National Toxicology Program

National Toxicology Program

ICCVAM Mission and Vision

A New Vision and Direction for ICCVAM

In early 2013, NIEHS and NTP announced a plan to make significant changes to the focus and priorities of both NICEATM and ICCVAM (see editorial by NIEHS and NTP Director Linda Birnbaum, Environmental Health Perspectives, February 2013). These changes will better align ICCVAM and NICEATM with the vision laid out by the National Academy of Sciences in the 2007 National Research Council report Toxicity Testing in the 21st Century: A Vision and a Strategy.

ICCVAM welcomed the opportunity to work with NICEATM to forge a new direction forward, and developed a document describing the initial steps towards this goal. The document discussed:

  • ICCVAM priority setting and scientific areas for immediate resource investment
  • Plans to improve communications with stakeholders and the public
  • Exploration of new paradigms for validation and utilization of alternative toxicological methods

In addition, ICCVAM stated the intent of member agencies to take a more active role in priority setting and operations of the Committee and to devote more effort to fewer focus areas.

ICCVAM made “A New Vision and Direction for ICCVAM” available in draft form for comment in September 2013. Attendees at that month’s meeting of the Scientific Advisory Committee on Alternative Toxicological Methods discussed the document and proposed initial steps.


ICCVAM's mission is to facilitate development, validation, and regulatory acceptance of new and revised regulatory test methods that reduce, refine, and replace the use of animals in testing while maintaining and promoting scientific quality and the protection of human health, animal health, and the environment.


ICCVAM's goal is to

  • Be recognized as a leading authority on test method development and validation both within the federal government and internationally

  • Play a leading role in:
    • Promoting high quality science as the basis of national and international regulatory policy
    • Setting and harmonizing international standards for scientific validation of test methods
    • Promoting and facilitating the development of priority alternative test methods
    • Identifying key alternative test methods and strategies and facilitating their validation and acceptance
    • Fostering humane and ethical approaches to testing that replace, reduce, and refine the use of animals
    • Promoting awareness and adoption of scientifically validated test methods by regulatory agencies both nationally and internationally

  • Develop internal and collaborative capacity to:
    • Ensure the scientific quality and integrity of its work
    • Implement reliable processes and operating procedures that are credible, effective and efficient
    • Build national and international partnerships with governmental and non-governmental groups, including academia, industry, advocacy groups, and other key stakeholders
    • Secure the necessary human and financial resources to effectively carry out its mission
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.