TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Benign Tumors Total 265/464(57.1%) 214/463(46.2%) Mean(sd) 57.2%(11.4) 46.2%(10.5) Range 19/52 - 38/50 17/51 - 33/50 Males 29/50 30/50 38/50 35/50 27/50 26/50 25/50 19/52 36/62 Females 33/50 28/50 20/52 17/51 23/50 22/50 24/50 17/50 30/60 --------------------------------------------------------------------------- Malignant Tumors Total 184/464(39.7%) 163/463(35.2%) Mean(sd) 39.7%(11.8) 35.3%(12.1) Range 15/52 - 32/50 8/52 - 26/50 Males 32/50 17/50 15/50 17/50 23/50 25/50 15/50 15/52 25/62 Females 26/50 18/50 8/52 9/51 21/50 19/50 16/50 23/50 23/60 --------------------------------------------------------------------------- Malignant and Benign Total 344/464(74.1%) 317/463(68.5%) Tumors Mean(sd) 74.3%(11.0) 68.4%(14.2) Range 29/52 - 44/50 24/51 - 46/50 Males 44/50 38/50 42/50 42/50 33/50 40/50 31/50 29/52 45/62 Females 46/50 39/50 25/52 24/51 35/50 34/50 32/50 36/50 46/60 --------------------------------------------------------------------------- Hemangioma Total 5/464(1.1%) 4/463(0.9%) Mean(sd) 1.1%(1.4) 0.9%(1.0) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 2/50 0/50 0/50 1/50 1/50 0/50 1/52 0/62 Females 0/50 1/50 1/52 0/51 0/50 1/50 0/50 1/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 22/464(4.7%) 6/463(1.3%) Mean(sd) 4.8%(3.3) 1.3%(2.0) Range 0/50 - 4/50 0/50 - 3/50 Males 3/50 4/50 0/50 3/50 4/50 3/50 0/50 4/52 1/62 Females 0/50 1/50 0/52 0/51 1/50 3/50 0/50 0/50 1/60 --------------------------------------------------------------------------- Hemangiosarcoma or Total 26/464(5.6%) 10/463(2.2%) Hemangioma Mean(sd) 5.7%(4.3) 2.2%(2.5) Range 0/50 - 6/50 0/50 - 4/50 Males 3/50 6/50 0/50 3/50 5/50 4/50 0/50 4/52 1/62 Females 0/50 2/50 1/52 0/51 1/50 4/50 0/50 1/50 1/60 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 5/464(1.1%) 8/463(1.7%) Mean(sd) 1.0%(1.3) 1.7%(1.6) Range 0/50 - 2/62 0/50 - 2/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 1/50 1/52 2/62 Females 1/50 0/50 1/52 1/51 0/50 2/50 0/50 2/50 1/60 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/464(0%) 0/463(0%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.0%(0.0) or Undifferentiated Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Malignant Lymphoma: Total 30/464(6.5%) 85/463(18.4%) Histiocytic, Mean(sd) 6.4%(4.1) 18.4%(7.1) Lymphocytic, Mixed, NOS, Range 0/50 - 5/50 4/51 - 15/50 or Undifferentiated Cell Type Males 5/50 2/50 0/50 0/50 4/50 5/50 3/50 5/52 6/62 Females 11/50 9/50 5/52 4/51 9/50 13/50 8/50 15/50 11/60 --------------------------------------------------------------------------- Osteoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Osteosarcoma Total 0/464(0%) 2/463(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 1/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/464(0%) 2/463(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 1/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 9/460(2%) 3/456(0.7%) Mean(sd) 2.0%(2.7) 0.7%(1.4) Range 0/49 - 4/50 0/50 - 2/50 Males 4/50 1/50 0/49 0/49 0/50 1/50 2/48 0/52 1/62 Females 1/49 0/50 0/49 0/49 0/50 0/50 2/50 0/50 0/59 --------------------------------------------------------------------------- Carcinoma Total 0/460(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/52 0/62 Females 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/460(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/52 0/62 Females 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/460(0%) 0/456(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/52 0/62 Females 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 2/461(0.4%) 0/456(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/49 - 0/49 Males 0/50 1/50 0/49 1/50 0/50 0/50 0/48 0/52 0/62 Females 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Pheochromocytoma Benign Total 4/454(0.9%) 5/449(1.1%) Mean(sd) 0.8%(1.0) 1.1%(1.5) Range 0/49 - 1/49 0/49 - 2/49 Males 0/49 1/49 1/49 0/49 1/50 0/50 0/46 0/51 1/61 Females 1/50 0/49 2/49 0/47 0/50 1/50 0/46 0/49 1/59 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/454(0%) 0/449(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/49 0/49 0/50 0/50 0/46 0/51 0/61 Females 0/50 0/49 0/49 0/47 0/50 0/50 0/46 0/49 0/59 --------------------------------------------------------------------------- Pheochromocytoma Total 0/454(0%) 1/449(0.2%) Malignant Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/49 0/49 0/49 0/50 0/50 0/46 0/51 0/61 Females 0/50 0/49 0/49 0/47 1/50 0/50 0/46 0/49 0/59 --------------------------------------------------------------------------- Pheochromocytoma: Total 4/454(0.9%) 6/449(1.3%) Benign, Complex, Mean(sd) 0.8%(1.0) 1.3%(1.4) Malignant, NOS Range 0/49 - 1/49 0/49 - 2/49 Males 0/49 1/49 1/49 0/49 1/50 0/50 0/46 0/51 1/61 Females 1/50 0/49 2/49 0/47 1/50 1/50 0/46 0/49 1/59 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/460(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Hemangioma Total 0/460(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 4/460(0.9%) 0/460(0%) Mean(sd) 0.9%(1.4) 0.0%(0.0) Range 0/49 - 2/50 0/50 - 0/50 Males 2/50 0/49 0/49 0/49 1/50 0/50 0/49 1/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/460(0%) 0/460(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/460(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/460(0%) 0/460(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Osteoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Osteosarcoma Total 0/464(0%) 2/463(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 1/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/464(0%) 2/463(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 1/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Astrocytoma Benign Total 0/461(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Meningioma Malignant Total 0/461(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/461(0%) 0/457(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/461(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Oligodendroglioma Total 0/461(0%) 0/457(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/461(0%) 0/457(0%) Glioma, or Astrocytoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/461(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Basosquamous Tumor Total 0/464(0%) 0/463(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibroma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibrosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/461(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- Hemangioma Total 0/461(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- Leiomyoma Total 0/461(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- Sarcoma Total 0/461(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/49 0/49 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 1/60 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Sarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/426(0%) 0/425(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/46 - 0/46 Males 0/45 0/48 0/40 0/45 0/47 0/49 0/48 0/47 0/57 Females 0/46 0/47 0/41 0/45 0/49 0/49 0/46 0/49 0/53 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 21/464(4.5%) 24/463(5.2%) Mean(sd) 4.6%(3.2) 5.2%(3.2) Range 0/50 - 5/50 1/52 - 6/50 Males 1/50 3/50 3/50 5/50 4/50 2/50 0/50 1/52 2/62 Females 6/50 4/50 1/52 1/51 3/50 2/50 2/50 2/50 3/60 --------------------------------------------------------------------------- Carcinoma Total 3/464(0.6%) 2/463(0.4%) Mean(sd) 0.7%(1.0) 0.4%(0.9) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 1/50 1/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 1/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 23/464(5%) 26/463(5.6%) Mean(sd) 5.0%(2.9) 5.7%(3.3) Range 1/52 - 5/50 1/52 - 6/50 Males 1/50 3/50 3/50 5/50 4/50 3/50 1/50 1/52 2/62 Females 6/50 4/50 1/52 1/51 4/50 2/50 3/50 2/50 3/60 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/463(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/463(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/463(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/463(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibrosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/50 - 1/62 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 1/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 2/464(0.4%) 0/463(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 5/464(1.1%) 0/463(0%) Mean(sd) 1.1%(1.7) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 0/50 2/50 2/50 0/50 0/50 0/50 0/52 1/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 2/464(0.4%) 0/463(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 6/464(1.3%) 0/463(0%) Mean(sd) 1.3%(2.2) 0.0%(0.0) Range 0/50 - 3/50 0/50 - 0/50 Males 0/50 0/50 2/50 3/50 0/50 0/50 0/50 0/52 1/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 8/464(1.7%) 0/463(0%) Mean(sd) 1.7%(2.7) 0.0%(0.0) Range 0/50 - 4/50 0/50 - 0/50 Males 0/50 0/50 2/50 4/50 0/50 0/50 0/50 1/52 1/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 2/462(0.4%) 3/456(0.7%) Mean(sd) 0.4%(0.9) 0.7%(1.0) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/50 0/49 0/49 0/50 1/50 1/50 0/52 0/62 Females 0/50 0/50 1/49 0/50 1/50 0/50 1/49 0/49 0/59 --------------------------------------------------------------------------- Carcinoma Total 0/462(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/49 0/59 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/462(0.4%) 3/456(0.7%) Mean(sd) 0.4%(0.9) 0.7%(1.0) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/50 0/49 0/49 0/50 1/50 1/50 0/52 0/62 Females 0/50 0/50 1/49 0/50 1/50 0/50 1/49 0/49 0/59 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 3/463(0.6%) 0/457(0%) Mean(sd) 0.6%(0.9) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 1/49 0/50 0/50 0/50 1/50 0/52 1/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/463(0.6%) 0/457(0%) Mean(sd) 0.6%(0.9) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 1/49 0/50 0/50 0/50 1/50 0/52 1/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/463(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Cholangiocarcinoma Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Cholangioma Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 2/464(0.4%) 1/461(0.2%) Mean(sd) 0.4%(0.9) 0.2%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 13/464(2.8%) 3/461(0.7%) Mean(sd) 2.8%(2.5) 0.7%(1.4) Range 0/50 - 3/50 0/50 - 2/50 Males 2/50 3/50 0/50 2/50 0/50 2/50 0/50 3/52 1/62 Females 0/50 0/50 0/50 0/51 1/50 2/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hepatoblastoma Total 2/464(0.4%) 0/461(0%) Mean(sd) 0.4%(1.1) 0.0%(0.0) Range 0/50 - 2/62 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 2/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 181/464(39%) 100/461(21.7%) Mean(sd) 39.1%(11.6) 21.5%(9.9) Range 11/52 - 29/50 3/50 - 20/50 Males 21/50 21/50 26/50 29/50 19/50 13/50 16/50 11/52 25/62 Females 20/50 11/50 8/50 10/51 13/50 12/50 3/50 6/50 17/60 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 93/464(20%) 33/461(7.2%) Mean(sd) 20.2%(8.6) 7.1%(7.1) Range 4/52 - 19/50 0/50 - 11/50 Males 19/50 7/50 11/50 11/50 10/50 13/50 8/50 4/52 10/62 Females 11/50 2/50 0/50 3/51 7/50 2/50 1/50 1/50 6/60 --------------------------------------------------------------------------- Hepatocellular Total 95/464(20.5%) 33/461(7.2%) Carcinoma or Mean(sd) 20.6%(8.4) 7.1%(7.1) Hepatoblastoma Range 4/52 - 19/50 0/50 - 11/50 Males 19/50 7/50 11/50 11/50 10/50 13/50 8/50 4/52 12/62 Females 11/50 2/50 0/50 3/51 7/50 2/50 1/50 1/50 6/60 --------------------------------------------------------------------------- Hepatocellular Total 241/464(51.9%) 127/461(27.5%) Carcinoma or Mean(sd) 52.1%(15.8) 27.4%(14.8) Hepatocellular Adenoma Range 13/52 - 36/50 4/50 - 29/50 Males 34/50 25/50 35/50 36/50 25/50 24/50 18/50 13/52 31/62 Females 29/50 13/50 8/50 13/51 17/50 14/50 4/50 7/50 22/60 --------------------------------------------------------------------------- Hepatocellular Total 241/464(51.9%) 127/461(27.5%) Carcinoma, Mean(sd) 52.1%(15.8) 27.4%(14.8) Hepatocellular Adenoma, Range 13/52 - 36/50 4/50 - 29/50 or Hepatoblastoma Males 34/50 25/50 35/50 36/50 25/50 24/50 18/50 13/52 31/62 Females 29/50 13/50 8/50 13/51 17/50 14/50 4/50 7/50 22/60 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/464(0%) 1/461(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/464(0%) 0/461(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/464(0%) 0/461(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 0/461(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/464(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/49 0/51 0/51 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 87/464(18.8%) 25/460(5.4%) Adenoma Mean(sd) 18.8%(4.9) 5.5%(3.0) Range 7/52 - 14/50 1/59 - 6/50 Males 8/50 12/50 14/50 8/50 7/50 11/50 9/50 7/52 11/62 Females 3/50 3/49 2/51 2/51 2/50 2/50 6/50 4/50 1/59 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 25/464(5.4%) 11/460(2.4%) Carcinoma Mean(sd) 5.4%(3.6) 2.4%(2.2) Range 1/52 - 6/50 0/51 - 3/50 Males 6/50 2/50 1/50 1/50 5/50 3/50 2/50 1/52 4/62 Females 1/50 2/49 0/51 0/51 0/50 1/50 2/50 3/50 2/59 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 106/464(22.8%) 35/460(7.6%) Carcinoma or Mean(sd) 22.9%(4.9) 7.7%(4.7) Alveolar/Bronchiolar Range 8/52 - 14/50 2/59 - 8/50 Adenoma Males 13/50 14/50 14/50 9/50 9/50 14/50 11/50 8/52 14/62 Females 4/50 5/49 2/51 2/51 2/50 3/50 8/50 7/50 2/59 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/464(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/49 0/51 0/51 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/49 0/51 0/51 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/464(0%) 0/460(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/49 0/51 0/51 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/464(0%) 0/460(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/49 0/51 0/51 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- Sarcoma Total 1/464(0.2%) 0/460(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/49 0/51 0/51 0/50 0/50 0/50 0/50 0/59 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/464(0%) 0/463(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Liposarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/464(0%) 0/463(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrous Histiocytoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/464(0%) 2/463(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 1/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 1/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/464(0%) 3/463(0.6%) Mean(sd) 0.0%(0.0) 0.6%(1.0) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 1/51 0/50 0/50 1/50 0/50 1/60 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/464(0%) 2/463(0.4%) or Adenoma Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 1/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/464(0%) 3/463(0.6%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 0.6%(1.0) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 1/51 0/50 0/50 1/50 0/50 1/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Myoepithelioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibroma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Fibrosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Lipoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Liposarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 2/463(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 1/50 0/50 0/52 0/51 1/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/462(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/47 0/50 0/59 --------------------------------------------------------------------------- Carcinoma Total 1/462(0.2%) 0/457(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/47 0/50 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/462(0%) 0/457(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/47 0/50 0/59 --------------------------------------------------------------------------- Sarcoma Total 1/462(0.2%) 0/457(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 1/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/47 0/50 0/59 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Papilloma Squamous or Total 0/464(0%) 1/463(0.2%) Papilloma Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 1/50 0/60 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 0/464(0%) 1/463(0.2%) Carcinoma, Papilloma Mean(sd) 0.0%(0.0) 0.2%(0.7) Squamous, or Papilloma Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 1/50 0/60 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Squamous Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 1/453(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/47 Females 0/50 0/49 0/51 0/50 1/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Carcinoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Cystadenoma Total 5/453(1.1%) Mean(sd) 1.1%(1.4) Range 0/50 - 2/51 Females 0/50 0/49 2/51 1/50 0/47 1/49 0/49 0/49 1/59 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 5/453(1.1%) Benign Mean(sd) 1.1%(1.5) Range 0/50 - 2/49 Females 0/50 2/49 0/51 1/50 0/47 1/49 0/49 0/49 1/59 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/453(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 5/453(1.1%) Benign, Malignant, NOS Mean(sd) 1.1%(1.5) Range 0/50 - 2/49 Females 0/50 2/49 0/51 1/50 0/47 1/49 0/49 0/49 1/59 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/453(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Hemangioma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/453(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/49 Females 0/50 1/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Liposarcoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Luteoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Teratoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Teratoma Benign Total 1/453(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/47 Females 0/50 0/49 0/51 0/50 1/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Teratoma Malignant Total 1/453(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/49 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 1/49 0/59 --------------------------------------------------------------------------- Teratoma NOS Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Thecoma Benign Total 1/453(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/49 Females 0/50 1/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/453(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/51 0/50 0/47 0/49 0/49 0/49 0/59 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 1/461(0.2%) 0/456(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 1/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Carcinoma Total 0/461(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/461(0.2%) 0/456(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 1/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Fibrosarcoma Total 0/461(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/461(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Hemangioma Total 0/461(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/461(0%) 0/456(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Sarcoma Total 1/461(0.2%) 0/456(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/48 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 0/396(0%) 0/379(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/49 - 0/49 Males 0/48 0/45 0/38 0/39 0/49 0/48 0/43 0/36 0/50 Females 0/49 0/43 0/35 0/38 0/47 0/42 0/40 0/36 0/49 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Squamous Cell Papilloma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 1/50 0/60 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 2/430(0.5%) 58/434(13.4%) Mean(sd) 0.4%(0.9) 13.3%(4.8) Range 0/49 - 1/44 3/48 - 9/47 Males 0/49 0/47 0/42 0/47 0/48 1/44 0/48 0/46 1/59 Females 9/49 8/47 4/45 9/47 4/48 7/49 5/46 3/48 9/55 --------------------------------------------------------------------------- Carcinoma Total 0/430(0%) 0/434(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/47 0/42 0/47 0/48 0/44 0/48 0/46 0/59 Females 0/49 0/47 0/45 0/47 0/48 0/49 0/46 0/48 0/55 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/430(0.5%) 58/434(13.4%) Mean(sd) 0.4%(0.9) 13.3%(4.8) Range 0/49 - 1/44 3/48 - 9/47 Males 0/49 0/47 0/42 0/47 0/48 1/44 0/48 0/46 1/59 Females 9/49 8/47 4/45 9/47 4/48 7/49 5/46 3/48 9/55 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/430(0%) 2/434(0.5%) Mean(sd) 0.0%(0.0) 0.5%(0.9) Range 0/49 - 0/49 0/49 - 1/48 Males 0/49 0/47 0/42 0/47 0/48 0/44 0/48 0/46 0/59 Females 0/49 0/47 0/45 0/47 1/48 1/49 0/46 0/48 0/55 --------------------------------------------------------------------------- Carcinoma Total 1/430(0.2%) 0/434(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/49 - 1/44 0/49 - 0/49 Males 0/49 0/47 0/42 0/47 0/48 1/44 0/48 0/46 0/59 Females 0/49 0/47 0/45 0/47 0/48 0/49 0/46 0/48 0/55 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/430(0.2%) 2/434(0.5%) Mean(sd) 0.3%(0.8) 0.5%(0.9) Range 0/49 - 1/44 0/49 - 1/48 Males 0/49 0/47 0/42 0/47 0/48 1/44 0/48 0/46 0/59 Females 0/49 0/47 0/45 0/47 1/48 1/49 0/46 0/48 0/55 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma Total 0/456(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/49 0/50 0/45 0/51 0/62 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/456(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/49 0/50 0/45 0/51 0/62 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/456(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/49 0/50 0/45 0/51 0/62 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Hemangioma Total 1/461(0.2%) 0/459(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/50 0/50 0/50 0/48 0/52 0/62 Females 0/50 0/50 0/51 0/51 0/50 0/49 0/49 0/49 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/461(0%) 0/459(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/48 0/52 0/62 Females 0/50 0/50 0/51 0/51 0/50 0/49 0/49 0/49 0/60 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/464(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- Carcinoma Total 0/464(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Osteosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 1/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/464(0%) 1/463(0.2%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 1/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 1/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Basal Cell Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/464(0%) 1/463(0.2%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.2%(0.7) Benign Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/464(0%) 1/463(0.2%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.2%(0.7) Benign, or Range 0/50 - 0/50 0/50 - 1/50 Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/464(0%) 0/463(0%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) (malignant or NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/464(0%) 1/463(0.2%) Basal Cell Adenoma, Mean(sd) 0.0%(0.0) 0.2%(0.7) Basosquamous Tumor Range 0/50 - 0/50 0/50 - 1/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Basal or Sq. Cell Total 1/464(0.2%) 1/463(0.2%) Carcinoma, Carcinoma, Mean(sd) 0.2%(0.6) 0.2%(0.7) Basosq. Tumor (M or B), Range 0/50 - 1/52 0/50 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/464(0%) 1/463(0.2%) Benign Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/464(0%) 0/463(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 1/464(0.2%) 2/463(0.4%) Mean(sd) 0.2%(0.7) 0.4%(0.9) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 1/50 0/52 0/51 0/50 1/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/464(0.6%) 1/463(0.2%) Mean(sd) 0.7%(1.0) 0.2%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 1/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 1/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Keratoacanthoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 1/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Lipoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/464(0%) 0/463(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Melanoma Benign Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Osteosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 0/464(0%) 0/463(0%) Carcinoma, Basal Cell Mean(sd) 0.0%(0.0) 0.0%(0.0) Carcinoma, Basosquamous Range 0/50 - 0/50 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 1/464(0.2%) 0/463(0%) Papilloma or Papilloma Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 1/464(0.2%) 0/463(0%) Papilloma, Papilloma, Mean(sd) 0.2%(0.6) 0.0%(0.0) Squamous Cell Carcinoma Range 0/50 - 1/52 0/50 - 0/50 or Keratoacanthoma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 1/464(0.2%) 0/463(0%) Papilloma, Papilloma, or Mean(sd) 0.2%(0.6) 0.0%(0.0) Keratoacanthoma Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Trichoepithelioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibroma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/52 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 1/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 0/464(0%) 15/463(3.2%) Sarcoma, Myxoma, Mean(sd) 0.0%(0.0) 3.2%(1.7) Myxosarcoma, or Fibrous Range 0/50 - 0/50 0/51 - 3/50 Histiocytoma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 2/50 3/50 2/52 0/51 1/50 1/50 2/50 2/50 2/60 --------------------------------------------------------------------------- Fibrosarcoma Total 0/464(0%) 9/463(1.9%) Mean(sd) 0.0%(0.0) 2.0%(1.7) Range 0/50 - 0/50 0/51 - 3/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 1/50 3/50 1/52 0/51 1/50 1/50 1/50 0/50 1/60 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 0/464(0%) 14/463(3%) Myxosarcoma, or Fibrous Mean(sd) 0.0%(0.0) 3.0%(1.7) Histiocytoma Range 0/50 - 0/50 0/51 - 3/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 2/50 3/50 1/52 0/51 1/50 1/50 2/50 2/50 2/60 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Myxosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 1/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/464(0%) 2/463(0.4%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.4%(0.9) NOS) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 1/50 0/52 1/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/464(0%) 2/463(0.4%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.4%(0.9) Schwannoma (benign, Range 0/50 - 0/50 0/50 - 1/50 malignant or NOS) Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 1/50 0/52 1/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 5/463(1.1%) Mean(sd) 0.0%(0.0) 1.1%(1.4) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 1/50 0/50 0/52 0/51 0/50 0/50 1/50 2/50 1/60 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 1/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrosarcoma Total 0/461(0%) 0/458(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/49 0/49 0/59 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/461(0%) 0/458(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/49 0/49 0/59 --------------------------------------------------------------------------- Hemangioma Total 1/461(0.2%) 1/458(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.7) Range 0/50 - 1/52 0/50 - 1/49 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/49 1/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/49 1/49 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 11/461(2.4%) 0/458(0%) Mean(sd) 2.4%(2.6) 0.0%(0.0) Range 0/49 - 4/50 0/50 - 0/50 Males 2/50 1/50 0/49 1/49 4/50 1/50 0/49 2/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/49 0/49 0/59 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/461(0%) 0/458(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/49 0/49 0/59 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/461(0%) 0/458(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/49 0/52 0/62 Females 0/50 0/50 0/50 0/51 0/50 0/50 0/49 0/49 0/59 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Hemangioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/464(0%) 1/463(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 3/464(0.6%) 0/463(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 1/50 1/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 22/464(4.7%) 19/463(4.1%) Carcinoma or Papilloma Mean(sd) 4.7%(2.0) 4.1%(3.5) Squamous Range 1/50 - 4/50 0/50 - 5/50 Males 1/50 2/50 2/50 3/50 4/50 3/50 1/50 3/52 3/62 Females 4/50 0/50 1/52 2/51 3/50 5/50 1/50 0/50 3/60 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 19/464(4.1%) 19/463(4.1%) Mean(sd) 4.1%(1.7) 4.1%(3.5) Range 1/50 - 3/50 0/50 - 5/50 Males 1/50 1/50 2/50 2/50 3/50 3/50 1/50 3/52 3/62 Females 4/50 0/50 1/52 2/51 3/50 5/50 1/50 0/50 3/60 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/50 - 1/62 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 1/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/50 - 1/62 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 1/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Fibrosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 5/462(1.1%) Mean(sd) 1.1%(2.1) Range 0/50 - 3/49 Males 0/50 0/50 3/49 1/49 0/50 0/50 1/50 0/52 0/62 --------------------------------------------------------------------------- Hemangioma Total 0/462(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/52 0/62 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrosarcoma Total 0/407(0%) 0/426(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/407(0%) 0/426(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Hemangioma Total 0/407(0%) 0/426(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/407(0%) 0/426(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/407(0%) 0/426(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Sarcoma Total 0/407(0%) 1/426(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/43 - 0/43 0/47 - 1/59 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 1/59 --------------------------------------------------------------------------- Thymoma Benign Total 0/407(0%) 0/426(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Thymoma Malignant Total 0/407(0%) 1/426(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/43 - 0/43 0/47 - 1/45 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 1/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Thymoma NOS Total 0/407(0%) 0/426(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/47 - 0/47 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 0/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/407(0%) 1/426(0.2%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/43 - 0/43 0/47 - 1/45 Males 0/43 0/42 0/47 0/41 0/46 0/45 0/38 0/47 0/58 Females 0/47 1/45 0/43 0/45 0/49 0/50 0/42 0/46 0/59 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/458(0%) 0/453(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/50 0/62 Females 0/50 0/49 0/47 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/458(0%) 0/453(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/50 0/62 Females 0/50 0/49 0/47 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/458(0%) 0/453(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/50 0/62 Females 0/50 0/49 0/47 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 4/458(0.9%) 14/453(3.1%) Mean(sd) 0.9%(1.1) 3.0%(3.6) Range 0/50 - 1/50 0/47 - 4/50 Males 0/50 1/50 0/49 0/49 1/50 1/50 0/48 1/50 0/62 Females 4/50 1/49 0/47 0/48 0/50 1/50 4/50 0/49 4/60 --------------------------------------------------------------------------- Carcinoma Total 1/458(0.2%) 1/453(0.2%) Mean(sd) 0.2%(0.5) 0.2%(0.7) Range 0/50 - 1/62 0/50 - 1/47 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/48 0/50 1/62 Females 0/50 0/49 1/47 0/48 0/50 0/50 0/50 0/49 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/458(1.1%) 15/453(3.3%) Mean(sd) 1.1%(1.0) 3.2%(3.4) Range 0/50 - 1/50 0/48 - 4/50 Males 0/50 1/50 0/49 0/49 1/50 1/50 0/48 1/50 1/62 Females 4/50 1/49 1/47 0/48 0/50 1/50 4/50 0/49 4/60 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Fibrosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Lipoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Squamous Cell Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Total 0/464(0%) 0/463(0%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adamantinoma Benign Total 1/464(0.2%) 0/463(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Odontoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Carcinoma or Papilloma Total 0/462(0%) 0/447(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/49 0/50 0/45 0/45 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Hemangioma Total 0/462(0%) 0/447(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/49 0/50 0/45 0/45 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/462(0%) 0/447(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/49 0/50 0/45 0/45 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/462(0%) 0/447(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/49 0/50 0/45 0/45 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- Papilloma Total 0/462(0%) 0/447(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/52 0/62 Females 0/49 0/50 0/45 0/45 0/50 0/50 0/50 0/49 0/59 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/463(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 1/463(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/50 Females 0/50 0/50 0/52 0/51 1/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Deciduoma Benign Total 0/463(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/463(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangioma Total 1/463(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/52 Females 0/50 0/50 1/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/463(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/50 Females 0/50 1/50 0/52 0/51 0/50 0/50 0/50 0/50 1/60 --------------------------------------------------------------------------- Leiomyoma Total 1/463(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/50 Females 0/50 1/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/463(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/52 Females 0/50 0/50 1/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Polyp Stromal Total 3/463(0.6%) Mean(sd) 0.7%(1.0) Range 0/52 - 1/50 Females 1/50 1/50 0/52 0/51 0/50 0/50 1/50 0/50 0/60 --------------------------------------------------------------------------- Sarcoma Total 1/463(0.2%) Mean(sd) 0.2%(0.7) Range 0/50 - 1/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 1/50 0/60 --------------------------------------------------------------------------- Sarcoma Stromal Total 4/463(0.9%) Mean(sd) 0.9%(1.0) Range 0/50 - 1/50 Females 1/50 0/50 0/52 1/51 1/50 0/50 0/50 0/50 1/60 --------------------------------------------------------------------------- Sarcoma Stromal or Total 7/463(1.5%) Polyp Stromal Mean(sd) 1.5%(1.3) Range 0/52 - 2/50 Females 2/50 1/50 0/52 1/51 1/50 0/50 1/50 0/50 1/60 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Leiomyosarcoma Total 0/463(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/463(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/463(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE GAVAGE CORN OIL (Updated 12/99) Males(9 studies) Females(9 studies) =========================================================================== Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/464(0%) 0/463(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/62 Females 0/50 0/50 0/52 0/51 0/50 0/50 0/50 0/50 0/60 ---------------------------------------------------------------------------