The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), on behalf of the Organisation for Economic Co-operation and Development (OECD) Validation Management Group—Non-Animal (VMG-NA) expert working group, requests the nomination of reference chemicals. Appropriate chemicals with supporting data will be used to validate in vitro metabolizing systems with the potential to interact with estrogen or androgen receptors. Specifically, chemicals are needed to characterize the usefulness and limitations of in vitro metabolizing systems for use in conjunction with estrogen receptor and androgen receptor transactivation assays.
Please submit data via email to NICEATM by June 2, 2014. You may use this Microsoft Excel form or submit data as Microsoft Word documents. Those submitting information should include name, affiliation, mailing address, phone, fax, email address, and sponsoring organization (if any) with the submission (columns A and B in Excel form). Name and Chemical Abstracts Service registry number (if available) should be specified for each chemical (columns D and E of Excel form).
Considerations for selection of appropriate chemicals include the ability of a chemical to interact with the estrogen receptor or androgen receptor (column F in Excel form) as an agonist or antagonist (column G in Excel form). Additional considerations (specify in columns H, I, and J in Excel form as appropriate) include:
Relevant references from the published literature will be very helpful (provide information on these in columns K and L of Excel form). However, data from past or ongoing validation studies, data in databases, or unpublished data is also welcomed.