National Toxicology Program

National Toxicology Program

Chemicals Associated with Site-Specific Tumor Induction in Mammary Gland

http://ntp.niehs.nih.gov/go/SA-39
Chemicals Associated with Site-Specific Tumor Induction in Mammary Gland
 Levels of Evidence of Carcinogenicity May Have Been Related
TRChemicalSalmonella ResultsRouteMale RatsFemale RatsMale MiceFemale MiceSex/SpeciesMultiple Tumor Sites
TR-049Acronycine Intraperitoneal InjectionP(P)ISIS    Yes
TR-575Acrylamide-,W+Dosed-WaterCE(CE)CE(CE)    Yes
TR-289Benzene-GavageCECECE(CE)    Yes
TR-4522,2-bis(Bromomethyl)-1,3-propanediol+,-,+Dosed-Feed(CE)(CE)CECE   (FM)Yes
TR-2881,3-Butadiene+Inhalation  CE(CE)    Yes
TR-4341,3-Butadiene+Inhalation  CE(CE)    Yes
TR-3792-Chloroacetophenone (CN)-InhalationNE(EE)NENE    No
TR-467Chloroprene-InhalationCE(CE)CE(CE)    Yes
TR-405C.I. Acid red 114+Dosed-WaterCECE   (FR)  Yes
TR-285C.I. Basic red 9 monohydrochloride+Dosed-FeedCECECECE (FR)  Yes
TR-091Clonitralid Dosed-FeedN(E)ISN    Yes
TR-207Cytembena+Intraperitoneal InjectionP(P)NN    Yes
TR-1622,4-Diaminotoluene (2,4-toluene diamine)+Dosed-FeedP(P)NP    Yes
TR-0281,2-Dibromo-3-chloropropane+GavageP(P)PP    Yes
TR-2101,2-Dibromoethane+InhalationP(P)P(P)    Yes
TR-4002,3-Dibromo-1-propanol+Topical ApplicationCE(CE)CECE    Yes
TR-0661,1-Dichloroethane-GavageN(E)NE    Yes
TR-0551,2-Dichloroethane+GavageP(P)P(P)    Yes
TR-2631,2-Dichloropropane (propylene dichloride)W+,W+GavageNE(EE)SESE    Yes
TR-342Dichlorvos+GavageSE(EE)SECE    Yes
TR-3723,3'-Dimethoxybenzidine dihydrochloride Dosed-WaterCE(CE)      Yes
TR-3903,3'-Dimethylbenzidine dihydrochloride+Dosed-WaterCE(CE)      Yes
TR-0542,4-Dinitrotoluene+Dosed-FeedP(P)NN    Yes
TR-548Endocrine disruptor (Ethinyl estradiol)
(F3T21)
 Dosed-FeedEEEE  (MR)   Yes
TR-545Endocrine disruptor (Genistein) Dosed-Feed     (FR)   
TR-326Ethylene oxide Inhalation  CE(CE)    Yes
TR-356Furosemide-,-Dosed-FeedEENENE(SE)    Yes
TR-374Glycidol+,+Gavage(CE)(CE)CE(CE)    Yes
TR-092Hydrazobenzene+Dosed-FeedP(P)NP    Yes
TR-499Indium phosphide InhalationCECECECE (FR)  Yes
TR-551Isoeugenol-,-GavageEENECEEE(MR)   Yes
TR-032Isophosphamide Intraperitoneal InjectionN(P)NP    Yes
TR-486Isoprene-Inhalation(CE)(SE)      Yes
TR-527Malachite green-Dosed-Feed (EE) NE    Yes
TR-306Methylene chloride+,-,+Inhalation(SE)(CE)CECE    Yes
TR-491Methyleugenol-Gavage(CE)CECECE    Yes
TR-146Nithiazide+Dosed-FeedN(P)PE    Yes
TR-1185-Nitroacenaphthene+Dosed-FeedP(P)NP    Yes
TR-337Nitrofurazone+Dosed-FeedEE(CE)NECE    Yes
TR-461Nitromethane-InhalationNE(CE)CECE    Yes
TR-504o-Nitrotoluene-,-Dosed-Feed(CE)(CE)CECE    Yes
TR-358Ochratoxin A-GavageCE(CE)      Yes
TR-060Phenesterin-,-GavageN(P)PP    Yes
TR-019Procarbazine hydrochloride-Intraperitoneal Injection(P)(P)PP    Yes
TR-193Reserpine-Dosed-FeedPNP(P)    Yes
TR-115Sulfallate+Dosed-FeedP(P)P(P)    Yes
TR-2512,4- & 2,6-Toluene diisocyanate+GavageP(P)NP    Yes
TR-153o-Toluidine hydrochloride+,-Dosed-FeedP(P)PP    Yes
TR-3841,2,3-Trichloropropane+,+GavageCE(CE)CECE    Yes
TR-510Urethane+,EDosed-Water  CE(CE)    Yes
TR-510Urethane + ethanol (combination) Dosed-Water         
TR-549Water disinfection byproducts (Bromochloroacetic acid) Dosed-WaterCE(CE)CECE    Yes
 Totals941014 
The number of chemicals causing tumors in Mammary Gland is 51.

Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment

Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative

Parentheses indicate the animal group in which a tumor occurred in the organ specified.

Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice

Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified.

NOTE: Blank space under the animal groups indicates no experiments were done.

The NTP is administratively located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

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