National Toxicology Program

National Toxicology Program

Alternative Methods for Acute Inhalation Toxicity

NICEATM is collaborating with the PETA International Science Consortium (PISC), the U.S. Environmental Protection Agency (EPA), and industry scientists to support a workgroup focused on inhalation toxicity. The workgroup met February 24-25, 2015, at EPA in Washington to define specifications for development and evaluation of an in vitro system to assess inhalation toxicity of multiwalled carbon nanotubes. Recommendations included designing a system that would include different lung cells co-cultured at an air-liquid interface and that would consider relevant human dosimetry and nanomaterial lifecycle transformations. These recommendations were central to a subsequent request for proposals issued by PISC for funding to develop an appropriate testing system; funding was awarded in September 2015.

This activity followed a NICEATM request for information (79 FR 35176, June 19, 2014) on devices and/or technologies currently used for identifying potential inhalation hazards.

View responses to this request

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.