Testing Information

Testing Status of Agents at NTP

CAS Registry Number: 57-63-6

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http://ntp.niehs.nih.gov/go/24414

Selected information from two of the National Library of Medicine's databases: ChemIDPlus1 and HSDB2.

Names (NTP)

  • Ethinyl estradiol
  • ETHINYL ESTRADIOL (ENDOCRINE DISRUPTOR)
  • ETHINYL ESTRADIOL PUBERTAL STUDY
  • 19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17-DIOL, (17ALPHA) (9CI)
  • Endocrine disruptor (Ethinyl estradiol)
  • ETHINYL ESTRADIOL (TRANSGENIC MODEL EVALUATION)
  • 19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17-DIOL, (17ALPHA) (9CI)
  • Pubertal ethinyl estradiol study
  • Transgenic model evaluation (Ethinyl estradiol)

Structure

Chemical Structure for Chemical Abstracts Service Registry Number 57-63-6 from NLM

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Chemical Properties2

Property Description
Color/Form
  • Hemihydrate, fine needles from methanol and water
Odor
  • None found
Taste
  • None found
Boiling Point
  • None found
Melting Point
  • 141-146 deg C
Molecular Weight
  • 296.41
Corrosivity
  • None found
Critical Temperature & Pressure
  • None found
Density/Specific Gravity
  • None found
Disassociation Constants
  • None found
Heat of Combustion
  • None found
Heat of Vaporization
  • None found
log P (octanol-water)
  • log Kow = 3.67
pH
  • None found
Solubilities
  • Solubility: 1 part in 6 of ethanol, 1 in 4 of ether, 1 in 5 of acetone, 1 in 4 of dioxane, and 1 in 20 of chloroform. Soluble in vegetable oils, and in solutions of fixed alkali hydroxides.
  • In water, 11.3 mg/l @ 27 deg C.
Spectral Properties
  • Optical rotation at 24 deg C for sodium line: 3.5 deg +/- 0.5 deg (c = 2 in dioxane); -29.5 deg +/- 1 deg (c = 2 in pyridine). UV max (ethanol): 281 nm (molar extinction coefficient; dielectric constant = 2040 +/- 60 g-moles/l)
Surface Tension
  • None found
Vapor Density
  • None found
Vapor Pressure
  • None found
Relative Evaporation Rate
  • None found
Viscosity
  • None found
Other Properties
  • Hemihydrate
  • Dehydrates after melting and further heating, mp 182-184 deg C.
  • Crystals, mp 152-153 deg C. Optical rotation at 20 deg C for sodium line: +3 deg (chloroform). /3-Acetate/
  • Needles from methanol, mp 200-202 deg. /3-Benzoate/

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Uses2

  • Estrogen. In combination with progestogen as oral contraceptive. Also used in combination with chlormadinone acetate, desogestrel, ethynodiol, gestodene, lynestrenol, norethindrone or norgestrel, ... Has been used in combination with dimethisterone, medroxyprogesterone, or megestrol acetate, ...
  • Therap cat (Vet): Estrogen
  • Ethinylestradiol is contained in most combination contraceptives

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Superlist Classes1

  • Reasonably anticipated to be a carcinogen

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Notes (Sources: NTP,HSDB,RTECS,MESH)1

  • None found

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Other Registry Numbers1

  • 77538-56-8
  • 406932-93-2

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)1

  • 4-06-00-06877 (Beilstein Handbook Reference)
  • Amenoron
  • BRN 2419975
  • Chee-O-Gen
  • Chee-O-Genf
  • 3,17-beta-Dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene
  • 3,17-beta-Dihydroxy-17-alpha-ethynyl-1,3,5(10)-oestratriene
  • Diogyn E
  • Diprol
  • Dyloform
  • EE
  • EE(sub 2)
  • EO
  • Esteed
  • Estigyn
  • Estinyl
  • Eston-E
  • Estoral
  • Estoral (orion)
  • Estorals
  • Estradiol, 17-ethynyl-
  • Estra-1,3,5(10)-triene-3,17-beta-diol, 17-alpha-ethynyl-
  • Ethidol
  • Ethinoral
  • 17-alpha-Ethinyl-3,17-dihydroxy-delta(sup 1,3,5)-estratriene
  • 17-Ethinylestradiol
  • 17-alpha-Ethinyl-17-beta-estradiol
  • 17-Ethinyl-3,17-estradiol
  • 17-alpha-Ethinylestra-1,3,5(10)-triene-3,17-beta-diol
  • Ethinyloestradiol
  • 17-Ethinyl-3,17-oestradiol
  • Ethinyl-oestranol
  • 17-alpha-Ethinyloestra-1,3,5(10)-triene-3,17-beta-diol
  • 17-alpha-Ethinyl-delta(sup 1,3,5(10))oestratriene-3,17-beta-diol
  • 17-Ethynyl-3,17-dihydroxy-1,3,5-oestratriene
  • Ethynylestradiol
  • 17-alpha-Ethynylestradiol
  • 17-alpha-Ethynylestradiol-17-beta
  • 17-alpha-Ethynyl-1,3,5(10)-estratriene-3,17-beta-diol
  • Ethynyloestradiol
  • 17-Ethynyloestradiol
  • 17-alpha-Ethynyl-17-beta-oestradiol
  • 17-alpha-Ethynyl-1,3,5(10)-oestratriene-3,17-beta-diol
  • 17-alpha-Ethynyl-1,3,5-oestratriene-3,17-beta-diol
  • Eticyclin
  • Eticyclol
  • Etinestrol
  • Etinestryl
  • Etinoestryl
  • Etistradiol
  • Feminone
  • Follicoral
  • Ginestrene
  • Inestra
  • Linoral
  • Lynoral
  • Menolyn
  • Microfollin
  • 19-Nor-17-alpha-pregna-1,3,5(10)-triene-20-yne-3,17-diol
  • (17-alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17,diol
  • Novestrol
  • NSC-10973
  • Oradiol
  • Orestralyn
  • Palonyl
  • Perovex
  • Primogyn
  • Primogyn C
  • Primogyn M
  • Progynon C
  • Spanestrin

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Links to Additional Information1

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Footnotes

1 Source: the National Library of Medicine's ChemIDPlus, 05/28/2009.

2 Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.

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Web page last updated on August 06, 2009