fewer Animals to Identify Chemical Eye Hazards: Revised Criteria Necessary to Maintain Equivalent Hazard Classification; Request for Comments 08-12-2011 2011-20537 View PDF
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3 76 FR 50221 - International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward 08-12-2011 2011-20540 View PDF
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4 76 FR 45254 - Report and Recommendations on the Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans 07-28-2011 2011-18639 NA PDF
5 76 FR 29752 - Nomination of In Vitro Test Methods for Detection and Quantification of Botulinum Neurotoxins and Detection of Non-Endotoxin Pyrogens; Data Request for Substances Evaluated by These Test Methods 05-23-2011 2011-12627 View PDF
6 76 FR 28781 - Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of an In Vitro Estrogen Receptor Transcriptional Activation Test Method for Endocrine Disruptor Chemical Screening: Notice of Availability and Request for Public Comments 05-18-2011 2011-12264 NA PDF
7 76 FR 23323 - Meeting of SACATM 04-26-2011 2011-10020 View PDF
8 76 FR 20672 - Recommendations on In Vitro Ocular Safety Testing Methods and Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints for Ocular Safety Testing 04-13-2011 2011-8398 NA PDF
9 76 FR 4113 - Announcement of an Independent Scientific Peer Review Panel Meeting on an In Vitro Estrogen Receptor Transcriptional Activation Test Method for Endocrine Disruptor Chemical Screening; Availability of Draft Background Review Document (BRD); Request for Comments 01-24-2011 2011-1329 View PDF
10 76 FR 2388 - Federal Agency Responses to ICCVAM Recommendations on Two Nonradioactive Versions of the LLNA for Assessing ACD Hazard Potential of Chemicals and Products, and Expanded Uses of the LLNA for Pesticide Formulations and Other Products; Notice of Availability 01-13-2011 2011-669 NA PDF

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2010
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 75 FR 62845 - Workshop Series on Best Practices for Regulatory Safety Testing: Assessing the Potential for Chemically Induced Eye Injuries and Chemically Induced Allergic Contact Dermatitis (ACD) 10-13-2010 2010-25676 View PDF
2 75 FR 57027 - Availability of Test Method Evaluation Reports: In Vitro Ocular Safety Testing Methods and Strategies, and Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints for Ocular Safety Testing; Notice of Transmittal to Federal Agencies 09-17-2010 2010-23262 NA PDF
3 75 FR 37443 - Availability of ICCVAM Test Method Evaluation Reports on Two Nonradioactive Versions of the Murine Local Lymph Node Assay for Assessing Allergic Contact Dermatitis Hazard Potential of Chemicals and Products, and Expanded Uses of the Local Lymph Node Assay for Pesticide Formulations and Other Products; Notice of Transmittal to Federal Agencies 06-29-2010 2010-15777 NA PDF
4 75 FR 32942 - Availability of the ICCVAM Biennial Progress Report 06-10-2010 2010-13952 NA PDF
5 75 FR 26757 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 05-12-2010 2010-11318 NA PDF
6 75 FR 25866 - Federal Agency Responses to ICCVAM Recommendations on the Murine Local Lymph Node Assay, An Alternative Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability 05-10-2010 2010-10954 NA PDF
7 75 FR 25867 - International Workshop on Alternative Methods To Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and Future Directions 05-10-2010 2010-10958 NA PDF

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2009
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 74 FR 62317 - Evaluation of In Vitro Estrogen Receptor Transcriptional Activation and In Vitro Cell Proliferation Assays for Endocrine Disruptor Chemical Screening: Request for Nominations for an Independent Expert Peer Review Panel and Submission of Relevant In Vitro and In Vivo Data 11-27-2009 E9-28278 View PDF
2 74 FR 50212 - Availability of the ICCVAM Test Method Evaluation Report on the Reduced Murine Local Lymph Node Assay (rLLNA); Availability of ICCVAM Recommended Murine Local Lymph Node Assay (LLNA) Performance Standards; Notice of Transmittal to Federal Agencies of ICCVAM Recommendations for the rLLNA, Updated LLNA Test Method Protocol, and LLNA Test Method Performance Standards 09-30-2009 E9-23534 NA PDF
3 74 FR 33444 - Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches: Notice of Availability and Request for Public Comments 07-13-2009 E9-16388 View PDF
4 74 FR 29214 - Meeting of SACATM: Amended Notice 06-19-2009 E9-14502 NA PDF
5 74 FR 26242 - Independent Scientific Peer Review Panel Report: Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability and Request for Public Comments 06-01-2009 E9-12360 View PDF
6 74 FR 19562 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 04-29-2009 E9-9845 NA PDF
7 74 FR 14556 - Announcement of an Independent Scientific Peer Review Panel on Alternative Ocular Safety Testing Methods; Availability of Draft Background Review Documents (BRD); Request for Comments 03-31-2009 E9-7220 View PDF
8 74 FR 8974 - Announcement of a Second Meeting of the Independent Scientific Peer Review Panel on the Murine Local Lymph Node Assay; Availability of Draft Background Review Documents (BRD); Request for Comments 02-27-2009 E9-4280 View PDF

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2008
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 73 FR 71003 - Availability of the ICCVAM Test Method Evaluation Report and Final Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies 11-24-2008 E8-27790 NA PDF
2 73 FR 63150 - Availability of the Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): NIH Publication No. 086529 10-23-2008 E8-25223 NA PDF
3 73 FR 29136 - Peer Review Panel Report on the Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay (LLNA): A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products: Notice of Availability and Request for Public Comments 05-20-2008 E8-11195 NA PDF
4 73 FR 25754 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 05-07-2008 E8-10010 View PDF
5 73 FR 18535 - Non-Animal Methods and Approach for Evaluating Eye Irritation Potential for Antimicrobial Cleaning Products (AMCPs): Request for Nominations for an Independent Expert Panel and Submission of Relevant Data 04-04-2008 E8-6969 View PDF
6 73 FR 15757 - Availability of the ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests and the Final Background Review Document for In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity; Notice of Transmittal of ICCVAM Test Method Recommendations to Federal Agencies 03-25-2008 E8-5936 View PDF
7 73 FR 1360 - Announcement of an Independent Scientific Peer Review Panel Meeting on the Murine Local Lymph Node Assay; Availability of Draft Background Review Documents; Request for Comments 01-08-2008 E7-25553 View PDF
8 73 FR 493 - Workshop on Acute Chemical Safety Testing 01-03-2008 E7-25536 View PDF

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2007
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 72 FR 72727 - Ten-Year Anniversary Symposium and Five-Year Plan 12-21-2007 E7-24799 NA PDF
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2 72 FR 65964 - Availability of TMER and Final BRDs on In Vitro Ocular Test Methods; Recommendations to Federal Agencies 11-26-2007 E7-22906 View PDF
3 72 FR 52130 - Draft Performance Standards for the Murine Local Lymph Node Assay: Request for Comments 09-12-2007 E7-18011 View PDF
4 72 FR 31582 - Request for Ocular Irritancy Test Data From Human, Rabbit, and In Vitro Studies Using Standardized Testing Methods 06-07-2007 E7-10966 NA PDF
5 72 FR 27815 - The Murine Local Lymph Node Assay: Request for Comments, Nominations of Scientific Experts, and Submission of Data 05-17-2007 E7-9544 View PDF
6 72 FR 26395 - Peer Review Panel Report on Five In Vitro Pyrogen Test Methods: Availability and Request for Public Comments 05-09-2007 E7-8896 View PDF
7 72 FR 26396 - Request for Data on the Use of Topical Anesthetics and Systemic Analgesics for In Vivo Eye Irritation Testing 05-09-2007 E7-8898 View PDF
8 72 FR 23831 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 05-01-2007 E7-8289 NA PDF
9 72 FR 23832 - Availability of Draft NICEATM-ICCVAM 5-Year Plan and Request for Public Comments; Announcement of a Town Meeting on the Draft NICEATM-ICCVAM 5-Year Plan 05-01-2007 E7-8290 View PDF

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2006
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 71 FR 74533 - Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Pyrogenicity Testing Methods; Request for Comments 12-11-2006 E6-21038 View PDF
2 71 FR 66959 - Availability of Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 11-16-2006 E6-19487 NA PDF
3 71 FR 66172 - Development of a NICEATM/ICCVAM 5-Year Plan to Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods into Federal Agency Testing Programs: Request for Public Comments 11-09-2006 E6-19094 View PDF
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4 71 FR 62480 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 10-25-2006 E6-17889 NA PDF
5 71 FR 60748 - Notice of Availability of the NICEATM Pre-Screen Evaluation of a Cell Proliferation Assay to Detect Estrogenic Activity: Request for Comments and Nominations of Other In Vitro Endocrine Disruptor Test Methods 10-13-2006 E6-17134 View PDF
6 71 FR 56997 - Notice of Availability of a Revised List of Recommended Reference Substances for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays 09-27-2006 E6-15972 NA PDF
7 71 FR 47505 - Scientific Workshop on Alternative Methods to Refine, Reduce, or Replace the Mouse LD50 Assay for Botulinum Toxin Testing; Request for In Vivo and In Vitro Data 08-16-2006 E6-13525 NA PDF
8 71 FR 39121 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 07-10-2006 E6-10790 NA PDF
9 71 FR 39122 - Availability of Peer Review Panel Report on the Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing and Request for Comments 07-10-2006 E6-10789 View PDF
10 71 FR 14229 - Announcement of an Independent Scientific Peer Review Meeting on the Use of In Vitro Testing Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests and Request for Comments 03-20-2006 E6-4075 View PDF
11 71 FR 13597 - Notice of Availability of a Revised List of Recommended Reference Substances for Validation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays: Request for Comments and Submission of In Vivo and In Vitro Data 03-15-2006 E6-3763 NA PDF
12 71 FR 4603 - Nomination to Hold a Workshop on Alternative Methods to Replace the Mouse LD50 Assay for Botulinum Toxin Potency Testing: Request for Comments, Nominations of Experts, and Submission of In Vivo and In Vitro Data 01-26-2006 E6-1019 View PDF

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2005
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 70 FR 74833 - Peer Panel Evaluation of In Vitro Pyrogenicity Testing Methods: Request for Comments, Nominations of Experts, and Submission of In Vivo and In Vitro Data 12-15-2005 E5-7410 View PDF
2 70 FR 68069 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) 11-08-2005 05-22320 NA PDF
3 70 FR 66451 - Second Expert Panel Report on In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 11-01-2005 05-21830 View PDF
4 70 FR 53676 - Announcement of Expert Panel Meeting to Evaluate Revised Analyses and Proposed Reference Substances for In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 09-08-2005 05-17939 NA PDF
5 70 FR 43149 - Availability of Revised Analyses and Proposed Reference Substances for In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 07-25-2005 05-14707 View PDF
6 70 FR 35687 - National Institute of Environmental Health Sciences 2006 Strategic Plan; Request for Comments and Nominations 06-20-2005 05-12129 NA PDF
7 70 FR 18037 - Ocular Toxicity Scientific Symposia: Mechanisms of Chemically-Induced Ocular Injury and Recovery and Minimizing Pain and Distress in Ocular Toxicity Testing 04-07-2005 05-7002 NA PDF
8 70 FR 14473 - Request for Nominations for an Independent Peer Review Panel to Evaluate In Vitro Testing Methods for Estimating Acute Oral Systemic Toxicity and Request for In Vivo and In Vitro Data 03-22-2005 05-5564 View PDF
9 70 FR 13512 - Request for Data on Non-Animal Methods and Approaches for Determining Skin and Eye Irritation Potential of Antimicrobial Cleaning Product Formulations; Request for Nominations for an Independent Expert Panel 03-21-2005 05-5471 View PDF
10 70 FR 13513 - Availability of Expert Panel Report on the Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 03-21-2005 05-5473 View PDF
11 70 FR 9661 - Second Request for Data on Chemicals Evaluated by In Vitro or In Vivo Ocular Irritancy Test Methods 02-25-2005 05-3831 View PDF

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2004
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 69 FR 70268 - Notice of Additional Data and Analyses for the Assessment of the Current Validation Status of In Vitro Testing Methods for Identifying Potential Ocular Irritants 12-02-2004 04-26594 NA PDF
2 69 FR 64081 - Notice of an Expert Panel Meeting to Assess the Current validation Status of In Vitro Testing Methods for Identifying Potential Ocular Irritants; Request for Comments 11-02-2004 04-24481 View PDF
3 69 FR 61504 - Availability of Updated Standardized In Vitro Cytotoxicity Test Method Protocols for Estimating Acute Oral Systemic Toxicity; Request for Existing In Vivo and In Vitro Acute Toxicity Data 10-18-2004 04-23335 NA PDF
4 69 FR 54298 - Notice of Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 09-07-2004 04-20292 NA PDF
5 69 FR 30693 - Notice of Availability of Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion 05-27-2004 04-12126 NA PDF
6 69 FR 21565 - Request for Nominations of Scientific Experts for Independent Expert Panel Evaluations and/or Other Reviews of In Vitro Testing Methods for Identifying Potential Ocular Irritants 04-20-2004 04-9032 NA PDF
7 69 FR 21564 - In Vitro Endocrine Disruptor Test Methods: Request for Comments and Nominations 04-20-2004 04-8980 NA PDF
8 69 FR 13859 - Request for Public Comment on the Nomination for Ocular Toxicity Test Methods and Related Activities and Request for Data on Chemicals Evaluated by In Vitro or In Vivo Ocular Irritancy Test Methods 03-23-2004 04-6487 NA PDF
9 69 FR 11448 - Notice of Availability of Agency Responses to ICCVAM Test Recommendations for the Revised Up-and-Down Procedure for Determining Acute Oral Toxicity and In Vitro Methods for Assessing Acute Systemic Toxicity 03-09-2004 04-5321 NA PDF
10 69 FR 7777 - Biennial Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability 02-18-2004 04-3528 NA PDF
11 69 FR 6674 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 02-10-2004 04-2931 NA PDF

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2003
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 68 FR 64636 - Request for Nominations and Submissions fo Alternative Test Methods for Evaluation by ICCVAM; Notice of the Availability of the Updated Document, "ICCVAM Guidelines for Nomination and Submission of New, Revised, and Alternative Test Methods" 11-13-2003 03-28560 NA PDF
2 68 FR 42067 - Request for Existing Dermal and Ocular Irritancy Chemical Test Data from Animal and Human Studies Using Standardized Testing Methods 07-15-2003 03-18011 NA PDF
3 68 FR 42066 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 07-15-2003 03-18012 NA PDF
4 68 FR 39104 - Notice of Availability of Proposed Minimum Performance Standards (MPS) for Three Types of In Vitro Methods for Assessing the Dermal Corrosivity Hazard Potential of Chemicals; Request for Comments 06-30-2003 03-16506 View PDF
5 68 FR 33171 - Notice of Availability of the Report: "Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays" 06-02-2003 03-13839 NA PDF

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2002
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 67 FR 77064 - Environmental Protection Agency: Revised Final Health Effects Test Guidelines; Acute Toxicity Testing - Background and Acute Oral Toxicity; Notice of Availability 12-12-2002 02-31612 NA PDF
2 67 FR 67203 - Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods 11-01-2002 02-27902 NA PDF
3 67 FR 64902 - Notice of Availability of an Expert Panel Report on the Current Validation Status of In Vitro Endocrine Disruptor Screening Methods and a Proposed List of Substances for Validation of In Vitro Endocrine Disruptor Screening Methods; Request for Comments 10-21-2002 02-26733 View PDF
4 67 FR 49706 - Availability of the Report, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Evaluation of EPISKIN(TM), EPIDERM(TM) (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals 07-30-2002 02-19261 NA PDF
5 67 FR 16415 - Notice of an Expert Panel Meeting to Assess the Current Validation Status of In Vitro Endocrine Disruptor Screening Methods; Request for Comments 04-04-2002 02-8328 View PDF
6 67 FR 11358 - Notice of Establishment; Scientific Advisory Committee on Alternative Toxicological Methods 03-12-2002 02-5932 NA PDF
7 67 FR 5845 - Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): Notice of Availability 02-06-2002 02-2907 NA PDF
8 67 FR 5842 - Report on the Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals; Notice of Availability and Request for Public Comments 02-06-2002 02-2905 NA PDF

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2001
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 66 FR 49685 - EPISKIN(TM), EPIDERM(TM), and Rat Skin Transcutaneous Electrical Resistance Methods: In Vitro Test methods Proposed for Assessing the Dermal Corrosivity Potential of Chemicals; Notice of Availability of a Background Review Document and Proposed ICCVAM Test Method Recommendations and Request for Public Comment 09-27-2001 01-24371 View PDF
2 66 FR 49686 - Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity; Notice of Availability and Request for Public Comment 09-27-2001 01-24370 View PDF
3 66 FR 49196 - Amended Notice of Meeting 09-25-2001 01-24034 NA PDF
4 66 FR 46020 - Meeting of the Advisory Committee on Alternative Toxicological Methods 08-30-2001 01-21987 NA PDF
5 66 FR 46066 - The Revised Draft Up-and-Down Procedure for Assessing Acute Oral Toxicity; Notice of Availability and Request for Public Comments: CORRECTION 08-30-2001 C1-15770 NA PDF
6 66 FR 36294 - Peer Review Panel for the Up-and-Down Procedure (UDP): Notice of Meeting 07-11-2001 01-17288 View PDF
7 66 FR 33550 - The Revised Draft Up-and-Down Procedure for Assessing Acute Oral Toxicity: Notice of Availability and Requests for Public Comments 06-21-2001 01-15770 NA PDF
8 66 FR 16278 - Request for Data and Nominations of Expert Scientists for an Independent Peer Review Evaluation of In Vitro Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays for Endocrint Disruptor Screening 03-22-2001 01-7228 NA PDF

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2000
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 65 FR 66549 - Meeting of the Advisory Committee on Alternative Toxicological Methods 11-03-2000 00-28342 NA PDF
2 65 FR 57203 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Workshop Agenda and Registration Information 09-20-2000 00-24244 NA PDF
3 65 FR 37400 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Request for Data and Suggested Expert Scientists 06-13-2000 00-14968 NA PDF
4 65 FR 35109 - Notice of Peer Review Meeting on the Revised Up-and-Down Procedure (UDP) as an Alternative Test Method for Assessing Acute Oral Toxicity; Request for Comments 05-31-2000 00-13734 NA PDF
5 65 FR 13289 - Notice of Expert Panel Meeting on the Frog Embryo Teratogenesis -- Xenopus 03-10-2000 00-6013 NA PDF
6 65 FR 8385 - Request for Data and Nomination of Expert Scientists To Participate in the Independent Peer Review Evaluation of the Revised Up-and-Down Procedure for Assessing Acute Oral Toxicity; Evaluation of the Up-and-Down Procedure 02-17-2000 00-4010 NA PDF
7 65 FR 7878 - Meeting of the Advisory Committee on Alternative Toxicological Methods 02-15-2000 00-3590 NA PDF

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1999
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 64 FR 67579 - Availability and Request for Comments on the Revised Guidance Document: Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 12-01-1999 99-31342 NA PDF
2 64 FR 50297 - Meeting of the Advisory Committee on Alternative Toxicological Methods 09-15-1999 99-24121 NA PDF
3 64 FR 48662 - Request for Data and Suggested Expert Panelists for Evaluation of the Current Status of the Frog Embryo Teratogenesis Assay--Xenopus (FETAX) 09-03-1999 99-23219 NA PDF
4 64 FR 33109 - Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential fo Chemicals, Report Now Available 06-18-1999 99-15725 NA PDF
5 64 FR 18040 - National Toxicology Program Special Emphasis Panel; Notice of Meeting 04-12-1999 99-9099 NA PDF
6 64 FR 14006 - The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds, Report Now Available 03-22-1999 99-6953 NA PDF
7 64 FR 6111 - Meeting of the Advisory Committee on Alternative Toxicological Methods 02-08-1999 99-24121 NA PDF

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1998
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 63 FR 57303 - Notice of Meeting to Review the Corrositex(R) Assay as an Alternative Test Method for Assessing the Skin Corrosivity Potential of Chemicals; Request for Comments 10-26-1998 98-28713 NA PDF
2 63 FR 40303 - Request for Comments on Test Methods Undergoing Review by the Interagency Coordinating Committee on the Validation fo Alternative Methods (ICCVAM) and the National Toxicology Program Interagency Center for the Evaluation of Alternative Methods 07-27-1998 98-20040 NA PDF
3 63 FR 37405 - Notice of Meeting to Review the Murine Local Lymph Node Assay (LLNA) as an Alternative Test Method for Contact Hypersensitivity; Request for Comments 07-09-1998 98-18320 NA PDF

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1997
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 62 FR 55649 - Notice of Meeting to Discuss the Procedures and Activities of the National Toxicology Program (NTP) Center for the Evaluation of Alternative Toxicological Methods and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 10-24-1997 97-28373 NA PDF
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2 62 FR 48290 - Notice of Establishment 09-12-1997 97-24273 NA PDF
3 62 FR 11901 - Validation and Regulatory Acceptance of Toxicological Test methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods, Now Available 03-12-1997 97-6288 NA PDF

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1994
No. Title Publication Date Notice Number Link to Public Comments Document Links
1 Validation and Acceptance of Alternative Testing Methods; Request for Comments 12-07-1994 94-30023 NA PDF
The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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