TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Benign Tumors Total 72/100(72%) Mean(sd) Range 72/100 - 72/100 Females 72/100 --------------------------------------------------------------------------- Malignant Tumors Total 42/100(42%) Mean(sd) Range 42/100 - 42/100 Females 42/100 --------------------------------------------------------------------------- Malignant and Benign Total 82/100(82%) Tumors Mean(sd) Range 82/100 - 82/100 Females 82/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma or Total 0/100(0%) Hemangioma Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 2/100(2%) Mean(sd) Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/100(0%) Monocytic, Mononuclear, Mean(sd) or Undifferentiated Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Malignant Lymphoma: Total 14/100(14%) Histiocytic, Mean(sd) Lymphocytic, Mixed, NOS, Range 14/100 - 14/100 or Undifferentiated Cell Type Females 14/100 --------------------------------------------------------------------------- Osteoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 1/94(1.1%) Mean(sd) Range 1/94 - 1/94 Females 1/94 --------------------------------------------------------------------------- Carcinoma Total 0/94(0%) Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/94(0%) Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/94(0%) Malignant Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/94(0%) Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Pheochromocytoma Benign Total 2/94(2.1%) Mean(sd) Range 2/94 - 2/94 Females 2/94 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/94(0%) Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- Pheochromocytoma Total 0/94(0%) Malignant Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- Pheochromocytoma: Total 2/94(2.1%) Benign, Complex, Mean(sd) Malignant, NOS Range 2/94 - 2/94 Females 2/94 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangioma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/98(0%) Malignant Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/98(0%) Malignant Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Astrocytoma Benign Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Meningioma Malignant Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/99(0%) Malignant, NOS Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Oligodendroglioma Total 0/99(0%) Malignant Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/99(0%) Glioma, or Astrocytoma Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Sarcoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Basosquamous Tumor Total 0/100(0%) Malignant Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/87(0%) Mean(sd) Range 0/87 - 0/87 Females 0/87 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 9/100(9%) Mean(sd) Range 9/100 - 9/100 Females 9/100 --------------------------------------------------------------------------- Carcinoma Total 2/100(2%) Mean(sd) Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 11/100(11%) Mean(sd) Range 11/100 - 11/100 Females 11/100 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Hemangioma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Sarcoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 3/94(3.2%) Mean(sd) Range 3/94 - 3/94 Females 3/94 --------------------------------------------------------------------------- Carcinoma Total 0/94(0%) Mean(sd) Range 0/94 - 0/94 Females 0/94 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/94(3.2%) Mean(sd) Range 3/94 - 3/94 Females 3/94 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangioma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 1/98(1%) Mean(sd) Range 1/98 - 1/98 Females 1/98 --------------------------------------------------------------------------- Carcinoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/98(1%) Mean(sd) Range 1/98 - 1/98 Females 1/98 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Sarcoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Cholangiocarcinoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Cholangioma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Hemangioma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Hepatoblastoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 56/99(56.6%) Mean(sd) Range 56/99 - 56/99 Females 56/99 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 18/99(18.2%) Mean(sd) Range 18/99 - 18/99 Females 18/99 --------------------------------------------------------------------------- Hepatocellular Total 18/99(18.2%) Carcinoma or Mean(sd) Hepatoblastoma Range 18/99 - 18/99 Females 18/99 --------------------------------------------------------------------------- Hepatocellular Total 61/99(61.6%) Carcinoma or Mean(sd) Hepatocellular Adenoma Range 61/99 - 61/99 Females 61/99 --------------------------------------------------------------------------- Hepatocellular Total 61/99(61.6%) Carcinoma, Mean(sd) Hepatocellular Adenoma, Range 61/99 - 61/99 or Hepatoblastoma Females 61/99 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/99(0%) Malignant Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/99(0%) Malignant Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- Sarcoma Total 0/99(0%) Mean(sd) Range 0/99 - 0/99 Females 0/99 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 7/98(7.1%) Adenoma Mean(sd) Range 7/98 - 7/98 Females 7/98 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 3/98(3.1%) Carcinoma Mean(sd) Range 3/98 - 3/98 Females 3/98 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 10/98(10.2%) Carcinoma or Mean(sd) Alveolar/Bronchiolar Range 10/98 - 10/98 Adenoma Females 10/98 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangioma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/98(0%) Malignant Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- Sarcoma Total 0/98(0%) Mean(sd) Range 0/98 - 0/98 Females 0/98 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/100(0%) Malignant Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Liposarcoma Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/100(0%) Malignant Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/100(0%) or Adenoma Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/100(0%) Carcinoma, or Adenoma Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Myoepithelioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Liposarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Papilloma Squamous or Total 0/100(0%) Papilloma Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Carcinoma, Papilloma Mean(sd) Squamous, or Papilloma Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Carcinoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Cystadenoma Total 5/97(5.2%) Mean(sd) Range 5/97 - 5/97 Females 5/97 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 2/97(2.1%) Benign Mean(sd) Range 2/97 - 2/97 Females 2/97 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/97(0%) Malignant Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 2/97(2.1%) Benign, Malignant, NOS Mean(sd) Range 2/97 - 2/97 Females 2/97 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/97(0%) Malignant Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Hemangioma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Liposarcoma Total 1/97(1%) Mean(sd) Range 1/97 - 1/97 Females 1/97 --------------------------------------------------------------------------- Luteoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Teratoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Teratoma Benign Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Teratoma Malignant Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Teratoma NOS Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Thecoma Benign Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/95(0%) Mean(sd) Range 0/95 - 0/95 Females 0/95 --------------------------------------------------------------------------- Carcinoma Total 1/95(1.1%) Mean(sd) Range 1/95 - 1/95 Females 1/95 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/95(1.1%) Mean(sd) Range 1/95 - 1/95 Females 1/95 --------------------------------------------------------------------------- Fibrosarcoma Total 0/95(0%) Mean(sd) Range 0/95 - 0/95 Females 0/95 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/95(0%) Mean(sd) Range 0/95 - 0/95 Females 0/95 --------------------------------------------------------------------------- Hemangioma Total 0/95(0%) Mean(sd) Range 0/95 - 0/95 Females 0/95 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/95(0%) Mean(sd) Range 0/95 - 0/95 Females 0/95 --------------------------------------------------------------------------- Sarcoma Total 0/95(0%) Mean(sd) Range 0/95 - 0/95 Females 0/95 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma Total 0/59(0%) Mean(sd) Range 0/59 - 0/59 Females 0/59 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Squamous Cell Papilloma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 9/86(10.5%) Mean(sd) Range 9/86 - 9/86 Females 9/86 --------------------------------------------------------------------------- Carcinoma Total 0/86(0%) Mean(sd) Range 0/86 - 0/86 Females 0/86 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 9/86(10.5%) Mean(sd) Range 9/86 - 9/86 Females 9/86 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/86(0%) Mean(sd) Range 0/86 - 0/86 Females 0/86 --------------------------------------------------------------------------- Carcinoma Total 0/86(0%) Mean(sd) Range 0/86 - 0/86 Females 0/86 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/86(0%) Mean(sd) Range 0/86 - 0/86 Females 0/86 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Hemangioma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- Sarcoma Total 0/97(0%) Mean(sd) Range 0/97 - 0/97 Females 0/97 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 2/100(2%) Mean(sd) Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 2/100(2%) Rhabdomyoma Mean(sd) Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Basal Cell Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/100(0%) Basosquamous Tumor Mean(sd) Benign Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/100(0%) Basosquamous Tumor Mean(sd) Benign, or Range 0/100 - 0/100 Trichoepithelioma Females 0/100 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/100(0%) or Basosquamous Tumor Mean(sd) (malignant or NOS) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/100(0%) Basal Cell Adenoma, Mean(sd) Basosquamous Tumor Range 0/100 - 0/100 (benign, malignant or NOS), or Trichoepithelioma Females 0/100 --------------------------------------------------------------------------- Basal or Sq. Cell Total 0/100(0%) Carcinoma, Carcinoma, Mean(sd) Basosq. Tumor (M or B), Range 0/100 - 0/100 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Females 0/100 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/100(0%) Benign Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/100(0%) Malignant Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Keratoacanthoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/100(0%) Malignant Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Melanoma Benign Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Carcinoma, Basal Cell Mean(sd) Carcinoma, Basosquamous Range 0/100 - 0/100 Tumor (malignant or NOS), or Carcinoma Females 0/100 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Papilloma or Papilloma Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Papilloma, Papilloma, Mean(sd) Squamous Cell Carcinoma Range 0/100 - 0/100 or Keratoacanthoma Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Papilloma, Papilloma, or Mean(sd) Keratoacanthoma Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Trichoepithelioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibroma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 2/100(2%) Sarcoma, Myxoma, Mean(sd) Myxosarcoma, or Fibrous Range 2/100 - 2/100 Histiocytoma Females 2/100 --------------------------------------------------------------------------- Fibrosarcoma Total 2/100(2%) Mean(sd) Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 2/100(2%) Myxosarcoma, or Fibrous Mean(sd) Histiocytoma Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Myxosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/100(0%) Schwannoma (malignant or Mean(sd) NOS) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/100(0%) Neurofibroma, or Mean(sd) Schwannoma (benign, Range 0/100 - 0/100 malignant or NOS) Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Hemangioma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/96(0%) Malignant Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/96(0%) Malignant Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Hemangioma Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/93(0%) Malignant Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Sarcoma Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Thymoma Benign Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Thymoma Malignant Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Thymoma NOS Total 0/93(0%) Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/93(0%) Malignant, NOS Mean(sd) Range 0/93 - 0/93 Females 0/93 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 1/96(1%) Mean(sd) Range 1/96 - 1/96 Females 1/96 --------------------------------------------------------------------------- Carcinoma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/96(1%) Mean(sd) Range 1/96 - 1/96 Females 1/96 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 9/96(9.4%) Mean(sd) Range 9/96 - 9/96 Females 9/96 --------------------------------------------------------------------------- Carcinoma Total 1/96(1%) Mean(sd) Range 1/96 - 1/96 Females 1/96 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 10/96(10.4%) Mean(sd) Range 10/96 - 10/96 Females 10/96 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adamantinoma Benign Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Odontoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Carcinoma or Papilloma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Hemangioma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- Papilloma Total 0/96(0%) Mean(sd) Range 0/96 - 0/96 Females 0/96 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Deciduoma Benign Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Granular Cell Tumor Total 1/100(1%) Benign Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Leiomyoma Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Polyp Stromal Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Sarcoma Stromal Total 2/100(2%) Mean(sd) Range 2/100 - 2/100 Females 2/100 --------------------------------------------------------------------------- Sarcoma Stromal or Total 3/100(3%) Polyp Stromal Mean(sd) Range 3/100 - 3/100 Females 3/100 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Leiomyosarcoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE VAGINAL WATER (Updated 12/99) Males(0 study) Females(1 study) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) Range 0/100 - 0/100 Females 0/100 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/100(1%) Mean(sd) Range 1/100 - 1/100 Females 1/100 ---------------------------------------------------------------------------