National Toxicology Program

National Toxicology Program

Alternative Methods for Acute Inhalation Toxicity

NICEATM is collaborating with the PETA International Science Consortium, the U.S. Environmental Protection Agency, and industry scientists to organize a workgroup focused on inhalation toxicity. Specifically, the workgroup will review the state of the science and determine technical needs for the development of a dynamic flow co-culture system to reduce or replace the use of animals for assessing the toxicity of inhaled nanomaterials. This activity follows a NICEATM request for information (79 FR 35176, June 19, 2014) on devices and/or technologies currently used for identifying potential inhalation hazards.

View responses to this request


NICEATM fosters the evaluation and promotion of alternative test methods for regulatory use in acute toxicity assessment. These efforts have focused primarily on toxicity testing for assessing potential hazards via the oral and dermal routes. NICEATM is broadening its focus to include identifying alternatives for assessing inhalation toxicity.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.