National Toxicology Program

National Toxicology Program

ICCVAM Annual and Biennial Reports

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The ICCVAM Authorization Act of 2000 directed ICCVAM to prepare a progress report on its first anniversary and biennially thereafter. The most recent report was published in June 2012 and covers the period from January 2010 to December 2011.

Cover of ICCVAM 2010-2011 Biennial
ReportView ICCVAM 2010-2011 Biennial Report (NIH Publication Number 12-7873)
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View the ICCVAM Authorization Act of 2000

During 2010 and 2011, NICEATM, ICCVAM, and ICCVAM member agencies contributed to the national and international endorsement and adoption of 14 new and updated alternative safety testing methods. Since ICCVAM was established, NICEATM, ICCVAM, and the ICCVAM member agencies have contributed to the regulatory acceptance of over 50 alternative methods to protect the health of people, animals, and the environment while reducing, refining, and replacing animal use.

Selected highlights from the report include:

  • On behalf of NICEATM and ICCVAM, NIEHS signed an agreement to add the Republic of Korea to the International Cooperation on Alternative Test Methods (ICATM). ICATM was established in 2009 by the United States, the European Union, Japan, and Canada to expedite the worldwide validation and regulatory acceptance of improved alternative test methods.

  • The Organisation for Economic Co-operation and Development (OECD) adopted an international guidance document prepared by NICEATM and ICCVAM that describes two in vitro test methods to reduce animal use to identify potentially poisonous substances. NICEATM led the international validation studies for the two in vitro test methods, which can reduce animal use by up to 50% for each test.

  • Federal agencies and the OECD adopted several new versions and applications of the murine local lymph node assay (LLNA), an alternative method recommended by ICCVAM to assess whether substances may cause allergic contact dermatitis. The recommendations reduce animal use for each test by 20-40% and support expanded use of the LLNA for nearly all testing situations. Two new “green” versions of the LLNA were adopted that do not require radioactive reagents and will allow laboratories worldwide to take advantage of animal welfare benefits provided by the LLNA.

  • Federal agencies adopted ICCVAM-recommended alternative test methods and procedures that will further reduce, refine, and replace animal use for eye safety testing. These include the routine use of medications to avoid pain and distress when it is necessary to use animals for required safety testing, and the first in vitro test method that can be used in a “bottom-up” approach to identify substances that are not considered eye hazards.

  • NICEATM, ICCVAM, and their ICATM partners convened the first international workshop on alternative methods for human and veterinary vaccine potency and safety testing. The workshop recommended priority research needed to develop improved and more efficient test methods that can also reduce, refine, and replace animal use. A focused workshop on human and veterinary rabies vaccine test methods was held in 2011, and additional focused workshops are planned for 2012 and 2013.

  • ICCVAM completed an international evaluation of an in vitro test method proposed as a screening test to identify substances with potential endocrine activity. The test method uses engineered human cells to identify substances that induce or inhibit activation of the human estrogen receptor. Use of this test method may reduce the number of animals necessary for endocrine disruptor screening.

  • NICEATM and ICCVAM convened two workshops on Best Practices for Regulatory Safety Testing to promote the use of improved and more efficient test methods that can also reduce, refine, and replace animal use. Participants learned how to select and use approved alternative methods to assess the safety or potential hazards of chemicals and products.

Past ICCVAM Reports

View ICCVAM 2008-2009 Biennial Report (NIH Publication Number 10-7612)

View ICCVAM 2006-2007 Biennial Report (NIH Publication Number 08-6529)

View ICCVAM 2004-2005 Biennial Report (NIH Publication Number 06-4516)

View ICCVAM Biennial Report (December 2003: NIH Publication Number 04-4509)

View ICCVAM Annual Progress Report (December 2001)

The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.