Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants (March 2005)
Addendum to the Expert Panel Report (November 2005)
ICCVAM convened an expert panel meeting on January 11-12, 2005 to consider four in vitro test methods proposed as potential screening methods for ocular corrosion or severe irritation:
NICEATM organized the 24-member international panel in collaboration with the ICCVAM and the European Centre for the Validation of Alternative Methods (now known as the European Union Reference Laboratory for Alternatives to Animal Testing). The panel was convened in response to a request by the U.S. Environmental Protection Agency for ICCVAM to evaluate the usefulness and limitations of in vitro ocular safety testing methods. The panel's conclusions and recommendations are contained in the Expert Panel Report published in March 2005.
The Panel reconvened for a teleconference in September 2005 to consider additional data and information. An Addendum to the Expert Panel Report, covering discussions at the September 2005 teleconference, was published in November 2005.
ICCVAM and its Ocular Toxicity Working Group considered the Expert Panel Report and Addendum, as well as public comments and comments of its scientific advisory committee, in developing final recommendations on the four test methods.