The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) is a permanent committee of the NIEHS under the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). ICCVAM is composed of representatives from 15 U.S. Federal regulatory and research agencies that require, use, generate, or disseminate toxicological and safety testing information.
ICCVAM was formally established in 2000 by the ICCVAM Authorization Act (42 U.S.C. 285l-3)
"To establish, wherever feasible, guidelines, recommendations, and regulations that promote the regulatory acceptance of new or revised scientifically valid toxicological tests that protect human and animal health and the environment while reducing, refining, or replacing animal tests and ensuring human safety and product effectiveness."
The ICCVAM Authorization Act defines the purposes of ICCVAM as follows:
ICCVAM functions in part by:
ICCVAM relies on stakeholders to carry out alternative test method research, development, and validation studies. ICCVAM's stakeholders include:
ICCVAM facilitates international collaboration on the development of alternative test methods through its membership in the International Cooperation on Alternative Test Methods and ICCVAM agency participation in the Test Guidelines Programme of the Organisation for Economic Co-operation and Development.
ICCVAM receives advice from the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM), a standing NTP advisory committee. SACATM members include stakeholders from regulated industries, animal protection organizations, academia, U.S. state or international regulatory bodies, and companies or organizations that develop, market, or use test methods.