Respiratory System

Lung - Crystals

    Narrative
    Lung - Crystals in a male B6C3F1/N mouse from a chronic study. Acicular, eosinophilic crystals and associated granulomatous inflammation are present in the alveoli.
    Lung - Crystals in a male B6C3F1/N mouse from a chronic study. The eosinophilic crystals are largely extracellular.
    Lung - Crystals in a male B6C3F1/N mouse from a chronic study. The larger crystals are extracellular, and the smaller crystals are within macrophages or multinucleated giant cells.
    Lung - Crystals in a male F344/N rat from a chronic study. These deeply eosinophilic, variably shaped crystals are associated with hemorrhage.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC