National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/40221

Presentations at 2011 Society of Toxicology Meeting

Society of Toxicology - 50th Annual Meeting
March 6-10, 2011 - Washington, DC, USA


Platform Presentations

Session: The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools

NICEATM Director Dr. William Stokes and retired ICCVAM Chair Dr. Marilyn Wind were Co-chairs of the session.

ICATM: Translating Science to Provide Improved Public Health Safety Assessment Tools
RADM William Stokes, D.V.M., National Institute of Environmental Health Sciences

NICEATM and ICCVAM: Recent ICATM Contributions and Future Plans
Marilyn Wind, Ph.D., U.S. Consumer Product Safety Commission (retired)

ECVAM: Recent Contributions to ICATM and REACH and Future Plans
Joachim Kreysa, Ph.D., European Centre for the Validation of Alternative Methods, EU Institute for Health and Consumer Protection

JaCVAM: Recent ICATM Contributions and Future Plans
Hajime Kojima, Ph.D., Japanese Center for the Validation of Alternative Methods, Japanese National Institute for Health Sciences

Health Canada’s Role in ICATM
Michael Inskip, Environmental Health Science Research Bureau, Health Canada

KoCVAM: Recent Progress and Future Plans
Soon Young Han, Ph.D., Korean Center for the Validation of Alternative Methods, Korean National Institute of Food and Drug Safety Evaluation


Poster Presentations

Please note: PDFs of poster presentations are large files and may take a few minutes to open.

Session: Alternatives to Mammalian Models for Testing

Abstract Number: 1016
Title: International Validation Study of an In Vitro Cell Proliferation Test Method for Screening Potential Estrogenic Agonists and Antagonists in MCF-7 Cells
Authors: F. Deal; W. Casey; P. Ceger; D. Allen; C. Yang; M. Nakamura; H. Kojima; A. Ono; H. Yoon; S. Han; W. Stokes
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Abstract Number: 1017
Title: Final Results of an International Validation Study of an In Vitro ER TA Test Method in BG-1 Cells
Authors: W. Casey; P. Ceger; F. Deal; D. Allen; G. Clark; P. Pazos; E. Grignard; J. de Lange; S. Bremer; M. Nakamura; H. Kojima; W. Stokes View Abstract
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Please note: Two graphs originally presented on this poster illustrated generalized curves of agonist and antagonist responses, but were not actual examples of curves generated during the validation study. These figures have been replaced with graphs of data produced during the BG1Luc validation study.

Session: Risk Assessment and Regulatory Policy Applications

Abstract Number: 1518
Title: ICCVAM Evaluation and Recommendations on the Nonradioactive LLNA: BrdU-ELISA for Evaluating Allergic Contact Dermatitis Hazards
Authors: A. Jacobs; J. Matheson; M. Wind; V. Malshet; J. Toy; W. Stokes
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Abstract Number: 1519
Title: ICCVAM Evaluation of the Local Lymph Node Assay (LLNA) for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans
Authors: P. Brown; J. Matheson; A. Jacobs; T. McMahon; D. Germolec; M. Wind; W. Stokes
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Abstract Number: 1520
Title: ICCVAM Evaluation and Recommendations on the Nonradioactive LLNA: DA for Evaluating Allergic Contact Dermatitis Hazards
Authors: J. Matheson; A. Jacobs; M. Wind; P. Brown; R. Ward; E. Margosches; W. Stokes
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Abstract Number: 1521
Title: Using Fewer Animals to Identify Chemical Eye Hazards: Revised Classification Criteria Necessary to Maintain Equivalent Hazard Labeling
Authors: W. Stokes; J. Haseman; E. Lipscomb; J. Truax; N. Johnson; B. Jones; D. Allen
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Session: Safety and Risk Assessment: Critical Characterizations for Chemicals and New Concerns

Abstract Number: 1553
Title: ICCVAM Recommendations on the Usefulness and Limitations of the Cytosensor® Microphysiometer (CM) Test Method For Ocular Safety Testing
Authors: J. Merrill; D. Lowther; A. Layton; J. Redden; M. Wind; W. Stokes
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Session: Disease Prevention

Abstract Number: 2581
Title: International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing
Authors: J. Kulpa-Eddy; R. McFarland; R. Isbrucker; M. Halder; H. Kojima; B. Jones; N. Johnson; D. Allen; E. Lipscomb; S. Morefield; W. Casey; W. Stokes
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