A January 2014 "Alternative Test Method Validation and Regulatory Acceptance Status Report" includes a comprehensive listing of test method evaluation activities undertaken by the partner organizations of the International Cooperation on Alternative Test Methods (ICATM). It also includes high-level summaries of ongoing validation studies and the status of peer reviews and harmonized recommendations. The report was prepared on behalf of ICATM by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), for the International Cooperation on Cosmetics Regulation.
The framework for ICATM was developed through a collaboration involving ICCVAM, the EURL ECVAM, the Japanese Center for the Validation of Alternative Methods (JaCVAM), and Health Canada. The goals of this framework are:
The purpose of the framework is to promote consistent and enhanced voluntary international cooperation, collaboration, and communication among national validation organizations in order to:
The framework addresses three critical areas of cooperation: validation studies, independent peer review of the validation of test methods, and the development of formal test method recommendations on alternative testing methods.
An updated Memorandum of Cooperation (MOC) to add the Korean Center for the Validation of Alternative Methods (KoCVAM) to the ICATM agreement was signed in March 2011.
ICCVAM is an interagency committee of the U.S. government that coordinates technical reviews of alternative test methods and cross-agency activities relating to validation, acceptance, and harmonization of test methods.
EURL ECVAM is a unit within the Institute of Health and Consumer Protection in the European Union’s Joint Research Centre. EURL ECVAM coordinates the validation of alternative test methods at the European Union level.
JaCVAM is part of the Japanese National Institute of Health Sciences, for which it coordinates the evaluation of alternative test methods.
Health Canada’s Environmental Health Science and Research Bureau coordinates the evaluation of alternative test methods in Canada.
Health Canada is a permanent member of the Canadian Council on Animal Care, which oversees the ethical use of animals in science in Canada.
KoCVAM coordinates the evaluation of alternative test methods in South Korea. KoCVAM is part of the National Institute of Food and Drug Safety Evaluation of the South Korean Food and Drug Administration.