NICEATM and the PETA International Science Consortium (PISC) are presenting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. During the webinar series, participants will (1) review the regulatory guidelines to define when and how acute systemic toxicity data are used for assessing inhalation toxicity hazard potential; (2) review existing alternative approaches for identifying chemicals likely to cause acute systemic toxicity via inhalation, which could include mechanism-based models, in vitro and in silico approaches; and (3) identify mechanisms of acute toxicity that may constitute key events in adverse outcome pathways for acute inhalation toxicity. The webinar series steering committee is comprised of members from government and nongovernment stakeholder organizations including NICEATM, PISC, The Dow Chemical Company, Simulations Plus, Inc., the Netherlands Organisation for Applied Scientific Research, and the U.S. Environmental Protection Agency.
NICEATM is collaborating with PISC, the U.S. Environmental Protection Agency (EPA), and industry scientists to support a workgroup focused on inhalation toxicity. The workgroup met February 24-25, 2015, at EPA in Washington to define specifications for development and evaluation of an in vitro system to assess inhalation toxicity of multiwalled carbon nanotubes. Recommendations included designing a system that would include different lung cells co-cultured at an air-liquid interface and that would consider relevant human dosimetry and nanomaterial lifecycle transformations. These recommendations were central to a subsequent request for proposals issued by PISC for funding to develop an appropriate testing system; funding was awarded in September 2015.
This activity followed a NICEATM request for information (79 FR 35176, June 19, 2014) on devices and/or technologies currently used for identifying potential inhalation hazards.