Complete report (1.1 MB, 159 pages)
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Please Note: A correction has been made to the document regarding the details for one of the the performance standards reference substances. This correction affects the content of Appendices E and F. If you have a hard copy of this document (NIH Publication No. 09-7357), please be aware of these revisions.
Correction to Performance Standards document (August 2010)Main Body Text
Appendix A: ICCVAM-Recommended Test Method Protocol (Updated 2008): The Murine Local Lymph Node Assay
Appendix B: Evaluating the Impact of Reducing the Sample Size from Five to Four Animals per Group on the Performance of the Ratio Rule of SI > 3 in LLNA Testing
Appendix C: Essential Test Method Components and Other Validation Considerations for the Murine Local Lymph Node Assay
Appendix D: Timeline for Development of the ICCVAM Murine Local Lymph Node Assay Performance Standards
Appendix E: Supporting Documents: Development of the ICCVAM LLNA Performance Standards
Appendix F: ICCVAM LLNA Performance Standards: Recommended Reference Substances