National Toxicology Program

National Toxicology Program

Reports





2012
No. Title Date Link
1 ICCVAM Test Method Evaluation Report: Identifying Chemical Eye Hazards with Fewer Animals 10-10-2012 Link
2 ICCVAM Biennial Progress Report 2010-2011 (NIH Publication No. 12-7873) 06-13-2012 Link
3 Informational Brochure: "Nominations and Submissions to ICCVAM: A Guide for Test Method Developers and Sponsors" 03-06-2012 Link
4 Informational Brochure: "NICEATM-ICCVAM: Advancing Public Health and Animal Welfare" 03-06-2012 Link
5 ICCVAM Test Method Evaluation Report - The LUMI-CELLĀ® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals 02-01-2012 Link

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2011
No. Title Date Link
1 ICCVAM Test Method Evaluation Report: Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans (NIH Publication No. 11-7709) 06-30-2011 Link
2 Independent Scientific Peer Review Panel Report: Evaluation of the LUMI-CELL ERĀ® (BG1Luc ER TA) Test Method 05-01-2011 Link

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2010
No. Title Date Link
1 ICCVAM Test Method Evaluation Report on a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and Labeling of Antimicrobial Cleaning Products (NIH Publication No. 10-7513) 09-13-2010 Link
2 ICCVAM Test Method Evaluation Report: Recommendation to Discontinue Use of the Low Volume Eye Test for Ocular Safety Testing (NIH Publication No. 10-7515) 09-13-2010 Link
3 ICCVAM Test Method Evaluation Report: Recommendations for Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints to Avoid or Minimize Pain and Distress in Ocular Safety Testing (NIH Publication No. 10-7514) 09-13-2010 Link
4 ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553) 09-13-2010 Link
5 ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7552) 06-29-2010 Link
6 ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products (NIH Publication No. 10-7512) 06-29-2010 Link
7 ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7551) 06-29-2010 Link
8 ICCVAM 2008-2009 Biennial Report (NIH Publication No. 10-7612) 06-10-2010 Link

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2009
No. Title Date Link
1 Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches 07-13-2009 Link
2 Independent Scientific Peer Review Panel Report - Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products 06-01-2009 Link
3 ICCVAM Test Method Evaluation Report - The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 09-6439) 03-01-2009 Link
4 Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations 03-01-2009 Link
5 Recommended Performance Standards: Murine Local Lymph Node Assay (NIH Publication No. 09-7357) 01-01-2009 Link

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2008
No. Title Date Link
1 Biennial Progress Report: Interagency Coordinating Committee on the Validation of Alternative Methods - 2006-2007 (NIH Publication No. 08-6529) 10-23-2008 Link
2 Independent Scientific Peer Review Panel Report - Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products 05-20-2008 Link
3 ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6392) 05-01-2008 Link
4 ICCVAM Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6391) 05-01-2008 Link
5 Report on the ICCVAM-NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce or Replace the Mouse LD50 Assay for Botulinum Toxin Testing (NIH Publication No. 08-6416) 03-28-2008 Link
6 The NICEATM-ICCVAM Five-Year Plan (2008-2012) (NIH Publication No. 08-6410) 02-05-2008 Link

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2007
No. Title Date Link
1 Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products 04-30-2007 Link

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2006
No. Title Date Link
1 Biennial Progress Report 2004-2005 - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 06-4516) 11-26-2006 Link
2 ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication No. 07-4517) 11-01-2006 Link
3 Background Review Document: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518) 11-01-2006 Link
4 ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests (NIH Publication No. 07-4519) 11-01-2006 Link
5 Biennial Progress Report 2004-2005 - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 06-4516) 10-24-2006 Link
6 NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity) 10-16-2006 Link
7 NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity) 10-16-2006 Link
8 Finalized Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors 09-28-2006 Link
9 Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing 06-01-2006 Link
10 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method (NIH Publication No. 06-4513) 03-12-2006 Link
11 Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512: Volume 1 of 2) 03-12-2006 Link
12 Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512: Volume 2 of 2) 03-12-2006 Link
13 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Rabbit Eye (IRE) Test Method (NIH Publication No. 06-4514) 03-12-2006 Link
14 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Hen's Egg Test - Chrorioallantoic Membrane (Het-CAM) Test Method (NIH Publication No. 06-4515) 03-12-2006 Link

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2005
No. Title Date Link
1 Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - ADDENDUM 11-12-2005 Link
2 Draft Report: Analysis of the Estimated Underclassification and Overclassification Likelihoods of the Current In Vivo Rabbit Eye Test for Hazard Classification 11-04-2005 Link
3 Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 03-12-2005 Link
4 NICEATM Draft Report: Interim Analysis of the Estimated Potential Underclassification Rates of the Current Rabbit Test for Detecting Ocular Corrosives and Severe Irritants 01-06-2005 Link
5 NICEATM Draft Technical Summary: Reduction of the Number of Animals Required for Ocular Irritancy Testing: A Brief Review of the Literature 01-04-2005 Link

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2004
No. Title Date Link
1 Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion (NIH Publication No. 04-4510) 05-10-2004 Link
2 ICCVAM Review of the In Vivo Rabbit Dermal Corrosivity Test 02-20-2004 Link
3 Interagency Coordinating Committee on the Validation of Alternative Methods: Mission, Vision and Strategic Priorities 02-11-2004 Link

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2003
No. Title Date Link
1 ICCVAM Biennial Progress Report 2002-2003 (NIH Publication No. 04-4509) 12-19-2003 Link
2 ICCVAM Guidelines for the Nomination and Submission of New, Revised and Alternative Test Methods (NIH Publication No. 03-4508) 09-01-2003 Link
3 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH Publication No. 03-4503) 05-01-2003 Link

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2002
No. Title Date Link
1 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4507) 09-01-2002 Link
2 Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays 09-01-2002 Link
3 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4505) 09-01-2002 Link
4 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Binding Assays (NIH Publication No. 03-4506) 09-01-2002 Link
5 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Binding Assays (NIH Publication No. 03-4504) 09-01-2002 Link
6 ICCVAM Evaluation of EPISKIN(TM), EpiDerm(TM), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals (NIH Publication No. 02-4502) 07-22-2002 Link

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2001
No. Title Date Link
1 Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 12-19-2001 Link
2 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501) (Table of Contents in HTML) 11-30-2001 Link
3 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501) (Table of Contents in HTML) 11-30-2001 Link
4 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501): Volume 1 11-12-2001 Link
5 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501): Volume 2 11-12-2001 Link
6 Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by ICCVAM and NICEATM (NIH Publication 01-4499) 08-17-2001 Link
7 Background Review Document - EPISKIN(TM), EpiDerm(TM)(EPI-200), and Rat Skin Transcutaneous Electrical Resistance (TER) - In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals 08-12-2001 Link
8 Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity: Based on Recommendations from an International Workshop Organized by ICCVAM and NICEATM 08-01-2001 Link
9 ICCVAM Recommendations on In Vitro Methods for Assessing Acute Systemic Toxicity (Appendix I of 2001 Workshop Report, NIH Publication No. 01-4499) 08-01-2001 Link
10 ICCVAM Procedures for Test Methods That Have Been Endorsed by ECVAM 04-23-2001 Link
11 ICCVAM Immunotoxicity Working Group Recommended Protocol for the Murine Local Lymph Node Assay (LLNA): Testing of Chemicals for Contact Sensitizing (Allergic Contact Dermatitis) Potential 01-12-2001 Link

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2000
No. Title Date Link
1 ICCVAM Authorization Act of 2000 (Public Law 106-545) 12-19-2000 Link
2 Background Review Document: Frog Embryo Teratogenesis Assay -- Xenopus (FETAX) 03-10-2000 Link

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1999
No. Title Date Link
1 Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to ICCVAM (NIH Publication 99-4496 - Superseded by NIH Publication 03-4508) 10-01-1999 Link
2 Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4495) 06-01-1999 Link
3 The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4494) 03-11-1999 Link

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1997
No. Title Date Link
1 Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 97-3981) 03-01-1997 Link
The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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