TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Benign Tumors Total 45/50(90%) 47/51(92.2%) Mean(sd) Range 45/50 - 45/50 47/51 - 47/51 Males 45/50 Females 47/51 --------------------------------------------------------------------------- Malignant Tumors Total 17/50(34%) 32/51(62.7%) Mean(sd) Range 17/50 - 17/50 32/51 - 32/51 Males 17/50 Females 32/51 --------------------------------------------------------------------------- Malignant and Benign Total 46/50(92%) 51/51(100%) Tumors Mean(sd) Range 46/50 - 46/50 51/51 - 51/51 Males 46/50 Females 51/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma or Total 1/50(2%) 0/51(0%) Hemangioma Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 9/50(18%) 17/51(33.3%) Monocytic, Mononuclear, Mean(sd) or Undifferentiated Range 9/50 - 9/50 17/51 - 17/51 Males 9/50 Females 17/51 --------------------------------------------------------------------------- Malignant Lymphoma: Total 2/50(4%) 0/51(0%) Histiocytic, Mean(sd) Lymphocytic, Mixed, NOS, Range 2/50 - 2/50 0/51 - 0/51 or Undifferentiated Cell Type Males 2/50 Females 0/51 --------------------------------------------------------------------------- Mesothelioma: Benign Total 2/50(4%) 0/51(0%) Mean(sd) Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 2/50(4%) 0/51(0%) Malignant, NOS Mean(sd) Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/49(0%) 4/51(7.8%) Mean(sd) Range 0/49 - 0/49 4/51 - 4/51 Males 0/49 Females 4/51 --------------------------------------------------------------------------- Carcinoma Total 0/49(0%) 0/51(0%) Mean(sd) Range 0/49 - 0/49 0/51 - 0/51 Males 0/49 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Ganglioneuroma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 14/49(28.6%) 3/50(6%) Mean(sd) Range 14/49 - 14/49 3/50 - 3/50 Males 14/49 Females 3/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 0/49(0%) 1/50(2%) Malignant Mean(sd) Range 0/49 - 0/49 1/50 - 1/50 Males 0/49 Females 1/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 14/49(28.6%) 4/50(8%) Benign, Complex, Mean(sd) Malignant, NOS Range 14/49 - 14/49 4/50 - 4/50 Males 14/49 Females 4/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/49(0%) 0/48(0%) Mean(sd) Range 0/49 - 0/49 0/48 - 0/48 Males 0/49 Females 0/48 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Chondroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chondrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chondrosarcoma or Total 0/50(0%) 0/51(0%) Chondroma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chordoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Astrocytoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/50(0%) 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/50(0%) 0/50(0%) Malignant, NOS Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 1/50(2%) 0/50(0%) Glioma, or Astrocytoma Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/34(0%) 5/44(11.4%) Mean(sd) Range 0/34 - 0/34 5/44 - 5/44 Males 0/34 Females 5/44 --------------------------------------------------------------------------- Carcinoma Total 1/34(2.9%) 2/44(4.5%) Mean(sd) Range 1/34 - 1/34 2/44 - 2/44 Males 1/34 Females 2/44 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/34(2.9%) 7/44(15.9%) Mean(sd) Range 1/34 - 1/34 7/44 - 7/44 Males 1/34 Females 7/44 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/34(0%) 0/44(0%) Mean(sd) Range 0/34 - 0/34 0/44 - 0/44 Males 0/34 Females 0/44 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/34(0%) 0/44(0%) Mean(sd) Range 0/34 - 0/34 0/44 - 0/44 Males 0/34 Females 0/44 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma NOS Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Melanoma NOS Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 6/49(12.2%) 3/50(6%) Mean(sd) Range 6/49 - 6/49 3/50 - 3/50 Males 6/49 Females 3/50 --------------------------------------------------------------------------- Carcinoma Total 0/49(0%) 2/50(4%) Mean(sd) Range 0/49 - 0/49 2/50 - 2/50 Males 0/49 Females 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 6/49(12.2%) 5/50(10%) Mean(sd) Range 6/49 - 6/49 5/50 - 5/50 Males 6/49 Females 5/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Nephroblastoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Stromal Nephroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Cholangiocarcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 1/50(2%) 1/50(2%) Mean(sd) Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hepatocellular Total 0/50(0%) 0/50(0%) Carcinoma or Mean(sd) Hepatoblastoma Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hepatocellular Total 1/50(2%) 1/50(2%) Carcinoma or Mean(sd) Hepatocellular Adenoma Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Hepatocellular Total 1/50(2%) 1/50(2%) Carcinoma, Mean(sd) Hepatocellular Adenoma, Range 1/50 - 1/50 1/50 - 1/50 or Hepatoblastoma Males 1/50 Females 1/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Alveolar/Bronchiolar Total 0/50(0%) 1/50(2%) Adenoma Mean(sd) Range 0/50 - 0/50 1/50 - 1/50 Males 0/50 Females 1/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 0/50(0%) 1/50(2%) Carcinoma Mean(sd) Range 0/50 - 0/50 1/50 - 1/50 Males 0/50 Females 1/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 0/50(0%) 2/50(4%) Carcinoma or Mean(sd) Alveolar/Bronchiolar Range 0/50 - 0/50 2/50 - 2/50 Adenoma Males 0/50 Females 2/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Plasma Cell Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoacanthoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Adenoma Total 0/50(0%) 1/51(2%) Mean(sd) Range 0/50 - 0/50 1/51 - 1/51 Males 0/50 Females 1/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 5/51(9.8%) Mean(sd) Range 0/50 - 0/50 5/51 - 5/51 Males 0/50 Females 5/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 6/51(11.8%) Mean(sd) Range 0/50 - 0/50 6/51 - 6/51 Males 0/50 Females 6/51 --------------------------------------------------------------------------- Fibroadenoma Total 0/50(0%) 21/51(41.2%) Mean(sd) Range 0/50 - 0/50 21/51 - 21/51 Males 0/50 Females 21/51 --------------------------------------------------------------------------- Fibroma Total 2/50(4%) 0/51(0%) Mean(sd) Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 2/50(4%) 22/51(43.1%) or Adenoma Mean(sd) Range 2/50 - 2/50 22/51 - 22/51 Males 2/50 Females 22/51 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 2/50(4%) 25/51(49%) Carcinoma, or Adenoma Mean(sd) Range 2/50 - 2/50 25/51 - 25/51 Males 2/50 Females 25/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chondroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chondrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Papilloma Squamous or Total 0/50(0%) 0/51(0%) Papilloma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma, Papilloma Mean(sd) Squamous, or Papilloma Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 0/50(0%) Benign, Malignant, NOS Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Luteoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/50(0%) Tumor, Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mixed Tumor Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/47(0%) 0/45(0%) Mean(sd) Range 0/47 - 0/47 0/45 - 0/45 Males 0/47 Females 0/45 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Paraganglioma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/50(0%) 0/51(0%) Malignant, NOS Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 39/44(88.6%) 38/50(76%) Mean(sd) Range 39/44 - 39/44 38/50 - 38/50 Males 39/44 Females 38/50 --------------------------------------------------------------------------- Carcinoma Total 0/44(0%) 2/50(4%) Mean(sd) Range 0/44 - 0/44 2/50 - 2/50 Males 0/44 Females 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 39/44(88.6%) 40/50(80%) Mean(sd) Range 39/44 - 39/44 40/50 - 40/50 Males 39/44 Females 40/50 --------------------------------------------------------------------------- Craniopharyngioma Total 0/44(0%) 0/50(0%) Mean(sd) Range 0/44 - 0/44 0/50 - 0/50 Males 0/44 Females 0/50 --------------------------------------------------------------------------- Ganglioneuroma Total 0/44(0%) 0/50(0%) Mean(sd) Range 0/44 - 0/44 0/50 - 0/50 Males 0/44 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/44(0%) 1/50(2%) Mean(sd) Range 0/44 - 0/44 1/50 - 1/50 Males 0/44 Females 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/44(0%) 0/50(0%) Mean(sd) Range 0/44 - 0/44 0/50 - 0/50 Males 0/44 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/44(0%) 1/50(2%) Mean(sd) Range 0/44 - 0/44 1/50 - 1/50 Males 0/44 Females 1/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/44(0%) 0/50(0%) Mean(sd) Range 0/44 - 0/44 0/50 - 0/50 Males 0/44 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/48(0%) Mean(sd) Range 0/48 - 0/48 Males 0/48 --------------------------------------------------------------------------- Carcinoma Total 0/48(0%) Mean(sd) Range 0/48 - 0/48 Males 0/48 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/48(0%) Mean(sd) Range 0/48 - 0/48 Males 0/48 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/48(0%) 0/50(0%) Mean(sd) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/48(0%) 0/50(0%) Mean(sd) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/48(0%) 0/50(0%) Mean(sd) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/48(0%) 0/50(0%) Mean(sd) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/50(0%) 0/51(0%) Rhabdomyoma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Basal Cell Adenoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 1/50(2%) 0/51(0%) Basosquamous Tumor Mean(sd) Benign Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 1/50(2%) 0/51(0%) Basosquamous Tumor Mean(sd) Benign, or Range 1/50 - 1/50 0/51 - 0/51 Trichoepithelioma Males 1/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/50(0%) 0/51(0%) or Basosquamous Tumor Mean(sd) (malignant or NOS) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 1/50(2%) 0/51(0%) Basal Cell Adenoma, Mean(sd) Basosquamous Tumor Range 1/50 - 1/50 0/51 - 0/51 (benign, malignant or NOS), or Trichoepithelioma Males 1/50 Females 0/51 --------------------------------------------------------------------------- Basal or Sq. Cell Total 2/50(4%) 0/51(0%) Carcinoma, Carcinoma, Mean(sd) Basosq. Tumor (M or B), Range 2/50 - 2/50 0/51 - 0/51 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 2/50 Females 0/51 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/50(0%) 0/51(0%) Benign Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Keratoacanthoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Melanoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Melanoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma, Basal Cell Mean(sd) Carcinoma, Basosquamous Range 0/50 - 0/50 0/51 - 0/51 Tumor (malignant or NOS), or Carcinoma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Papilloma or Papilloma Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 1/50(2%) 0/51(0%) Papilloma, Papilloma, Mean(sd) Squamous Cell Carcinoma Range 1/50 - 1/50 0/51 - 0/51 or Keratoacanthoma Males 1/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 1/50(2%) 0/51(0%) Papilloma, Papilloma, or Mean(sd) Keratoacanthoma Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Trichoepithelioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 0/50(0%) 0/51(0%) Sarcoma, Myxoma, Mean(sd) Myxosarcoma, or Fibrous Range 0/50 - 0/50 0/51 - 0/51 Histiocytoma Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 0/50(0%) 0/51(0%) Myxosarcoma, or Fibrous Mean(sd) Histiocytoma Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibroma or Total 0/50(0%) 0/51(0%) Schwannoma benign Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/50(0%) 0/51(0%) Schwannoma (malignant or Mean(sd) NOS) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/50(0%) 0/51(0%) Neurofibroma, or Mean(sd) Schwannoma (benign, Range 0/50 - 0/50 0/51 - 0/51 malignant or NOS) Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Astrocytoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chordoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Glioma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Basal Cell Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 2/50(4%) 0/51(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/50(4%) 0/51(0%) Mean(sd) Range 2/50 - 2/50 0/51 - 0/51 Males 2/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoid Tumor Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/50(0%) 0/51(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 4/50(8%) Mean(sd) Range 4/50 - 4/50 Males 4/50 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/35(0%) 0/44(0%) Mean(sd) Range 0/35 - 0/35 0/44 - 0/44 Males 0/35 Females 0/44 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/35(0%) 0/44(0%) Mean(sd) Range 0/35 - 0/35 0/44 - 0/44 Males 0/35 Females 0/44 --------------------------------------------------------------------------- Thymoma Benign Total 0/35(0%) 0/44(0%) Mean(sd) Range 0/35 - 0/35 0/44 - 0/44 Males 0/35 Females 0/44 --------------------------------------------------------------------------- Thymoma Malignant Total 0/35(0%) 0/44(0%) Mean(sd) Range 0/35 - 0/35 0/44 - 0/44 Males 0/35 Females 0/44 --------------------------------------------------------------------------- Thymoma NOS Total 0/35(0%) 0/44(0%) Mean(sd) Range 0/35 - 0/35 0/44 - 0/44 Males 0/35 Females 0/44 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/35(0%) 0/44(0%) Malignant, NOS Mean(sd) Range 0/35 - 0/35 0/44 - 0/44 Males 0/35 Females 0/44 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/48(0%) 1/50(2%) Mean(sd) Range 0/48 - 0/48 1/50 - 1/50 Males 0/48 Females 1/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 2/48(4.2%) 0/50(0%) Mean(sd) Range 2/48 - 2/48 0/50 - 0/50 Males 2/48 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/48(0%) 6/50(12%) Mean(sd) Range 0/48 - 0/48 6/50 - 6/50 Males 0/48 Females 6/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/48(4.2%) 6/50(12%) Mean(sd) Range 2/48 - 2/48 6/50 - 6/50 Males 2/48 Females 6/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/48(2.1%) 0/50(0%) Mean(sd) Range 1/48 - 1/48 0/50 - 0/50 Males 1/48 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/48(2.1%) 3/50(6%) Mean(sd) Range 1/48 - 1/48 3/50 - 3/50 Males 1/48 Females 3/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/48(4.2%) 3/50(6%) Mean(sd) Range 2/48 - 2/48 3/50 - 3/50 Males 2/48 Females 3/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 1/50(2%) 1/51(2%) Mean(sd) Range 1/50 - 1/50 1/51 - 1/51 Males 1/50 Females 1/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Paraganglioma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/51(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adamantinoma Benign Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Odontoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 1/50(2%) 0/51(0%) Mean(sd) Range 1/50 - 1/50 0/51 - 0/51 Males 1/50 Females 0/51 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/48(0%) 0/48(0%) Mean(sd) Range 0/48 - 0/48 0/48 - 0/48 Males 0/48 Females 0/48 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 0/48(0%) 1/48(2.1%) Mean(sd) Range 0/48 - 0/48 1/48 - 1/48 Males 0/48 Females 1/48 --------------------------------------------------------------------------- Leiomyoma Total 0/48(0%) 0/48(0%) Mean(sd) Range 0/48 - 0/48 0/48 - 0/48 Males 0/48 Females 0/48 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/48(0%) 0/48(0%) Mean(sd) Range 0/48 - 0/48 0/48 - 0/48 Males 0/48 Females 0/48 --------------------------------------------------------------------------- Papilloma Total 0/48(0%) 1/48(2.1%) Mean(sd) Range 0/48 - 0/48 1/48 - 1/48 Males 0/48 Females 1/48 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Deciduoma Benign Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Deciduoma NOS Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Fibroma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/51(0%) Malignant Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Polyp Stromal Total 2/51(3.9%) Mean(sd) Range 2/51 - 2/51 Females 2/51 --------------------------------------------------------------------------- Sarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Sarcoma Stromal Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Sarcoma Stromal or Total 2/51(3.9%) Polyp Stromal Mean(sd) Range 2/51 - 2/51 Females 2/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/51(2%) Mean(sd) Range 1/51 - 1/51 Females 1/51 --------------------------------------------------------------------------- Schwannoma NOS Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Polyp Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/51(0%) Mean(sd) Range 0/51 - 0/51 Females 0/51 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS DERMAL NEAT (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/51(0%) Mean(sd) Range 0/50 - 0/50 0/51 - 0/51 Males 0/50 Females 0/51 ---------------------------------------------------------------------------