Testing Information

Testing Status of Agents at NTP

Manganese sulfate monohydrate

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http://ntp.niehs.nih.gov/go/TS-M88035

CASRN: 10034-96-5

Related: MANGANESE SULFATE (CAS 7785-87-7)

Formula: O4-S.Mn.H2-O

Synonyms/Common Names:

  • SULFURIC ACID, MANGANESE(2+) SALT (1:1), MONOHYDRATE

Known Uses:

Fertilizers. Feed additive. Intermediate in paints, varnishes, ceramics, textile dyes, and medicines.

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C61143A) Completed 
    • NTIS No. PB94-217148
      Citation: Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CAS No. 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C61143A) Completed 
    • NTIS No. PB94-217148
      Citation: Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CAS No. 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,0.16,2.50, M: 0,0.313,5.0 %/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C61143B) Report Complete 
    • TR-428 (NTIS No. PB94-217148)  (Peer Review 06/23/1992)
      Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CAS No. 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R & M: 0, 1500, 5000, AND 15000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (393357) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (468058) Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (178715) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (800201) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

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Web page last updated on November 19, 2009