TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Benign Tumors Total 99/101(98%) 87/100(87%) Mean(sd) 98.0%(0.0) 87.0%(1.4) Range 49/50 - 49/50 43/50 - 44/50 Males 49/50 50/51 Females 43/50 44/50 --------------------------------------------------------------------------- Malignant Tumors Total 61/101(60.4%) 39/100(39%) Mean(sd) 60.5%(7.8) 39.0%(7.1) Range 28/51 - 33/50 17/50 - 22/50 Males 33/50 28/51 Females 22/50 17/50 --------------------------------------------------------------------------- Malignant and Benign Total 101/101(100%) 92/100(92%) Tumors Mean(sd) 100.0%(0.0) 92.0%(2.8) Range 50/50 - 50/50 45/50 - 47/50 Males 50/50 51/51 Females 47/50 45/50 --------------------------------------------------------------------------- Hemangioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 0/101(0%) 1/100(1%) Hemangioma Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 47/101(46.5%) 29/100(29%) Monocytic, Mononuclear, Mean(sd) 46.6%(7.6) 29.0%(7.1) or Undifferentiated Range 21/51 - 26/50 12/50 - 17/50 Males 26/50 21/51 Females 17/50 12/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 0/101(0%) 0/100(0%) Histiocytic, Mean(sd) 0.0%(0.0) 0.0%(0.0) Lymphocytic, Mixed, NOS, Range 0/50 - 0/50 0/50 - 0/50 or Undifferentiated Cell Type Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 3/101(3%) 0/100(0%) Malignant, NOS Mean(sd) 3.0%(1.3) 0.0%(0.0) Range 1/50 - 2/51 0/50 - 0/50 Males 1/50 2/51 Females 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 3/101(3%) 0/100(0%) Mean(sd) 3.0%(1.3) 0.0%(0.0) Range 1/50 - 2/51 0/50 - 0/50 Males 1/50 2/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Ganglioneuroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 43/101(42.6%) 8/100(8%) Mean(sd) 42.7%(7.6) 8.0%(8.5) Range 19/51 - 24/50 1/50 - 7/50 Males 24/50 19/51 Females 1/50 7/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 1/101(1%) 0/100(0%) Malignant Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 44/101(43.6%) 8/100(8%) Benign, Complex, Mean(sd) 43.7%(9.0) 8.0%(8.5) Malignant, NOS Range 19/51 - 25/50 1/50 - 7/50 Males 25/50 19/51 Females 1/50 7/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/98(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/48 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Chondroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma or Total 0/101(0%) 0/100(0%) Chondroma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Astrocytoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma NOS Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/101(0%) 0/100(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/101(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/101(0%) 0/100(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 1/101(1%) 1/100(1%) Malignant Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/51 - 1/50 0/50 - 1/50 Males 1/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 1/101(1%) 1/100(1%) Glioma, or Astrocytoma Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/51 - 1/50 0/50 - 1/50 Males 1/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 9/101(8.9%) 9/98(9.2%) Mean(sd) 9.0%(12.7) 9.2%(1.7) Range 0/51 - 9/50 4/50 - 5/48 Males 9/50 0/51 Females 5/48 4/50 --------------------------------------------------------------------------- Carcinoma Total 8/101(7.9%) 2/98(2%) Mean(sd) 8.0%(2.9) 2.1%(0.1) Range 3/51 - 5/50 1/50 - 1/48 Males 5/50 3/51 Females 1/48 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 17/101(16.8%) 11/98(11.2%) Mean(sd) 17.0%(15.6) 11.3%(1.8) Range 3/51 - 14/50 5/50 - 6/48 Males 14/50 3/51 Females 6/48 5/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/98(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/48 - 0/48 Males 0/50 0/51 Females 0/48 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 2/98(2%) Mean(sd) 0.0%(0.0) 2.0%(2.8) Range 0/50 - 0/50 0/48 - 2/50 Males 0/50 0/51 Females 0/48 2/50 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Melanoma NOS Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 7/99(7.1%) 0/99(0%) Mean(sd) 7.1%(1.6) 0.0%(0.0) Range 3/50 - 4/49 0/50 - 0/50 Males 3/50 4/49 Females 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/99(0%) 1/99(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/49 - 1/50 Males 0/50 0/49 Females 1/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/99(7.1%) 1/99(1%) Mean(sd) 7.1%(1.6) 1.0%(1.4) Range 3/50 - 4/49 0/49 - 1/50 Males 3/50 4/49 Females 1/50 0/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 3/101(3%) 0/100(0%) Mean(sd) 3.0%(4.2) 0.0%(0.0) Range 0/51 - 3/50 0/50 - 0/50 Males 3/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/101(4%) 0/100(0%) Mean(sd) 4.0%(5.7) 0.0%(0.0) Range 0/51 - 4/50 0/50 - 0/50 Males 4/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Nephroblastoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Stromal Nephroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Cholangiocarcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 0/50 1/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 6/101(5.9%) 2/100(2%) Mean(sd) 6.0%(5.7) 2.0%(0.0) Range 1/51 - 5/50 1/50 - 1/50 Males 5/50 1/51 Females 1/50 1/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 2/101(2%) 0/100(0%) Mean(sd) 2.0%(2.8) 0.0%(0.0) Range 0/51 - 2/50 0/50 - 0/50 Males 2/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 2/101(2%) 0/100(0%) Carcinoma or Mean(sd) 2.0%(2.8) 0.0%(0.0) Hepatoblastoma Range 0/51 - 2/50 0/50 - 0/50 Males 2/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 8/101(7.9%) 2/100(2%) Carcinoma or Mean(sd) 8.0%(8.5) 2.0%(0.0) Hepatocellular Adenoma Range 1/51 - 7/50 1/50 - 1/50 Males 7/50 1/51 Females 1/50 1/50 --------------------------------------------------------------------------- Hepatocellular Total 8/101(7.9%) 2/100(2%) Carcinoma, Mean(sd) 8.0%(8.5) 2.0%(0.0) Hepatocellular Adenoma, Range 1/51 - 7/50 1/50 - 1/50 or Hepatoblastoma Males 7/50 1/51 Females 1/50 1/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Alveolar/Bronchiolar Total 4/101(4%) 0/100(0%) Adenoma Mean(sd) 3.9%(5.5) 0.0%(0.0) Range 0/50 - 4/51 0/50 - 0/50 Males 0/50 4/51 Females 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 1/101(1%) 1/100(1%) Carcinoma Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 1/51 Females 1/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 5/101(5%) 1/100(1%) Carcinoma or Mean(sd) 4.9%(6.9) 1.0%(1.4) Alveolar/Bronchiolar Range 0/50 - 5/51 0/50 - 1/50 Adenoma Males 0/50 5/51 Females 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Plasma Cell Tumor Total 0/101(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Plasma Cell Tumor Total 0/101(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoacanthoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/101(1%) 5/100(5%) Mean(sd) 1.0%(1.4) 5.0%(1.4) Range 0/51 - 1/50 2/50 - 3/50 Males 1/50 0/51 Females 2/50 3/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/101(1%) 5/100(5%) Mean(sd) 1.0%(1.4) 5.0%(1.4) Range 0/51 - 1/50 2/50 - 3/50 Males 1/50 0/51 Females 2/50 3/50 --------------------------------------------------------------------------- Fibroadenoma Total 9/101(8.9%) 57/100(57%) Mean(sd) 8.9%(1.6) 57.0%(21.2) Range 4/51 - 5/50 21/50 - 36/50 Males 5/50 4/51 Females 36/50 21/50 --------------------------------------------------------------------------- Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 9/101(8.9%) 57/100(57%) or Adenoma Mean(sd) 8.9%(1.6) 57.0%(21.2) Range 4/51 - 5/50 21/50 - 36/50 Males 5/50 4/51 Females 36/50 21/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 9/101(8.9%) 60/100(60%) Carcinoma, or Adenoma Mean(sd) 8.9%(1.6) 60.0%(19.8) Range 4/51 - 5/50 23/50 - 37/50 Males 5/50 4/51 Females 37/50 23/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 0/50 1/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) 0/99(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/49 --------------------------------------------------------------------------- Chondroma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Chondrosarcoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Osteoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Papilloma Squamous or Total 3/101(3%) 0/100(0%) Papilloma Mean(sd) 3.0%(4.2) 0.0%(0.0) Range 0/50 - 3/51 0/50 - 0/50 Males 0/50 3/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 3/101(3%) 0/100(0%) Carcinoma, Papilloma Mean(sd) 3.0%(4.2) 0.0%(0.0) Squamous, or Papilloma Range 0/50 - 3/51 0/50 - 0/50 Males 0/50 3/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/101(2%) 0/100(0%) Mean(sd) 2.0%(2.8) 0.0%(0.0) Range 0/50 - 2/51 0/50 - 0/50 Males 0/50 2/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/100(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/100(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 0/100(0%) Benign, Malignant, NOS Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/100(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/100(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/100(0%) Tumor, Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 Females 0/50 0/50 --------------------------------------------------------------------------- Mixed Tumor Benign Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 1/94(1.1%) 0/91(0%) Mean(sd) 1.1%(1.5) 0.0%(0.0) Range 0/46 - 1/48 0/44 - 0/44 Males 1/48 0/46 Females 0/44 0/47 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Paraganglioma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/101(0%) 0/100(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 37/101(36.6%) 49/100(49%) Mean(sd) 36.4%(31.7) 49.0%(7.1) Range 7/50 - 30/51 22/50 - 27/50 Males 7/50 30/51 Females 22/50 27/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 37/101(36.6%) 49/100(49%) Mean(sd) 36.4%(31.7) 49.0%(7.1) Range 7/50 - 30/51 22/50 - 27/50 Males 7/50 30/51 Females 22/50 27/50 --------------------------------------------------------------------------- Craniopharyngioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Ganglioneuroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/101(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/101(0%) 0/100(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Basal Cell Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/101(0%) 0/100(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/101(0%) 0/100(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign, or Range 0/50 - 0/50 0/50 - 0/50 Trichoepithelioma Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/101(0%) 0/100(0%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) (malignant or NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/101(0%) 0/100(0%) Basal Cell Adenoma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Basosquamous Tumor Range 0/50 - 0/50 0/50 - 0/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 7/101(6.9%) 0/100(0%) Carcinoma, Carcinoma, Mean(sd) 6.9%(1.3) 0.0%(0.0) Basosq. Tumor (M or B), Range 3/50 - 4/51 0/50 - 0/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 3/50 4/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/101(0%) 0/100(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/101(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 7/101(6.9%) 0/100(0%) Mean(sd) 6.9%(1.3) 0.0%(0.0) Range 3/50 - 4/51 0/50 - 0/50 Males 3/50 4/51 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Melanoma Malignant Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 0/50 1/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/101(0%) 0/100(0%) Carcinoma, Basal Cell Mean(sd) 0.0%(0.0) 0.0%(0.0) Carcinoma, Basosquamous Range 0/50 - 0/50 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/101(0%) 0/100(0%) Papilloma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 7/101(6.9%) 0/100(0%) Papilloma, Papilloma, Mean(sd) 6.9%(1.3) 0.0%(0.0) Squamous Cell Carcinoma Range 3/50 - 4/51 0/50 - 0/50 or Keratoacanthoma Males 3/50 4/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 7/101(6.9%) 0/100(0%) Papilloma, Papilloma, or Mean(sd) 6.9%(1.3) 0.0%(0.0) Keratoacanthoma Range 3/50 - 4/51 0/50 - 0/50 Males 3/50 4/51 Females 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 1/101(1%) 1/100(1%) Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/51 - 1/50 0/50 - 1/50 Males 1/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 1/101(1%) 1/100(1%) Sarcoma, Myxoma, Mean(sd) 1.0%(1.4) 1.0%(1.4) Myxosarcoma, or Fibrous Range 0/51 - 1/50 0/50 - 1/50 Histiocytoma Males 1/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 0/101(0%) 0/100(0%) Myxosarcoma, or Fibrous Mean(sd) 0.0%(0.0) 0.0%(0.0) Histiocytoma Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma or Total 0/101(0%) 0/100(0%) Schwannoma benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 1/101(1%) 0/100(0%) Schwannoma (malignant or Mean(sd) 1.0%(1.4) 0.0%(0.0) NOS) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 1/101(1%) 0/100(0%) Neurofibroma, or Mean(sd) 1.0%(1.4) 0.0%(0.0) Schwannoma (benign, Range 0/50 - 1/51 0/50 - 0/50 malignant or NOS) Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Astrocytoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Basal Cell Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/101(0%) 0/100(0%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoid Tumor Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/101(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/101(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 Females 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 79/101(78.2%) Mean(sd) 78.4%(19.3) Range 33/51 - 46/50 Males 46/50 33/51 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Sarcoma Total 0/88(0%) 0/94(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/42 Females 0/49 0/45 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/88(0%) 0/94(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/42 Females 0/49 0/45 --------------------------------------------------------------------------- Thymoma Benign Total 0/88(0%) 0/94(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/42 Females 0/49 0/45 --------------------------------------------------------------------------- Thymoma Malignant Total 0/88(0%) 0/94(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/42 Females 0/49 0/45 --------------------------------------------------------------------------- Thymoma NOS Total 0/88(0%) 0/94(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/42 Females 0/49 0/45 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/88(0%) 0/94(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/42 Females 0/49 0/45 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 11/101(10.9%) 7/100(7%) Mean(sd) 10.9%(1.6) 7.0%(4.2) Range 5/51 - 6/50 2/50 - 5/50 Males 6/50 5/51 Females 2/50 5/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 11/101(10.9%) 7/100(7%) Mean(sd) 10.9%(1.6) 7.0%(4.2) Range 5/51 - 6/50 2/50 - 5/50 Males 6/50 5/51 Females 2/50 5/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 2/101(2%) 2/100(2%) Mean(sd) 2.0%(2.8) 2.0%(0.0) Range 0/51 - 2/50 1/50 - 1/50 Males 2/50 0/51 Females 1/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/101(2%) 2/100(2%) Mean(sd) 2.0%(2.8) 2.0%(0.0) Range 0/51 - 2/50 1/50 - 1/50 Males 2/50 0/51 Females 1/50 1/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/101(1%) 0/100(0%) Carcinoma or Papilloma Mean(sd) 1.0%(1.4) 0.0%(0.0) Squamous Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adamantinoma Benign Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Deciduoma NOS Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 0/50 1/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/100(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 1/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 8/100(8%) Mean(sd) 8.0%(0.0) Range 4/50 - 4/50 Females 4/50 4/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 9/100(9%) Polyp Stromal Mean(sd) 9.0%(1.4) Range 4/50 - 5/50 Females 4/50 5/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS GAVAGE METHYL CELLULOSE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/101(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/101(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 Females 0/50 0/50 ---------------------------------------------------------------------------