NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 FINAL#3,REVISION #1 Facility: Battelle Columbus Laboratory Chemical CAS #: 68603-42-9 Lock Date: 09/06/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2| | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | X X X | Fibrosis | | Hepatodiaphragmatic Nodule | X X X X X X X X| Inflammation, Chronic | 1 2 2 2 3 1 1 2 1 2 1 1 1 1 1 1 1 | Mixed Cell Focus | | Pigmentation, Hemosiderin | | Vacuolization Cytoplasmic | 1 2 2 3 1 3 1 1 1 1 2| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | Hepatocyte, Hyperplasia, Adenomatous | | Hepatocyte, Necrosis | | Hepatocyte, Centrilobular, | | Degeneration | 3 | Hepatocyte, Centrilobular, Necrosis | 3 | Serosa, Necrosis, Fibrinoid | | |__________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 4 4 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2| | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Oral Mucosa | | Gingival, Hyperplasia, Squamous | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 2 | Acinus, Atrophy | 2 3 2 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Inflammation, Chronic Active | | Epithelium, Hyperplasia | | Epithelium, Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Ulcer | | |__________________________________________________________________________| Tooth | + | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 1 2 1 1 1 1 1 2 2| Inflammation, Chronic Active | 3 | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 3 2 2 2 3| Degeneration, Fatty | 1 1 1 2 1 2 1 1 2 1| Fibrosis | 2| Hyperplasia | 4 2 1 2 1 3 1 2 2 2| Hypertrophy | 2 2 2 2 2 2 1 | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2| | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Necrosis | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + M + + + + M M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 2 2 2 2 2 2 2 | Pars Distalis, Hyperplasia | 2 3 2 2 2 2 2 2 1 3 3 2 | Pars Intermedia, Cyst | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 2 2 1 1 2 1 1 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | Inflammation, Chronic Active | 1 1 2 | Duct, Cyst | 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 4 3 4 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 4 4 4 3 4 | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2| | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Hemosiderin | | Inguinal, Ectasia | | Mediastinal, Pigmentation, | | Hemosiderin | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 2 1 2| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Hemosiderin | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | 2 4 | Necrosis | | Pigmentation, Hemosiderin | 3 | Capsule, Inflammation, Granulomatous | 4 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 2 1 1 1 2 2 2 1 2 2 3| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Skin, Site of Application,| | Hyperkeratosis | 1 | Epidermis, Skin, Site of Application,| | Hyperplasia | 1 | Epidermis, Skin, Site of Application,| | Parakeratosis | | Epidermis, Skin, Site of Application,| | Ulcer | | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | | Skin, Site of Application, | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2| | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 3 3 | |__________________________________________________________________________| Skeletal Muscle | + | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Inflammation, Granulomatous | 1 3 | Alveolar Epithelium, Hyperplasia | 4 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1| Mediastinum, Necrosis | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 2 1 | Respiratory Epithelium, Hyperplasia | 3 | Vein, Turbinate, Septum, Thrombosis | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + | Anterior Chamber, Cornea, Iris, | | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2| | 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Synechia | | Cornea, Inflammation, Chronic | | Lens, Cataract | 2 4 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Cyst | 2 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy, Chronic | 1 1 2 2 2 1 1 1 2 2 2 2 1 1 2 1 2 2 1 2 2 2 2 1 2| Pigmentation, Hemosiderin | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| Renal Tubule, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 7 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 6 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X| 31 | Clear Cell Focus | X X | 5 | Fibrosis | 2 | 1 2.0| Hepatodiaphragmatic Nodule | X X | 10 | Inflammation, Chronic | 2 1 2 1 2 1 1 1 1 1 2 1 | 29 1.4| Mixed Cell Focus | X | 1 | Pigmentation, Hemosiderin | 2 | 1 2.0| Vacuolization Cytoplasmic | 1 1 1 1 1 3 1 1 1 1 2 1| 23 1.4| Bile Duct, Hyperplasia | 2 1 1 2 2 1 2 2 1 1 1 1 1 1 1 1| 26 1.2| Hepatocyte, Hyperplasia, Adenomatous | 3 | 1 3.0| Hepatocyte, Necrosis | 2 | 1 2.0| Hepatocyte, Centrilobular, | | | Degeneration | 2 | 2 2.5| Hepatocyte, Centrilobular, Necrosis | | 1 3.0| Serosa, Necrosis, Fibrinoid | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Mesentery | + + | 4 | Fat, Necrosis | 4 | 3 4.0| |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | Gingival, Hyperplasia, Squamous | 3 | 1 3.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Granulomatous | | 1 2.0| Acinus, Atrophy | 1 1 1 1 3 1 4 1 2 1 1 2 1 1 1| 19 1.6| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Inflammation, Chronic Active | 3 | 1 3.0| Epithelium, Hyperplasia | 3 2 | 2 2.5| Epithelium, Ulcer | 4 | 1 4.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Ulcer | 4 | 1 4.0| |__________________________________________________________________________|____________| Tooth | | 1 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 1 2 2 2 2 1 1 2 1 1| 22 1.5| Inflammation, Chronic Active | | 1 3.0| Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 2 1 2| 8 2.1| Degeneration, Fatty | 2 1 1 4 4 1 2 1 1 1 2 1 | 22 1.5| Fibrosis | | 1 2.0| Hyperplasia | 2 2 2 2 1 2 2 1 1 2 3 2 | 22 1.9| Hypertrophy | 2 2 2 | 10 1.9| Necrosis | 4 | 1 4.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + M + + + + M + + M +| 42 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 3 2 2 2 2 2 2 1 3 3 2 2 2 2 3| 23 2.1| Pars Distalis, Hyperplasia | 2 2 2 3 3 1 2 2 | 20 2.2| Pars Intermedia, Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 2 1 1 1 2 | 17 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Hyperplasia | 1 2 | 4 2.0| Inflammation, Chronic Active | 2 3 3 | 6 2.0| Duct, Cyst | 3 | 2 3.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 3 | 7 3.1| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dysplasia | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 | 1 4.0| Hyperplasia | 4 3 4 4 4 4 3 | 12 3.8| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + | 41 | Pigmentation, Hemosiderin | 1 | 1 1.0| Inguinal, Ectasia | 2 | 1 2.0| Mediastinal, Pigmentation, | | | Hemosiderin | 1 2 1 1 2 2 2 2 1 1 1 1 2 1 2 1 1 1 | 38 1.3| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pigmentation, Hemosiderin | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 3 | 3 3.0| Necrosis | 4 | 1 4.0| Pigmentation, Hemosiderin | | 1 3.0| Capsule, Inflammation, Granulomatous | | 1 4.0| |__________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + + + + + + + M + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Hyperplasia, Cystic | 2 1 2 2 2 2 2 2 2 2 2 3 2 1 2 3 2 2 2 1 2 2| 44 1.9| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Skin, Site of Application,| | | Hyperkeratosis | 2 1 | 3 1.3| Epidermis, Skin, Site of Application,| | | Hyperplasia | 3 3 | 3 2.3| Epidermis, Skin, Site of Application,| | | Parakeratosis | 1 | 1 1.0| Epidermis, Skin, Site of Application,| | | Ulcer | 4 1 | 2 2.5| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 2 1 | 2 1.5| Skin, Site of Application, | | | Inflammation, Chronic Active | 3 3 | 3 2.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteopetrosis | | 2 3.0| |__________________________________________________________________________|____________| Skeletal Muscle | + + | 3 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 2 2 1 1 | 7 1.4| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Inflammation, Granulomatous | 3 | 3 2.3| Alveolar Epithelium, Hyperplasia | 2 | 2 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 2 1 1 1 1 1 1| 22 1.0| Mediastinum, Necrosis | 3 | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 4 1.5| Respiratory Epithelium, Hyperplasia | | 1 3.0| Vein, Turbinate, Septum, Thrombosis | 4 | 1 4.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 6 | Anterior Chamber, Cornea, Iris, | | | Synechia | 4 | 1 4.0| Cornea, Inflammation, Chronic | 2 | 1 2.0| Lens, Cataract | 2 2 3 | 5 2.6| Retina, Atrophy | 4 4 | 3 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | 2 3 | 2 2.5| Cyst | 2 | 2 2.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 50 1.0| Nephropathy, Chronic | 2 2 2 2 1 2 1 2 2 1 2 2 2 1 2 1 1 2 2 1 2 2| 47 1.6| Pigmentation, Hemosiderin | 3 1 2 1 1 1 1 1 1 1 1 1 1 3 3 1 1 1 1 2 1 2 2| 48 1.3| Renal Tubule, Hyperplasia | 2 2 | 2 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| | | 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5| DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7| | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +| Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X| Clear Cell Focus | X | Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X X X X X X| Inflammation, Chronic | 2 1 1 1 1 1 2 1 1 1 1 1 1 1| Mixed Cell Focus | X X| Vacuolization Cytoplasmic | 2 1 1 1 1 2 2 2 1 1 | Bile Duct, Hyperplasia | 2 3 1 1 2 1 1 1 2 1| Hepatocyte, Hyperplasia, Adenomatous | 4 | Hepatocyte, Necrosis | | Hepatocyte, Centrilobular, | | Degeneration | | |__________________________________________________________________________| Mesentery | + | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Hyperplasia, Squamous | 4 | __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5| DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7| | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 1 2 2 2 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Inflammation, Chronic Active | 3 2 | Mineralization | 3 | Epithelium, Hyperplasia | 3 2 | Epithelium, Ulcer | 4 4 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Epithelium, Erosion | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 1 2 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 3 | Atrophy | 2 | Degeneration, Cystic | 1 3 3 | Degeneration, Fatty | 2 1 2 1 1 1 1 1 | Hyperplasia | 2 1 1 1 2 2 2 | Hypertrophy | 2 3 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5| DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7| | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Hyperplasia | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 3 2 2 3 3 2 2 2 2 2 2 1 2 1 2| Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 3| Pars Intermedia, Cyst | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Thymus | | C-Cell, Hyperplasia | 1 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 3 2 2 | Duct, Cyst | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 4 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Endometrium, Hyperplasia, Cystic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 4 4 3 3 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5| DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7| | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Mediastinal, Pigmentation, | | Hemosiderin | 1 2 1 2 1 1 1 2 1 1 1 1 2 1 2| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 4 | Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 1| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation, Chronic Active | | Inflammation, Suppurative | | Epidermis, Hyperplasia | | Epidermis, Skin, Site of Application,| | Hyperkeratosis | 2 2 1 2 1 2 2 1 1 2 4 1 2 1 2 2 1 2 1 2 1 1 1| Epidermis, Skin, Site of Application,| | Hyperplasia | 2 2 2 2 2 1 1 3 2 2 1 2 2 3 2 1 1 1 2 2 2 1 2| Epidermis, Skin, Site of Application,| | Parakeratosis | 2 1 1 2 1 1| Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 2 2 2 2 1 2 1 1 1 2 2 1 2 2 2 2 1 1 1 2 2 2 1 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Osteopetrosis | 3 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5| DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7| | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | | Inflammation, Chronic Active | 1 2 1 1 1 1| Inflammation, Granulomatous | | Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 | Respiratory Epithelium, Hyperplasia | 3 3 | Respiratory Epithelium, Metaplasia, | | Squamous | 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | Lens, Cataract | 4 | Retina, Atrophy | 4 | __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5| DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7| | 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| Nephropathy, Chronic | 2 1 1 3 2 2 2 1 2 2 2 2 2 1 2 3 3 2 3 2 2 1| Pigmentation, Hemosiderin | 1 1 2 1 1 3 1 1 1 1 2 1 1 1 1 2 1 1 1 2 1| Renal Tubule, Hyperplasia | 4 1 4 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 20 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| | DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| | | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 5 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 4 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X| 17 | Clear Cell Focus | X X X | 4 | Hematopoietic Cell Proliferation | | 1 2.0| Hepatodiaphragmatic Nodule | X X X X | 11 | Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 2 2 1| 26 1.2| Mixed Cell Focus | | 2 | Vacuolization Cytoplasmic | 2 1 2 1 1 1 1 2 2 1| 20 1.4| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | 21 1.2| Hepatocyte, Hyperplasia, Adenomatous | | 1 4.0| Hepatocyte, Necrosis | 3 2 | 2 2.5| Hepatocyte, Centrilobular, | | | Degeneration | 4 | 1 4.0| |__________________________________________________________________________|____________| Mesentery | + + + + | 5 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| | DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| | | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Fat, Necrosis | 4 4 4 4 | 4 4.0| |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Hyperplasia, Squamous | | 1 4.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 1 1 3 2 | 13 1.5| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 | 1 3.0| Inflammation, Chronic Active | 2 | 3 2.3| Mineralization | | 1 3.0| Epithelium, Hyperplasia | 3 2 3 | 5 2.6| Epithelium, Ulcer | 4 | 3 4.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 1 2.0| Epithelium, Erosion | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | 2 | 1 2.0| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 1 2 1 1 2 2 1 1 2 2 1 2 2| 16 1.6| Atrium, Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| | DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| | | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Atrophy | | 1 2.0| Degeneration, Cystic | 2 3 2 | 6 2.3| Degeneration, Fatty | 1 2 2 1 1 1 | 14 1.3| Hyperplasia | 2 2 1 1 2 1 2| 14 1.6| Hypertrophy | 3 | 3 2.7| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 | 2 1.5| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M + M + + M + + + + + + + + +| 46 | Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 2 2 3 2 2 2 2 2 2 4 3 2| 27 2.2| Pars Distalis, Hyperplasia | 2 2 2 2 2 3 3| 19 2.1| Pars Intermedia, Cyst | 2 | 2 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Thymus | 3 | 1 3.0| C-Cell, Hyperplasia | 1 2 1 | 7 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | 1 2 | 6 2.2| Duct, Cyst | 3 | 1 3.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| | DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| | | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Cyst | 4 2 4 4 | 8 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 4 | 1 4.0| Endometrium, Hyperplasia, Cystic | 3| 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 4 4 4 4 4 4 4 | 14 3.9| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + +| 36 | Mediastinal, Pigmentation, | | | Hemosiderin | 1 2 2 2 1 2 1 1 2 2 2 2 1 2 1 1 1 1 1 1| 35 1.4| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 3 | 4 2.5| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 4 | 3 4.0| Hyperplasia, Cystic | 2 2 2 2 2 4 2 2 2 2 2 3 1 1 1 1 3 2 1 2 2 2 2| 40 2.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 2 | Inflammation, Chronic Active | 2 | 1 2.0| Inflammation, Suppurative | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| | DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| | | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Epidermis, Hyperplasia | 3 | 1 3.0| Epidermis, Skin, Site of Application,| | | Hyperkeratosis | 2 2 2 1 2 2 1 1 1 2 2 1 2 2 1 2 2 2 1 1 1 2| 45 1.6| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 2 2 1 1 2 2 2 1 1 2 1 1 1 2 2 2 2 2 1 2 2 2| 46 1.7| Epidermis, Skin, Site of Application,| | | Parakeratosis | 1 1 1 1 1 | 11 1.2| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 2 2 2 2 1 2 2 2 1 2 1 1 1 2 2 2 2 2 1 2 2 2| 46 1.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 2 | 2 2.5| Osteopetrosis | 3 | 2 3.0| |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | |__________________________________________________________________________|____________| Spinal Cord | + | 1 | Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 4 | 1 4.0| Hemorrhage | 1 | 1 1.0| Inflammation, Chronic Active | 1 2 1 1 1 1 2 2 2 1 | 16 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| | DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| | | 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Inflammation, Granulomatous | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1| 24 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 3 | 4 2.8| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 3 | 3 2.3| Respiratory Epithelium, Hyperplasia | 2 3 | 4 2.8| Respiratory Epithelium, Metaplasia, | | | Squamous | | 1 3.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 2 | Lens, Cataract | | 1 4.0| Retina, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0| Nephropathy, Chronic | 3 2 4 1 2 2 2 2 2 1 2 1 2 2 2 3 1 3 2 2 4 2 3 2| 46 2.1| Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2| 46 1.2| Renal Tubule, Hyperplasia | 1 3 4 1 | 8 2.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2| DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9| | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Perforation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Ulcer | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | | Hepatodiaphragmatic Nodule | X X X X X X | Inflammation, Chronic | 1 2 1 1 1 1 | Vacuolization Cytoplasmic | 3 1 3 1 1 1 1 2 3 1 1 2 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 | Hepatocyte, Degeneration, Cystic | 1 | Hepatocyte, Centrilobular, | | Degeneration | 4 3 | |__________________________________________________________________________| Mesentery | | Fat, Inflammation, Chronic Active | | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Inflammation, Chronic | | Active | | Pharyngeal, Hyperplasia, Squamous | 4 | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2| DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9| | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 1 1 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 4 | Inflammation, Chronic Active | 3 3 3 2 3 3 | Epithelium, Hyperplasia | 2 3 3 3 3 3 3 4 | Epithelium, Ulcer | 2 4 4 4 4 2 4 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Epithelium, Erosion | 2 | Epithelium, Hyperplasia | 2 | Glands, Hyperplasia | | |__________________________________________________________________________| Tongue | | Hyperplasia, Squamous | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 2 | Pulmonary Artery, Mineralization | 2 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 1 1 2 3 2 1 1 | Mineralization | 1 | Atrium, Thrombosis | 4 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 1 3 2 2 2 | Degeneration, Fatty | 3 2 1 2 1 2 1 2 2 | Hyperplasia | 1 1 2 2 1 2 | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2| DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9| | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hypertrophy | 1 3 2 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + M M + + + + + + M + +| Hyperplasia | 2 1 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 2 2 2 2 1 2 2 | Pars Distalis, Hyperplasia | 2 3 2 2 3 4 2 2 2 2 2 | Pars Intermedia, Cyst | 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 2 1 2 2 2 1 | Bilateral, Duct, Cyst | | Duct, Cyst | 2 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 3 2 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Vagina | + | Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2| DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9| | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 4 4 4 3 3 4 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + +| Mediastinal, Congestion | 3 | Mediastinal, Pigmentation, | | Hemosiderin | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + M + M + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hematopoietic Cell Proliferation | 3 | Capsule, Fibrosis | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 1 3 2 2 2 4 2 2 2 3 2 2 2 3 2 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Epidermis, Skin, Site of Application,| | Hyperkeratosis | 2 2 2 2 3 1 2 2 2 2 3 2 2 2 2 2 1 2 2 2 1 2 2 1| Epidermis, Skin, Site of Application,| | Hyperplasia | 3 2 3 2 3 3 3 2 2 3 3 3 2 2 2 2 2 1 3 3 3 1 3 2 2| Epidermis, Skin, Site of Application,| | Parakeratosis | 2 1 3 1 3 2 2 2 3 2 2 1 2 2 | Epidermis, Skin, Site of Application,| | Ulcer | 3 2 4 2 1 | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 2 2 2 2 2 2 3 2 2 2 3 2 2 2 1 2 2 1 3 3 2 1 3 3 2| Skin, Site of Application, | | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2| DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9| | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Inflammation, Chronic Active | 2 2 2 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 1 | Inflammation, Granulomatous | | Metaplasia, Osseous | 1 | Alveolar Epithelium, Hyperplasia | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 3 | Respiratory Epithelium, Hyperplasia | 3 2 | Respiratory Epithelium, Metaplasia, | | Squamous | 3 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + | Bilateral, Inflammation, Suppurative | 4 | Lens, Cataract | 2 | Retina, Atrophy | | __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2| DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9| | 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2| Nephropathy, Chronic | 3 4 4 4 4 4 3 2 2 3 3 3 2 2 2 4 1 3 3 3 2 2 2 1| Pigmentation, Hemosiderin | 2 2 1 2 1 1 1 1 2 2 1 1 1 2 2 1 2 1 1 3 1 1 1 1| Renal Tubule, Hyperplasia | 4 1 4 1 1 2 1 1 4 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 32 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| | | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Perforation | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 6 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Ulcer | 4 | 1 4.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X| 4 | Clear Cell Focus | X | 1 | Hepatodiaphragmatic Nodule | X X X X X X X X | 14 | Inflammation, Chronic | 2 1 1 1 1 1 1 | 13 1.2| Vacuolization Cytoplasmic | 1 1 1 2 3 1 1 2 1| 22 1.5| Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 | 16 1.1| Hepatocyte, Degeneration, Cystic | | 1 1.0| Hepatocyte, Centrilobular, | | | Degeneration | | 2 3.5| |__________________________________________________________________________|____________| Mesentery | + + | 2 | Fat, Inflammation, Chronic Active | 4 | 1 4.0| Fat, Necrosis | 4 | 1 4.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| | | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Oral Mucosa | + + | 3 | Gingival, Inflammation, Chronic | | | Active | 3 | 1 3.0| Pharyngeal, Hyperplasia, Squamous | | 1 4.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 1 1 1 1 | 11 1.1| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 2 3.5| Inflammation, Chronic Active | 3 3 2 3 | 10 2.8| Epithelium, Hyperplasia | 4 2 3 2 3 | 13 2.9| Epithelium, Ulcer | 4 4 3 4 | 11 3.5| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Epithelium, Erosion | | 1 2.0| Epithelium, Hyperplasia | | 1 2.0| Glands, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Tongue | + | 1 | Hyperplasia, Squamous | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | | 1 2.0| Pulmonary Artery, Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 1 2 2 1 1 1| 14 1.5| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| | | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Atrium, Thrombosis | | 3 3.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 1 3 3 | 8 2.1| Degeneration, Fatty | 1 3 3 2 3 2 2 | 16 2.0| Hyperplasia | 2 1 3 3 2 | 11 1.8| Hypertrophy | 3 1 | 7 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 3 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 | Hyperplasia | 1 | 3 1.3| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 2 2 2 1 2 2 2 2 2 | 17 1.9| Pars Distalis, Hyperplasia | 2 2 1 2 2 1 2 3 | 19 2.2| Pars Intermedia, Cyst | | 2 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1| 7 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 | 3 2.0| Inflammation, Chronic Active | 1 | 8 1.6| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| | | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Bilateral, Duct, Cyst | 3 | 1 3.0| Duct, Cyst | | 1 2.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 3 3 2 | 8 2.6| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Vagina | + | 2 | Inflammation, Suppurative | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 4 | 10 3.6| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + +| 36 | Mediastinal, Congestion | | 1 3.0| Mediastinal, Pigmentation, | | | Hemosiderin | 1 1 1 1 2 1 2 1 1 1 2 2 2 1 1 1| 34 1.2| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hematopoietic Cell Proliferation | | 1 3.0| Capsule, Fibrosis | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| | | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 1 2 2 2 2| 40 2.1| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 1.5| Epidermis, Skin, Site of Application,| | | Hyperkeratosis | 2 2 2 2 1 2 1 1 2 1 1 2 2 1 2 1 2 1 1 1 2 2 2| 47 1.7| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 3 3 3 2 3 1 2 2 3 2 2 2 3 2 3 1 2 2 4 1 1 2 2 3| 50 2.3| Epidermis, Skin, Site of Application,| | | Parakeratosis | 2 1 3 1 1 2 2 3 3 | 23 2.0| Epidermis, Skin, Site of Application,| | | Ulcer | 2 2 2 2 | 9 2.2| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 2 2 3 3 1 3 1 1 1 3 1 1 2 2 2 3 1 2 1 3 2 2 2 3| 49 2.0| Skin, Site of Application, | | | Inflammation, Chronic Active | 2 2 | 6 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 2 1 2 2 1 | 9 1.4| Inflammation, Granulomatous | 1 | 1 1.0| Metaplasia, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 2 | 3 1.7| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| | | 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 3 2.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 3 2.3| Respiratory Epithelium, Hyperplasia | 2 | 3 2.3| Respiratory Epithelium, Metaplasia, | | | Squamous | | 2 2.5| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 5 | Bilateral, Inflammation, Suppurative | | 1 4.0| Lens, Cataract | 3 4 4 | 4 3.3| Retina, Atrophy | 4 4 4 | 3 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Mineralization | 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1| 47 1.2| Nephropathy, Chronic | 2 3 1 3 3 2 3 1 2 4 4 2 3 3 1 3 3 3 2 2 3 3| 46 2.7| Pigmentation, Hemosiderin | 1 1 2 1 1 2 1 1 1 2 1 1 1 1 1 2 2 3 1 1 1 1 1| 47 1.4| Renal Tubule, Hyperplasia | 1 4 2 1 1 1| 15 1.9| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | 2 3 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5| DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4| | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X | Hepatodiaphragmatic Nodule | X X X | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 | Mineralization | | Vacuolization Cytoplasmic | 1 2 2 1 1 1 1 3 2 2 2 2 1 1| Bile Duct, Hyperplasia | 3 1 1 1 2 1 2 1 2 2 2 1 1 2 2 3 1 2 2 1 2 2 2| Hepatocyte, Degeneration, Cystic | 1 1 1 2 1 1 1 | Hepatocyte, Necrosis | 1 | Hepatocyte, Centrilobular, | | Degeneration | 3| Hepatocyte, Centrilobular, Necrosis | 3 | |__________________________________________________________________________| Mesentery | + + + +| Inflammation, Chronic Active | | Fat, Necrosis | 4 4 4 4| |__________________________________________________________________________| Oral Mucosa | + | __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5| DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4| | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 2 1 2 1 1 | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Duct, Cyst | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 3 3 | Inflammation, Chronic Active | 2 2 2 2 2 | Mineralization | 3 3 3 2 | Perforation | X | Epithelium, Hyperplasia | 3 2 2 3 3 3 3 3 | Epithelium, Ulcer | 4 4 4 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 3 3 2 3 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Aorta, Mineralization | 3 3 2 4 3 | Pulmonary Artery, Mineralization | 3 3 4 3 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 3 2 3 2 2 2 1 3 2 2 2 2 3 3 2 | Inflammation, Suppurative | | Mineralization | 3 2 3 2 | Atrium, Thrombosis | 3 4 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 | Degeneration, Fatty | 1 2 1 1 2 2 1 2 1 2 2 2 2 2 1 1 1| __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5| DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4| | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hyperplasia | 1 1 1 2 2 2 2 | Hypertrophy | 1 | Necrosis | 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 2 1 1 1 1 2 2 2| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 3 2 2 3 3 3 2 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 1 3 2 2 | Pars Distalis, Hyperplasia | 2 2 2 2 2 3 | Pars Intermedia, Cyst | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 2 | Follicle, Cyst | 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | |__________________________________________________________________________| Penis | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | Inflammation, Chronic Active | 1 1 2 2 2 1 2 3 2 2 1 2 2 2 1 1 2 2 2 2 2 3 2 2 1| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Multilocular | 4 2 3 2 2 | __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5| DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4| | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Inflammation, Chronic Active | 2 3 2 2 2 2 2 2 3 2 2 2 1 2 3 2 1 2 4 3 2 2 2| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic | 2 3 2 2 | Arteriole, Necrosis, Fibrinoid | 2 3 2 2 | Bilateral, Germinal Epithelium, | | Atrophy | 4 | Germinal Epithelium, Atrophy | 4 4 4 3 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia | 4 3 3 4 4 4 3 4 4 3 3 2 4 4| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + +| Mediastinal, Pigmentation, | | Hemosiderin | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Infiltration Cellular, Histiocyte | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 2 | Hematopoietic Cell Proliferation | 3 | Necrosis | | Red Pulp, Depletion Cellular | 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5| DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4| | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | Hyperplasia, Cystic | 1 3 2 2 3 2 2 1 1 4 2 2 2 2 2 2 2 3 1 2 2| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Prepuce, Inflammation, Chronic Active| | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Callus | | Fibrous Osteodystrophy | 3 4 4 3 4 4 2 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hemorrhage | 3 | Inflammation, Chronic Active | 1 | Inflammation, Granulomatous | 1 1 | Inflammation, Suppurative | 3 | Mineralization | 3 2 | Alveolar Epithelium, Hyperplasia | 3 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1| Interstitium, Mineralization | 3 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5| DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4| | 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 2 3 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | | Respiratory Epithelium, Hyperplasia | 3 3 2 3 2 | Respiratory Epithelium, Metaplasia, | | Squamous | 2 4 2 | Vein, Turbinate, Septum, Thrombosis | 4 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | Lens, Cataract | 4 | Retina, Atrophy | 4 | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 2 3 2 3 | Hydronephrosis | | Mineralization | 2 2 3 | Nephropathy, Chronic | 2 2 3 3 4 2 4 4 2 3 3 4 3 3 3 2 2 4 4 4 3 4 2 2 2| Pigmentation, Hemosiderin | 3 1 1 1 1 1 2 2 1 1 1 3 1 1 1 1 1 1 1 1 1 2| Renal Tubule, Hyperplasia | 2 3 3 4 2 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | 2 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 44 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 2 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 3| 2 3.5| Ulcer | 4 | 1 4.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 3 | Clear Cell Focus | | 3 | Hepatodiaphragmatic Nodule | X X X X X X | 9 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 | 20 1.1| Mineralization | 1 | 1 1.0| Vacuolization Cytoplasmic | 2 3 1 1 3 1 1 1 1 1 1 2 1| 27 1.5| Bile Duct, Hyperplasia | 1 2 2 1 1 2 1 3 3 2 3 2 3 1 1 1 2 1 1 2 2 2 1 2| 47 1.7| Hepatocyte, Degeneration, Cystic | 2 | 8 1.3| Hepatocyte, Necrosis | | 1 1.0| Hepatocyte, Centrilobular, | | | Degeneration | 3 | 2 3.0| Hepatocyte, Centrilobular, Necrosis | 4 | 2 3.5| |__________________________________________________________________________|____________| Mesentery | + + + +| 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Inflammation, Chronic Active | 3| 1 3.0| Fat, Necrosis | 4 4 4 | 7 4.0| |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 1 1| 11 1.4| Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Duct, Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 3 3 | 6 3.0| Inflammation, Chronic Active | 2 2 2 3 3 4 3 3 3 2| 15 2.5| Mineralization | | 4 2.8| Perforation | X X X| 4 | Epithelium, Hyperplasia | 3 3 2 3 3 4 2 3 2 3| 18 2.8| Epithelium, Ulcer | 4 4 4 4 4 4 4 4 4 | 13 3.8| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Mineralization | 1 2 | 7 2.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 | 1 2.0| Aorta, Mineralization | 3 | 6 3.0| Pulmonary Artery, Mineralization | | 4 3.3| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 1 1 2 2 1 2 2 2 2 2 3 2 1 2 2 2 2 1 1 | 37 2.0| Inflammation, Suppurative | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Mineralization | 1 | 5 2.2| Atrium, Thrombosis | 4 3 2 | 6 3.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 2 2 | 3 2.0| Degeneration, Fatty | 1 1 1 2 1 1 1 2 1 2 1 2 1 1 2 1 1 2 2| 36 1.4| Hyperplasia | 2 2 2 2 2 2| 13 1.8| Hypertrophy | 1 | 2 1.0| Necrosis | | 1 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 2 1 2 3 2 2 2| 20 1.6| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + M + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 3 2 2| 14 2.6| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | 2 1 2 1 2 3 1 2 1 2 2| 16 1.8| Pars Distalis, Hyperplasia | 1 2 2 2 1 2 3| 13 2.0| Pars Intermedia, Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 1 1 | 6 1.5| Follicle, Cyst | | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 3 2.0| Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 2 2 3 1 2 2 2 3 1 2 2 2 1| 47 1.9| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Multilocular | 2 3 2 1 | 9 2.3| Inflammation, Chronic Active | 2 2 1 3 2 3 2 2 2 1 2 2 3 3 2 2 2 3 2 1 3 1 2| 46 2.1| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | | 1 4.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Arteriole, Inflammation, Chronic | 2 2 2 2 1| 9 2.0| Arteriole, Necrosis, Fibrinoid | 2 2 2 2 1| 9 2.0| Bilateral, Germinal Epithelium, | | | Atrophy | | 1 4.0| Germinal Epithelium, Atrophy | 4 3 4 4 4 4| 10 3.8| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 | 12 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Hyperplasia | 4 4 4 4 4 4 3 3| 22 3.6| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 35 | Mediastinal, Pigmentation, | | | Hemosiderin | 2 1 1 1 1 2 1 1 1 1 2 1 1 1| 29 1.1| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Ectasia | 3 | 1 3.0| Infiltration Cellular, Histiocyte | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 3 1 | 6 2.2| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis | 2 | 1 2.0| Red Pulp, Depletion Cellular | 4 | 2 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + M + + + + + + + + M + + + + + + + + + + +| 48 | Cyst | | 2 3.0| Hyperplasia, Cystic | 3 3 2 3 3 2 3 2 3 2 2 3 2 2 2| 36 2.2| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Prepuce, Inflammation, Chronic Active| 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Callus | 4 | 1 4.0| Fibrous Osteodystrophy | 3 2 | 10 3.3| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Hemorrhage | | 1 3.0| |__________________________________________________________________________|____________| Peripheral Nerve | + + | 3 | |__________________________________________________________________________|____________| Spinal Cord | + + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 | 1 1.0| Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 1 | 2 1.0| Inflammation, Granulomatous | | 2 1.0| Inflammation, Suppurative | | 1 3.0| Mineralization | | 2 2.5| Alveolar Epithelium, Hyperplasia | 2 | 2 2.5| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 2 | 7 1.1| Interstitium, Mineralization | | 2 2.5| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 3 3 | 9 2.4| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 3 | 2 2.5| Respiratory Epithelium, Hyperplasia | 3 3 3 3 | 9 2.8| Respiratory Epithelium, Metaplasia, | | | Squamous | | 3 2.7| Vein, Turbinate, Septum, Thrombosis | 4 | 2 4.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| | DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| | | 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Lens, Cataract | 3 | 2 3.5| Retina, Atrophy | 4 | 2 4.0| |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 3 | 8 2.6| Hydronephrosis | 2 | 1 2.0| Mineralization | | 3 2.3| Nephropathy, Chronic | 2 3 2 4 1 3 1 4 3 1 3 2 4 4 3 1 2 3 3 2 4 2 4 4| 49 2.8| Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1| 43 1.2| Renal Tubule, Hyperplasia | 2 3 3 1 1 1 1 | 13 2.2| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 3 | 2 2.5| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4| DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4| | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X | Clear Cell Focus | X X | Eosinophilic Focus | | Fibrosis | | Hepatodiaphragmatic Nodule | X X X X | Inflammation, Chronic | 1 1 2 2 1 2 1 1 1 1 1 1 1 1| Vacuolization Cytoplasmic | 3 3 2 2 1 3 1 2 2 1 1 1 2 2 1 1 1 1 | Bile Duct, Hyperplasia | 2 1 2 2 2 1 2 2 2 2 2 2 2 1 1 2 2 2 1 2 1 2 2 1| Hepatocyte, Degeneration, Cystic | 2 1 2 1 | Hepatocyte, Necrosis | 2 2 | Hepatocyte, Centrilobular, | | Degeneration | 2 | Hepatocyte, Centrilobular, Necrosis | | |__________________________________________________________________________| Mesentery | + + + + | Accessory Spleen | | Inflammation, Chronic Active | 3 | Fat, Necrosis | 4 4 | |__________________________________________________________________________| Oral Mucosa | | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4| DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4| | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Gingival, Hyperplasia | | Gingival, Inflammation, Chronic | | Active | | Pharyngeal, Hyperplasia, Squamous | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 1 1 2 1 1 2 1 2 2 1 4 2| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 3 2 | Inflammation, Chronic Active | 3 2 3 3 | Mineralization | | Perforation | X | Epithelium, Hyperplasia | 3 2 3 3 3 3 2 | Epithelium, Ulcer | 4 4 4 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 1 1 2 2 2 2 2 2 1 2 1 1 2 2 1 2 1 2 1 1 2 | Mineralization | | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | Degeneration, Cystic | 2 2 1 | Degeneration, Fatty | 2 1 2 1 1 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2 | Hyperplasia | 2 2 2 2 2 1 1 1 1 2 2 1 2 2 | __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4| DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4| | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hypertrophy | 2 2 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 1 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + M| Hyperplasia | 2 2 3 2 2 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Hematoidin | 3 | Pars Distalis, Cyst | 2 1 2 | Pars Distalis, Hyperplasia | 2 2 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + + + | Inflammation, Chronic Active | 2 | Inflammation, Suppurative | 3 4 | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1 3 2 1 2 2| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Multilocular | 2 2 2 1 2 | Inflammation, Chronic Active | 4 4 2 2 2 2 2 2 2 2 2 2 1 2 2 2 3 2 3 4 2 2 2 2 2| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4| DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4| | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic | 1 1 2 2 2 2 | Arteriole, Necrosis, Fibrinoid | 1 2 2 2 2 | Germinal Epithelium, Atrophy | 4 4 2 4 4 2 | Interstitial Cell, Hyperplasia | 1 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 4 4 4 3 4 4 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + +| Mediastinal, Hyperplasia, Lymphoid | 2 | Mediastinal, Pigmentation, | | Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Plasma Cell | 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 2 3 | Hematopoietic Cell Proliferation | 3 3 | Hyperplasia | 3 | |__________________________________________________________________________| Thymus | + + + M + + + M + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hyperplasia, Cystic | 1 2 2 1 2 2 1 2 2 2 1 2 3 3 2 1 4 2 2 3 2 2| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4| DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4| | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Epidermis, Skin, Site of Application,| | Hyperkeratosis | 2 1 2 2 2 2 2 2 2 2 1 1 1 1 | Epidermis, Skin, Site of Application,| | Hyperplasia | 2 1 1 1 1 1 1 1 2 1 1 2 1 2 1 2 2 1 2 1 2 1| Epidermis, Skin, Site of Application,| | Parakeratosis | 1 1 1 | Epidermis, Skin, Site of Application,| | Ulcer | | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 2 1 1 1 1 1 1 2 1 2 2 1 2 1 2 2 1 1 2 2 1| Skin, Site of Application, Hemorrhage| | Skin, Site of Application, | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 4 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Inflammation, Chronic Active | 1 | Alveolar Epithelium, Hyperplasia | 3 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 | Interstitium, Mineralization | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 1 | __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4| DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4| | 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Inflammation, Suppurative | | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 2 | Respiratory Epithelium, Hyperplasia | 3 3 2 2 | Respiratory Epithelium, Metaplasia, | | Squamous | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | | Cornea, Mineralization | | Lens, Cataract | 3 | Retina, Atrophy | 4 | |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 2 | Cyst | 3 2 3 2 | Mineralization | | Nephropathy, Chronic | 4 1 4 2 3 2 2 2 2 3 4 2 2 2 4 2 3 3 3 3 2 1 2 2 2| Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Hyperplasia | 3 3 1 1 2 3 3 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | | Inflammation, Chronic Active | | __________________________________________|__________________________________________________________________________ Page 57 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 5 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 5 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X| 13 | Clear Cell Focus | X X X X | 6 | Eosinophilic Focus | X | 1 | Fibrosis | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X | 9 | Inflammation, Chronic | 1 1 2 1 1 1 1 1 1 1 1| 25 1.2| Vacuolization Cytoplasmic | 1 1 1 2 2 1 2 2 1 2 1 1 2 1 3 2 2 1| 36 1.6| Bile Duct, Hyperplasia | 1 1 1 2 2 2 1 2 2 1 3 1 3 1 1 1 1 1 2 1 1 2 1 1| 48 1.6| Hepatocyte, Degeneration, Cystic | 1 1 1 1 | 8 1.3| Hepatocyte, Necrosis | 1 | 3 1.7| Hepatocyte, Centrilobular, | | | Degeneration | | 1 2.0| Hepatocyte, Centrilobular, Necrosis | 3 | 1 3.0| |__________________________________________________________________________|____________| Mesentery | + + + | 7 | Accessory Spleen | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Inflammation, Chronic Active | | 1 3.0| Fat, Necrosis | 4 | 3 4.0| |__________________________________________________________________________|____________| Oral Mucosa | + + | 2 | Gingival, Hyperplasia | 3 | 1 3.0| Gingival, Inflammation, Chronic | | | Active | 3 | 1 3.0| Pharyngeal, Hyperplasia, Squamous | 3 | 1 3.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 1 3 1 2 1 2| 22 1.6| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 4| 5 2.8| Inflammation, Chronic Active | 4 3 2 3| 8 2.9| Mineralization | 1 3 | 2 2.0| Perforation | X | 2 | Epithelium, Hyperplasia | 3 3 3 3 3 2 3 2 3| 16 2.8| Epithelium, Ulcer | 4 4 4 4| 7 4.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 3 3 2 2 | 6 2.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | 3 2 2 3 | 4 2.5| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 1 2 2 2 2 2 1 2 2 1 2 2 2 2 3 1 1 2 4 3 2 2| 43 1.8| Mineralization | 3 3 1 | 3 2.3| Atrium, Thrombosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 | 2 1.0| Degeneration, Cystic | 2 | 4 1.8| Degeneration, Fatty | 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 2 2 2 1 3 | 40 1.6| Hyperplasia | 2 1 1 2 2 1 2 | 21 1.6| Hypertrophy | 2 1 2 | 6 1.7| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 1 1 1 2 2 1 1 2 2 1 2| 19 1.5| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + M + + + + + + +| 46 | Hyperplasia | 2 3 2 2 3 3 3 3 3 2 | 15 2.5| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pigmentation, Hematoidin | | 1 3.0| Pars Distalis, Cyst | 2 1 2 3 | 7 1.9| Pars Distalis, Hyperplasia | 2 2 2 2 2 3| 10 2.1| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 2 1 | 11 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | | 3 | Inflammation, Chronic Active | | 1 2.0| Inflammation, Suppurative | | 2 3.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 3 2 3 2| 46 2.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Multilocular | 1 2 1 | 8 1.6| Inflammation, Chronic Active | 3 2 3 2 2 2 2 2 2 2 1 2 4 2 3 2 2 4 2 2 4 2| 47 2.3| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Arteriole, Inflammation, Chronic | 2 2 1 2 2 | 11 1.7| Arteriole, Necrosis, Fibrinoid | 2 2 1 2 2 | 10 1.8| Germinal Epithelium, Atrophy | 4 4 4 4 2 4 4 4 4 | 15 3.6| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 | 12 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 3 4 3 4 4 3 3 4 3 4 4 4 2 | 22 3.6| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + | 30 | Mediastinal, Hyperplasia, Lymphoid | | 1 2.0| Mediastinal, Pigmentation, | | | Hemosiderin | 1 1 2 1 1 1 1 1 1 2 2 | 26 1.1| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Plasma Cell | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 | 2 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 3| 5 2.8| Hematopoietic Cell Proliferation | 2 | 3 2.7| Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + M +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 4 4 4 4 4 | 6 4.0| Hyperplasia, Cystic | 2 3 3 2 2 3 2 3 3 3 2 1 2 2 3 3 3 3 3 2 2 2| 44 2.2| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 2 4.0| Epidermis, Skin, Site of Application,| | | Hyperkeratosis | 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1 1 2 2 1 2| 36 1.4| Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 2 1 2 2 2 2 2 1 2 1 2 2 2 1 2 1 1 2 1 1 2 2 2| 46 1.5| Epidermis, Skin, Site of Application,| | | Parakeratosis | 2 1 1 2 1 1 | 9 1.2| Epidermis, Skin, Site of Application,| | | Ulcer | 2 | 1 2.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 2 1 2 2 1 2 2 1 2 1 2 2 2 1 2 1 1 2 1 1 1 2 2| 45 1.5| Skin, Site of Application, Hemorrhage| 4 | 1 4.0| Skin, Site of Application, | | | Inflammation, Chronic Active | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 3 2 4 4 4 4 2 | 12 2.9| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 4 | 1 4.0| Inflammation, Chronic Active | 1 2 3 1 2 3 3 | 8 2.0| Alveolar Epithelium, Hyperplasia | 1 4 2 | 4 2.5| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 | 13 1.0| Interstitium, Mineralization | 3 2 3 3 | 4 2.8| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 3 | 7 2.0| Inflammation, Suppurative | 3 | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 3 | 4 2.3| Respiratory Epithelium, Hyperplasia | 2 2 3 | 7 2.4| Respiratory Epithelium, Metaplasia, | | | Squamous | 2 | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 3 | Cornea, Inflammation, Chronic Active | 2 | 1 2.0| Cornea, Mineralization | 3 | 1 3.0| Lens, Cataract | 3 | 2 3.0| Retina, Atrophy | 4 | 2 4.0| |__________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| | | 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | | 1 2.0| Cyst | 2 2 3 3 3 | 9 2.6| Mineralization | 2 2 1 | 3 1.7| Nephropathy, Chronic | 1 1 3 3 2 3 4 1 2 2 2 2 2 4 4 4 4 3 3 4 4 4 2 3 4| 50 2.7| Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0| Renal Tubule, Hyperplasia | 1 1 2 2 1| 13 1.9| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calculus Gross Observation | X | 1 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7| DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2| | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Ulcer | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X | Hepatodiaphragmatic Nodule | X X X X | Inflammation, Chronic | 1 1 1 2 1 1 1 1 1 2 2 | Vacuolization Cytoplasmic | 3 2 1 2 1 1 1 1 2 2 1 2 2 2 1 | Bile Duct, Hyperplasia | 2 2 1 2 2 1 1 2 2 2 2 2 1 1 3 1 1 3 1 2 1 1 2 2 2| Hepatocyte, Degeneration, Cystic | 1 1 | Hepatocyte, Necrosis | 2 | Portal Vein, Thrombosis | 2 | |__________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 4 4 | |__________________________________________________________________________| Oral Mucosa | | Gingival, Inflammation, Chronic | | Active | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 1 2 1 1 1 1 1 1 2| __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7| DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2| | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 1 2 3 2 | Foreign Body | X | Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 | Mineralization | | Perforation | X X X | Epithelium, Hyperplasia | 3 3 3 3 2 3 2 3 3 | Epithelium, Ulcer | 4 4 4 4 4 4 4 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 | Mineralization | | Epithelium, Erosion | 2 3 | Epithelium, Ulcer | 2 4 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | Pulmonary Artery, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Chronic | 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| Mineralization | | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Atypia Cellular | 1 | Degeneration, Cystic | 2 1 | Degeneration, Fatty | 2 1 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 | Hyperplasia | 1 2 2 2 1 2 1 2 1 1 1 2| Hypertrophy | 3 2 | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7| DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2| | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Necrosis | 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 1 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + M + + + + + + + M + + + + M| Hyperplasia | 2 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 | Pars Distalis, Hyperplasia | 2 3 2 | Pars Intermedia, Cyst | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 2 1 2 2 2 2 1 3 2 2 3 2 1 2 2| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Multilocular | 2 2 3 | Inflammation, Chronic Active | 2 4 2 2 2 2 2 2 2 3 4 1 2 2 2 3 2 1 2 3 2 2 2| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic | 2 2 3 2 2 | Arteriole, Necrosis, Fibrinoid | 2 2 3 2 2 | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7| DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2| | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Bilateral, Germinal Epithelium, | | Atrophy | | Germinal Epithelium, Atrophy | 4 3 4 4 3 4 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 4 4 3 3 3 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + +| Mediastinal, Pigmentation, | | Hemosiderin | 1 1 1 1 1 1 2 2 1 1 3 1 2 1 1 1 1| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | | Red Pulp, Depletion Cellular | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Parathyroid Gland | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 4 3 | Hyperplasia, Cystic | 2 2 2 2 3 4 2 3 2 3 1 2 2 1 3 1 2 3 2 3 2 2 2| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Hyperkeratosis | 4 | Epidermis, Hyperplasia | 4 | Epidermis, Skin, Site of Application,| | __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7| DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2| | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Hyperkeratosis | 2 2 1 2 2 1 1 2 1 2 2 1 2 2 2 2 3 2 2 2 3 2 2| Epidermis, Skin, Site of Application,| | Hyperplasia | 2 2 1 2 3 2 3 3 1 3 2 2 2 3 3 3 2 2 3 2 3 3 3 3 2| Epidermis, Skin, Site of Application,| | Parakeratosis | 2 2 1 1 2 1 2 2 2 2 2 2 2 2 2 | Epidermis, Skin, Site of Application,| | Ulcer | 1 | Sebaceous Gland, Skin, Site of | | Application, Hyperplasia | 2 2 1 2 2 2 3 3 1 2 2 2 2 3 3 3 2 2 3 2 2 2 3 3 2| Skin, Site of Application, | | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mineralization | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1| Interstitium, Mineralization | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 4 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 | Respiratory Epithelium, Hyperplasia | 2 4 | Respiratory Epithelium, Metaplasia, | | __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7| DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2| | 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Squamous | 2 | Vein, Turbinate, Septum, Thrombosis | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + +| Lens, Cataract | 4 4 3 4 4 4| Retina, Atrophy | 4 4 4 4 4 4| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Cyst | 2 2 3 | Mineralization | | Nephropathy, Chronic | 3 3 3 4 2 2 2 2 2 4 2 3 3 3 4 2 2 2 3 4 4 2 3 2| Pigmentation, Hemosiderin | 3 1 1 1 1 1 1 2 1 1 2 1 1 2 3 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Hyperplasia | 2 1 4 2 1 3 3 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 3 | __________________________________________|__________________________________________________________________________ Page 70 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Ulcer | 4 | 1 4.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 3 | Clear Cell Focus | X | 2 | Hepatodiaphragmatic Nodule | X X X X | 8 | Inflammation, Chronic | 1 1 1 1 1 2 2 1 3 1 1 1 2| 24 1.3| Vacuolization Cytoplasmic | 3 1 3 2 1 1 3 1 3 2 2 3 2 2 3 2 2 1| 33 1.8| Bile Duct, Hyperplasia | 2 1 1 1 2 2 2 2 2 2 2 2 2 3 1 2 1 2 2 3 1 1 2 1 2| 50 1.7| Hepatocyte, Degeneration, Cystic | 2 | 3 1.3| Hepatocyte, Necrosis | | 1 2.0| Portal Vein, Thrombosis | | 1 2.0| |__________________________________________________________________________|____________| Mesentery | + + + + | 6 | Fat, Necrosis | 4 4 4 | 5 4.0| |__________________________________________________________________________|____________| Oral Mucosa | + + | 2 | Gingival, Inflammation, Chronic | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Active | 2 | 1 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 1 3 4 2 1 1 2 1 2 2 1 2| 25 1.5| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 3 3 2 3 | 8 2.4| Foreign Body | | 1 | Inflammation, Chronic Active | 3 4 3 2 2 3 | 14 2.9| Mineralization | 1 3 | 2 2.0| Perforation | X | 4 | Epithelium, Hyperplasia | 3 3 3 2 3 1 2 2 4 | 18 2.7| Epithelium, Ulcer | 4 4 4 3 4 4 | 13 3.9| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 3.0| Mineralization | 3 2 3 2 | 4 2.5| Epithelium, Erosion | | 2 2.5| Epithelium, Ulcer | | 3 3.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | 3 3 3 3 | 4 3.0| Pulmonary Artery, Mineralization | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Chronic | 2 2 1 2 2 1 2 2 3 2 2 3 1 3 1 2 3 2 2| 42 1.9| Mineralization | 3 2 3 1 | 4 2.3| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Atypia Cellular | | 1 1.0| Degeneration, Cystic | 2 | 3 1.7| Degeneration, Fatty | 2 1 1 2 1 1 2 1 2 1 1 1 1 2 2 1 1 2 1 2 1| 38 1.3| Hyperplasia | 2 2 2 2 1 2 1 2 2 2 2 1| 24 1.6| Hypertrophy | 2 2 2 | 5 2.2| Necrosis | | 1 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 2 2 2 2 1 2 2 1 | 16 1.7| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 | Hyperplasia | 2 2 3 3 4 3 | 8 2.8| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Pars Distalis, Cyst | 3 2| 3 2.3| Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 3 3| 12 2.3| Pars Intermedia, Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 1 1 2| 11 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Hyperplasia | 1 | 3 1.7| Inflammation, Chronic Active | 2 2 1 2 2 2 1 2 2 2 2 2 2 1 2 2 4 2 1 2 2 2 2| 46 1.9| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Multilocular | 3 | 4 2.5| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 1 3 2 4 2 3 2 2 2 2 2 2| 46 2.2| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Arteriole, Inflammation, Chronic | 2 2 2 2 2 2 2 2 | 13 2.1| Arteriole, Necrosis, Fibrinoid | 2 2 2 2 2 2 2 2 | 13 2.1| Bilateral, Germinal Epithelium, | | | Atrophy | 4 | 1 4.0| Germinal Epithelium, Atrophy | 4 2 2 4 3 2 4 2 4 4 | 16 3.3| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 | 13 1.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 3 4 4 4 4 3 4 3| 16 3.6| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 37 | Mediastinal, Pigmentation, | | | Hemosiderin | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 33 1.2| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 3 | 3 2.7| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia, Lymphoid | 4| 1 4.0| Red Pulp, Depletion Cellular | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + + + + M + + + + + +| 48 | Ectopic Parathyroid Gland | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 4 3.3| Hyperplasia, Cystic | 2 2 1 2 3 2 3 2 1 4 2 2 2 2 3 2 2 3 2 1 | 43 2.2| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epidermis, Hyperkeratosis | | 1 4.0| Epidermis, Hyperplasia | | 1 4.0| Epidermis, Skin, Site of Application,| | | Hyperkeratosis | 2 1 2 2 3 1 3 2 2 2 2 1 1 3 2 1 2 1 2 2 2 2 2 2 2| 48 1.9| Epidermis, Skin, Site of Application,| | | Hyperplasia | 3 2 3 3 3 3 3 2 2 2 2 2 1 3 1 3 2 2 2 3 2 2 3 2 3| 50 2.4| Epidermis, Skin, Site of Application,| | | Parakeratosis | 2 2 2 2 1 3 1 2 2 3 2 2 1| 28 1.9| Epidermis, Skin, Site of Application,| | | Ulcer | | 1 1.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 2 2 3 3 3 3 2 2 2 2 2 2 1 2 1 2 2 2 1 3 2 2 1 2 3| 50 2.2| Skin, Site of Application, | | | Inflammation, Chronic Active | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 2 4 3 | 6 3.2| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 2 | 2 2.5| Alveolar Epithelium, Hyperplasia | 4 | 1 4.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 | 12 1.0| Interstitium, Mineralization | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 2 2 3 2 2 | 10 2.1| Nasolacrimal Duct, Inflammation, | | | Suppurative | 3 3 3 | 4 2.8| Respiratory Epithelium, Hyperplasia | 3 3 3 3 3 2 3 | 9 2.9| Respiratory Epithelium, Metaplasia, | | | Squamous | 3 2 | 3 2.3| Vein, Turbinate, Septum, Thrombosis | 4 4 | 2 4.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 8 | Lens, Cataract | 4 4 | 8 3.9| Retina, Atrophy | 4 4 | 8 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 10/09/00 Route: SKIN APPLICATION Time: 12:16:56 __________________________________________________________________________________________________________________________________ | 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| | DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| | | 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Accumulation, Hyaline Droplet | 2 | 1 2.0| Cyst | 2 2 3 2| 7 2.3| Mineralization | 3 3 2 | 3 2.7| Nephropathy, Chronic | 2 3 1 2 3 2 3 3 2 4 2 4 4 3 2 3 4 3 4 2 2 1 4 2 2| 49 2.7| Pigmentation, Hemosiderin | 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 4 1 1 1 1 1| 50 1.2| Renal Tubule, Hyperplasia | 2 1 2 2 4 4 3 | 15 2.3| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 77 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------