TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Benign Tumors Total 36/50(72%) 24/51(47.1%) Mean(sd) Range 36/50 - 36/50 24/51 - 24/51 Males 36/50 Females 24/51 --------------------------------------------------------------------------- Malignant Tumors Total 17/50(34%) 26/51(51%) Mean(sd) Range 17/50 - 17/50 26/51 - 26/51 Males 17/50 Females 26/51 --------------------------------------------------------------------------- Malignant and Benign Total 43/50(86%) 40/51(78.4%) Tumors Mean(sd) Range 43/50 - 43/50 40/51 - 40/51 Males 43/50 Females 40/51 --------------------------------------------------------------------------- Hemangioma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/50(2%) 4/51(7.8%) Mean(sd) Range 1/50 - 1/50 4/51 - 4/51 Males 1/50 Females 4/51 --------------------------------------------------------------------------- Hemangiosarcoma or Total 2/50(4%) 4/51(7.8%) Hemangioma Mean(sd) Range 2/50 - 2/50 4/51 - 4/51 Males 2/50 Females 4/51 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 3/50(6%) 1/51(2%) Mean(sd) Range 3/50 - 3/50 1/51 - 1/51 Males 3/50 Females 1/51 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 1/50(2%) 0/51(0%) Monocytic, Mononuclear, Mean(sd) or Undifferentiated Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Malignant Lymphoma: Total 4/50(8%) 9/51(17.6%) Histiocytic, Mean(sd) Lymphocytic, Mixed, NOS, Range 4/50 - 4/50 9/51 - 9/51 or Undifferentiated Cell Type Males 4/50 Females 9/51 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Pheochromocytoma Benign Total 0/49(0%) 0/51(0%) Mean(sd) Range 0/49 - 0/49 0/51 - 0/51 Males 0/49 Females 0/51 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/49(0%) 0/51(0%) Mean(sd) Range 0/49 - 0/49 0/51 - 0/51 Males 0/49 Females 0/51 --------------------------------------------------------------------------- Pheochromocytoma Total 0/49(0%) 1/51(2%) Malignant Mean(sd) Range 0/49 - 0/49 1/51 - 1/51 Males 0/49 Females 1/51 --------------------------------------------------------------------------- Pheochromocytoma: Total 0/49(0%) 1/51(2%) Benign, Complex, Mean(sd) Malignant, NOS Range 0/49 - 0/49 1/51 - 1/51 Males 0/49 Females 1/51 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Astrocytoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Meningioma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/50(0%) 0/51(0%) Malignant, NOS Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Oligodendroglioma Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/50(0%) 0/51(0%) Glioma, or Astrocytoma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Basosquamous Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/49(0%) 0/51(0%) Mean(sd) Range 0/49 - 0/49 0/51 - 0/51 Males 0/49 Females 0/51 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 3/50(6%) 1/51(2%) Mean(sd) Range 3/50 - 3/50 1/51 - 1/51 Males 3/50 Females 1/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 2/51(3.9%) Mean(sd) Range 0/50 - 0/50 2/51 - 2/51 Males 0/50 Females 2/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/50(6%) 3/51(5.9%) Mean(sd) Range 3/50 - 3/50 3/51 - 3/51 Males 3/50 Females 3/51 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/50(2%) 1/51(2%) Mean(sd) Range 1/50 - 1/50 1/51 - 1/51 Males 1/50 Females 1/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 3/50(6%) 0/51(0%) Mean(sd) Range 3/50 - 3/50 0/51 - 0/51 Males 3/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/50(6%) 0/51(0%) Mean(sd) Range 3/50 - 3/50 0/51 - 0/51 Males 3/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 2/50(4%) 0/51(0%) Mean(sd) Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/50(4%) 0/51(0%) Mean(sd) Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Cholangiocarcinoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Cholangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Hepatoblastoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 26/50(52%) 15/51(29.4%) Mean(sd) Range 26/50 - 26/50 15/51 - 15/51 Males 26/50 Females 15/51 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 6/50(12%) 8/51(15.7%) Mean(sd) Range 6/50 - 6/50 8/51 - 8/51 Males 6/50 Females 8/51 --------------------------------------------------------------------------- Hepatocellular Total 6/50(12%) 8/51(15.7%) Carcinoma or Mean(sd) Hepatoblastoma Range 6/50 - 6/50 8/51 - 8/51 Males 6/50 Females 8/51 --------------------------------------------------------------------------- Hepatocellular Total 30/50(60%) 22/51(43.1%) Carcinoma or Mean(sd) Hepatocellular Adenoma Range 30/50 - 30/50 22/51 - 22/51 Males 30/50 Females 22/51 --------------------------------------------------------------------------- Hepatocellular Total 30/50(60%) 22/51(43.1%) Carcinoma, Mean(sd) Hepatocellular Adenoma, Range 30/50 - 30/50 22/51 - 22/51 or Hepatoblastoma Males 30/50 Females 22/51 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 12/50(24%) 3/51(5.9%) Adenoma Mean(sd) Range 12/50 - 12/50 3/51 - 3/51 Males 12/50 Females 3/51 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 3/50(6%) 1/51(2%) Carcinoma Mean(sd) Range 3/50 - 3/50 1/51 - 1/51 Males 3/50 Females 1/51 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 15/50(30%) 4/51(7.8%) Carcinoma or Mean(sd) Alveolar/Bronchiolar Range 15/50 - 15/50 4/51 - 4/51 Adenoma Males 15/50 Females 4/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/50(0%) 0/51(0%) or Adenoma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/50(0%) 0/51(0%) Carcinoma, or Adenoma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Myoepithelioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Papilloma Squamous or Total 0/50(0%) 0/51(0%) Papilloma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma, Papilloma Mean(sd) Squamous, or Papilloma Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Cystadenoma Total 3/51(5.9%) Mean(sd) Range 3/51 - 3/51 Females 3/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/51(0%) Benign Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/51(0%) Malignant Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 0/51(0%) Benign, Malignant, NOS Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/51(0%) Malignant Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/51(2%) Mean(sd) Range 1/51 - 1/51 Females 1/51 --------------------------------------------------------------------------- Liposarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Luteoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Teratoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Teratoma Benign Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Teratoma Malignant Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Teratoma NOS Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Thecoma Benign Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/46(0%) 0/48(0%) Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/48(0%) 4/50(8%) Mean(sd) Range 0/48 - 0/48 4/50 - 4/50 Males 0/48 Females 4/50 --------------------------------------------------------------------------- Carcinoma Total 0/48(0%) 0/50(0%) Mean(sd) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/48(0%) 4/50(8%) Mean(sd) Range 0/48 - 0/48 4/50 - 4/50 Males 0/48 Females 4/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/48(2.1%) 0/50(0%) Mean(sd) Range 1/48 - 1/48 0/50 - 0/50 Males 1/48 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/48(0%) 0/50(0%) Mean(sd) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/48(2.1%) 0/50(0%) Mean(sd) Range 1/48 - 1/48 0/50 - 0/50 Males 1/48 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/49(0%) Mean(sd) Range 0/49 - 0/49 Males 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/49(0%) Mean(sd) Range 0/49 - 0/49 Males 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/49(0%) Mean(sd) Range 0/49 - 0/49 Males 0/49 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/50(0%) 0/51(0%) Rhabdomyoma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Basal Cell Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/50(0%) 0/51(0%) Basosquamous Tumor Mean(sd) Benign Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/50(0%) 0/51(0%) Basosquamous Tumor Mean(sd) Benign, or Range 0/50 - 0/50 0/51 - 0/51 Trichoepithelioma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/50(0%) 0/51(0%) or Basosquamous Tumor Mean(sd) (malignant or NOS) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/50(0%) 0/51(0%) Basal Cell Adenoma, Mean(sd) Basosquamous Tumor Range 0/50 - 0/50 0/51 - 0/51 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal or Sq. Cell Total 0/50(0%) 0/51(0%) Carcinoma, Carcinoma, Mean(sd) Basosq. Tumor (M or B), Range 0/50 - 0/50 0/51 - 0/51 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/50(0%) 0/51(0%) Benign Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Keratoacanthoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Melanoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma, Basal Cell Mean(sd) Carcinoma, Basosquamous Range 0/50 - 0/50 0/51 - 0/51 Tumor (malignant or NOS), or Carcinoma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Papilloma or Papilloma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Papilloma, Papilloma, Mean(sd) Squamous Cell Carcinoma Range 0/50 - 0/50 0/51 - 0/51 or Keratoacanthoma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Papilloma, Papilloma, or Mean(sd) Keratoacanthoma Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Trichoepithelioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 0/50(0%) 1/51(2%) Sarcoma, Myxoma, Mean(sd) Myxosarcoma, or Fibrous Range 0/50 - 0/50 1/51 - 1/51 Histiocytoma Males 0/50 Females 1/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 0/50(0%) 1/51(2%) Myxosarcoma, or Fibrous Mean(sd) Histiocytoma Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Myxosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/50(0%) 0/51(0%) Schwannoma (malignant or Mean(sd) NOS) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/50(0%) 0/51(0%) Neurofibroma, or Mean(sd) Schwannoma (benign, Range 0/50 - 0/50 0/51 - 0/51 malignant or NOS) Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Hemangioma Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/42(0%) 0/48(0%) Malignant Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Sarcoma Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Thymoma Benign Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Thymoma Malignant Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Thymoma NOS Total 0/42(0%) 0/48(0%) Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/42(0%) 0/48(0%) Malignant, NOS Mean(sd) Range 0/42 - 0/42 0/48 - 0/48 Males 0/42 Females 0/48 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 3/51(5.9%) Mean(sd) Range 0/50 - 0/50 3/51 - 3/51 Males 0/50 Females 3/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 3/51(5.9%) Mean(sd) Range 0/50 - 0/50 3/51 - 3/51 Males 0/50 Females 3/51 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adamantinoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Odontoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma or Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/51(2%) Mean(sd) Range 1/51 - 1/51 Females 1/51 --------------------------------------------------------------------------- Carcinoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Deciduoma Benign Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/51(0%) Benign Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/51(2%) Mean(sd) Range 1/51 - 1/51 Females 1/51 --------------------------------------------------------------------------- Leiomyoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Polyp Stromal Total 1/51(2%) Mean(sd) Range 1/51 - 1/51 Females 1/51 --------------------------------------------------------------------------- Sarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Sarcoma Stromal Total 1/51(2%) Mean(sd) Range 1/51 - 1/51 Females 1/51 --------------------------------------------------------------------------- Sarcoma Stromal or Total 2/51(3.9%) Polyp Stromal Mean(sd) Range 2/51 - 2/51 Females 2/51 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Leiomyosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 ---------------------------------------------------------------------------