National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/41625

Alternative Methods for Acute Inhalation Toxicity

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NICEATM requests available data and information on devices and/or technologies currently used for identifying potential inhalation hazards. Submitted information will be used to assess the state of the science and determine the technical needs for a dynamic nonanimal system to assess the potential toxicity of inhaled chemicals or nanomaterials. Submit data, information, and comments to NICEATM. Responses should include submitter’s name, affiliation or sponsoring organization, and contact information (mailing address, telephone, email).

Background

NICEATM fosters the evaluation and promotion of alternative test methods for regulatory use in acute toxicity assessment. These efforts to date have focused primarily on toxicity testing for assessing potential hazards via the oral and dermal routes with limited efforts directed to identifying alternatives for assessing inhalation toxicity.

Therefore, NICEATM is interested in receiving information on the state of the science regarding alternative test methods and testing strategies for acute inhalation toxicity. Submitted information will be used to determine the technical requirements for developing effective inhalation toxicity tools to assess potential chemical or nanomaterial hazards without using animals.

Request for Data or Information on Relevant Activities

NICEATM requests that respondents provide information on any activities relevant to the development and/or validation of alternatives to in vivo inhalation toxicity test methods currently required by regulatory agencies. This could include submission of substance-specific data derived from nonanimal tests to identify acute inhalation hazard potential. If available, corresponding in vivo data for these substances are also requested, including data from any ethical human or animal studies or accidental human exposures.

The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.