National Toxicology Program

National Toxicology Program

Webinar on Lessons Learned in Application of the OHAT Framework for Systematic Review and Evidence Integration to Case Studies

July 31, 2014, 12:30 - 3:30 PM EDT, Webinar

The NTP plans to hold a public webinar, “Lessons Learned in Application of the OHAT Framework for Systematic Review and Evidence Integration to Case Studies.” The OHAT has developed a systematic review framework, the OHAT Approach, to address environmental health questions by extending approaches developed for clinical medicine to address the greater range of data relevant to environmental health sciences (e.g., human, animal, and mechanistic studies) (available at the OHAT Implementation of Systematic Review page). The OHAT adapted guidance from authorities on systematic-review and sought advice during development of the OHAT Approach through consultation with technical experts in systematic review and human health assessment as well as scientific advisory groups and the public.

The approach includes seven steps that provide a framework for incorporating systematic review and evidence integration into NTP literature-based, non-cancer health assessments. The framework, released as the Draft OHAT Approach in February 2013 and published in April 2014, was assessed and refined through application of the procedures to case-study evaluations. OHAT applied the approach to two case studies: (1) an evaluation of the association of bisphenol A (BPA) exposure with obesity and (2) an evaluation of the association of perflurooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) exposure with immunotoxicity.

The purpose of this webinar is to present lessons learned during the case-study process. The meeting will be conducted in a presentation and discussion format. The first part of the webinar will consist of a series of topic or “lesson” focused presentations, followed by a short question-and-answer period. The second part of the webinar will be a general discussion period when the public can make brief comments on or ask questions about the application of the OHAT Approach to the case studies and lessons learned.

Federal Register Notice


Registration for Webinar:

Registration for the webinar is required and is open from June 17, 2014 through July 28, 2014. Registrants will receive instructions by email on accessing the webinar on or before July 28, 2014. Registrants are encouraged to access this website to stay abreast of current information about this event.

Public Participation:

As noted above, the meeting format includes time after each lesson-presentation and during the general discussion session for the public to ask questions or make brief remarks. Individuals with disabilities who need accommodations to participate in this event should contact Dr. Andrew Rooney.

For further information see the OHAT Implementation of Systematic Review page

Contact Information for meeting:

Andrew A. Rooney, Ph.D.
Deputy Director, OHAT
P.O. Box 12233, Mail Drop K2-04
Research Triangle Park, NC 27709

Phone: (919) 541-2999
eFax: (301) 480-3299

Note: Individuals with disabilities who need accommodation must request it at least five business days prior to the meeting. TTY users should contact the Federal TTY Relay Service at 800-877-8339. Otherwise, contact Dr. Rooney for assistance.

The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.