September 3-5, 2014
William H. Natcher Conference Center
National Institutes of Health
Bethesda, Maryland, USA
Workshop report: Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. 2016. Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report [published online ahead of print 22 Jan 2016]. Regulatory Toxicology & Pharmacology.
Read article summarizing the workshop in NIEHS Environmental Factor newsletter (October 2014)
The traditional model of toxicology testing, which involves treating animals with test substances and observing outcomes, may not be sufficient to serve future scientific and regulatory needs. The science of toxicology is turning towards a new model based on a better understanding of toxicity mechanisms, which will enable prediction of toxic effects in humans.
A key element of a mechanistic understanding of a specific toxicity is the construction of an adverse outcome pathway for that toxicity. An adverse outcome pathway is a conceptual framework constructed from existing knowledge that relates exposure of a type of toxic substance to subsequent molecular and cellular changes that result in illness or injury to an individual or population.
Effective communication between researchers and regulators is a critical determinant of whether new methods or approaches are efficiently translated from the scientific bench to regulatory decision-making practice. This workshop brought together over 100 scientists from industry, academia, U.S. and international regulatory agencies, and animal welfare groups to explore how scientific progress in adverse outcome pathway concepts can improve regulatory assessment of chemical toxicity.