TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Benign Tumors Total 197/299(65.9%) 207/302(68.5%) Mean(sd) 65.9%(13.7) 68.6%(10.8) Range 26/50 - 43/50 28/52 - 40/50 Males 35/50 38/50 43/50 26/50 27/50 28/49 Females 28/52 40/50 29/50 39/50 34/50 37/50 --------------------------------------------------------------------------- Malignant Tumors Total 151/299(50.5%) 149/302(49.3%) Mean(sd) 50.5%(15.9) 49.3%(6.1) Range 16/50 - 39/50 22/50 - 30/50 Males 16/50 21/50 39/50 22/50 29/50 24/49 Females 27/52 22/50 25/50 23/50 30/50 22/50 --------------------------------------------------------------------------- Malignant and Benign Total 260/299(87%) 270/302(89.4%) Tumors Mean(sd) 87.0%(9.5) 89.5%(5.7) Range 35/50 - 49/50 41/52 - 47/50 Males 43/50 46/50 49/50 35/50 45/50 42/49 Females 41/52 47/50 45/50 47/50 44/50 46/50 --------------------------------------------------------------------------- Hemangioma Total 6/299(2%) 11/302(3.6%) Mean(sd) 2.0%(2.5) 3.6%(2.3) Range 0/50 - 3/50 0/50 - 3/50 Males 2/50 0/50 3/50 0/50 1/50 0/49 Females 3/52 3/50 2/50 2/50 0/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 30/299(10%) 10/302(3.3%) Mean(sd) 10.0%(4.2) 3.3%(2.4) Range 2/50 - 8/50 0/50 - 3/50 Males 4/50 2/50 6/50 6/50 8/50 4/49 Females 3/52 2/50 0/50 1/50 3/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 36/299(12%) 21/302(7%) Hemangioma Mean(sd) 12.0%(5.5) 6.9%(3.1) Range 2/50 - 9/50 2/50 - 6/52 Males 6/50 2/50 9/50 6/50 9/50 4/49 Females 6/52 5/50 2/50 3/50 3/50 2/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 1/299(0.3%) 11/302(3.6%) Mean(sd) 0.3%(0.8) 3.6%(2.6) Range 0/50 - 1/50 0/50 - 3/50 Males 0/50 0/50 0/50 1/50 0/50 0/49 Females 3/52 1/50 3/50 1/50 0/50 3/50 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/299(0%) 0/302(0%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.0%(0.0) or Undifferentiated Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 15/299(5%) 52/302(17.2%) Histiocytic, Mean(sd) 5.0%(3.7) 17.3%(7.3) Lymphocytic, Mixed, NOS, Range 0/50 - 5/50 3/50 - 13/50 or Undifferentiated Cell Type Males 3/50 0/50 5/50 2/50 4/50 1/49 Females 7/52 12/50 8/50 13/50 9/50 3/50 --------------------------------------------------------------------------- Osteoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/299(0%) 2/302(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.0) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 1/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/299(0%) 2/302(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.0) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 1/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 9/299(3%) 3/302(1%) Mean(sd) 3.0%(4.0) 1.0%(1.1) Range 0/50 - 5/50 0/52 - 1/50 Males 0/50 5/50 0/50 0/50 2/50 2/49 Females 0/52 0/50 1/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/300(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Pheochromocytoma Benign Total 1/298(0.3%) 7/301(2.3%) Mean(sd) 0.3%(0.8) 2.3%(2.0) Range 0/49 - 1/50 0/51 - 2/50 Males 1/50 0/49 0/50 0/50 0/50 0/49 Females 0/51 2/50 0/50 2/50 1/50 2/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/298(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 0/49 0/50 0/50 0/50 0/49 Females 0/51 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 0/298(0%) 0/301(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 0/49 0/50 0/50 0/50 0/49 Females 0/51 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 1/298(0.3%) 7/301(2.3%) Benign, Complex, Mean(sd) 0.3%(0.8) 2.3%(2.0) Malignant, NOS Range 0/49 - 1/50 0/51 - 2/50 Males 1/50 0/49 0/50 0/50 0/50 0/49 Females 0/51 2/50 0/50 2/50 1/50 2/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/299(0.7%) 3/302(1%) Mean(sd) 0.7%(1.0) 1.0%(1.1) Range 0/50 - 1/50 0/52 - 1/50 Males 0/50 1/50 0/50 0/50 1/50 0/49 Females 0/52 1/50 0/50 0/50 1/50 1/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Astrocytoma Benign Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/299(0%) 0/302(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/299(0%) 0/302(0%) Glioma, or Astrocytoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Basosquamous Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 1/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Leiomyoma Total 1/299(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Males 0/50 1/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Sarcoma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 0/50 0/50 1/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/283(0%) 0/292(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/52 - 0/52 Males 0/49 0/45 0/49 0/48 0/47 0/45 Females 0/52 0/49 0/49 0/49 0/47 0/46 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 8/299(2.7%) 10/302(3.3%) Mean(sd) 2.7%(1.6) 3.3%(2.4) Range 0/50 - 2/49 0/50 - 3/50 Males 2/50 0/50 1/50 2/50 1/50 2/49 Females 2/52 1/50 3/50 0/50 1/50 3/50 --------------------------------------------------------------------------- Carcinoma Total 1/299(0.3%) 5/302(1.7%) Mean(sd) 0.3%(0.8) 1.6%(1.4) Range 0/50 - 1/50 0/50 - 2/52 Males 1/50 0/50 0/50 0/50 0/50 0/49 Females 2/52 0/50 1/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 9/299(3%) 15/302(5%) Mean(sd) 3.0%(2.1) 5.0%(2.7) Range 0/50 - 3/50 1/50 - 4/50 Males 3/50 0/50 1/50 2/50 1/50 2/49 Females 4/52 1/50 4/50 1/50 2/50 3/50 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 0/49 Females 0/52 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/299(0.7%) 1/302(0.3%) Mean(sd) 0.7%(1.7) 0.3%(0.8) Range 0/50 - 2/49 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 2/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/299(0.7%) 1/302(0.3%) Mean(sd) 0.7%(1.7) 0.3%(0.8) Range 0/50 - 2/49 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 2/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/299(0.7%) 1/302(0.3%) Mean(sd) 0.7%(1.7) 0.3%(0.8) Range 0/50 - 2/49 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 2/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 0/49 Females 0/52 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 3/298(1%) 3/301(1%) Mean(sd) 1.0%(1.7) 1.0%(1.1) Range 0/50 - 2/49 0/52 - 1/50 Males 2/49 0/50 0/50 1/50 0/50 0/49 Females 0/52 0/50 1/50 0/50 1/50 1/49 --------------------------------------------------------------------------- Carcinoma Total 2/298(0.7%) 1/301(0.3%) Mean(sd) 0.7%(1.0) 0.3%(0.8) Range 0/49 - 1/50 0/52 - 1/50 Males 0/49 1/50 0/50 0/50 1/50 0/49 Females 0/52 0/50 1/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/298(1.7%) 4/301(1.3%) Mean(sd) 1.7%(1.5) 1.3%(1.6) Range 0/50 - 2/49 0/52 - 2/50 Males 2/49 1/50 0/50 1/50 1/50 0/49 Females 0/52 0/50 2/50 0/50 1/50 1/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 2/299(0.7%) 0/302(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 1/50 0/50 1/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/299(0.7%) 0/302(0%) Mean(sd) 0.7%(1.6) 0.0%(0.0) Range 0/50 - 2/50 0/52 - 0/52 Males 0/50 2/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/299(1.3%) 0/302(0%) Mean(sd) 1.3%(2.4) 0.0%(0.0) Range 0/50 - 3/50 0/52 - 0/52 Males 0/50 3/50 0/50 1/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Cholangiocarcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/49 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 1/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 2/299(0.7%) 3/302(1%) Mean(sd) 0.7%(1.6) 1.0%(1.7) Range 0/50 - 2/50 0/52 - 2/50 Males 0/50 0/50 2/50 0/50 0/50 0/49 Females 0/52 1/50 2/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 18/299(6%) 4/302(1.3%) Mean(sd) 6.0%(5.2) 1.3%(1.6) Range 0/50 - 7/50 0/50 - 2/50 Males 3/50 0/50 5/50 2/50 7/50 1/49 Females 1/52 0/50 0/50 1/50 2/50 0/50 --------------------------------------------------------------------------- Hepatoblastoma Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/52 - 1/50 Males 0/50 0/50 0/50 1/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 155/299(51.8%) 151/302(50%) Mean(sd) 51.8%(13.5) 50.1%(12.2) Range 19/50 - 37/50 18/50 - 32/50 Males 24/50 31/50 37/50 22/50 19/50 22/49 Females 20/52 32/50 18/50 32/50 23/50 26/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 89/299(29.8%) 45/302(14.9%) Mean(sd) 29.7%(19.9) 14.9%(7.0) Range 9/49 - 35/50 3/50 - 12/52 Males 10/50 12/50 35/50 12/50 11/50 9/49 Females 12/52 5/50 10/50 3/50 10/50 5/50 --------------------------------------------------------------------------- Hepatocellular Total 90/299(30.1%) 46/302(15.2%) Carcinoma or Mean(sd) 30.1%(19.8) 15.2%(6.8) Hepatoblastoma Range 9/49 - 35/50 3/50 - 12/52 Males 10/50 12/50 35/50 13/50 11/50 9/49 Females 12/52 5/50 10/50 3/50 10/50 6/50 --------------------------------------------------------------------------- Hepatocellular Total 199/299(66.6%) 176/302(58.3%) Carcinoma or Mean(sd) 66.5%(15.0) 58.3%(6.1) Hepatocellular Adenoma Range 28/50 - 46/50 27/52 - 33/50 Males 29/50 39/50 46/50 28/50 28/50 29/49 Females 27/52 33/50 27/50 33/50 28/50 28/50 --------------------------------------------------------------------------- Hepatocellular Total 200/299(66.9%) 176/302(58.3%) Carcinoma, Mean(sd) 66.9%(14.8) 58.3%(6.1) Hepatocellular Adenoma, Range 28/50 - 46/50 27/52 - 33/50 or Hepatoblastoma Males 29/50 39/50 46/50 29/50 28/50 29/49 Females 27/52 33/50 27/50 33/50 28/50 28/50 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/52 - 1/50 Males 0/50 0/50 1/50 0/50 0/50 0/49 Females 0/52 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 1/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 61/299(20.4%) 13/302(4.3%) Adenoma Mean(sd) 20.4%(5.9) 4.3%(3.0) Range 6/50 - 13/50 1/52 - 4/50 Males 13/50 11/50 13/50 11/50 6/50 7/49 Females 1/52 4/50 4/50 2/50 1/50 1/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 27/299(9%) 15/302(5%) Carcinoma Mean(sd) 9.1%(5.5) 5.0%(4.9) Range 1/50 - 8/50 0/50 - 7/50 Males 1/50 5/50 2/50 4/50 8/50 7/49 Females 1/52 2/50 2/50 0/50 7/50 3/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 85/299(28.4%) 27/302(8.9%) Carcinoma or Mean(sd) 28.4%(2.2) 9.0%(4.7) Alveolar/Bronchiolar Range 12/49 - 15/50 2/52 - 8/50 Adenoma Males 14/50 15/50 15/50 15/50 14/50 12/49 Females 2/52 6/50 5/50 2/50 8/50 4/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 2/302(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.0) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 0/50 1/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 1/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 1/299(0.3%) 0/302(0%) Malignant Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 1/299(0.3%) 0/302(0%) Malignant Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 3/302(1%) Mean(sd) 0.0%(0.0) 1.0%(1.1) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 3/302(1%) Mean(sd) 0.0%(0.0) 1.0%(1.1) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/299(0%) 0/302(0%) or Adenoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/299(0%) 3/302(1%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 1.0%(1.1) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Myoepithelioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/50 - 1/52 Males 1/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Papilloma Squamous or Total 0/299(0%) 1/302(0.3%) Papilloma Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/299(0%) 1/302(0.3%) Carcinoma, Papilloma Mean(sd) 0.0%(0.0) 0.3%(0.8) Squamous, or Papilloma Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Cystadenoma Total 15/301(5%) Mean(sd) 5.0%(2.7) Range 0/50 - 4/50 Females 3/52 2/49 0/50 3/50 4/50 3/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/301(0.3%) Benign Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/301(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 1/301(0.3%) Benign, Malignant, NOS Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 1/301(0.3%) Malignant Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 3/301(1%) Mean(sd) 1.0%(2.5) Range 0/52 - 3/49 Females 0/52 3/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 1/301(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/49 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Teratoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Teratoma Benign Total 1/301(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/49 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Teratoma Malignant Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Teratoma NOS Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Thecoma Benign Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/301(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Fibrosarcoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/301(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/262(0%) 0/243(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/47 - 0/47 0/43 - 0/43 Males 0/47 0/41 0/46 0/43 0/40 0/45 Females 0/43 0/43 0/38 0/37 0/44 0/38 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Papilloma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/287(0.3%) 44/297(14.8%) Mean(sd) 0.3%(0.8) 14.9%(4.1) Range 0/48 - 1/49 5/48 - 10/47 Males 0/48 0/48 1/49 0/45 0/48 0/49 Females 6/52 7/50 7/50 5/48 10/47 9/50 --------------------------------------------------------------------------- Carcinoma Total 0/287(0%) 1/297(0.3%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/48 - 0/48 0/52 - 1/48 Males 0/48 0/48 0/49 0/45 0/48 0/49 Females 0/52 0/50 0/50 1/48 0/47 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/287(0.3%) 45/297(15.2%) Mean(sd) 0.3%(0.8) 15.2%(3.7) Range 0/48 - 1/49 6/52 - 10/47 Males 0/48 0/48 1/49 0/45 0/48 0/49 Females 6/52 7/50 7/50 6/48 10/47 9/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 2/287(0.7%) 2/297(0.7%) Mean(sd) 0.7%(1.1) 0.7%(1.0) Range 0/48 - 1/45 0/52 - 1/50 Males 0/48 1/48 0/49 1/45 0/48 0/49 Females 0/52 1/50 1/50 0/48 0/47 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/287(0%) 0/297(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/52 - 0/52 Males 0/48 0/48 0/49 0/45 0/48 0/49 Females 0/52 0/50 0/50 0/48 0/47 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/287(0.7%) 2/297(0.7%) Mean(sd) 0.7%(1.1) 0.7%(1.0) Range 0/48 - 1/45 0/52 - 1/50 Males 0/48 1/48 0/49 1/45 0/48 0/49 Females 0/52 1/50 1/50 0/48 0/47 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/298(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/298(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/298(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/299(0%) 0/302(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Basal Cell Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/299(0%) 0/302(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/299(0%) 0/302(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign, or Range 0/50 - 0/50 0/52 - 0/52 Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/299(0%) 0/302(0%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) (malignant or NOS) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/299(0%) 0/302(0%) Basal Cell Adenoma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Basosquamous Tumor Range 0/50 - 0/50 0/52 - 0/52 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 0/299(0%) 0/302(0%) Carcinoma, Carcinoma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Basosq. Tumor (M or B), Range 0/50 - 0/50 0/52 - 0/52 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/299(0%) 0/302(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/50 - 1/52 Males 1/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/299(0.7%) 2/302(0.7%) Mean(sd) 0.7%(1.0) 0.7%(1.0) Range 0/50 - 1/50 0/52 - 1/50 Males 1/50 0/50 0/50 1/50 0/50 0/49 Females 0/52 1/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/299(0%) 0/302(0%) Carcinoma, Basal Cell Mean(sd) 0.0%(0.0) 0.0%(0.0) Carcinoma, Basosquamous Range 0/50 - 0/50 0/52 - 0/52 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/299(0%) 0/302(0%) Papilloma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/299(0%) 0/302(0%) Papilloma, Papilloma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Cell Carcinoma Range 0/50 - 0/50 0/52 - 0/52 or Keratoacanthoma Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/299(0%) 0/302(0%) Papilloma, Papilloma, or Mean(sd) 0.0%(0.0) 0.0%(0.0) Keratoacanthoma Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibroma Total 1/299(0.3%) 0/302(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/52 - 0/52 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 2/299(0.7%) 9/302(3%) Sarcoma, Myxoma, Mean(sd) 0.7%(1.6) 3.0%(2.0) Myxosarcoma, or Fibrous Range 0/50 - 2/50 0/50 - 3/52 Histiocytoma Males 0/50 2/50 0/50 0/50 0/50 0/49 Females 3/52 1/50 1/50 2/50 0/50 2/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/299(0.3%) 6/302(2%) Mean(sd) 0.3%(0.8) 2.0%(1.7) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 2/52 0/50 1/50 1/50 0/50 2/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 1/299(0.3%) 9/302(3%) Myxosarcoma, or Fibrous Mean(sd) 0.3%(0.8) 3.0%(2.0) Histiocytoma Range 0/50 - 1/50 0/50 - 3/52 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 3/52 1/50 1/50 2/50 0/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Myxosarcoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/299(0%) 0/302(0%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.0%(0.0) NOS) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/299(0%) 0/302(0%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.0%(0.0) Schwannoma (benign, Range 0/50 - 0/50 0/52 - 0/52 malignant or NOS) Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 3/302(1%) Mean(sd) 0.0%(0.0) 1.0%(1.1) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 1/52 1/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 11/299(3.7%) 5/302(1.7%) Mean(sd) 3.7%(2.4) 1.7%(2.0) Range 0/50 - 3/49 0/50 - 2/50 Males 0/50 1/50 2/50 3/50 2/50 3/49 Females 1/52 2/50 0/50 0/50 2/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/299(0%) 0/302(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 1/299(0.3%) 1/302(0.3%) Malignant Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/50 - 1/52 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/299(0.3%) 1/302(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/52 - 1/50 Males 0/50 1/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 2/299(0.7%) 6/302(2%) Carcinoma or Papilloma Mean(sd) 0.7%(1.0) 2.0%(3.1) Squamous Range 0/50 - 1/50 0/52 - 4/50 Males 0/50 1/50 1/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 1/50 0/50 4/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/299(0.3%) 5/302(1.7%) Mean(sd) 0.3%(0.8) 1.7%(2.3) Range 0/50 - 1/50 0/52 - 3/50 Males 0/50 0/50 1/50 0/50 0/50 0/49 Females 0/52 1/50 0/50 1/50 0/50 3/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 3/299(1%) Mean(sd) 1.0%(1.7) Range 0/50 - 2/50 Males 1/50 2/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Hemangioma Total 1/238(0.4%) 0/265(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/31 - 1/45 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 1/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/238(0%) 0/265(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Sarcoma Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Thymoma Benign Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Thymoma Malignant Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Thymoma NOS Total 0/238(0%) 0/265(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/238(0%) 0/265(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/31 - 0/31 0/41 - 0/41 Males 0/31 0/37 0/37 0/43 0/45 0/45 Females 0/41 0/48 0/38 0/47 0/50 0/41 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 9/299(3%) 17/302(5.6%) Mean(sd) 3.0%(3.0) 5.6%(2.0) Range 0/50 - 4/50 2/50 - 4/50 Males 0/50 4/50 2/50 0/50 1/50 2/49 Females 3/52 4/50 2/50 2/50 4/50 2/50 --------------------------------------------------------------------------- Carcinoma Total 2/299(0.7%) 1/302(0.3%) Mean(sd) 0.7%(1.0) 0.3%(0.8) Range 0/50 - 1/50 0/50 - 1/52 Males 1/50 0/50 0/50 0/50 0/50 1/49 Females 1/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 11/299(3.7%) 18/302(6%) Mean(sd) 3.7%(3.0) 6.0%(2.1) Range 0/50 - 4/50 2/50 - 4/50 Males 1/50 4/50 2/50 0/50 1/50 3/49 Females 4/52 4/50 2/50 2/50 4/50 2/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/299(0%) 1/302(0.3%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.3%(0.8) Squamous Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/299(0%) 1/302(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/52 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adamantinoma Benign Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma or Papilloma Total 0/299(0%) 0/300(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/299(0%) 1/300(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/299(0%) 0/300(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/299(0.3%) 0/300(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 1/49 Females 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 0/299(0%) 0/300(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/302(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/302(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/302(0%) Benign Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/302(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/302(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 11/302(3.6%) Mean(sd) 3.7%(2.0) Range 1/52 - 3/50 Females 1/52 3/50 3/50 1/50 2/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 1/302(0.3%) Mean(sd) 0.3%(0.8) Range 0/52 - 1/50 Females 0/52 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 12/302(4%) Polyp Stromal Mean(sd) 4.0%(1.8) Range 1/52 - 3/50 Females 1/52 3/50 3/50 1/50 2/50 2/50 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Leiomyosarcoma Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/302(0%) Mean(sd) 0.0%(0.0) Range 0/52 - 0/52 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE DERMAL ETHANOL (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/299(0%) 0/302(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/52 - 0/52 Males 0/50 0/50 0/50 0/50 0/50 0/49 Females 0/52 0/50 0/50 0/50 0/50 0/50 ---------------------------------------------------------------------------