National Toxicology Program

Preliminary Agenda Topics

Update of NTP Activities

• NTP News Update (592 kb) - August 2009
• NTP News Update (676 kb) - October 2009

Center for the Evaluation of Risks to Human Reproduction (CERHR)

• CERHR Evaluation Process(200 kb)
• CERHR Concept:  (120 kb) State of the Science Evaluation on Environmental Exposures and Diabetes and Obesity
  

Contract Concept Reviews

Background Materials

• Use of Contracts in the NTP Testing Program (68 kb)

Contract Concept Reviews

• Background for Concept Review (72 kb)
• Contact Concept Review: Analytical Chemistry Support for NTP (80 kb) (ACTION)
• Contract Concept Review: Laboratory Studies for the NTP to Evaluate Toxicity following Early Life Exposure to Chemicals (80 kb) (ACTION)

Review of NTP Host Susceptibility Branch Research and Testing Program

Background Materials

• Overview of HSB (24 kb)
• Mission and development of programmatic research/testing projects  (24 kb)
• NIEHS/NTP-Perlegen Resequencing Project (44 kb)
• ADME and Toxicogenetics
• Benzene ADME in genetically diverse mouse strains (Project 1) (76 kb)
• Benzene ADME phenotypes and haplotype association analysis in multiple inbred mouse strains (Project 2) (76 kb)
• Benzene low dose inhalation-induced hematotoxicity and genotoxicity phenotypes and haplotype association analyses (Project 3) (64 kb)
• Environmental Cardiotoxins
  • Studies to identify environmental cardiotoxins and susceptibilities to cardiotoxicity (Project 4) (68 kb)
• Aging, Cancer, and Disease
  • Aging and disease phenotyping in multiple inbred mouse strains (Project 5) (36 kb)
  • Development of a short-term cancer bioassay using multiple p53 haploinsufficient F1 inbred strains (Project 6) (68 kb)
  • Alkylanilines class study (Project 7) (36 kb)
  • Impact of sex and strain on the performance of genomic signatures of hepatocarcinogenesis (Project 8) (32 kb)

NIEHS/NTP Nominations and Concepts

• Background Material for NTP Testing Program Nominations

• Butterbur
Background (760 kb)
Public Comments

• Evening primrose oil
Background (532 kb)
Public Comments

• Hydroquinone
  
Background (452 kb)
Public Comments

• Silica flour
Background (700 kb)
Public Comments


• Valerian extracts and oil
  Background (1.5 Mb)
  Public Comments


• Draft NTP Research Concept: Butterbur(80 kb)
• Draft NTP Research Concept: Evening primrose oil(1.6 Mb)
• Draft NTP Research Concept: Hydroquinone(112 kb)
• Draft NTP Research Concept: Silica flour(88 kb)
• Draft NTP Research Concept: Valerian extracts and oil(120 kb)

NTPs Dietary Supplements and Herbal Medicines Initiative

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