TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Benign Tumors Total 959/1004(95.5%) 810/1001(80.9%) Mean(sd) 95.5%(3.3) 80.9%(3.9) Range 44/50 - 50/50 37/50 - 45/51 Males 49/50 47/50 49/52 44/50 50/50 46/50 49/51 50/51 50/50 49/50 47/50 47/50 47/50 49/50 47/50 45/50 47/50 49/50 50/50 48/50 Females 38/50 41/50 40/50 40/50 40/50 40/50 45/51 40/50 43/50 42/50 37/50 40/50 40/50 42/50 43/50 41/50 43/50 39/50 39/50 37/50 --------------------------------------------------------------------------- Malignant Tumors Total 675/1004(67.2%) 438/1001(43.8%) Mean(sd) 67.2%(10.9) 43.8%(9.9) Range 20/50 - 42/50 13/51 - 30/50 Males 36/50 34/50 38/52 26/50 35/50 37/50 28/51 32/51 20/50 42/50 27/50 32/50 39/50 37/50 35/50 36/50 38/50 41/50 30/50 32/50 Females 27/50 25/50 24/50 16/50 21/50 30/50 13/51 21/50 14/50 30/50 17/50 19/50 21/50 22/50 30/50 22/50 21/50 21/50 24/50 20/50 --------------------------------------------------------------------------- Malignant and Benign Total 988/1004(98.4%) 932/1001(93.1%) Tumors Mean(sd) 98.4%(2.4) 93.1%(3.1) Range 45/50 - 50/50 44/50 - 49/50 Males 50/50 49/50 51/52 45/50 50/50 50/50 50/51 51/51 50/50 50/50 49/50 48/50 48/50 49/50 49/50 49/50 50/50 50/50 50/50 50/50 Females 46/50 48/50 45/50 46/50 46/50 49/50 47/51 45/50 48/50 48/50 45/50 47/50 44/50 47/50 49/50 45/50 49/50 47/50 46/50 45/50 --------------------------------------------------------------------------- Hemangioma Total 3/1004(0.3%) 1/1001(0.1%) Mean(sd) 0.3%(0.7) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 1/52 0/50 1/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 7/1004(0.7%) 1/1001(0.1%) Mean(sd) 0.7%(1.2) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 1/50 1/50 0/51 0/51 0/50 0/50 0/50 2/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 10/1004(1%) 2/1001(0.2%) Hemangioma Mean(sd) 1.0%(1.4) 0.2%(0.6) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 1/52 0/50 2/50 1/50 0/51 0/51 0/50 1/50 0/50 2/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 3/1004(0.3%) 2/1001(0.2%) Mean(sd) 0.3%(0.7) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 1/52 0/50 1/50 0/50 0/51 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 547/1004(54.5%) 293/1001(29.3%) Monocytic, Mononuclear, Mean(sd) 54.5%(10.7) 29.3%(7.6) or Undifferentiated Range 16/50 - 37/50 8/51 - 21/50 Males 32/50 27/50 32/52 22/50 26/50 31/50 20/51 27/51 16/50 37/50 18/50 29/50 29/50 30/50 31/50 28/50 27/50 35/50 25/50 25/50 Females 14/50 15/50 19/50 8/50 14/50 21/50 8/51 15/50 9/50 16/50 11/50 13/50 17/50 18/50 21/50 14/50 14/50 13/50 18/50 15/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 2/1004(0.2%) 2/1001(0.2%) Histiocytic, Mean(sd) 0.2%(0.6) 0.2%(0.6) Lymphocytic, Mixed, NOS, Range 0/50 - 1/50 0/50 - 1/50 or Undifferentiated Cell Type Males 0/50 0/50 0/52 1/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign Total 1/1004(0.1%) 1/1001(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 26/1004(2.6%) 2/1001(0.2%) Malignant, NOS Mean(sd) 2.6%(2.0) 0.2%(0.6) Range 0/50 - 4/50 0/50 - 1/50 Males 1/50 0/50 2/52 0/50 1/50 1/50 1/51 0/51 1/50 2/50 1/50 1/50 0/50 2/50 2/50 2/50 2/50 2/50 4/50 1/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 25/1004(2.5%) 1/1001(0.1%) Mean(sd) 2.5%(2.0) 0.1%(0.4) Range 0/50 - 4/50 0/50 - 1/50 Males 1/50 0/50 2/52 0/50 1/50 1/50 1/51 0/51 0/50 2/50 1/50 1/50 0/50 2/50 2/50 2/50 2/50 2/50 4/50 1/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 4/1004(0.4%) 5/1001(0.5%) Mean(sd) 0.4%(0.8) 0.5%(0.9) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 1/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 4/1004(0.4%) 5/1001(0.5%) Mean(sd) 0.4%(0.8) 0.5%(0.9) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 1/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 9/1000(0.9%) 13/999(1.3%) Mean(sd) 0.9%(1.2) 1.3%(1.8) Range 0/50 - 2/48 0/50 - 3/50 Males 0/50 1/50 1/52 1/50 2/48 0/50 1/50 1/51 1/50 0/50 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 1/50 2/50 1/50 1/50 1/51 0/50 3/50 0/50 0/50 0/50 0/49 1/50 2/50 0/49 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1000(0%) 1/999(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/48 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Ganglioneuroma Total 1/996(0.1%) 0/993(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/47 0/52 0/50 0/49 0/50 1/50 0/51 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/51 0/50 0/50 0/48 0/49 0/50 0/49 0/50 0/50 0/47 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 243/996(24.4%) 27/993(2.7%) Mean(sd) 24.4%(9.7) 2.7%(1.9) Range 5/50 - 23/50 0/50 - 3/50 Males 16/49 14/47 14/52 9/50 7/49 9/50 5/50 6/51 17/50 7/50 15/49 17/49 10/50 14/50 17/50 7/50 14/50 23/50 8/50 14/50 Females 2/50 3/50 1/50 0/50 1/50 1/49 1/51 1/50 1/50 2/48 1/49 3/50 2/49 1/50 3/50 1/47 1/50 2/50 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 4/996(0.4%) 4/993(0.4%) Mean(sd) 0.4%(0.8) 0.4%(0.8) Range 0/47 - 1/49 0/50 - 1/48 Males 1/49 0/47 0/52 0/50 0/49 0/50 1/50 0/51 1/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 1/50 0/50 0/50 0/49 0/51 1/50 0/50 1/48 0/49 0/50 0/49 0/50 0/50 0/47 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 29/996(2.9%) 5/993(0.5%) Malignant Mean(sd) 2.9%(3.0) 0.5%(0.9) Range 0/47 - 6/49 0/50 - 1/47 Males 1/49 0/47 1/52 1/50 6/49 2/50 1/50 3/51 1/50 4/50 2/49 1/49 2/50 0/50 1/50 1/50 0/50 1/50 0/50 1/50 Females 1/50 0/50 0/50 1/50 0/50 0/49 0/51 0/50 1/50 0/48 0/49 0/50 0/49 0/50 0/50 1/47 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 268/996(26.9%) 36/993(3.6%) Benign, Complex, Mean(sd) 26.9%(8.8) 3.6%(2.0) Malignant, NOS Range 7/50 - 23/50 0/50 - 3/48 Males 16/49 14/47 14/52 10/50 12/49 10/50 7/50 9/51 19/50 10/50 17/49 18/49 11/50 14/50 18/50 8/50 14/50 23/50 8/50 16/50 Females 3/50 3/50 2/50 1/50 1/50 1/49 1/51 2/50 2/50 3/48 1/49 3/50 2/49 1/50 3/50 2/47 3/50 2/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibrosarcoma Total 1/1000(0.1%) 0/997(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 1/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Chondroma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma or Total 1/1004(0.1%) 0/1001(0%) Chondroma Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 2/1004(0.2%) 0/1001(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 1/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 4/1004(0.4%) 5/1001(0.5%) Mean(sd) 0.4%(0.8) 0.5%(0.9) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 1/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 4/1004(0.4%) 5/1001(0.5%) Mean(sd) 0.4%(0.8) 0.5%(0.9) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 1/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Astrocytoma Benign Total 1/1004(0.1%) 1/999(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 5/1004(0.5%) 1/999(0.1%) Mean(sd) 0.5%(1.2) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 2/52 0/50 1/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/1004(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1004(0%) 1/999(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 1/1004(0.1%) 1/999(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/1004(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma NOS Total 0/1004(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 2/1004(0.2%) 0/999(0%) Benign Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 1/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/1004(0%) 1/999(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1004(0.1%) 0/999(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/1004(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 1/1004(0.1%) 0/999(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 1/1004(0.1%) 0/999(0%) Malignant, NOS Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 1/1004(0.1%) 0/999(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 1/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 3/1004(0.3%) 1/999(0.1%) Malignant Mean(sd) 0.3%(0.7) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/1004(0%) 1/999(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 11/1004(1.1%) 5/999(0.5%) Glioma, or Astrocytoma Mean(sd) 1.1%(1.4) 0.5%(0.9) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 2/52 1/50 1/50 1/50 1/51 0/51 0/50 0/50 0/50 0/50 1/50 1/50 1/50 2/50 0/50 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 1/49 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/49 1/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1004(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 66/998(6.6%) 89/968(9.2%) Mean(sd) 6.6%(3.1) 9.2%(6.0) Range 1/50 - 7/48 0/50 - 11/49 Males 3/50 3/48 3/52 1/50 4/50 4/50 4/50 3/51 2/50 5/49 2/50 2/50 3/50 1/50 5/50 5/50 7/48 2/50 3/50 4/50 Females 5/47 5/50 5/49 3/42 3/45 3/50 1/51 4/48 0/50 11/49 2/47 1/45 4/50 4/49 10/50 10/49 7/49 4/49 3/49 4/50 --------------------------------------------------------------------------- Carcinoma Total 29/998(2.9%) 30/968(3.1%) Mean(sd) 2.9%(3.7) 3.1%(3.2) Range 0/50 - 7/50 0/49 - 6/49 Males 0/50 2/48 2/52 0/50 7/50 1/50 0/50 2/51 0/50 5/49 0/50 0/50 1/50 2/50 0/50 3/50 1/48 1/50 1/50 1/50 Females 1/47 1/50 0/49 1/42 4/45 4/50 1/51 1/48 1/50 6/49 0/47 0/45 1/50 1/49 0/50 2/49 1/49 1/49 2/49 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 95/998(9.5%) 118/968(12.2%) Mean(sd) 9.5%(5.4) 12.2%(7.7) Range 1/50 - 11/50 1/50 - 17/49 Males 3/50 5/48 5/52 1/50 11/50 5/50 4/50 5/51 2/50 10/49 2/50 2/50 4/50 3/50 5/50 8/50 8/48 3/50 4/50 5/50 Females 6/47 6/50 5/49 4/42 7/45 7/50 2/51 5/48 1/50 17/49 2/47 1/45 4/50 5/49 10/50 12/49 8/49 5/49 5/49 6/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 2/998(0.2%) 0/968(0%) Mean(sd) 0.2%(0.9) 0.0%(0.0) Range 0/50 - 2/50 0/47 - 0/47 Males 0/50 0/48 0/52 0/50 2/50 0/50 0/50 0/51 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 Females 0/47 0/50 0/49 0/42 0/45 0/50 0/51 0/48 0/50 0/49 0/47 0/45 0/50 0/49 0/50 0/49 0/49 0/49 0/49 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/998(0.1%) 0/968(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/47 - 0/47 Males 0/50 0/48 0/52 0/50 0/50 0/50 0/50 1/51 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 Females 0/47 0/50 0/49 0/42 0/45 0/50 0/51 0/48 0/50 0/49 0/47 0/45 0/50 0/49 0/50 0/49 0/49 0/49 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/1004(0.2%) 0/1001(0%) Mean(sd) 0.2%(0.9) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 0/50 0/52 2/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Melanoma NOS Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 0/954(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/0 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/0 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/954(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/0 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/0 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/954(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/0 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/0 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibroma Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 2/1004(0.2%) 1/998(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 1/1004(0.1%) 0/998(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Hemangiosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/1004(0.1%) 1/1001(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 6/1004(0.6%) 1/1001(0.1%) Mean(sd) 0.6%(1.3) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 2/50 0/50 0/50 0/50 2/50 1/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/1004(0.1%) 2/1001(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 7/1004(0.7%) 1/1001(0.1%) Mean(sd) 0.7%(1.3) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 2/50 0/50 0/50 1/50 2/50 1/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/1004(0.7%) 1/1001(0.1%) Mean(sd) 0.7%(1.3) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 2/50 0/50 0/50 1/50 2/50 1/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 2/1004(0.2%) 2/1001(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 36/997(3.6%) 18/997(1.8%) Mean(sd) 3.6%(2.7) 1.8%(2.1) Range 0/50 - 5/50 0/50 - 3/50 Males 0/50 2/47 0/52 2/50 1/49 5/50 2/51 1/51 2/50 4/50 4/50 1/49 2/49 2/50 3/50 2/50 1/50 1/50 1/49 0/50 Females 0/50 2/49 0/50 3/50 2/50 1/50 0/51 0/50 3/50 1/50 0/50 0/50 1/50 0/50 2/49 1/49 1/50 0/50 0/49 1/50 --------------------------------------------------------------------------- Carcinoma Total 10/997(1%) 7/997(0.7%) Mean(sd) 1.0%(1.7) 0.7%(1.5) Range 0/50 - 3/50 0/50 - 3/49 Males 0/50 0/47 0/52 0/50 0/49 0/50 0/51 0/51 0/50 1/50 0/50 0/49 1/49 0/50 1/50 3/50 2/50 1/50 1/49 0/50 Females 1/50 1/49 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 1/50 3/49 0/49 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 46/997(4.6%) 25/997(2.5%) Mean(sd) 4.6%(3.3) 2.5%(2.7) Range 0/50 - 5/50 0/50 - 5/49 Males 0/50 2/47 0/52 2/50 1/49 5/50 2/51 1/51 2/50 5/50 4/50 1/49 3/49 2/50 4/50 5/50 3/50 2/50 2/49 0/50 Females 1/50 3/49 0/50 3/50 2/50 1/50 0/51 1/50 3/50 1/50 0/50 0/50 1/50 1/50 5/49 1/49 1/50 0/50 0/49 1/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 1/1002(0.1%) 1/1000(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/1002(0.1%) 1/1000(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 1/1002(0.1%) 0/1000(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 8/1002(0.8%) 0/1000(0%) Mean(sd) 0.8%(1.2) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 0/50 1/52 1/50 0/49 1/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 1/50 2/50 1/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1002(0%) 1/1000(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 8/1002(0.8%) 1/1000(0.1%) Mean(sd) 0.8%(1.2) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 1/52 1/50 0/49 1/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 1/50 2/50 1/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 1/1002(0.1%) 0/1000(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Nephroblastoma Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1002(0.1%) 0/1000(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Stromal Nephroma Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Cholangiocarcinoma Total 0/1002(0%) 1/1000(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1002(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 23/1002(2.3%) 4/1000(0.4%) Mean(sd) 2.3%(3.0) 0.4%(1.0) Range 0/50 - 5/50 0/50 - 2/50 Males 2/50 0/50 0/52 0/50 0/50 2/50 0/50 0/51 5/50 1/50 5/50 0/50 2/49 1/50 1/50 1/50 1/50 1/50 1/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 2/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 7/1002(0.7%) 1/1000(0.1%) Mean(sd) 0.7%(1.5) 0.1%(0.4) Range 0/52 - 3/49 0/50 - 1/50 Males 1/50 1/50 0/52 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 3/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 7/1002(0.7%) 1/1000(0.1%) Carcinoma or Mean(sd) 0.7%(1.5) 0.1%(0.4) Hepatoblastoma Range 0/52 - 3/49 0/50 - 1/50 Males 1/50 1/50 0/52 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 3/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 28/1002(2.8%) 5/1000(0.5%) Carcinoma or Mean(sd) 2.8%(3.3) 0.5%(1.1) Hepatocellular Adenoma Range 0/52 - 5/50 0/50 - 2/50 Males 3/50 1/50 0/52 0/50 0/50 2/50 0/50 0/51 5/50 1/50 5/50 0/50 4/49 1/50 1/50 1/50 2/50 1/50 1/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 2/50 0/50 0/50 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 28/1002(2.8%) 5/1000(0.5%) Carcinoma, Mean(sd) 2.8%(3.3) 0.5%(1.1) Hepatocellular Adenoma, Range 0/52 - 5/50 0/50 - 2/50 or Hepatoblastoma Males 3/50 1/50 0/52 0/50 0/50 2/50 0/50 0/51 5/50 1/50 5/50 0/50 4/49 1/50 1/50 1/50 2/50 1/50 1/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 2/50 0/50 0/50 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Alveolar/Bronchiolar Total 24/1002(2.4%) 14/999(1.4%) Adenoma Mean(sd) 2.4%(3.2) 1.4%(1.7) Range 0/52 - 7/50 0/50 - 3/50 Males 1/50 2/49 0/52 2/50 2/50 0/50 0/51 1/51 1/50 7/50 2/50 1/50 0/50 0/49 1/50 0/50 1/50 1/50 2/50 0/50 Females 0/50 1/50 1/50 1/50 0/50 2/50 1/51 0/50 0/50 1/50 0/50 0/50 0/50 1/50 3/50 1/49 0/50 0/49 0/50 2/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 7/1002(0.7%) 6/999(0.6%) Carcinoma Mean(sd) 0.7%(1.1) 0.6%(0.9) Range 0/50 - 2/52 0/50 - 1/50 Males 0/50 1/49 2/52 0/50 1/50 0/50 1/51 0/51 0/50 1/50 0/50 0/50 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 1/49 0/50 0/49 1/50 1/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 31/1002(3.1%) 19/999(1.9%) Carcinoma or Mean(sd) 3.1%(3.5) 1.9%(1.8) Alveolar/Bronchiolar Range 0/50 - 8/50 0/50 - 3/50 Adenoma Males 1/50 3/49 2/52 2/50 3/50 0/50 1/51 1/51 1/50 8/50 2/50 1/50 0/50 1/49 1/50 0/50 1/50 1/50 2/50 0/50 Females 1/50 1/50 1/50 1/50 0/50 2/50 1/51 0/50 1/50 1/50 0/50 0/50 1/50 1/50 3/50 1/49 0/50 0/49 1/50 3/50 --------------------------------------------------------------------------- Carcinoma Total 0/1002(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1002(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/1002(0.1%) 1/999(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/49 0/50 - 1/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1002(0%) 0/999(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Plasma Cell Tumor Total 0/1004(0%) 0/1001(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Hemangiosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Plasma Cell Tumor Total 0/1004(0%) 0/1001(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Hemangiosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoacanthoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Adenoma Total 2/1004(0.2%) 23/1001(2.3%) Mean(sd) 0.2%(0.6) 2.3%(2.4) Range 0/50 - 1/50 0/50 - 4/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/50 0/50 4/50 1/50 2/50 3/51 0/50 0/50 2/50 0/50 0/50 1/50 2/50 2/50 0/50 1/50 2/50 2/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/1004(0.2%) 32/1001(3.2%) Mean(sd) 0.2%(0.9) 3.2%(2.6) Range 0/50 - 2/50 0/50 - 4/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 2/50 0/50 0/50 Females 3/50 2/50 0/50 0/50 2/50 2/50 0/51 4/50 0/50 4/50 3/50 1/50 2/50 1/50 3/50 0/50 2/50 1/50 1/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/1004(0.4%) 54/1001(5.4%) Mean(sd) 0.4%(1.0) 5.4%(3.1) Range 0/50 - 2/50 0/50 - 6/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 2/50 0/50 0/50 Females 3/50 3/50 0/50 4/50 3/50 4/50 3/51 4/50 0/50 6/50 3/50 1/50 3/50 3/50 4/50 0/50 3/50 3/50 3/50 1/50 --------------------------------------------------------------------------- Fibroadenoma Total 42/1004(4.2%) 431/1001(43.1%) Mean(sd) 4.2%(3.5) 43.1%(10.7) Range 0/50 - 6/50 12/50 - 30/50 Males 1/50 0/50 1/52 0/50 3/50 2/50 0/51 0/51 4/50 3/50 2/50 1/50 2/50 3/50 6/50 1/50 4/50 3/50 1/50 5/50 Females 27/50 13/50 19/50 19/50 17/50 28/50 15/51 25/50 12/50 21/50 19/50 15/50 22/50 29/50 30/50 23/50 25/50 22/50 25/50 25/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 44/1004(4.4%) 446/1001(44.6%) or Adenoma Mean(sd) 4.4%(3.7) 44.6%(11.1) Range 0/50 - 7/50 12/50 - 32/50 Males 1/50 1/50 1/52 0/50 3/50 2/50 0/51 0/51 4/50 3/50 2/50 1/50 2/50 3/50 7/50 1/50 4/50 3/50 1/50 5/50 Females 27/50 13/50 19/50 22/50 17/50 28/50 18/51 25/50 12/50 22/50 19/50 15/50 23/50 31/50 32/50 23/50 26/50 24/50 25/50 25/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 46/1004(4.6%) 467/1001(46.7%) Carcinoma, or Adenoma Mean(sd) 4.6%(3.8) 46.7%(11.5) Range 0/50 - 7/50 12/50 - 32/50 Males 1/50 1/50 1/52 0/50 3/50 2/50 0/51 0/51 4/50 3/50 2/50 1/50 2/50 3/50 7/50 1/50 4/50 5/50 1/50 5/50 Females 30/50 14/50 19/50 22/50 18/50 29/50 18/51 27/50 12/50 25/50 22/50 16/50 25/50 32/50 32/50 23/50 27/50 25/50 26/50 25/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibrosarcoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 1/1004(0.1%) 1/998(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondroma Total 1/1004(0.1%) 0/998(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/1004(0%) 1/998(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 1/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 4/1004(0.4%) 1/998(0.1%) Mean(sd) 0.4%(0.8) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/52 0/50 1/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/49 0/50 0/50 1/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1004(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/49 0/50 0/50 0/50 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Papilloma Squamous or Total 10/1004(1%) 12/1001(1.2%) Papilloma Mean(sd) 1.0%(1.4) 1.2%(1.6) Range 0/50 - 2/50 0/50 - 2/50 Males 1/50 0/50 2/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 1/50 1/50 1/50 0/50 0/50 0/50 1/50 2/50 Females 0/50 0/50 0/50 0/50 1/50 2/50 0/51 2/50 1/50 1/50 1/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 0/50 2/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1004(0.1%) 5/1001(0.5%) Mean(sd) 0.1%(0.4) 0.5%(1.1) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 1/50 2/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 11/1004(1.1%) 17/1001(1.7%) Carcinoma, Papilloma Mean(sd) 1.1%(1.4) 1.7%(1.9) Squamous, or Papilloma Range 0/50 - 2/50 0/50 - 3/50 Males 1/50 0/50 2/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 1/50 1/50 1/50 0/50 0/50 1/50 1/50 2/50 Females 0/50 1/50 0/50 0/50 1/50 2/50 1/51 2/50 1/50 1/50 1/50 0/50 0/50 3/50 2/50 0/50 0/50 0/50 0/50 2/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 3/1004(0.3%) 2/1001(0.2%) Mean(sd) 0.3%(0.7) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 1/1000(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/51 Females 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/1000(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 9/1000(0.9%) Benign Mean(sd) 0.9%(1.4) Range 0/50 - 2/50 Females 0/50 2/50 0/50 0/50 0/50 2/50 1/51 1/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/49 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/1000(0.1%) Malignant Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 10/1000(1%) Benign, Malignant, NOS Mean(sd) 1.0%(1.4) Range 0/50 - 2/50 Females 0/50 2/50 0/50 1/50 0/50 2/50 1/51 1/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/49 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/1000(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 1/1000(0.1%) Malignant Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 2/1000(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1000(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/1000(0%) Tumor, Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 1/1000(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 18/999(1.8%) 0/998(0%) Mean(sd) 1.8%(2.7) 0.0%(0.0) Range 0/50 - 5/49 0/50 - 0/50 Males 0/50 0/48 0/52 0/50 5/49 3/50 0/51 1/51 1/50 0/50 0/50 0/49 2/49 0/50 1/50 0/50 2/50 0/50 1/50 2/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/999(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/48 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 18/999(1.8%) 0/998(0%) Mean(sd) 1.8%(2.7) 0.0%(0.0) Range 0/50 - 5/49 0/50 - 0/50 Males 0/50 0/48 0/52 0/50 5/49 3/50 0/51 1/51 1/50 0/50 0/50 0/49 2/49 0/50 1/50 0/50 2/50 0/50 1/50 2/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/999(0%) 0/998(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/48 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Mixed Tumor Benign Total 2/999(0.2%) 0/998(0%) Mean(sd) 0.2%(0.9) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 0/48 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/49 0/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 6/924(0.6%) 2/916(0.2%) Mean(sd) 0.6%(1.2) 0.2%(0.7) Range 0/38 - 2/47 0/46 - 1/45 Males 0/38 1/47 1/51 1/46 0/47 0/49 0/44 0/50 0/50 0/47 0/43 0/48 0/48 2/47 0/41 0/48 0/39 0/45 0/49 1/47 Females 1/45 0/46 0/46 0/46 0/49 0/47 0/46 0/47 0/48 0/48 0/45 0/47 0/48 0/48 0/46 0/46 0/42 0/38 0/42 1/46 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Paraganglioma Benign Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 2/1004(0.2%) 1/1001(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma: Benign, Total 2/1004(0.2%) 1/1001(0.1%) Malignant, NOS Mean(sd) 0.2%(0.6) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Squamous Cell Carcinoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/1004(0.2%) 3/1001(0.3%) Mean(sd) 0.2%(0.6) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 1/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 274/996(27.5%) 478/992(48.2%) Mean(sd) 27.5%(9.1) 48.1%(12.2) Range 7/50 - 23/50 15/49 - 36/50 Males 9/50 23/50 13/52 8/50 14/50 10/50 8/51 7/50 8/49 20/50 15/50 11/48 19/49 14/50 13/50 15/49 17/49 17/49 15/50 18/50 Females 16/46 26/50 23/50 21/50 28/50 20/49 30/51 16/49 36/50 24/50 28/50 26/50 18/50 27/49 35/50 15/49 31/50 16/49 20/50 22/50 --------------------------------------------------------------------------- Carcinoma Total 4/996(0.4%) 11/992(1.1%) Mean(sd) 0.4%(1.1) 1.1%(1.5) Range 0/50 - 2/50 0/50 - 2/49 Males 0/50 0/50 0/52 0/50 1/50 0/50 0/51 0/50 0/49 0/50 2/50 1/48 0/49 0/50 0/50 0/49 0/49 0/49 0/50 0/50 Females 1/46 2/50 0/50 0/50 1/50 2/49 0/51 0/49 1/50 0/50 2/50 0/50 1/50 0/49 1/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 278/996(27.9%) 489/992(49.3%) Mean(sd) 27.9%(9.2) 49.2%(12.6) Range 7/50 - 23/50 15/49 - 37/50 Males 9/50 23/50 13/52 8/50 15/50 10/50 8/51 7/50 8/49 20/50 17/50 12/48 19/49 14/50 13/50 15/49 17/49 17/49 15/50 18/50 Females 17/46 28/50 23/50 21/50 29/50 22/49 30/51 16/49 37/50 24/50 30/50 26/50 19/50 27/49 36/50 15/49 31/50 16/49 20/50 22/50 --------------------------------------------------------------------------- Craniopharyngioma Total 0/996(0%) 0/992(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/46 - 0/46 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/50 0/49 0/50 0/50 0/48 0/49 0/50 0/50 0/49 0/49 0/49 0/50 0/50 Females 0/46 0/50 0/50 0/50 0/50 0/49 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Ganglioneuroma Total 0/996(0%) 0/992(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/46 - 0/46 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/50 0/49 0/50 0/50 0/48 0/49 0/50 0/50 0/49 0/49 0/49 0/50 0/50 Females 0/46 0/50 0/50 0/50 0/50 0/49 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 2/996(0.2%) 4/992(0.4%) Mean(sd) 0.2%(0.6) 0.4%(0.8) Range 0/50 - 1/50 0/46 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/50 0/49 0/50 0/50 0/48 0/49 0/50 1/50 0/49 0/49 0/49 0/50 0/50 Females 0/46 0/50 0/50 0/50 1/50 0/49 0/51 0/49 1/50 0/50 0/50 0/50 0/50 0/49 0/50 1/49 0/50 0/49 0/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 1/996(0.1%) 0/992(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/46 - 0/46 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/50 0/49 0/50 0/50 0/48 0/49 1/50 0/50 0/49 0/49 0/49 0/50 0/50 Females 0/46 0/50 0/50 0/50 0/50 0/49 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/996(0.3%) 4/992(0.4%) Mean(sd) 0.3%(0.7) 0.4%(0.8) Range 0/50 - 1/50 0/46 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 1/50 0/49 0/50 0/50 0/48 0/49 1/50 1/50 0/49 0/49 0/49 0/50 0/50 Females 0/46 0/50 0/50 0/50 1/50 0/49 0/51 0/49 1/50 0/50 0/50 0/50 0/50 0/49 0/50 1/49 0/50 0/49 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 1/996(0.1%) 0/992(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/46 - 0/46 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/50 0/49 0/50 0/50 0/48 0/49 0/50 0/50 0/49 0/49 0/49 0/50 0/50 Females 0/46 0/50 0/50 0/50 0/50 0/49 0/51 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 4/999(0.4%) Mean(sd) 0.4%(1.0) Range 0/49 - 2/50 Males 0/49 0/50 0/52 0/48 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/49 1/50 0/49 2/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/999(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/52 0/48 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/999(0.4%) Mean(sd) 0.4%(1.0) Range 0/49 - 2/50 Males 0/49 0/50 0/52 0/48 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/49 1/50 0/49 2/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 0/1001(0%) 0/996(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 0/50 0/49 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1001(0%) 0/996(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 0/50 0/49 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1001(0%) 0/996(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 0/50 0/49 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/1001(0.1%) 0/996(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/49 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 0/50 0/49 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 0/1004(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 1/1004(0.1%) 0/1001(0%) Rhabdomyoma Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 5/1004(0.5%) 0/1001(0%) Mean(sd) 0.5%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 1/50 0/50 1/50 1/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 6/1004(0.6%) 0/1001(0%) Mean(sd) 0.6%(1.1) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 2/50 0/50 0/50 0/50 1/50 0/50 1/50 1/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Basal Cell Adenoma Total 10/1004(1%) 2/1001(0.2%) Mean(sd) 1.0%(1.4) 0.2%(0.6) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 1/50 0/50 1/51 0/51 0/50 1/50 2/50 0/50 0/50 0/50 2/50 0/50 0/50 1/50 1/50 1/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 13/1004(1.3%) 2/1001(0.2%) Basosquamous Tumor Mean(sd) 1.3%(1.5) 0.2%(0.6) Benign Range 0/50 - 2/50 0/50 - 1/50 Males 1/50 0/50 0/52 0/50 1/50 0/50 2/51 0/51 0/50 1/50 2/50 0/50 0/50 1/50 2/50 0/50 0/50 1/50 1/50 1/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 16/1004(1.6%) 4/1001(0.4%) Basosquamous Tumor Mean(sd) 1.6%(1.7) 0.4%(1.0) Benign, or Range 0/50 - 2/50 0/50 - 2/50 Trichoepithelioma Males 1/50 0/50 0/52 0/50 1/50 0/50 2/51 0/51 0/50 2/50 2/50 0/50 0/50 1/50 2/50 1/50 0/50 1/50 2/50 1/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 4/1004(0.4%) 2/1001(0.2%) Mean(sd) 0.4%(0.8) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 1/52 0/50 1/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 6/1004(0.6%) 3/1001(0.3%) or Basosquamous Tumor Mean(sd) 0.6%(1.1) 0.3%(0.7) (malignant or NOS) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 1/52 2/50 1/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 22/1004(2.2%) 7/1001(0.7%) Basal Cell Adenoma, Mean(sd) 2.2%(1.7) 0.7%(1.3) Basosquamous Tumor Range 0/50 - 2/50 0/50 - 2/50 (benign, malignant or NOS), or Trichoepithelioma Males 1/50 0/50 1/52 2/50 2/50 1/50 2/51 0/51 0/50 2/50 2/50 0/50 0/50 1/50 2/50 1/50 0/50 2/50 2/50 1/50 Females 0/50 0/50 2/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 2/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 85/1004(8.5%) 18/1001(1.8%) Carcinoma, Carcinoma, Mean(sd) 8.5%(4.2) 1.8%(1.9) Basosq. Tumor (M or B), Range 2/50 - 12/50 0/50 - 4/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 2/50 5/50 3/52 4/50 6/50 4/50 4/51 4/51 5/50 12/50 4/50 2/50 3/50 4/50 5/50 4/50 5/50 3/50 3/50 3/50 Females 1/50 1/50 2/50 0/50 1/50 1/50 1/51 4/50 0/50 0/50 0/50 2/50 1/50 1/50 1/50 1/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 3/1004(0.3%) 0/1001(0%) Benign Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 2/1004(0.2%) 1/1001(0.1%) Malignant Mean(sd) 0.2%(0.9) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 2/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 1/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiopericytoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 43/1004(4.3%) 2/1001(0.2%) Mean(sd) 4.3%(3.6) 0.2%(0.6) Range 0/50 - 7/50 0/50 - 1/50 Males 1/50 0/50 1/52 2/50 3/50 2/50 2/51 3/51 5/50 7/50 1/50 1/50 3/50 1/50 4/50 3/50 3/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 2/1004(0.2%) 2/1001(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 1/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Malignant Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 1/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 3/1004(0.3%) 1/1001(0.1%) Mean(sd) 0.3%(0.7) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 1/50 1/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 9/1004(0.9%) 4/1001(0.4%) Carcinoma, Basal Cell Mean(sd) 0.9%(1.3) 0.4%(0.8) Carcinoma, Basosquamous Range 0/50 - 2/50 0/50 - 1/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 1/50 2/52 2/50 1/50 1/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 20/1004(2%) 8/1001(0.8%) Mean(sd) 2.0%(2.2) 0.8%(1.5) Range 0/50 - 4/50 0/50 - 3/50 Males 0/50 4/50 0/52 1/50 1/50 1/50 0/51 1/51 0/50 3/50 1/50 1/50 0/50 2/50 0/50 0/50 2/50 0/50 1/50 2/50 Females 1/50 1/50 0/50 0/50 1/50 0/50 0/51 3/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 20/1004(2%) 8/1001(0.8%) Papilloma or Papilloma Mean(sd) 2.0%(2.2) 0.8%(1.5) Range 0/50 - 4/50 0/50 - 3/50 Males 0/50 4/50 0/52 1/50 1/50 1/50 0/51 1/51 0/50 3/50 1/50 1/50 0/50 2/50 0/50 0/50 2/50 0/50 1/50 2/50 Females 1/50 1/50 0/50 0/50 1/50 0/50 0/51 3/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 66/1004(6.6%) 11/1001(1.1%) Papilloma, Papilloma, Mean(sd) 6.6%(4.1) 1.1%(1.5) Squamous Cell Carcinoma Range 1/50 - 10/50 0/50 - 3/50 or Keratoacanthoma Males 1/50 5/50 2/52 3/50 4/50 3/50 3/51 4/51 5/50 10/50 2/50 2/50 3/50 3/50 4/50 3/50 5/50 1/50 1/50 2/50 Females 1/50 1/50 0/50 0/50 1/50 1/50 1/51 3/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 63/1004(6.3%) 10/1001(1%) Papilloma, Papilloma, or Mean(sd) 6.3%(4.1) 1.0%(1.5) Keratoacanthoma Range 1/52 - 10/50 0/50 - 3/50 Males 1/50 4/50 1/52 3/50 4/50 3/50 2/51 4/51 5/50 10/50 2/50 2/50 3/50 3/50 4/50 3/50 5/50 1/50 1/50 2/50 Females 1/50 1/50 0/50 0/50 1/50 1/50 0/51 3/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 3/1004(0.3%) 2/1001(0.2%) Mean(sd) 0.3%(0.7) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibroma Total 56/1004(5.6%) 15/1001(1.5%) Mean(sd) 5.6%(3.2) 1.5%(1.6) Range 0/52 - 5/50 0/50 - 2/50 Males 5/50 3/50 0/52 1/50 1/50 5/50 1/51 2/51 4/50 3/50 4/50 1/50 4/50 5/50 3/50 1/50 3/50 3/50 5/50 2/50 Females 2/50 0/50 0/50 0/50 0/50 1/50 0/51 1/50 1/50 1/50 0/50 0/50 2/50 1/50 1/50 2/50 0/50 1/50 0/50 2/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 71/1004(7.1%) 22/1001(2.2%) Sarcoma, Myxoma, Mean(sd) 7.1%(3.3) 2.2%(2.1) Myxosarcoma, or Fibrous Range 1/52 - 6/50 0/50 - 3/50 Histiocytoma Males 5/50 5/50 1/52 1/50 1/50 5/50 3/51 2/51 5/50 3/50 4/50 2/50 6/50 5/50 3/50 2/50 5/50 3/50 5/50 5/50 Females 3/50 1/50 0/50 1/50 0/50 1/50 0/51 2/50 1/50 1/50 0/50 0/50 2/50 1/50 1/50 2/50 0/50 3/50 0/50 3/50 --------------------------------------------------------------------------- Fibrosarcoma Total 9/1004(0.9%) 4/1001(0.4%) Mean(sd) 0.9%(1.4) 0.4%(0.8) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 1/50 1/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 2/50 0/50 0/50 2/50 Females 1/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 1/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 16/1004(1.6%) 7/1001(0.7%) Myxosarcoma, or Fibrous Mean(sd) 1.6%(2.1) 0.7%(1.2) Histiocytoma Range 0/50 - 3/50 0/50 - 2/50 Males 0/50 2/50 1/52 0/50 0/50 0/50 2/51 0/51 1/50 0/50 0/50 1/50 2/50 0/50 0/50 1/50 3/50 0/50 0/50 3/50 Females 1/50 1/50 0/50 1/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 2/50 0/50 1/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 2/1004(0.2%) 0/1001(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma or Total 0/1004(0%) 0/1001(0%) Schwannoma benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 3/1004(0.3%) 0/1001(0%) Mean(sd) 0.3%(0.9) 0.0%(0.0) Range 0/50 - 2/52 0/50 - 0/50 Males 0/50 0/50 2/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 12/1004(1.2%) 1/1001(0.1%) Schwannoma (malignant or Mean(sd) 1.2%(1.7) 0.1%(0.4) NOS) Range 0/50 - 3/50 0/50 - 1/50 Males 0/50 1/50 2/52 0/50 0/50 0/50 1/51 0/51 0/50 1/50 1/50 0/50 0/50 0/50 2/50 0/50 3/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 12/1004(1.2%) 1/1001(0.1%) Neurofibroma, or Mean(sd) 1.2%(1.7) 0.1%(0.4) Schwannoma (benign, Range 0/50 - 3/50 0/50 - 1/50 malignant or NOS) Males 0/50 1/50 2/52 0/50 0/50 0/50 1/51 0/51 0/50 1/50 1/50 0/50 0/50 0/50 2/50 0/50 3/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 5/1004(0.5%) 3/1001(0.3%) Mean(sd) 0.5%(0.9) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 0/51 0/51 1/50 0/50 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 9/1004(0.9%) 1/1001(0.1%) Mean(sd) 0.9%(1.7) 0.1%(0.4) Range 0/50 - 3/50 0/50 - 1/50 Males 0/50 1/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 1/50 0/50 0/50 0/50 0/50 2/50 0/50 3/50 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Astrocytoma Benign Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Benign Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 1/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibroma Total 1/1003(0.1%) 0/1000(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 4/1003(0.4%) 0/1000(0%) Mean(sd) 0.4%(1.4) 0.0%(0.0) Range 0/50 - 3/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 3/50 1/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1003(0.1%) 0/1000(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 1/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/1003(0.3%) 1/1000(0.1%) Mean(sd) 0.3%(1.0) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 2/1003(0.2%) 0/1000(0%) Mean(sd) 0.2%(0.9) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 0/50 0/52 2/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1003(0%) 0/1000(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1003(0.1%) 0/1000(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Basal Cell Adenoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/1004(0.1%) 2/1001(0.2%) Carcinoma or Papilloma Mean(sd) 0.1%(0.4) 0.2%(0.6) Squamous Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/1004(0.1%) 2/1001(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/50 - 1/51 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 1/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoid Tumor Benign Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/1004(0%) 1/1001(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 889/1003(88.6%) Mean(sd) 88.6%(6.0) Range 37/50 - 49/51 Males 47/50 37/50 46/52 42/50 48/50 44/50 48/51 49/51 47/50 39/49 45/50 46/50 44/50 46/50 46/50 41/50 45/50 41/50 46/50 42/50 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Sarcoma Total 0/942(0%) 0/949(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/44 - 0/44 Males 0/46 0/41 0/49 0/42 0/45 0/49 0/51 0/49 0/48 0/48 0/48 0/41 0/48 0/48 0/50 0/46 0/49 0/49 0/46 0/49 Females 0/44 0/41 0/46 0/44 0/47 0/49 0/48 0/49 0/49 0/50 0/48 0/48 0/49 0/47 0/50 0/47 0/50 0/49 0/46 0/48 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/942(0%) 1/949(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/46 - 0/46 0/44 - 1/44 Males 0/46 0/41 0/49 0/42 0/45 0/49 0/51 0/49 0/48 0/48 0/48 0/41 0/48 0/48 0/50 0/46 0/49 0/49 0/46 0/49 Females 0/44 0/41 0/46 1/44 0/47 0/49 0/48 0/49 0/49 0/50 0/48 0/48 0/49 0/47 0/50 0/47 0/50 0/49 0/46 0/48 --------------------------------------------------------------------------- Thymoma Benign Total 2/942(0.2%) 5/949(0.5%) Mean(sd) 0.2%(0.6) 0.5%(1.2) Range 0/46 - 1/48 0/41 - 2/46 Males 0/46 0/41 0/49 0/42 0/45 0/49 0/51 0/49 1/48 0/48 0/48 0/41 1/48 0/48 0/50 0/46 0/49 0/49 0/46 0/49 Females 1/44 0/41 2/46 0/44 1/47 0/49 0/48 0/49 0/49 0/50 0/48 0/48 0/49 0/47 0/50 1/47 0/50 0/49 0/46 0/48 --------------------------------------------------------------------------- Thymoma Malignant Total 2/942(0.2%) 1/949(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.4) Range 0/46 - 1/46 0/44 - 1/49 Males 0/46 0/41 0/49 0/42 0/45 0/49 0/51 0/49 0/48 0/48 0/48 0/41 0/48 0/48 0/50 1/46 0/49 1/49 0/46 0/49 Females 0/44 0/41 0/46 0/44 0/47 0/49 0/48 0/49 0/49 0/50 0/48 0/48 0/49 0/47 0/50 0/47 0/50 1/49 0/46 0/48 --------------------------------------------------------------------------- Thymoma NOS Total 0/942(0%) 0/949(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/44 - 0/44 Males 0/46 0/41 0/49 0/42 0/45 0/49 0/51 0/49 0/48 0/48 0/48 0/41 0/48 0/48 0/50 0/46 0/49 0/49 0/46 0/49 Females 0/44 0/41 0/46 0/44 0/47 0/49 0/48 0/49 0/49 0/50 0/48 0/48 0/49 0/47 0/50 0/47 0/50 0/49 0/46 0/48 --------------------------------------------------------------------------- Thymoma: Benign, Total 4/942(0.4%) 6/949(0.6%) Malignant, NOS Mean(sd) 0.4%(0.9) 0.6%(1.2) Range 0/46 - 1/46 0/41 - 2/46 Males 0/46 0/41 0/49 0/42 0/45 0/49 0/51 0/49 1/48 0/48 0/48 0/41 1/48 0/48 0/50 1/46 0/49 1/49 0/46 0/49 Females 1/44 0/41 2/46 0/44 1/47 0/49 0/48 0/49 0/49 0/50 0/48 0/48 0/49 0/47 0/50 1/47 0/50 1/49 0/46 0/48 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 0/1002(0%) 0/997(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/49 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 116/1002(11.6%) 101/997(10.1%) Mean(sd) 11.5%(5.9) 10.1%(4.0) Range 1/49 - 12/51 2/50 - 9/50 Males 3/50 2/50 6/52 10/50 1/49 5/50 12/51 7/51 8/50 6/50 7/50 4/50 4/49 5/50 9/50 3/50 10/50 7/50 2/50 5/50 Females 4/50 6/50 8/50 5/50 5/50 4/49 9/51 6/50 4/50 2/50 3/50 3/50 9/50 3/49 7/50 4/49 6/50 5/49 5/50 3/50 --------------------------------------------------------------------------- Carcinoma Total 11/1002(1.1%) 19/997(1.9%) Mean(sd) 1.1%(1.4) 1.9%(1.7) Range 0/52 - 2/50 0/50 - 2/49 Males 2/50 2/50 0/52 0/50 1/49 0/50 0/51 1/51 1/50 0/50 1/50 1/50 0/49 0/50 0/50 1/50 0/50 1/50 0/50 0/50 Females 2/50 2/50 1/50 0/50 2/50 1/49 0/51 2/50 0/50 0/50 1/50 1/50 1/50 0/49 1/50 2/49 1/50 0/49 0/50 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 127/1002(12.7%) 120/997(12%) Mean(sd) 12.7%(5.4) 12.0%(4.3) Range 2/50 - 12/51 2/50 - 10/50 Males 5/50 4/50 6/52 10/50 2/49 5/50 12/51 8/51 9/50 6/50 8/50 5/50 4/49 5/50 9/50 4/50 10/50 8/50 2/50 5/50 Females 6/50 8/50 9/50 5/50 7/50 5/49 9/51 8/50 4/50 2/50 4/50 4/50 10/50 3/49 8/50 6/49 7/50 5/49 5/50 5/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 9/1002(0.9%) 4/997(0.4%) Mean(sd) 0.9%(1.0) 0.4%(0.8) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 1/52 1/50 1/49 0/50 0/51 0/51 0/50 0/50 0/50 1/50 0/49 0/50 0/50 1/50 1/50 1/50 1/50 0/50 Females 1/50 0/50 0/50 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 1/50 0/49 1/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 12/1002(1.2%) 5/997(0.5%) Mean(sd) 1.2%(1.9) 0.5%(0.9) Range 0/50 - 3/50 0/50 - 1/50 Males 1/50 0/50 0/52 0/50 1/49 0/50 0/51 0/51 0/50 3/50 0/50 0/50 0/49 1/50 1/50 0/50 3/50 1/50 1/50 0/50 Females 0/50 0/50 1/50 0/50 0/50 0/49 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 1/50 1/49 0/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 21/1002(2.1%) 9/997(0.9%) Mean(sd) 2.1%(2.2) 0.9%(1.4) Range 0/50 - 4/50 0/50 - 2/50 Males 1/50 1/50 1/52 1/50 2/49 0/50 0/51 0/51 0/50 3/50 0/50 1/50 0/49 1/50 1/50 1/50 4/50 2/50 2/50 0/50 Females 1/50 0/50 1/50 0/50 0/50 0/49 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/49 0/50 0/49 2/50 1/49 1/50 2/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1004(0%) 2/1001(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.9) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 5/1004(0.5%) 9/1001(0.9%) Carcinoma or Papilloma Mean(sd) 0.5%(0.9) 0.9%(1.4) Squamous Range 0/50 - 1/50 0/50 - 2/50 Males 1/50 0/50 1/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 1/50 2/50 0/51 1/50 1/50 0/50 0/50 0/50 0/50 1/50 2/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 5/1004(0.5%) 7/1001(0.7%) Mean(sd) 0.5%(0.9) 0.7%(1.2) Range 0/50 - 1/50 0/50 - 2/50 Males 1/50 0/50 1/52 0/50 0/50 0/50 0/51 0/51 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 1/50 2/50 0/51 1/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adamantinoma Benign Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/1004(0%) 1/1001(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1004(0%) 2/1001(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 0/1004(0%) 0/1001(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Carcinoma Total 1/991(0.1%) 0/989(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/49 0/52 0/49 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/43 0/50 0/49 1/49 0/50 0/50 0/50 0/50 0/48 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/51 0/50 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/49 0/48 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 3/991(0.3%) 2/989(0.2%) Mean(sd) 0.3%(0.7) 0.2%(0.6) Range 0/50 - 1/48 0/50 - 1/49 Males 0/50 0/49 1/52 0/49 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/43 0/50 0/49 1/49 0/50 0/50 0/50 0/50 1/48 Females 0/50 0/50 1/49 0/49 0/50 1/50 0/51 0/50 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/49 0/48 0/50 0/49 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/991(0%) 0/989(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/49 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/43 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/48 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/51 0/50 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/49 0/48 0/50 0/49 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/991(0.1%) 0/989(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/49 0/52 0/49 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/43 1/50 0/49 0/49 0/50 0/50 0/50 0/50 0/48 Females 0/50 0/50 0/49 0/49 0/50 0/50 0/51 0/50 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/49 0/48 0/50 0/49 0/50 --------------------------------------------------------------------------- Papilloma Total 2/991(0.2%) 2/989(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/48 0/50 - 1/49 Males 0/50 0/49 1/52 0/49 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/43 0/50 0/49 0/49 0/50 0/50 0/50 0/50 1/48 Females 0/50 0/50 1/49 0/49 0/50 1/50 0/51 0/50 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/49 0/48 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 3/1001(0.3%) Mean(sd) 0.3%(1.0) Range 0/50 - 2/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 2/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 4/1001(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/51 Females 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 1/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma NOS Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/1001(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1001(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 2/1001(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 1/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 2/1001(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/50 Females 0/50 1/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 128/1001(12.8%) Mean(sd) 12.8%(7.4) Range 1/50 - 13/50 Females 1/50 9/50 13/50 4/50 9/50 6/50 6/51 5/50 13/50 12/50 1/50 5/50 5/50 2/50 4/50 10/50 2/50 8/50 7/50 6/50 --------------------------------------------------------------------------- Sarcoma Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 5/1001(0.5%) Mean(sd) 0.5%(1.1) Range 0/50 - 2/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 2/50 0/50 0/50 1/50 1/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 133/1001(13.3%) Polyp Stromal Mean(sd) 13.3%(7.4) Range 1/50 - 13/50 Females 1/50 9/50 13/50 4/50 9/50 6/50 6/51 5/50 13/50 12/50 1/50 7/50 5/50 2/50 5/50 11/50 3/50 8/50 7/50 6/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 2/1001(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1001(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Fibrosarcoma Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/1001(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Total 1/1001(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1001(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS ORAL FEED (Updated 12/99) Males(20 studies) Females(20 studies) =========================================================================== Adenoma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 9/1004(0.9%) 6/1001(0.6%) Mean(sd) 0.9%(1.2) 0.6%(1.1) Range 0/50 - 2/51 0/50 - 2/50 Males 0/50 0/50 1/52 0/50 0/50 0/50 1/51 2/51 1/50 0/50 1/50 0/50 1/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 2/50 0/50 0/50 1/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 10/1004(1%) 6/1001(0.6%) Mean(sd) 1.0%(1.4) 0.6%(1.1) Range 0/50 - 2/50 0/50 - 2/50 Males 0/50 0/50 1/52 0/50 0/50 0/50 1/51 2/51 1/50 0/50 1/50 0/50 2/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 2/50 0/50 0/50 1/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/1004(0.1%) 0/1001(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/52 0/50 0/50 0/50 0/51 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 ---------------------------------------------------------------------------