TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Benign Tumors Total 309/331(93.4%) 276/330(83.6%) Mean(sd) 93.5%(1.5) 84.1%(4.7) Range 46/50 - 48/50 39/50 - 45/50 Males 47/51 46/50 74/80 47/50 48/50 47/50 Females 45/50 43/50 63/80 43/50 43/50 39/50 --------------------------------------------------------------------------- Malignant Tumors Total 240/331(72.5%) 160/330(48.5%) Mean(sd) 72.6%(7.2) 48.6%(10.9) Range 31/51 - 40/50 16/50 - 32/50 Males 31/51 39/50 58/80 38/50 40/50 34/50 Females 16/50 27/50 38/80 32/50 26/50 21/50 --------------------------------------------------------------------------- Malignant and Benign Total 322/331(97.3%) 310/330(93.9%) Tumors Mean(sd) 97.5%(1.8) 94.2%(2.8) Range 76/80 - 50/50 45/50 - 48/50 Males 50/51 50/50 76/80 49/50 48/50 49/50 Females 48/50 48/50 73/80 48/50 48/50 45/50 --------------------------------------------------------------------------- Hemangioma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 0/331(0%) 0/330(0%) Hemangioma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 1/331(0.3%) 1/330(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/51 - 1/50 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 205/331(61.9%) 102/330(30.9%) Monocytic, Mononuclear, Mean(sd) 61.4%(7.6) 30.8%(9.9) or Undifferentiated Range 25/51 - 35/50 8/50 - 22/50 Males 25/51 35/50 54/80 30/50 32/50 29/50 Females 8/50 15/50 26/80 22/50 19/50 12/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 0/331(0%) 2/330(0.6%) Histiocytic, Mean(sd) 0.0%(0.0) 0.7%(1.0) Lymphocytic, Mixed, NOS, Range 0/51 - 0/51 0/50 - 1/50 or Undifferentiated Cell Type Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 0/50 1/50 --------------------------------------------------------------------------- Mesothelioma: Benign Total 3/331(0.9%) 0/330(0%) Mean(sd) 0.9%(1.0) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 1/50 1/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 8/331(2.4%) 1/330(0.3%) Malignant, NOS Mean(sd) 2.6%(2.1) 0.3%(0.8) Range 0/50 - 3/50 0/50 - 1/50 Males 1/51 1/50 1/80 0/50 3/50 2/50 Females 0/50 0/50 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 5/331(1.5%) 1/330(0.3%) Mean(sd) 1.7%(2.3) 0.3%(0.8) Range 0/50 - 3/50 0/50 - 1/50 Males 1/51 0/50 0/80 0/50 3/50 1/50 Females 0/50 0/50 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 3/331(0.9%) 0/330(0%) Mean(sd) 1.0%(1.1) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 1/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 3/331(0.9%) 0/330(0%) Mean(sd) 1.0%(1.1) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 1/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 3/330(0.9%) 3/329(0.9%) Mean(sd) 0.9%(1.0) 0.9%(1.0) Range 0/51 - 1/49 0/50 - 1/50 Males 0/51 1/49 1/80 1/50 0/50 0/50 Females 0/50 1/50 1/80 1/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/330(0%) 1/329(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/49 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 1/49 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Ganglioneuroma Total 0/329(0%) 0/329(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/79 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/49 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 97/329(29.5%) 23/329(7%) Mean(sd) 29.3%(9.6) 6.9%(3.7) Range 9/50 - 23/51 2/50 - 7/50 Males 23/51 11/49 24/79 9/50 13/50 17/50 Females 7/50 2/50 6/80 3/50 2/49 3/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 1/329(0.3%) 1/329(0.3%) Mean(sd) 0.2%(0.5) 0.3%(0.8) Range 0/51 - 1/79 0/50 - 1/49 Males 0/51 0/49 1/79 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 1/49 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 11/329(3.3%) 1/329(0.3%) Malignant Mean(sd) 3.4%(2.7) 0.3%(0.8) Range 0/50 - 4/50 0/50 - 1/49 Males 2/51 2/49 2/79 4/50 1/50 0/50 Females 0/50 0/50 0/80 0/50 1/49 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 106/329(32.2%) 25/329(7.6%) Benign, Complex, Mean(sd) 32.2%(9.0) 7.6%(3.4) Malignant, NOS Range 12/50 - 25/51 2/50 - 7/50 Males 25/51 13/49 25/79 12/50 14/50 17/50 Females 7/50 2/50 6/80 3/50 4/49 3/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/322(0%) 0/327(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/45 0/79 0/50 0/47 0/50 Females 0/50 0/50 0/80 0/50 0/47 0/50 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Chondroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma or Total 0/331(0%) 0/330(0%) Chondroma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/50 0/80 1/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 1/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 1/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Astrocytoma Benign Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/331(0%) 4/328(1.2%) Mean(sd) 0.0%(0.0) 1.2%(1.6) Range 0/51 - 0/51 0/48 - 2/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 1/50 1/80 0/50 0/50 2/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 1/331(0.3%) 1/328(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/51 0/48 - 1/50 Males 1/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma NOS Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/331(0%) 0/328(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/331(0%) 0/328(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/331(0%) 0/328(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/331(0%) 0/328(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 1/331(0.3%) 5/328(1.5%) Glioma, or Astrocytoma Mean(sd) 0.3%(0.8) 1.6%(2.0) Range 0/50 - 1/51 0/48 - 2/50 Males 1/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 2/50 1/80 0/50 0/50 2/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/48 - 0/48 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 17/329(5.2%) 22/321(6.9%) Mean(sd) 4.8%(2.7) 6.3%(5.0) Range 1/49 - 7/80 0/50 - 10/78 Males 3/50 1/49 7/80 2/50 1/50 3/50 Females 5/48 0/50 10/78 4/49 1/49 2/47 --------------------------------------------------------------------------- Carcinoma Total 10/329(3%) 12/321(3.7%) Mean(sd) 3.2%(3.3) 4.0%(3.3) Range 1/80 - 5/50 0/47 - 4/49 Males 1/50 1/49 1/80 1/50 1/50 5/50 Females 1/48 3/50 1/78 3/49 4/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 27/329(8.2%) 34/321(10.6%) Mean(sd) 8.0%(4.5) 10.2%(4.2) Range 2/50 - 8/50 2/47 - 7/49 Males 4/50 2/49 8/80 3/50 2/50 8/50 Females 6/48 3/50 11/78 7/49 5/49 2/47 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/329(0%) 0/321(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/48 - 0/48 Males 0/50 0/49 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/78 0/49 0/49 0/47 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/329(0%) 0/321(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/48 - 0/48 Males 0/50 0/49 0/80 0/50 0/50 0/50 Females 0/48 0/50 0/78 0/49 0/49 0/47 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibroma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/51 - 0/51 0/50 - 1/80 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 2/330(0.6%) Mean(sd) 0.0%(0.0) 0.4%(1.0) Range 0/51 - 0/51 0/50 - 2/80 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 2/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/51 - 1/80 0/50 - 0/50 Males 0/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/51 - 1/80 0/50 - 0/50 Males 0/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 1/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Melanoma NOS Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibroma Total 1/331(0.3%) 0/329(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 1/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/49 --------------------------------------------------------------------------- Schwannoma Benign Total 2/331(0.6%) 0/329(0%) Mean(sd) 0.6%(0.9) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/50 1/80 1/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/49 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/329(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/49 --------------------------------------------------------------------------- Schwannoma NOS Total 0/331(0%) 0/329(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 2/331(0.6%) 1/330(0.3%) Mean(sd) 0.6%(0.9) 0.3%(0.8) Range 0/50 - 1/51 0/50 - 1/50 Males 1/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/331(0.6%) 1/330(0.3%) Mean(sd) 0.6%(0.9) 0.3%(0.8) Range 0/50 - 1/51 0/50 - 1/50 Males 1/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/51 - 0/51 0/50 - 1/80 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 0/50 0/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/51 - 0/51 0/50 - 1/80 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 31/324(9.6%) 6/324(1.9%) Mean(sd) 10.2%(10.1) 1.7%(1.5) Range 2/79 - 15/50 0/50 - 3/80 Males 5/51 3/45 2/79 15/50 2/49 4/50 Females 0/50 0/49 3/80 1/50 1/46 1/49 --------------------------------------------------------------------------- Carcinoma Total 7/324(2.2%) 1/324(0.3%) Mean(sd) 2.3%(2.1) 0.3%(0.8) Range 0/49 - 2/45 0/50 - 1/50 Males 2/51 2/45 1/79 2/50 0/49 0/50 Females 0/50 0/49 0/80 1/50 0/46 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 38/324(11.7%) 7/324(2.2%) Mean(sd) 12.5%(11.2) 2.0%(1.7) Range 3/79 - 17/50 0/50 - 2/50 Males 7/51 5/45 3/79 17/50 2/49 4/50 Females 0/50 0/49 3/80 2/50 1/46 1/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Papilloma Total 0/327(0%) 1/324(0.3%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/51 - 0/51 0/50 - 1/46 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 1/46 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 2/327(0.6%) 0/324(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/47 0/79 1/50 0/50 1/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/327(0.6%) 0/324(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/47 0/79 1/50 0/50 1/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Lipoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Nephroblastoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Oncocytoma Benign Total 1/327(0.3%) 0/324(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/47 0/79 1/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- Stromal Nephroma Total 0/327(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/47 0/79 0/50 0/50 0/50 Females 0/50 0/48 0/80 0/50 0/46 0/50 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Cholangiocarcinoma Total 0/330(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/330(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/330(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 6/330(1.8%) 5/330(1.5%) Mean(sd) 1.9%(1.3) 1.4%(1.1) Range 0/49 - 2/51 0/50 - 2/80 Males 2/51 0/49 1/80 1/50 1/50 1/50 Females 1/50 0/50 2/80 1/50 0/50 1/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 0/330(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 0/330(0%) 0/330(0%) Carcinoma or Mean(sd) 0.0%(0.0) 0.0%(0.0) Hepatoblastoma Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 6/330(1.8%) 5/330(1.5%) Carcinoma or Mean(sd) 1.9%(1.3) 1.4%(1.1) Hepatocellular Adenoma Range 0/49 - 2/51 0/50 - 2/80 Males 2/51 0/49 1/80 1/50 1/50 1/50 Females 1/50 0/50 2/80 1/50 0/50 1/50 --------------------------------------------------------------------------- Hepatocellular Total 6/330(1.8%) 5/330(1.5%) Carcinoma, Mean(sd) 1.9%(1.3) 1.4%(1.1) Hepatocellular Adenoma, Range 0/49 - 2/51 0/50 - 2/80 or Hepatoblastoma Males 2/51 0/49 1/80 1/50 1/50 1/50 Females 1/50 0/50 2/80 1/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Alveolar/Bronchiolar Total 3/331(0.9%) 5/330(1.5%) Adenoma Mean(sd) 1.0%(1.1) 1.4%(1.1) Range 0/50 - 1/51 0/50 - 2/80 Males 1/51 0/50 0/80 1/50 0/50 1/50 Females 1/50 1/50 2/80 0/50 0/50 1/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 0/331(0%) 0/330(0%) Carcinoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 3/331(0.9%) 5/330(1.5%) Carcinoma or Mean(sd) 1.0%(1.1) 1.4%(1.1) Alveolar/Bronchiolar Range 0/50 - 1/51 0/50 - 2/80 Adenoma Males 1/51 0/50 0/80 1/50 0/50 1/50 Females 1/50 1/50 2/80 0/50 0/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Plasma Cell Tumor Total 0/331(0%) 0/330(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Plasma Cell Tumor Total 0/331(0%) 0/330(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoacanthoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Adenoma Total 1/331(0.3%) 6/330(1.8%) Mean(sd) 0.3%(0.8) 2.0%(1.8) Range 0/50 - 1/51 0/80 - 2/50 Males 1/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 1/50 0/80 2/50 0/50 2/50 --------------------------------------------------------------------------- Carcinoma Total 0/331(0%) 11/330(3.3%) Mean(sd) 0.0%(0.0) 3.7%(4.3) Range 0/51 - 0/51 0/80 - 6/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 2/50 1/50 0/80 6/50 1/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/331(0.3%) 17/330(5.2%) Mean(sd) 0.3%(0.8) 5.7%(5.6) Range 0/50 - 1/51 0/80 - 8/50 Males 1/51 0/50 0/80 0/50 0/50 0/50 Females 3/50 2/50 0/80 8/50 1/50 3/50 --------------------------------------------------------------------------- Fibroadenoma Total 22/331(6.6%) 121/330(36.7%) Mean(sd) 6.6%(4.3) 37.6%(14.6) Range 1/50 - 7/50 12/50 - 29/50 Males 2/51 2/50 6/80 1/50 7/50 4/50 Females 16/50 15/50 22/80 12/50 29/50 27/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 23/331(6.9%) 125/330(37.9%) or Adenoma Mean(sd) 6.9%(4.1) 38.9%(13.5) Range 1/50 - 7/50 22/80 - 29/50 Males 3/51 2/50 6/80 1/50 7/50 4/50 Females 17/50 16/50 22/80 14/50 29/50 27/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 23/331(6.9%) 132/330(40%) Carcinoma, or Adenoma Mean(sd) 6.9%(4.1) 41.3%(12.8) Range 1/50 - 7/50 22/80 - 30/50 Males 3/51 2/50 6/80 1/50 7/50 4/50 Females 19/50 17/50 22/80 17/50 30/50 27/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 1/50 --------------------------------------------------------------------------- Lipoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Papilloma Squamous or Total 4/331(1.2%) 3/330(0.9%) Papilloma Mean(sd) 1.3%(1.0) 1.0%(1.7) Range 0/51 - 1/50 0/50 - 2/50 Males 0/51 1/50 0/80 1/50 1/50 1/50 Females 1/50 0/50 0/80 0/50 2/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 3/330(0.9%) Mean(sd) 0.0%(0.0) 0.9%(1.6) Range 0/51 - 0/51 0/50 - 2/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 2/50 --------------------------------------------------------------------------- Squamous Cell Total 4/331(1.2%) 6/330(1.8%) Carcinoma, Papilloma Mean(sd) 1.3%(1.0) 1.9%(1.8) Squamous, or Papilloma Range 0/51 - 1/50 0/50 - 2/50 Males 0/51 1/50 0/80 1/50 1/50 1/50 Females 1/50 0/50 1/80 0/50 2/50 2/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 3/330(0.9%) Mean(sd) 0.0%(0.0) 0.9%(1.6) Range 0/51 - 0/51 0/50 - 2/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 2/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 1/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/329(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/329(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/329(0.3%) Benign Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/49 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/329(0.3%) Malignant Mean(sd) 0.2%(0.5) Range 0/50 - 1/80 Females 0/50 0/49 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 2/329(0.6%) Benign, Malignant, NOS Mean(sd) 0.6%(0.9) Range 0/50 - 1/50 Females 0/50 0/49 1/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 1/329(0.3%) Benign Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/49 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/329(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 0/329(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/329(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/329(0%) Tumor, Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/329(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 13/323(4%) 2/325(0.6%) Mean(sd) 4.4%(3.0) 0.6%(0.9) Range 0/79 - 4/51 0/50 - 1/49 Males 4/51 3/45 0/79 3/50 1/48 2/50 Females 0/50 1/49 1/80 0/50 0/47 0/49 --------------------------------------------------------------------------- Carcinoma Total 1/323(0.3%) 0/325(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/51 - 1/45 0/50 - 0/50 Males 0/51 1/45 0/79 0/50 0/48 0/50 Females 0/50 0/49 0/80 0/50 0/47 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 14/323(4.3%) 2/325(0.6%) Mean(sd) 4.8%(3.4) 0.6%(0.9) Range 0/79 - 4/45 0/50 - 1/49 Males 4/51 4/45 0/79 3/50 1/48 2/50 Females 0/50 1/49 1/80 0/50 0/47 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/323(0%) 0/325(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/45 0/79 0/50 0/48 0/50 Females 0/50 0/49 0/80 0/50 0/47 0/49 --------------------------------------------------------------------------- Mixed Tumor Benign Total 0/323(0%) 0/325(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/45 0/79 0/50 0/48 0/50 Females 0/50 0/49 0/80 0/50 0/47 0/49 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 4/323(1.2%) 0/316(0%) Mean(sd) 0.9%(2.1) 0.0%(0.0) Range 0/50 - 4/77 0/49 - 0/49 Males 0/50 0/48 4/77 0/50 0/48 0/50 Females 0/49 0/43 0/79 0/47 0/50 0/48 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Paraganglioma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/331(0%) 0/330(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 1/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 120/325(36.9%) 171/326(52.5%) Mean(sd) 38.9%(16.4) 53.7%(12.2) Range 15/80 - 33/49 18/49 - 33/50 Males 20/50 21/48 15/80 33/49 15/48 16/50 Females 33/50 29/48 32/80 30/50 29/49 18/49 --------------------------------------------------------------------------- Carcinoma Total 2/325(0.6%) 6/326(1.8%) Mean(sd) 0.7%(1.1) 2.1%(3.2) Range 0/50 - 1/48 0/50 - 4/48 Males 0/50 1/48 0/80 1/49 0/48 0/50 Females 0/50 4/48 0/80 1/50 1/49 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 121/325(37.2%) 177/326(54.3%) Mean(sd) 39.2%(16.5) 55.8%(13.8) Range 15/80 - 33/49 18/49 - 33/48 Males 20/50 22/48 15/80 33/49 15/48 16/50 Females 33/50 33/48 32/80 31/50 30/49 18/49 --------------------------------------------------------------------------- Craniopharyngioma Total 0/325(0%) 0/326(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/48 0/80 0/49 0/48 0/50 Females 0/50 0/48 0/80 0/50 0/49 0/49 --------------------------------------------------------------------------- Ganglioneuroma Total 0/325(0%) 0/326(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/48 0/80 0/49 0/48 0/50 Females 0/50 0/48 0/80 0/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/325(0.3%) 1/326(0.3%) Mean(sd) 0.3%(0.8) 0.3%(0.8) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/48 0/80 0/49 0/48 1/50 Females 0/50 0/48 0/80 1/50 0/49 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/325(0%) 1/326(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/48 0/80 0/49 0/48 0/50 Females 0/50 0/48 1/80 0/50 0/49 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/325(0.3%) 2/326(0.6%) Mean(sd) 0.3%(0.8) 0.6%(0.9) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/48 0/80 0/49 0/48 1/50 Females 0/50 0/48 1/80 1/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/325(0%) 0/326(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/48 0/80 0/49 0/48 0/50 Females 0/50 0/48 0/80 0/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/328(0.3%) Mean(sd) 0.3%(0.8) Range 0/51 - 1/50 Males 0/51 0/48 0/79 0/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/51 - 0/51 Males 0/51 0/48 0/79 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/328(0.3%) Mean(sd) 0.3%(0.8) Range 0/51 - 1/50 Males 0/51 0/48 0/79 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/49 - 0/49 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/49 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/49 - 0/49 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/49 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/49 - 0/49 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/49 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/49 - 0/49 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/49 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) Mean(sd) 0.0%(0.0) Range 0/51 - 0/51 Males 0/51 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/331(0%) 2/330(0.6%) Mean(sd) 0.0%(0.0) 0.7%(1.0) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 1/50 0/80 0/50 0/50 1/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/331(0%) 0/330(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Basal Cell Adenoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/51 - 1/80 0/50 - 0/50 Males 0/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 1/331(0.3%) 0/330(0%) Basosquamous Tumor Mean(sd) 0.2%(0.5) 0.0%(0.0) Benign Range 0/51 - 1/80 0/50 - 0/50 Males 0/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 2/331(0.6%) 1/330(0.3%) Basosquamous Tumor Mean(sd) 0.6%(0.9) 0.2%(0.5) Benign, or Range 0/51 - 1/50 0/50 - 1/80 Trichoepithelioma Males 0/51 1/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 2/331(0.6%) 0/330(0%) Mean(sd) 0.7%(1.0) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 1/50 0/80 0/50 1/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 2/331(0.6%) 0/330(0%) or Basosquamous Tumor Mean(sd) 0.7%(1.0) 0.0%(0.0) (malignant or NOS) Range 0/51 - 1/50 0/50 - 0/50 Males 0/51 1/50 0/80 0/50 1/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 4/331(1.2%) 1/330(0.3%) Basal Cell Adenoma, Mean(sd) 1.2%(1.6) 0.2%(0.5) Basosquamous Tumor Range 0/51 - 2/50 0/50 - 1/80 (benign, malignant or NOS), or Trichoepithelioma Males 0/51 2/50 1/80 0/50 1/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 33/331(10%) 5/330(1.5%) Carcinoma, Carcinoma, Mean(sd) 9.6%(4.4) 1.6%(1.5) Basosq. Tumor (M or B), Range 3/50 - 8/50 0/50 - 2/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 5/51 3/50 11/80 3/50 3/50 8/50 Females 1/50 2/50 1/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/331(0%) 0/330(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/331(0%) 0/330(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 21/331(6.3%) 0/330(0%) Mean(sd) 5.9%(4.9) 0.0%(0.0) Range 0/50 - 6/50 0/50 - 0/50 Males 3/51 1/50 9/80 0/50 2/50 6/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 4/331(1.2%) 0/330(0%) Mean(sd) 1.2%(1.0) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 1/51 1/50 1/80 0/50 0/50 1/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/331(0.3%) 2/330(0.6%) Mean(sd) 0.3%(0.8) 0.7%(1.0) Range 0/50 - 1/51 0/80 - 1/50 Males 1/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 3/331(0.9%) 2/330(0.6%) Carcinoma, Basal Cell Mean(sd) 1.0%(1.1) 0.7%(1.0) Carcinoma, Basosquamous Range 0/80 - 1/51 0/80 - 1/50 Tumor (malignant or NOS), or Carcinoma Males 1/51 1/50 0/80 0/50 1/50 0/50 Females 1/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 9/331(2.7%) 2/330(0.6%) Mean(sd) 2.9%(3.3) 0.7%(1.0) Range 0/50 - 4/50 0/50 - 1/50 Males 1/51 0/50 1/80 3/50 0/50 4/50 Females 0/50 1/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 9/331(2.7%) 2/330(0.6%) Papilloma or Papilloma Mean(sd) 2.9%(3.3) 0.7%(1.0) Range 0/50 - 4/50 0/50 - 1/50 Males 1/51 0/50 1/80 3/50 0/50 4/50 Females 0/50 1/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 29/331(8.8%) 4/330(1.2%) Papilloma, Papilloma, Mean(sd) 8.4%(5.3) 1.3%(1.6) Squamous Cell Carcinoma Range 1/50 - 8/50 0/80 - 2/50 or Keratoacanthoma Males 5/51 1/50 10/80 3/50 2/50 8/50 Females 1/50 2/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 28/331(8.5%) 2/330(0.6%) Papilloma, Papilloma, or Mean(sd) 8.1%(5.3) 0.7%(1.0) Keratoacanthoma Range 1/50 - 8/50 0/50 - 1/50 Males 4/51 1/50 10/80 3/50 2/50 8/50 Females 0/50 1/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 1/331(0.3%) 1/330(0.3%) Mean(sd) 0.3%(0.8) 0.2%(0.5) Range 0/51 - 1/50 0/50 - 1/80 Males 0/51 1/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibroma Total 8/331(2.4%) 7/330(2.1%) Mean(sd) 2.7%(3.5) 2.3%(3.2) Range 0/51 - 4/50 0/80 - 4/50 Males 0/51 0/50 0/80 1/50 3/50 4/50 Females 2/50 4/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 14/331(4.2%) 13/330(3.9%) Sarcoma, Myxoma, Mean(sd) 4.6%(3.1) 4.3%(4.5) Myxosarcoma, or Fibrous Range 1/80 - 4/50 0/80 - 6/50 Histiocytoma Males 1/51 1/50 1/80 3/50 4/50 4/50 Females 3/50 6/50 0/80 2/50 2/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 5/331(1.5%) 4/330(1.2%) Mean(sd) 1.6%(1.5) 1.3%(1.6) Range 0/50 - 2/50 0/80 - 2/50 Males 1/51 1/50 1/80 2/50 0/50 0/50 Females 1/50 1/50 0/80 2/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 6/331(1.8%) 6/330(1.8%) Myxosarcoma, or Fibrous Mean(sd) 1.9%(1.3) 2.0%(1.8) Histiocytoma Range 0/50 - 2/50 0/80 - 2/50 Males 1/51 1/50 1/80 2/50 1/50 0/50 Females 1/50 2/50 0/80 2/50 1/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma or Total 0/331(0%) 0/330(0%) Schwannoma benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/331(0%) 0/330(0%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.0%(0.0) NOS) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/331(0%) 0/330(0%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.0%(0.0) Schwannoma (benign, Range 0/51 - 0/51 0/50 - 0/50 malignant or NOS) Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/331(0.3%) 2/330(0.6%) Mean(sd) 0.3%(0.8) 0.7%(1.0) Range 0/51 - 1/50 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 1/50 0/50 Females 0/50 1/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Astrocytoma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/51 - 1/80 0/50 - 0/50 Males 0/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibroma Total 0/328(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/328(0.3%) 0/330(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/51 - 1/79 0/50 - 0/50 Males 0/51 0/49 1/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/328(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/328(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/328(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/328(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/328(0.3%) 0/330(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/49 0/50 - 0/50 Males 0/51 1/49 0/79 0/50 0/50 0/49 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Basal Cell Adenoma Total 1/331(0.3%) 0/330(0%) Mean(sd) 0.2%(0.5) 0.0%(0.0) Range 0/51 - 1/80 0/50 - 0/50 Males 0/51 0/50 1/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/331(0%) 1/330(0.3%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.3%(0.8) Squamous Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 1/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoid Tumor Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/331(0%) 0/330(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 264/329(80.2%) Mean(sd) 79.6%(11.0) Range 33/51 - 46/50 Males 33/51 39/49 70/80 34/50 46/50 42/49 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Sarcoma Total 0/303(0%) 0/309(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/44 0/69 0/45 0/49 0/50 Females 0/49 0/44 0/70 0/48 0/48 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/303(0%) 0/309(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/44 0/69 0/45 0/49 0/50 Females 0/49 0/44 0/70 0/48 0/48 0/50 --------------------------------------------------------------------------- Thymoma Benign Total 1/303(0.3%) 1/309(0.3%) Mean(sd) 0.4%(0.9) 0.2%(0.6) Range 0/46 - 1/45 0/49 - 1/70 Males 0/46 0/44 0/69 1/45 0/49 0/50 Females 0/49 0/44 1/70 0/48 0/48 0/50 --------------------------------------------------------------------------- Thymoma Malignant Total 0/303(0%) 0/309(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/44 0/69 0/45 0/49 0/50 Females 0/49 0/44 0/70 0/48 0/48 0/50 --------------------------------------------------------------------------- Thymoma NOS Total 0/303(0%) 0/309(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/49 - 0/49 Males 0/46 0/44 0/69 0/45 0/49 0/50 Females 0/49 0/44 0/70 0/48 0/48 0/50 --------------------------------------------------------------------------- Thymoma: Benign, Total 1/303(0.3%) 1/309(0.3%) Malignant, NOS Mean(sd) 0.4%(0.9) 0.2%(0.6) Range 0/46 - 1/45 0/49 - 1/70 Males 0/46 0/44 0/69 1/45 0/49 0/50 Females 0/49 0/44 1/70 0/48 0/48 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/330(0%) 0/329(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/49 0/80 0/50 0/50 0/50 Females 0/50 0/49 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 36/330(10.9%) 34/329(10.3%) Mean(sd) 10.3%(4.5) 9.8%(4.7) Range 2/50 - 14/80 2/50 - 13/80 Males 6/51 5/49 14/80 4/50 5/50 2/50 Females 4/50 5/49 13/80 7/50 2/50 3/50 --------------------------------------------------------------------------- Carcinoma Total 3/330(0.9%) 4/329(1.2%) Mean(sd) 0.9%(1.0) 1.2%(1.0) Range 0/49 - 1/51 0/50 - 1/50 Males 1/51 0/49 1/80 1/50 0/50 0/50 Females 1/50 1/49 1/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 39/330(11.8%) 37/329(11.2%) Mean(sd) 11.1%(4.9) 10.6%(5.3) Range 2/50 - 15/80 2/50 - 14/80 Males 7/51 5/49 15/80 5/50 5/50 2/50 Females 5/50 5/49 14/80 8/50 2/50 3/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 4/330(1.2%) 5/329(1.5%) Mean(sd) 1.3%(1.6) 1.7%(2.3) Range 0/51 - 2/50 0/80 - 3/50 Males 0/51 1/49 0/80 2/50 1/50 0/50 Females 3/50 1/49 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 3/330(0.9%) 3/329(0.9%) Mean(sd) 0.9%(1.6) 0.8%(1.2) Range 0/51 - 2/50 0/50 - 2/80 Males 0/51 0/49 1/80 2/50 0/50 0/50 Females 0/50 0/49 2/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/330(2.1%) 8/329(2.4%) Mean(sd) 2.2%(3.0) 2.4%(2.3) Range 0/51 - 4/50 0/50 - 3/50 Males 0/51 1/49 1/80 4/50 1/50 0/50 Females 3/50 1/49 2/80 2/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 1/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/331(0.3%) 3/330(0.9%) Carcinoma or Papilloma Mean(sd) 0.3%(0.8) 1.0%(1.7) Squamous Range 0/51 - 1/50 0/50 - 2/50 Males 0/51 0/50 0/80 1/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 2/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/331(0.3%) 3/330(0.9%) Mean(sd) 0.3%(0.8) 1.0%(1.7) Range 0/51 - 1/50 0/50 - 2/50 Males 0/51 0/50 0/80 1/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 2/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adamantinoma Benign Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/320(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/42 0/79 0/50 0/48 0/50 Females 0/50 0/45 0/80 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 0/320(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/42 0/79 0/50 0/48 0/50 Females 0/50 0/45 0/80 0/50 0/49 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/320(0.3%) 0/324(0%) Mean(sd) 0.4%(1.0) 0.0%(0.0) Range 0/51 - 1/42 0/50 - 0/50 Males 0/51 1/42 0/79 0/50 0/48 0/50 Females 0/50 0/45 0/80 0/50 0/49 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/320(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/42 0/79 0/50 0/48 0/50 Females 0/50 0/45 0/80 0/50 0/49 0/50 --------------------------------------------------------------------------- Papilloma Total 0/320(0%) 0/324(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/42 0/79 0/50 0/48 0/50 Females 0/50 0/45 0/80 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/330(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma NOS Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/330(0.3%) Mean(sd) 0.2%(0.5) Range 0/50 - 1/80 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/330(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/330(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/80 1/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 57/330(17.3%) Mean(sd) 17.5%(6.4) Range 4/50 - 13/50 Females 10/50 13/50 12/80 11/50 7/50 4/50 --------------------------------------------------------------------------- Sarcoma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 1/330(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/80 0/50 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 58/330(17.6%) Polyp Stromal Mean(sd) 17.8%(5.9) Range 5/50 - 13/50 Females 10/50 13/50 12/80 11/50 7/50 5/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 1/330(0.3%) Mean(sd) 0.2%(0.5) Range 0/50 - 1/80 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/330(0.3%) Mean(sd) 0.2%(0.5) Range 0/50 - 1/80 Females 0/50 0/50 1/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/330(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 1/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/330(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/331(0%) 1/330(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/51 - 0/51 0/50 - 1/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 1/50 0/50 0/80 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 6/331(1.8%) 4/330(1.2%) Mean(sd) 1.6%(1.4) 1.2%(1.6) Range 0/50 - 3/80 0/50 - 2/50 Males 1/51 0/50 3/80 0/50 1/50 1/50 Females 0/50 1/50 1/80 2/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 6/331(1.8%) 5/330(1.5%) Mean(sd) 1.6%(1.4) 1.6%(1.5) Range 0/50 - 3/80 0/50 - 2/50 Males 1/51 0/50 3/80 0/50 1/50 1/50 Females 1/50 1/50 1/80 2/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/331(0%) 0/330(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/51 - 0/51 0/50 - 0/50 Males 0/51 0/50 0/80 0/50 0/50 0/50 Females 0/50 0/50 0/80 0/50 0/50 0/50 ---------------------------------------------------------------------------